The sex of an individual is determined by the sex chromosomes contributed by the sperm and egg, with the sperm determining whether an X or Y chromosome is donated. Thomas Morgan studied sex-linked inheritance in fruit flies and discovered that eye color was located on the X chromosome. Some traits are located on the sex chromosomes and their inheritance depends on the parent's sex. Many known sex-linked traits are X-linked due to the X chromosome's larger size. Examples of sex-linked disorders include hemophilia, color blindness, and Duchenne muscular dystrophy.
The document discusses the human genome and genetic disorders. It defines what a genome is and describes human chromosomes. It explains different types of genetic disorders including recessive, dominant, sex-linked, and chromosomal disorders. As examples, it discusses disorders like phenylketonuria (PKU), cystic fibrosis, sickle cell anemia, color blindness, and Down syndrome. It also describes chromosomal abnormalities that can occur like trisomies and monosomies.
The document discusses sex determination and sex-linked inheritance and disorders. It explains that sex is determined by the sex chromosomes contributed by the sperm and egg, with females typically providing an X chromosome and males providing either an X or Y chromosome. It describes how some traits are located on the sex chromosomes and are thus sex-linked in their inheritance. Examples of sex-linked traits and disorders are provided, such as hemophilia and color blindness, with males being at greater risk for sex-linked recessive disorders. Punnett squares and pedigrees are discussed as tools for predicting sex-linked inheritance patterns.
Human heredity is determined by chromosomes and genes. There are 22 pairs of autosomes and one pair of sex chromosomes, which are either XX in females or XY in males. Genes located on the sex chromosomes, including the X chromosome, can be inherited in sex-linked patterns. Pedigree analysis is used to study inheritance patterns by examining traits over multiple generations in families. Autosomal traits can be inherited dominantly, recessively, or multifactorial based on environmental influences. Examples are provided of several genetic disorders and their modes of inheritance.
There are several classes of hereditary diseases:
1) Diseases of simple genetic architecture are caused by a single gene and follow recognizable patterns of inheritance. They are usually rare.
2) Diseases of complex genetic architecture do not have clear patterns of inheritance and are influenced by multiple genes and the environment. They are more common.
3) Genetic disorders can be caused by abnormalities in chromosomes, single genes, or a combination of genetic and environmental factors. They result in conditions like cystic fibrosis, sickle cell anemia, muscular dystrophy, and Down syndrome. Changes in chromosome number, structure, or sex chromosomes can also cause genetic disorders.
This document summarizes key aspects of heredity and prenatal development. It discusses how chromosomes and genes influence traits and development. It describes genetic abnormalities like Down syndrome and sex-linked disorders. Prenatal testing methods like amniocentesis and ultrasound are outlined. Factors impacting fertility and conception chances are noted. The three stages of prenatal development - germinal, embryonic, and fetal - are briefly defined.
This document provides an overview of several human genetic disorders, including descriptions of their symptoms and inheritance patterns. Autosomal recessive disorders discussed include cystic fibrosis, galactosemia, and phenylketonuria. Autosomal dominant disorders include breast cancer, colon cancer, and Huntington's disease. Nondisjunction disorders cause aneuploidy and include Down syndrome, Patau syndrome, and Edwards syndrome. Other sections cover sex-linked disorders like Turner syndrome and Klinefelter syndrome, as well as fragile X syndrome, metabolic disorders, teratogens, genomic imprinting disorders like Prader-Willi and Angelman's syndromes, and rare conditions such as progeria. Throughout, the document provides statistics
Human genetics and heredity can now be studied with greater understanding thanks to advances like the Human Genome Project. The project mapped all human DNA which contains around 31,000 genes packed into the 46 chromosomes in every human cell. This has led to insights into inherited traits and diseases, new genetic tests, and holds promise for gene therapy to treat conditions. However, the power of genetic knowledge also raises ethical issues society must address around manipulating the human genome.
The sex of an individual is determined by the sex chromosomes contributed by the sperm and egg, with the sperm determining whether an X or Y chromosome is donated. Thomas Morgan studied sex-linked inheritance in fruit flies and discovered that eye color was located on the X chromosome. Some traits are located on the sex chromosomes and their inheritance depends on the parent's sex. Many known sex-linked traits are X-linked due to the X chromosome's larger size. Examples of sex-linked disorders include hemophilia, color blindness, and Duchenne muscular dystrophy.
The document discusses the human genome and genetic disorders. It defines what a genome is and describes human chromosomes. It explains different types of genetic disorders including recessive, dominant, sex-linked, and chromosomal disorders. As examples, it discusses disorders like phenylketonuria (PKU), cystic fibrosis, sickle cell anemia, color blindness, and Down syndrome. It also describes chromosomal abnormalities that can occur like trisomies and monosomies.
The document discusses sex determination and sex-linked inheritance and disorders. It explains that sex is determined by the sex chromosomes contributed by the sperm and egg, with females typically providing an X chromosome and males providing either an X or Y chromosome. It describes how some traits are located on the sex chromosomes and are thus sex-linked in their inheritance. Examples of sex-linked traits and disorders are provided, such as hemophilia and color blindness, with males being at greater risk for sex-linked recessive disorders. Punnett squares and pedigrees are discussed as tools for predicting sex-linked inheritance patterns.
Human heredity is determined by chromosomes and genes. There are 22 pairs of autosomes and one pair of sex chromosomes, which are either XX in females or XY in males. Genes located on the sex chromosomes, including the X chromosome, can be inherited in sex-linked patterns. Pedigree analysis is used to study inheritance patterns by examining traits over multiple generations in families. Autosomal traits can be inherited dominantly, recessively, or multifactorial based on environmental influences. Examples are provided of several genetic disorders and their modes of inheritance.
There are several classes of hereditary diseases:
1) Diseases of simple genetic architecture are caused by a single gene and follow recognizable patterns of inheritance. They are usually rare.
2) Diseases of complex genetic architecture do not have clear patterns of inheritance and are influenced by multiple genes and the environment. They are more common.
3) Genetic disorders can be caused by abnormalities in chromosomes, single genes, or a combination of genetic and environmental factors. They result in conditions like cystic fibrosis, sickle cell anemia, muscular dystrophy, and Down syndrome. Changes in chromosome number, structure, or sex chromosomes can also cause genetic disorders.
This document summarizes key aspects of heredity and prenatal development. It discusses how chromosomes and genes influence traits and development. It describes genetic abnormalities like Down syndrome and sex-linked disorders. Prenatal testing methods like amniocentesis and ultrasound are outlined. Factors impacting fertility and conception chances are noted. The three stages of prenatal development - germinal, embryonic, and fetal - are briefly defined.
This document provides an overview of several human genetic disorders, including descriptions of their symptoms and inheritance patterns. Autosomal recessive disorders discussed include cystic fibrosis, galactosemia, and phenylketonuria. Autosomal dominant disorders include breast cancer, colon cancer, and Huntington's disease. Nondisjunction disorders cause aneuploidy and include Down syndrome, Patau syndrome, and Edwards syndrome. Other sections cover sex-linked disorders like Turner syndrome and Klinefelter syndrome, as well as fragile X syndrome, metabolic disorders, teratogens, genomic imprinting disorders like Prader-Willi and Angelman's syndromes, and rare conditions such as progeria. Throughout, the document provides statistics
Human genetics and heredity can now be studied with greater understanding thanks to advances like the Human Genome Project. The project mapped all human DNA which contains around 31,000 genes packed into the 46 chromosomes in every human cell. This has led to insights into inherited traits and diseases, new genetic tests, and holds promise for gene therapy to treat conditions. However, the power of genetic knowledge also raises ethical issues society must address around manipulating the human genome.
Chromosomes contain genes and determine inheritance patterns. During meiosis, chromosome pairs segregate and assort independently. Sex chromosomes determine biological sex - females are XX and males are XY. X-linked traits affect males more due to hemizygosity. Nondisjunction can result in chromosomal abnormalities like Down syndrome. Structural changes like inversions, translocations, deletions and duplications also impact inheritance. Linkage maps gene position and crossover frequency. Different modes of inheritance exist like autosomal dominant, recessive, and X-linked traits.
This document discusses chromosomal inheritance and genetics. It covers Mendel's laws of segregation and independent assortment. It describes sex chromosomes and sex linkage. Examples of sex-linked traits like hemophilia and color blindness are provided. Nondisjunction, examples like Down Syndrome, and structural changes in chromosomes like inversions and translocations are defined. Finally, it discusses modes of inheritance including autosomal dominant, autosomal recessive, sex-linked dominant, and sex-linked recessive traits.
Chromosomal abnormalities can cause genetic disorders by changing the number or structure of chromosomes. Some abnormalities are caused by changes in the number of sex chromosomes, such as Turner syndrome (XO) in females which causes short stature and infertility. Klinefelter syndrome (XXY) in males results in breast development and infertility. Fragile X syndrome, the most common inherited cause of intellectual disability, is caused by a trinucleotide repeat expansion in the FMR1 gene on the X chromosome.
Sex-linked genes exhibit unique patterns of inheritance depending on the sex chromosome system of the species. In humans, females have two X chromosomes and males have one X and one Y chromosome. The Y chromosome contains the SRY gene which triggers male development. Females serve as the default sex since they only need one X chromosome to develop, while males require specific signaling to develop as males. Abnormal chromosome numbers, called aneuploidies, can cause conditions like Down syndrome, Klinefelter syndrome, and Turner syndrome. Chromosomal mutations such as deletions, inversions, duplications, and translocations can also cause genetic disorders and occur during meiosis. Genomic imprinting and mitochondrial DNA inheritance are exceptions to
Based on the information provided, here are my responses:
- The inheritance pattern shown in this pedigree is autosomal recessive. Cystic fibrosis is caused by mutations in the CFTR gene and follows an autosomal recessive pattern of inheritance.
- III-1 is likely a carrier (heterozygous for a CF mutation). His wife is unlikely a carrier.
- III-2 and II-3 are also likely carriers since they each had an affected child but are unaffected themselves.
- The odds that IV-5 would have an affected son is 25% since each parent is a carrier. There is a 50% chance they would pass on a CF mutation to each child and a 25% chance both would
This document discusses genetic disorders caused by abnormalities in human chromosomes. It begins by describing karyotyping and the banding patterns used to identify chromosomes. It then describes several types of numerical chromosome abnormalities including aneuploidy, where there is an extra or missing chromosome, and polyploidy, where there are extra sets of chromosomes. Structural abnormalities are also outlined, such as deletions, duplications, inversions, translocations, and ring chromosomes. Specific genetic disorders are then examined in more detail, including Down syndrome caused by trisomy 21, Edward's syndrome from trisomy 18, and Patau's syndrome involving trisomy 13. Sex chromosome disorders like Klinefelter syndrome (XXY
Mutations are changes in DNA that may occur in somatic or germ cells. Most mutations are neutral, but some can be harmful, causing diseases like cancer, or beneficial by improving survival. Mutations can involve chromosomes, such as deletions, inversions, duplications, or translocations, or genes through point mutations, insertions, deletions, or frameshifts. Examples of diseases caused by mutations include Down syndrome from chromosome nondisjunction, sickle cell anemia from a single nucleotide substitution, and cystic fibrosis from a three base pair deletion.
This document summarizes several genetic mutations and diseases. It discusses examples of animal mutations like one-eyed kittens. It then covers several human genetic diseases caused by mutations, including hypertrichosis (werewolf syndrome), harlequin ichthyosis affecting skin growth, Down syndrome, Turner syndrome, Klinefelter syndrome, cystic fibrosis, sickle cell anemia, color blindness, albinism, achondroplasia (dwarfism), and hairy ears. It provides links for further research on genetic disorders and assigning a blog post on a selected syndrome.
The document discusses human genetics and chromosomal disorders. It describes how genomes contain genetic information, and the human genome contains 23 pairs of chromosomes including 22 autosomal chromosome pairs and one pair of sex chromosomes. It explains recessive and dominant disorders such as phenylketonuria (PKU), cystic fibrosis, dwarfism, and Huntington's disease. It also discusses sex-linked disorders including red-green color blindness, hemophilia, and Duchenne muscular dystrophy. Finally, it summarizes chromosomal disorders caused by nondisjunction, including Down syndrome, Turner syndrome, and Klinefelter syndrome.
This document discusses several topics related to human genetics and inheritance:
- Single gene traits in humans like widow's peak and dimples are controlled by dominant and recessive alleles.
- Blood type is determined by multiple alleles at a single gene locus.
- Height and skin color are polygenic traits controlled by multiple genes interacting together.
- A person's environment can also influence their traits, such as diet and medical care affecting height.
- Sex is determined by the X and Y chromosomes, with females having XX and males having XY.
This document discusses human genetics and genetic disorders. It explains that genes located on chromosomes control human traits and can cause disorders if mutated or in an abnormal number. Some examples of genetic disorders mentioned are cystic fibrosis caused by a recessive gene mutation, sickle cell anemia caused by a codominant allele, and Down syndrome caused by an extra 21st chromosome. Pedigrees and karyotypes are tools that can be used to study genetics and identify genetic disorders in families.
X-linked recessive traits are inherited in a pattern where females can be carriers but typically do not exhibit symptoms, while males with a single copy of the recessive gene will exhibit the trait. Examples of X-linked recessive conditions discussed in the document include red-green color blindness and hemophilia A. Color blindness affects approximately 1 in 12 men and results in the inability to distinguish between certain colors, while hemophilia A is a bleeding disorder caused by a lack of clotting factor VIII. Other genetic conditions discussed include Down syndrome, Turner syndrome, and Klinefelter syndrome.
This document provides information on various human genetic disorders including their symptoms, causes, populations affected, and available treatments. Some of the genetic disorders discussed include Down syndrome, sickle cell anemia, cystic fibrosis, phenylketonuria, albinism, Marfan syndrome, Klinefelter syndrome, and Turner syndrome. The causes include chromosomal abnormalities, single gene mutations, and multifactorial inheritance patterns. Treatments range from managing symptoms to dietary modifications to gene or stem cell therapies.
Types of chromosomes and special forms of chromosomesdhanamram
This document discusses different types of chromosomes, including autosomes, allosomes, giant chromosomes, and various chromosomal abnormalities. It describes:
- The 44 autosomes that contain non-sex genetic information in humans. Common abnormalities like Down syndrome involve irregularities with autosome 21.
- The two allosomes (sex chromosomes) in humans - XX in females and XY in males. Conditions like Turner syndrome, Triple X syndrome, and Klinefelter syndrome involve atypical sex chromosome combinations.
- Giant chromosomes called polytene chromosomes and lampbrush chromosomes that are found in certain tissues of some organisms and have unique structures.
1. Humans have 23 pairs of chromosomes, including one pair of sex chromosomes that determine gender (XX for females and XY for males).
2. A karyotype is created by photographing chromosomes during cell division and pairing them to identify any abnormalities.
3. Pedigrees are family trees that show genetic traits and can help genetic counselors understand genotypes within a family.
4. There are four main human blood types (A, B, AB, and O) determined by the presence or absence of antigens on red blood cells, and a person's blood type affects their ability to donate and receive blood.
This document discusses genetic disorders and mutations. It covers several key topics: types of genetic disorders like single gene, chromosomal, and multifactorial disorders; different types of mutations like point mutations, deletions, and repeats; patterns of inheritance like autosomal dominant, recessive, and sex-linked; specific genetic disorders and the genes/chromosomes involved; and techniques for studying chromosomes like karyotyping, FISH, and spectral karyotyping. Common chromosomal disorders discussed include Down syndrome, Klinefelter syndrome, and Turner syndrome. The document provides an overview of genetic concepts, disorders, and terminology.
Genetic disorders can result from mutations in DNA, including single gene mutations, chromosomal abnormalities, and multifactorial inheritance. Single gene mutations can be caused by changes like deletions, insertions, repeats, and point mutations that interfere with protein synthesis. These mutations can be passed through autosomal dominant, autosomal recessive, or sex-linked inheritance patterns. Common genetic disorders include cystic fibrosis, sickle cell anemia, Tay-Sachs disease, and disorders caused by errors in lysosomal storage like Gaucher disease. Chromosomal abnormalities like Down syndrome, Klinefelter syndrome, and Turner syndrome result from errors in chromosome number or structure during cell division.
The document discusses human genetics and genetic disorders. It provides information on normal human karyotypes, sex determination, and inheritance patterns of genetic diseases. Key points include that humans normally have 22 pairs of autosomes and 1 pair of sex chromosomes, with females being 46 XX and males 46 XY. Genetic diseases can be hereditary, familial, or congenital. The Lyon hypothesis states that in females, one X chromosome is randomly inactivated in each cell. Examples of genetic disorders discussed include Down syndrome, Turner syndrome, Klinefelter syndrome, and various lysosomal storage diseases.
The document defines chromosomal aberrations as any deviation in the number or structure of chromosomes. It describes two main types: structural aberrations like deletions and translocations, and numerical aberrations involving gains or losses of whole chromosomes. Several conditions are discussed, including Turner syndrome, Klinefelter syndrome, and various trisomies. The phenotypes and karyotypes of each condition are summarized.
Chromosomes contain genes and determine inheritance patterns. During meiosis, chromosome pairs segregate and assort independently. Sex chromosomes determine biological sex - females are XX and males are XY. X-linked traits affect males more due to hemizygosity. Nondisjunction can result in chromosomal abnormalities like Down syndrome. Structural changes like inversions, translocations, deletions and duplications also impact inheritance. Linkage maps gene position and crossover frequency. Different modes of inheritance exist like autosomal dominant, recessive, and X-linked traits.
This document discusses chromosomal inheritance and genetics. It covers Mendel's laws of segregation and independent assortment. It describes sex chromosomes and sex linkage. Examples of sex-linked traits like hemophilia and color blindness are provided. Nondisjunction, examples like Down Syndrome, and structural changes in chromosomes like inversions and translocations are defined. Finally, it discusses modes of inheritance including autosomal dominant, autosomal recessive, sex-linked dominant, and sex-linked recessive traits.
Chromosomal abnormalities can cause genetic disorders by changing the number or structure of chromosomes. Some abnormalities are caused by changes in the number of sex chromosomes, such as Turner syndrome (XO) in females which causes short stature and infertility. Klinefelter syndrome (XXY) in males results in breast development and infertility. Fragile X syndrome, the most common inherited cause of intellectual disability, is caused by a trinucleotide repeat expansion in the FMR1 gene on the X chromosome.
Sex-linked genes exhibit unique patterns of inheritance depending on the sex chromosome system of the species. In humans, females have two X chromosomes and males have one X and one Y chromosome. The Y chromosome contains the SRY gene which triggers male development. Females serve as the default sex since they only need one X chromosome to develop, while males require specific signaling to develop as males. Abnormal chromosome numbers, called aneuploidies, can cause conditions like Down syndrome, Klinefelter syndrome, and Turner syndrome. Chromosomal mutations such as deletions, inversions, duplications, and translocations can also cause genetic disorders and occur during meiosis. Genomic imprinting and mitochondrial DNA inheritance are exceptions to
Based on the information provided, here are my responses:
- The inheritance pattern shown in this pedigree is autosomal recessive. Cystic fibrosis is caused by mutations in the CFTR gene and follows an autosomal recessive pattern of inheritance.
- III-1 is likely a carrier (heterozygous for a CF mutation). His wife is unlikely a carrier.
- III-2 and II-3 are also likely carriers since they each had an affected child but are unaffected themselves.
- The odds that IV-5 would have an affected son is 25% since each parent is a carrier. There is a 50% chance they would pass on a CF mutation to each child and a 25% chance both would
This document discusses genetic disorders caused by abnormalities in human chromosomes. It begins by describing karyotyping and the banding patterns used to identify chromosomes. It then describes several types of numerical chromosome abnormalities including aneuploidy, where there is an extra or missing chromosome, and polyploidy, where there are extra sets of chromosomes. Structural abnormalities are also outlined, such as deletions, duplications, inversions, translocations, and ring chromosomes. Specific genetic disorders are then examined in more detail, including Down syndrome caused by trisomy 21, Edward's syndrome from trisomy 18, and Patau's syndrome involving trisomy 13. Sex chromosome disorders like Klinefelter syndrome (XXY
Mutations are changes in DNA that may occur in somatic or germ cells. Most mutations are neutral, but some can be harmful, causing diseases like cancer, or beneficial by improving survival. Mutations can involve chromosomes, such as deletions, inversions, duplications, or translocations, or genes through point mutations, insertions, deletions, or frameshifts. Examples of diseases caused by mutations include Down syndrome from chromosome nondisjunction, sickle cell anemia from a single nucleotide substitution, and cystic fibrosis from a three base pair deletion.
This document summarizes several genetic mutations and diseases. It discusses examples of animal mutations like one-eyed kittens. It then covers several human genetic diseases caused by mutations, including hypertrichosis (werewolf syndrome), harlequin ichthyosis affecting skin growth, Down syndrome, Turner syndrome, Klinefelter syndrome, cystic fibrosis, sickle cell anemia, color blindness, albinism, achondroplasia (dwarfism), and hairy ears. It provides links for further research on genetic disorders and assigning a blog post on a selected syndrome.
The document discusses human genetics and chromosomal disorders. It describes how genomes contain genetic information, and the human genome contains 23 pairs of chromosomes including 22 autosomal chromosome pairs and one pair of sex chromosomes. It explains recessive and dominant disorders such as phenylketonuria (PKU), cystic fibrosis, dwarfism, and Huntington's disease. It also discusses sex-linked disorders including red-green color blindness, hemophilia, and Duchenne muscular dystrophy. Finally, it summarizes chromosomal disorders caused by nondisjunction, including Down syndrome, Turner syndrome, and Klinefelter syndrome.
This document discusses several topics related to human genetics and inheritance:
- Single gene traits in humans like widow's peak and dimples are controlled by dominant and recessive alleles.
- Blood type is determined by multiple alleles at a single gene locus.
- Height and skin color are polygenic traits controlled by multiple genes interacting together.
- A person's environment can also influence their traits, such as diet and medical care affecting height.
- Sex is determined by the X and Y chromosomes, with females having XX and males having XY.
This document discusses human genetics and genetic disorders. It explains that genes located on chromosomes control human traits and can cause disorders if mutated or in an abnormal number. Some examples of genetic disorders mentioned are cystic fibrosis caused by a recessive gene mutation, sickle cell anemia caused by a codominant allele, and Down syndrome caused by an extra 21st chromosome. Pedigrees and karyotypes are tools that can be used to study genetics and identify genetic disorders in families.
X-linked recessive traits are inherited in a pattern where females can be carriers but typically do not exhibit symptoms, while males with a single copy of the recessive gene will exhibit the trait. Examples of X-linked recessive conditions discussed in the document include red-green color blindness and hemophilia A. Color blindness affects approximately 1 in 12 men and results in the inability to distinguish between certain colors, while hemophilia A is a bleeding disorder caused by a lack of clotting factor VIII. Other genetic conditions discussed include Down syndrome, Turner syndrome, and Klinefelter syndrome.
This document provides information on various human genetic disorders including their symptoms, causes, populations affected, and available treatments. Some of the genetic disorders discussed include Down syndrome, sickle cell anemia, cystic fibrosis, phenylketonuria, albinism, Marfan syndrome, Klinefelter syndrome, and Turner syndrome. The causes include chromosomal abnormalities, single gene mutations, and multifactorial inheritance patterns. Treatments range from managing symptoms to dietary modifications to gene or stem cell therapies.
Types of chromosomes and special forms of chromosomesdhanamram
This document discusses different types of chromosomes, including autosomes, allosomes, giant chromosomes, and various chromosomal abnormalities. It describes:
- The 44 autosomes that contain non-sex genetic information in humans. Common abnormalities like Down syndrome involve irregularities with autosome 21.
- The two allosomes (sex chromosomes) in humans - XX in females and XY in males. Conditions like Turner syndrome, Triple X syndrome, and Klinefelter syndrome involve atypical sex chromosome combinations.
- Giant chromosomes called polytene chromosomes and lampbrush chromosomes that are found in certain tissues of some organisms and have unique structures.
1. Humans have 23 pairs of chromosomes, including one pair of sex chromosomes that determine gender (XX for females and XY for males).
2. A karyotype is created by photographing chromosomes during cell division and pairing them to identify any abnormalities.
3. Pedigrees are family trees that show genetic traits and can help genetic counselors understand genotypes within a family.
4. There are four main human blood types (A, B, AB, and O) determined by the presence or absence of antigens on red blood cells, and a person's blood type affects their ability to donate and receive blood.
This document discusses genetic disorders and mutations. It covers several key topics: types of genetic disorders like single gene, chromosomal, and multifactorial disorders; different types of mutations like point mutations, deletions, and repeats; patterns of inheritance like autosomal dominant, recessive, and sex-linked; specific genetic disorders and the genes/chromosomes involved; and techniques for studying chromosomes like karyotyping, FISH, and spectral karyotyping. Common chromosomal disorders discussed include Down syndrome, Klinefelter syndrome, and Turner syndrome. The document provides an overview of genetic concepts, disorders, and terminology.
Genetic disorders can result from mutations in DNA, including single gene mutations, chromosomal abnormalities, and multifactorial inheritance. Single gene mutations can be caused by changes like deletions, insertions, repeats, and point mutations that interfere with protein synthesis. These mutations can be passed through autosomal dominant, autosomal recessive, or sex-linked inheritance patterns. Common genetic disorders include cystic fibrosis, sickle cell anemia, Tay-Sachs disease, and disorders caused by errors in lysosomal storage like Gaucher disease. Chromosomal abnormalities like Down syndrome, Klinefelter syndrome, and Turner syndrome result from errors in chromosome number or structure during cell division.
The document discusses human genetics and genetic disorders. It provides information on normal human karyotypes, sex determination, and inheritance patterns of genetic diseases. Key points include that humans normally have 22 pairs of autosomes and 1 pair of sex chromosomes, with females being 46 XX and males 46 XY. Genetic diseases can be hereditary, familial, or congenital. The Lyon hypothesis states that in females, one X chromosome is randomly inactivated in each cell. Examples of genetic disorders discussed include Down syndrome, Turner syndrome, Klinefelter syndrome, and various lysosomal storage diseases.
The document defines chromosomal aberrations as any deviation in the number or structure of chromosomes. It describes two main types: structural aberrations like deletions and translocations, and numerical aberrations involving gains or losses of whole chromosomes. Several conditions are discussed, including Turner syndrome, Klinefelter syndrome, and various trisomies. The phenotypes and karyotypes of each condition are summarized.
Similar to Sex linked inheritance and pedigree analysis.ppt (20)
This document provides an overview of wound healing, its functions, stages, mechanisms, factors affecting it, and complications.
A wound is a break in the integrity of the skin or tissues, which may be associated with disruption of the structure and function.
Healing is the body’s response to injury in an attempt to restore normal structure and functions.
Healing can occur in two ways: Regeneration and Repair
There are 4 phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This document also describes the mechanism of wound healing. Factors that affect healing include infection, uncontrolled diabetes, poor nutrition, age, anemia, the presence of foreign bodies, etc.
Complications of wound healing like infection, hyperpigmentation of scar, contractures, and keloid formation.
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.pptHenry Hollis
The History of NZ 1870-1900.
Making of a Nation.
From the NZ Wars to Liberals,
Richard Seddon, George Grey,
Social Laboratory, New Zealand,
Confiscations, Kotahitanga, Kingitanga, Parliament, Suffrage, Repudiation, Economic Change, Agriculture, Gold Mining, Timber, Flax, Sheep, Dairying,
🔥🔥🔥🔥🔥🔥🔥🔥🔥
إضغ بين إيديكم من أقوى الملازم التي صممتها
ملزمة تشريح الجهاز الهيكلي (نظري 3)
💀💀💀💀💀💀💀💀💀💀
تتميز هذهِ الملزمة بعِدة مُميزات :
1- مُترجمة ترجمة تُناسب جميع المستويات
2- تحتوي على 78 رسم توضيحي لكل كلمة موجودة بالملزمة (لكل كلمة !!!!)
#فهم_ماكو_درخ
3- دقة الكتابة والصور عالية جداً جداً جداً
4- هُنالك بعض المعلومات تم توضيحها بشكل تفصيلي جداً (تُعتبر لدى الطالب أو الطالبة بإنها معلومات مُبهمة ومع ذلك تم توضيح هذهِ المعلومات المُبهمة بشكل تفصيلي جداً
5- الملزمة تشرح نفسها ب نفسها بس تكلك تعال اقراني
6- تحتوي الملزمة في اول سلايد على خارطة تتضمن جميع تفرُعات معلومات الجهاز الهيكلي المذكورة في هذهِ الملزمة
واخيراً هذهِ الملزمة حلالٌ عليكم وإتمنى منكم إن تدعولي بالخير والصحة والعافية فقط
كل التوفيق زملائي وزميلاتي ، زميلكم محمد الذهبي 💊💊
🔥🔥🔥🔥🔥🔥🔥🔥🔥
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
Chapter wise All Notes of First year Basic Civil Engineering.pptxDenish Jangid
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
A Visual Guide to 1 Samuel | A Tale of Two HeartsSteve Thomason
These slides walk through the story of 1 Samuel. Samuel is the last judge of Israel. The people reject God and want a king. Saul is anointed as the first king, but he is not a good king. David, the shepherd boy is anointed and Saul is envious of him. David shows honor while Saul continues to self destruct.
This presentation was provided by Rebecca Benner, Ph.D., of the American Society of Anesthesiologists, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
2. Wait…. What?????
• What’s a “mosaic”?
• Remember the FLUID
MOSAIC MODEL????
– The Plasma Membrane
– P.S. What is a Plasma Membrane?
• An individual (organism, artwork, organelle)
made up of smaller, different ”pieces”…
• So, in a way, WE ARE MOSAICS, too!
4. Why????
• Because a cat’s fur color is linked to two different
alleles on the “X” chromosome
• And…For a cat to have more than two colors…
• It must have TWO X CHROMOSOMES!
6. Sex-Linked Inheritance
• Remember, Females have XX and Males are XY.
– The Y has very few genes - mainly those that contribute to male
characteristics. (Only about 87 genes total.)
– The X much more genetic information – for gender and other
characteristics. (About 2050 genes!)
7. Sex-Linked Inheritance
• Some genes for a disorder/disease are located on
one of the sex chromosomes
• If the gene is linked to the “Y” chromosome,
women will not have the disorder.
– Why? _________________________________
• If the gene is linked to the “X” chromosome, and it
is recessive, women will not express the disorder.
– Why?
______________________________________
• If the gene on “X” is dominant… both will express
it!
8. Who is usually affected by
Sex-Linked Disorders?
• MEN! Genes for certain traits are on
the X chromosome only…
– Since Men only have one X chromosome
then they are more likely to have the
disorder
– Women are somewhat protected since
they have two X chromosomes and are
less likely to inherit receive disorders.
• If women receive a recessive gene on one X
chromosome, they are called “carriers”
because they “carry” the gene but don’t
express the disorder
9. Sex-Linked Disorders
• Affected males never pass the disease to their
sons
– Men give their “Y” to their sons!
• Affected males pass the defective X
chromosome to all of their daughters, who are
described as carriers
– This means they carry the disease-causing allele
but generally show no symptoms
• Female carriers pass the defective X
chromosome to…
– half their sons (affected by the disease)
– half their daughters (who are carriers)
– The other children inherit the normal copy of
the chromosome
10. How do you solve Sex-linked
Problems?
• You determine which trait
(or disorder) is dominant or
recessive
• Set up a punnett square
using XX for females and
XY for males.
– Assign alleles for X only!
• Solve as usual, keeping in
mind that the Y
chromosome has no allele!
Genotypes: XRXr , XRY
Phenotypes: All offspring
have red eyes.
If Red eyes are dominant and
sex-linked, show the cross
between a homozygous red eyed
female and a white eyed male.
11. Your Turn!
• Hemophilia is a sex-linked trait where XH gives
normal blood clotting and is dominant to the
hemophilia allele Xh
• Identify the genotypes of…
1) a woman with normal blood clotting whose father
had hemophilia
2) a normal man whose father had hemophilia.
• What is the probability that a mating between these
two individuals will produce a child, regardless of sex,
that has hemophilia?
12. Set up the Punnett Square!
- a woman with normal blood clotting whose
father had hemophilia XHXh
- a normal man whose father had hemophilia
XHY
Genotypes:
Phenotypes:
13. What are some X-linked disorders?
• ALD
• Hypertrichosis
• Duchenne muscular dystrophy
• Hunter Syndrome
• Menkes disease(kinky hair syndrome)
• Hemophilia
• Color blindness
• Inherited diabetes (Type 1)
14. ALD (Adrenoleukodystrophy)
• A deadly genetic disease that is a result
of fatty acid buildup caused by the enzymes
not functioning properly
• Causes damage to the nerves, resulting in
neurological issues and, later, death
15. Hypertrichosis
• An abnormal amount of hair growth over the
body
– Informally called werewolf syndrome, because the
appearance is similar to the mythical werewolf
21. Menke’s Disease
(Kinky Hair Syndrome)
• Rapid deterioration of the nervous system.
• Weak muscle tone, sagging facial features,
seizures, developmental delay, and
intellectual disability caused by enzymes not
functioning
• Children with Menkes syndrome typically
begin to develop symptoms during infancy
and often do not live past age 6
23. Hemophilia
• The “Royal Blood Disease” impairs the body's
ability to make blood clots
– Clots are needed to stop bleeding
• This results in people bleeding longer after an
injury and an increased risk of bleeding inside
joints or the brain
25. Tay-Sachs
• Tay-Sachs disease is a rare inherited disorder
that progressively destroys nerve cells
(neurons) in the brain and spine
• Enzymes are the culprit AGAIN!
• Paralysis of the nerves cause eventual death
27. Duchene Muscular Dystrophy
• Duchenne muscular dystrophy (DMD) is a
genetic disorder characterized by progressive
muscle degeneration and weakness
• Until relatively recently, boys with DMD
usually did not survive much beyond their
teen years
– Advances in cardiac and respiratory care means
that survival into the early 30s is becoming more
common
29. PKU (PhenylKetonUrea)
• Decreased metabolism of the amino
acid phenylalanine
– Enzymes can’t break it down!
• Untreated PKU can lead to intellectual
disability, seizures and death
31. Cystic Fibrosis (CF)
• A genetic disorder that affects mostly the
lungs, but also the pancreas, liver, kidneys,
and intestine Cystic Fibrosis
• The enzymes required to break down mucous
are not functioning, so the mucous collects
and clogs…
33. SCID
• What happens when your immune system
doesn’t work???
– https://www.nytimes.com/video/u
s/100000004077071/the-boy-in-
the-bubble.html
34. Albinism
• Albinism is an inherited genetic condition that
reduces the amount of melanin pigment
formed in the skin, hair and/or eyes. Albinism
occurs in all racial and ethnic groups
throughout the world.
– As well as other species!