Sex determination is the process by which an organism develops as male or female. It can be identified by morphological, anatomical and physiological characteristics. Historically it was determined based on primary and secondary sex characteristics, but scientific study began after the discovery of sex chromosomes in 1902. There are two main theories of sex determination - genetic theories involving sex chromosomes and physiological theories related to metabolic differences. In most species, including humans, the presence of two X chromosomes determines female development while one X and one Y chromosome determines male development.
Sex Determination definition.
Chromosomal Sex Determination.
Primary sex determination.
Secondary Sex determination.
Genetic mechanism.
Environmental Sex Determination.
Conclusion.
Sex Determination definition.
Chromosomal Sex Determination.
Primary sex determination.
Secondary Sex determination.
Genetic mechanism.
Environmental Sex Determination.
Conclusion.
chromosomal aberrations
Variation in chromosomal structure or number
changes in the number of sets of chromosomes (ploidy), changes in the number of individual chromosomes (somy), or changes in appearance of individual chromosomes through mutation-induced rearrangements. They can be associated with genetic diseases or with species differences
Mujahid Hussain, Department of Botany, University of Sargodha, Sargodha, Punjab, Pakistan
A cytological technique to detect the nature of adjacent chromosomal regions by using different staining technique assisted with some pre treatment of metaphase chromosomes prepared on the slides
Reference
Moeller, Karla T., "Temperature-Dependent Sex Determination in Reptiles". Embryo Project Encyclopedia (2013-02-01). ISSN: 1940-5030
Morjan, Carrie L. 2003. “How Rapidly Can Maternal Behavior Affecting Primary Sex Ratio Evolve in a Reptile with Environmental Sex Determination ?”
Shine, Richard. 1999. “Why Is Sex Determined by Nest Temperature in Many Reptiles?” 14(5): 186–89.
Wapstra, Erik et al. 2006. “Maternal Basking Behavior Determines Offspring Sex in a Viviparous Reptile.” : 230–32.
chromosomal aberrations
Variation in chromosomal structure or number
changes in the number of sets of chromosomes (ploidy), changes in the number of individual chromosomes (somy), or changes in appearance of individual chromosomes through mutation-induced rearrangements. They can be associated with genetic diseases or with species differences
Mujahid Hussain, Department of Botany, University of Sargodha, Sargodha, Punjab, Pakistan
A cytological technique to detect the nature of adjacent chromosomal regions by using different staining technique assisted with some pre treatment of metaphase chromosomes prepared on the slides
Reference
Moeller, Karla T., "Temperature-Dependent Sex Determination in Reptiles". Embryo Project Encyclopedia (2013-02-01). ISSN: 1940-5030
Morjan, Carrie L. 2003. “How Rapidly Can Maternal Behavior Affecting Primary Sex Ratio Evolve in a Reptile with Environmental Sex Determination ?”
Shine, Richard. 1999. “Why Is Sex Determined by Nest Temperature in Many Reptiles?” 14(5): 186–89.
Wapstra, Erik et al. 2006. “Maternal Basking Behavior Determines Offspring Sex in a Viviparous Reptile.” : 230–32.
Sex-determination and Sex-linked Inheritance.pptxSeemaGaikwad15
The sexually reproducing organisms are classified into two types such as monoecious (hermaphrodite) and dioecious. In monoecious organisms, both male and female gametes (sex cells) are produced by a single individual. The organisms in which both male and female gametes are produced by different individuals are called dioecious. Living organisms, with a very few exceptions, are differentiated into male and female individuals. The sexes of the individuals are genetically determined.
The biological system that determines the development of sexual characteristics in an organism is called sex determination.
There are two different systems of sex determination- Chromosomal sex determination and Non-genetic sex determination.
Sex determination is important to distinguish an organism as male, female and hermaphrodite. XX-XO sex determination is one type of determination which is found in plants and insects
Heredity or Hereditary is the process of passing the traits and characteristics from parents to offsprings.
The offspring cells get their features and characteristics aka genetic information from their mother and father.
Non mendelian inheritance / cytoplasmic inheritance / Extranuclear InheritanceMahammed Faizan
Inheritance of traits from parents to off springs from cytoplasmic organelle genetic material is known as extra nuclear inheritance.
it is mainly responsible due to DNA present in cytoplasmic organelle.
total genes present in cytoplasm is know as as plasmon.
Ethical and bio-safety issues related to GM cropsMahammed Faizan
a seminar presentation on ethical and bio-safety issues related GM crops.
impact of gm crops on human, animal and environmental health.
safety measure related transgenic crops.
international governmental bodies
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
2. A sex-determination system is a biological
system that determines the development
of sexual characteristics in an organism.
These can be identified by morphological,
anatomical and physiological characters.
3. Earlier the sex determination was done
based on sexual primary and secondary
characters.
But, the scientific study on sex
determination was done after the dicovery
of sex chromosomes by Mc.clung(1902).
4. A. Primary Sexual Differentiation – these
strucutres are directly related to
gonads,ovaries and testes.
B. Secondary Sexual Differentiation – overall
appearance of the organism characters like
breast growth in case of females and beard
growth in case of males.
6. Sex determination:- is a biological system that
determines the development
of sexual characteristics in an organism.
Sexual differentiation:- is the process of
development of the differences between
males and females from an undifferentiated
zygote.
7. there are 2 types,
1.Genetic theories:-
a)Alternate dominance theory.
b)Heterogamosis theory or chromosomal theory.
c)Genic balance theory.
2.Physiological theories.
a)Metabolic diffrentiation theory.
b)Quantitative theory.
8. It was given by CASTLE.
for fertilization 2 types of gametes should
require, from single type of gamets fertilization
is not possible.
During fertilization if male gametes are
determiner then the offsprings will be male
vice versa in case of female.
Now a days it is not acceptable.
9. Give by CORREN by cytological and genetical
experiments.
During fertilization heterogametic of one sex and
homogametic of onether sex.
In 1902 Mc.clung observed cytologically in grass
hopper,by his observation he stated thatfemale
have even number of chromosome and males have
odd number of chromosomes.
In 1905 E.V.Wilson and N.M.Stevens confirmed his
experiments.
10. Thus, wilson concluded that,during observation
in inset cytology
As the femlaes are both the same X
chromosomes hence he named it as
HOMOGAMATIC CHROMOSOMES or
HOMOCHROMOSES.
as the males contain only one X chromosome
and onther Y chromosomes he named it as
HETEROGAMATIC CHROMOSOMES or
HETEROCHROMOSOMES.
later it was specified to gametes not to
organism.
11.
12. The theory of genic balance given by CALVIN BRIDGES
(1926) states that instead of XY chromosomes, sex is
determined by the genic balance or ratio between X-
chromosomes and autosome genomes.
The theory is basically applicable to Drosophila
melanogaster. He found that the genic ratio X /А of 1.0
produces fertile females. A genic ratio (X /А) of 0.5 forms a
male fruitfully. This occurs in XY + 2A as well as X0 + 2A. It
means that expression of maleness is not controlled by Y-
chromosome but is instead localised on autosomes.
The X-chromosomes, however, carry female determining
genes like Sxl. Bridges further proposed that a genic ratio of
less than 0.5 (e.g., XY + ЗА or X/ЗА or 0.33) produced
infertile meta-males (super males) while a genic ratio
between 0.5 and 1.0 produces intersexes with a lot of
morphological and sexual abnormalities.
13. Chromosome Complement X / A Ratio Sexual Morphology:-
X X X + 2A=3/2 or 1.5=Metafemale
X X X + ЗА=3/3 or 1.0=Female
XX + 2A=2/2 or 1.0=Female
X X + ЗА=2/3 or 0.67=Inter sex
X X X + 4A=3/4 or 0.75=Inter sex
XO + 2A=1/2 or 0.5=Male
XY + 2A=1/2 or 0.5=Male
XY + ЗА=1/3 or 0.33=Metamale
Sterile meta-females (super females) are produced with the
genic ratio of 1.5 (3X/2A). The sterile meta-males and meta-
females have been called glamour boys and girls of fly
world by DODSON.
14. It was proposed by RIDDLE.
According to him sex determination is
depend on male and female metabolic
condition not on sex chromosomes
To prove his theory he gave example of sex
inversion.
15. It was proposed by GOLD SMITH.
According to him sex determination is
depend on harmone quantity and a
harmonal balance.
17. presence of sex chromosomes. In females their will
2 X chromosomes and in case of male there will be one X
and onether Y chromosome will be there.
18. Male part in case of plants is known as STAMINATE and female part is
known as PISTILLATE.
SEX FORMS IN CASE OF PLANTS.
1. Hermaphrodite
individual plant bears only hermaphrodite flowers. This is common in
cereal crops and in pulses.
2. Monoecious
individual plant bears both staminate and pistillate flowers. An
example is corn (maize).
3. Androecious
referred to as male, individual plant bears only staminate flowers.
Examples are the male date and the male papaya.
4. Gynoecious
referred to as female, individual plant bears only pistillate flowers. An
example is the female date palm.
5. Andromonoecious individual plant bears both hermaphrodite and staminate flowers.
6. Gynomonoecious individual plant bears both hermaphrodite and pistillate flowers.
7. Trimonoecious or polygamous
same individual plant bears hermaphrodite, staminate, and pistillate
flowers. This is found in papaya.
19.
20. SHARP in 1934 had concluded that sex chromosome are
not only factor for sex determination even interaction of
gene and environment plays an vital role.
example:-
tomato with deficiency of carbohydrates leads to
absence of male sex and nitogen deficiency lead
females sex.(Shaffner)
When cucumber plants exposes to sharp light for long
duration leads to male sex.(Edmond 1930)
21. A gynandromorph is an organism that contains
both male and female characteristics. The
term gynandromorph, from Greek "gyne" female, "andro"
male, and “.morphé" form. Types of Gynandromorphs:
Depending upon the position of sex tissue:-
1. Bilateral Gynanders:
Some times one half of the body shows female characters
while other half shows male characters.
2. Anterior-Posterior Gynanders:
anterior region of the animal body has the characteristics of
one sex and posterior half region has the characteristics of
the other sex.
3. Sex Piebalds:
body consists of female tissue having spots of male tissue
scattered irregularly.
23. Sex determination help in selection of plants for crop
improvement.
Sex determination helps in identification of plants by
which it will save the time.
ex:-Nutmeg,kokum.
24. Life Sciences,fundamentals and practices-2,Pranav
kumar and usha mina,5th edition,2016.
Principles of genetics,D.Peter Snustd and
J.Simmons,7th edition
Genetics,B.D.Singh,2nd edition, 1 jan 2009.