This document discusses various modes of inheritance including sex-linked, sex-influenced, sex-limited, quantitative, and epistasis. It provides examples of X-linked traits like color blindness, hemophilia, and muscular dystrophy. It also describes quantitative inheritance being controlled by multiple genes and influenced by factors like dominance, additive effects, and epistasis. Quantitative trait loci are defined as the chromosomal positions where genes affecting quantitative traits are located.
Biotechnology for Crop Improvement.
Molecular Plant Breeding-Marker Assisted Breeding/Selection.
Comparison between three main and commonly discussed marker systems- RFLP, RAPD and AFLP.
Basic Understanding for Simple Sequence Repeats, SCAR and CAPS.
Strategies to overcome food shortages using molecular plant breeding approaches, Application of various molecular marker systems and examples.
Reference List.
Presenter: Brenda Chong
Marker Assisted Selection in Crop BreedingPawan Chauhan
Marker Assisted Selection is a value addition to conventional methods of Crop Breeding. It has been gaining importance in plant breeding with new generation of plant breeders and to get accurate and fast desired result from plant breeding.
Biotechnology for Crop Improvement.
Molecular Plant Breeding-Marker Assisted Breeding/Selection.
Comparison between three main and commonly discussed marker systems- RFLP, RAPD and AFLP.
Basic Understanding for Simple Sequence Repeats, SCAR and CAPS.
Strategies to overcome food shortages using molecular plant breeding approaches, Application of various molecular marker systems and examples.
Reference List.
Presenter: Brenda Chong
Marker Assisted Selection in Crop BreedingPawan Chauhan
Marker Assisted Selection is a value addition to conventional methods of Crop Breeding. It has been gaining importance in plant breeding with new generation of plant breeders and to get accurate and fast desired result from plant breeding.
Targeted Induced Local Lesions IN Genome. Mutations (Single base pair substitution) are created by traditionally used chemical mutagens. Identify SNPs and / or INDELS in a gene / genes of interest from a mutagenized population.
The term balanced tertiary trisomic has three words of which (1) “trisomic” indicates the presence of extra chromosome, (2) “tertiary” indicates that the extra chromosome is a trans-located chromosome, and (3) “balanced” refers to the breeding behaviour of the trisomic.
Ramage defined the BTT as a tertiary trisomic constructed in such a way that the dominant allele of a marker gene, closely linked with the translocation breakpoint of the extra chromosome is carried on the extra chromosome, and the recessive allele is carried on the two normal chromosomes that constitute the diploid complement. The dominant marker gene may be located on the centromere segment or the trans-located segment of the extra chromosome.
My presentation held at the 1st European Conference on Political Attitudes and Mentalities (ECPAM 2012) conference, Bucharest, Romania, September 3-5, 2012.
Electronic paper link:
http://mass.aitia.ai/images/publikaciok/2012-ecpam-replication_case_studies-camera_ready.pdf
Abstract: This paper examines model replication in the context of agent-based simulation through two case studies. Replication of a computational model and validation of its results is an essential tool for scientific researchers, but it is rarely used by modelers. In our work we address the question of validating and verifying simulations in general, and summarize our experience in approaching different models through replication with different motivations. Two models are discussed in details. The first one is an agent-based spatial adaptation of a numerical model, while the second experiment addresses the exact replication of an existing economic model.
Targeted Induced Local Lesions IN Genome. Mutations (Single base pair substitution) are created by traditionally used chemical mutagens. Identify SNPs and / or INDELS in a gene / genes of interest from a mutagenized population.
The term balanced tertiary trisomic has three words of which (1) “trisomic” indicates the presence of extra chromosome, (2) “tertiary” indicates that the extra chromosome is a trans-located chromosome, and (3) “balanced” refers to the breeding behaviour of the trisomic.
Ramage defined the BTT as a tertiary trisomic constructed in such a way that the dominant allele of a marker gene, closely linked with the translocation breakpoint of the extra chromosome is carried on the extra chromosome, and the recessive allele is carried on the two normal chromosomes that constitute the diploid complement. The dominant marker gene may be located on the centromere segment or the trans-located segment of the extra chromosome.
My presentation held at the 1st European Conference on Political Attitudes and Mentalities (ECPAM 2012) conference, Bucharest, Romania, September 3-5, 2012.
Electronic paper link:
http://mass.aitia.ai/images/publikaciok/2012-ecpam-replication_case_studies-camera_ready.pdf
Abstract: This paper examines model replication in the context of agent-based simulation through two case studies. Replication of a computational model and validation of its results is an essential tool for scientific researchers, but it is rarely used by modelers. In our work we address the question of validating and verifying simulations in general, and summarize our experience in approaching different models through replication with different motivations. Two models are discussed in details. The first one is an agent-based spatial adaptation of a numerical model, while the second experiment addresses the exact replication of an existing economic model.
RNA- A polymer of ribonucleotides, is a single stranded structure. There are three major types of RNA- m RNA,t RNA and r RNA. Besides that there are small nuclear,micro RNAs, small interfering and heterogeneous RNAs. Each of them has a specific structure and performs a specific function.
Powerpoint Search Engine has collection of slides related to specific topics. Write the required keyword in the search box and it fetches you the related results.
Study: The Future of VR, AR and Self-Driving CarsLinkedIn
We asked LinkedIn members worldwide about their levels of interest in the latest wave of technology: whether they’re using wearables, and whether they intend to buy self-driving cars and VR headsets as they become available. We asked them too about their attitudes to technology and to the growing role of Artificial Intelligence (AI) in the devices that they use. The answers were fascinating – and in many cases, surprising.
This SlideShare explores the full results of this study, including detailed market-by-market breakdowns of intention levels for each technology – and how attitudes change with age, location and seniority level. If you’re marketing a tech brand – or planning to use VR and wearables to reach a professional audience – then these are insights you won’t want to miss.
The SlideShare 101 is a quick start guide if you want to walk through the main features that the platform offers. This will keep getting updated as new features are launched.
The SlideShare 101 replaces the earlier "SlideShare Quick Tour".
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
Genetics- Chapter 5 - Principles of inheritance and variation.docxAjay Kumar Gautam
Genetics is a branch of biology concerned with the study of genes, genetic variation, and heredity in organisms. Though heredity had been observed for millennia, Gregor Mendel, Moravian scientist and Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene.
This presentation intends to explore the sex-linked characters along with some fatal diseases of human beings, their cause, consequences and other issues.
Allelic and Non-allelic interactions : Complete dominance; Incomplete dominance-in Four O'clock plant, Mirabilis jalapa and Snapdragon, Antirrhinum majus ; Co-dominance- MN blood group, AB blood group, Roan coat colour in shorthorn breed of cattle; Inheritance of Comb pattern in Poultry; Epistasis -Dominant - Fruit colour in Summer squash, Recessive - Coat colour in mice; Complementary gene interaction -Purple flower colour in Sweet pea (Lathyrus odoratus)
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
6. genes found on a sex chromosome
X-linked genes are genes found on the
X chromosome, symbolized by Xr
, XR
,
Y0
.
Y-linked genes are found on the Y
chromosome, symbolized by X0
, YR
, Yr
7. X-linked Inheritance
T. H. Morgan (1910) in his studies on inheritance of genes
in Drosophila discovered that the pattern of inheritance .the
first study of x- linked inheritance for eye gene colour in
drosophila.
White eyed female x Red eyed male
Red eyed female x white eye in male .
8.
9. Examples of X-linked traits:
1. Color Blindness
2. Hemophilia
3. Muscular Dystrophy
4. Icthyosis simplex (scaly skin)
10. Colorblindness
A person with normal color vision seen a number seven in
the circle above.
Those who are color blind usually do not see any number at
all.
12. Hemophilia
Hemophilia- Lacking in the
ability to clot blood
There is a gene on the “X”
chromosome that control
blood clotting
People who have
hemophilia are missing the
protein to clot blood
They can bleed to death by
minor cut.
13. Muscular Dystrophy
- Results in
weakening/lo
ss of muscles
- Caused by
defective
version of
gene that
codes for
muscle
15. Sex Limited
These are characters only expressed in one sex. They may be
caused by genes on either autosomal or sex chromosomes.
The traits limited to only one sex due toanatomical
diffirences are called a sex limited traits.
Examples:1.Female sterility in Drosophila 2.Gene for milk
production indairy cattle effected only cows
16. Quantitative Inheritance
A Quantitative inheritance it is controlled by many genes. Therefore,
it is known quantitative inheritance and also polygenic inheritance.
Quantitative traits = phenotypes differ in quantity rather than type
(such as height)
In a genetically heterogeneous population, genotypes are formed by
segregation and recombination.
18. MULTIPLE FACTER
HYPOTHESIS
Multiple facter hypothesis was originally postulated
by YULE in 1906. and multiple Gene model
Developed by geneticist .H.Nilsson
Ehle in 1910 explain 1.Inheritance of kernel colour
in wheat.
19. Multiple gene hypothesis:
range of phenotypes can be accounted for
by cumulative effect of many alleles.
Polygenes: Additive allele; nonadditive allele
1 phenotypic traits can be measured eg. weight or
height
2 two or more loci (genes) could account for
phenotype in an additive or cumulative way
3 each loci may be occupied by an additive allele,
which contributes a constant amount to the
phenotype, or a nonadditive allele which does not
4 The contribution by each allele
may be small and is approx equal
5 together the alleles contribute to a single
phenotypic character with substantial variation.
21. An example: wheat kernel colour.
Cross true-breeding plants with white berries to
true-breeding plants with dark red berries.
The resultingF1 all exhibit an intermediate color.
When the F1s are crossed, the result is a range
of color.
22. Wheat kernel Color
True-breeding plants with white vs. red
berries were crossed to create an
F1of intermediate color, then the F1
plants were crossed to produce the
range of colors.
The curve is called a normal
distribution, with the largest
number of individuals in the
intermediate range, with fewer at
each extreme.
23. Additive
When the combined effects of
alleles at different loci are equal
to the sum of their individual
effects
24. Dominance
The phenomenon of F1 hybrid
being identical to one of its a
character is turmed as
dominance .
1.Incomplete dominance
2.complete dominance 3.co-
dominance
25. OVER DOMINANCE
In cases of some genes the intensity
of character governed by them is
greaterin heterozygotes than in two
concerned homozygotes this situation
is knows overdominance.
Example ABO blood group systems
in Humans.
26. Epistasis
Epistasis is an intraction between alleles at two
gene loci that affect a single trait which may
sometimes resemble a dominance intraction
between two diffirent alleles at the some locus
Epistasis modifies the characteristics 9:3:3:1 ratio
27. Quantitative Trait Loci(QTL)
A Locus is that position in a chromosome at which a
gene is situated.
Thus a quantitative trait loci (QTL) is the chromosome site
at which a gene /group of genes affecting a quantitative is
located