This document presents information on sensitivity analysis techniques. It discusses how sensitivity analysis is used to determine how changes to independent variables impact dependent variables given certain assumptions. It also describes how sensitivity analysis can predict outcomes if a situation differs from key predictions. Various sensitivity analysis methods are outlined, including correlation and screening techniques, regression analysis, and analyzing oscillations through measuring behavior patterns like period and amplitude. An example of applying sensitivity analysis to a simple supply chain model is also provided.
The document is an introduction to sensitivity analysis that contains three exploratory exercises demonstrating how changes to parameter values affect system behavior in system dynamics models. The first exercise explores a lemonade stand model and finds that while parameter changes alter the appearance of behavior, they do not change the overall behavior mode. The second exercise on an epidemics model shows that different parameter changes can create different types of behavior changes. The exercises are intended to help readers understand how to identify important parameters for sensitivity testing and how parameter values can influence system dynamics.
Sensitivity analysis determines how sensitive the optimal solution is to changes made to the original linear programming model after obtaining the optimal solution. It is important because it allows analysts to check how changes to the data in the model, such as the coefficients, constraints, or variables, would affect the optimal solution and gives the model dynamic characteristics to handle potential future changes.
-What is Sensitivity Analysis in Project Risk Management?
-Example on Sensitivity Analysis….
-Types of Sensitivity Analysis……
-Advantages & Disadvantages
Concept of optimization, optimization parameters and factorial designManikant Prasad Shah
Optimization involves systematically designing experiments to improve formulations by accounting for all influencing factors. Factorial design is a technique used in optimization that involves studying the effect of multiple factors simultaneously. It depends on factors, their levels, and variables. There are two main types of factorial design: full factorial design and fractional factorial design. Full factorial design tests every combination of factors and levels but becomes impractical with more than 5 factors. Fractional factorial design reduces the number of runs needed to study many factors.
The document discusses various optimization methods used in the pharmaceutical industry including evolutionary operations, simplex method, Lagrangian method, search method, and canonical analysis. It provides examples of how each method can be applied to optimize different parameters of a tablet formulation such as concentrations of excipients, compression force, and disintegrant levels to minimize disintegration time and friability while meeting constraints. The search method example involves using a five-factor central composite design to optimize tablet properties and identify the best formulation based on constraints for multiple response variables.
Sensitivity analysis examines how changes to independent variables like sales, costs, or prices impact a dependent variable like net income. It involves developing a forecast income statement, identifying which costs are fixed and variable, and then adjusting the independent variables to see their effect on net income. This allows analysis of best, worst, and partial cases to inform decision making and resource allocation under different assumptions. However, sensitivity analysis does not provide definitive results and relies on assumptions.
This document discusses various optimization techniques used in pharmaceutical product development including EVOP method, statistical designs like simplex method and response surface methodology, contour design, and factorial designs. It provides details on each technique such as the basic concepts, advantages, disadvantages and examples. EVOP method involves making small repeated changes to a formulation to optimize it but requires more time. Statistical designs help optimize formulations with 1-3 variables. Contour design uses constraints to optimize multiple response variables. Response surface methodology uses statistical techniques to build empirical models and optimize responses influenced by several variables. Factorial designs study the effects of individual and interacting input parameters on experimental outcomes.
This document presents information on sensitivity analysis techniques. It discusses how sensitivity analysis is used to determine how changes to independent variables impact dependent variables given certain assumptions. It also describes how sensitivity analysis can predict outcomes if a situation differs from key predictions. Various sensitivity analysis methods are outlined, including correlation and screening techniques, regression analysis, and analyzing oscillations through measuring behavior patterns like period and amplitude. An example of applying sensitivity analysis to a simple supply chain model is also provided.
The document is an introduction to sensitivity analysis that contains three exploratory exercises demonstrating how changes to parameter values affect system behavior in system dynamics models. The first exercise explores a lemonade stand model and finds that while parameter changes alter the appearance of behavior, they do not change the overall behavior mode. The second exercise on an epidemics model shows that different parameter changes can create different types of behavior changes. The exercises are intended to help readers understand how to identify important parameters for sensitivity testing and how parameter values can influence system dynamics.
Sensitivity analysis determines how sensitive the optimal solution is to changes made to the original linear programming model after obtaining the optimal solution. It is important because it allows analysts to check how changes to the data in the model, such as the coefficients, constraints, or variables, would affect the optimal solution and gives the model dynamic characteristics to handle potential future changes.
-What is Sensitivity Analysis in Project Risk Management?
-Example on Sensitivity Analysis….
-Types of Sensitivity Analysis……
-Advantages & Disadvantages
Concept of optimization, optimization parameters and factorial designManikant Prasad Shah
Optimization involves systematically designing experiments to improve formulations by accounting for all influencing factors. Factorial design is a technique used in optimization that involves studying the effect of multiple factors simultaneously. It depends on factors, their levels, and variables. There are two main types of factorial design: full factorial design and fractional factorial design. Full factorial design tests every combination of factors and levels but becomes impractical with more than 5 factors. Fractional factorial design reduces the number of runs needed to study many factors.
The document discusses various optimization methods used in the pharmaceutical industry including evolutionary operations, simplex method, Lagrangian method, search method, and canonical analysis. It provides examples of how each method can be applied to optimize different parameters of a tablet formulation such as concentrations of excipients, compression force, and disintegrant levels to minimize disintegration time and friability while meeting constraints. The search method example involves using a five-factor central composite design to optimize tablet properties and identify the best formulation based on constraints for multiple response variables.
Sensitivity analysis examines how changes to independent variables like sales, costs, or prices impact a dependent variable like net income. It involves developing a forecast income statement, identifying which costs are fixed and variable, and then adjusting the independent variables to see their effect on net income. This allows analysis of best, worst, and partial cases to inform decision making and resource allocation under different assumptions. However, sensitivity analysis does not provide definitive results and relies on assumptions.
This document discusses various optimization techniques used in pharmaceutical product development including EVOP method, statistical designs like simplex method and response surface methodology, contour design, and factorial designs. It provides details on each technique such as the basic concepts, advantages, disadvantages and examples. EVOP method involves making small repeated changes to a formulation to optimize it but requires more time. Statistical designs help optimize formulations with 1-3 variables. Contour design uses constraints to optimize multiple response variables. Response surface methodology uses statistical techniques to build empirical models and optimize responses influenced by several variables. Factorial designs study the effects of individual and interacting input parameters on experimental outcomes.
Optimization is defined as choosing the best element from available alternatives to make a design, system, or decision as fully perfect as possible. In pharmaceutical formulation and process development, optimization determines the experimental conditions that result in optimal performance. It helps identify important variables, measure interactions between variables, and find the best solution within the domain studied. The process involves independent variables like formulation ingredients that are under the formulator's control and dependent variables like dissolution rate that are outcomes. Optimization has applications in formulation development, clinical chemistry, medicinal chemistry, and pharmacokinetic studies.
This document analyzes the potential for computer aided marketing in the produce industry. It discusses the benefits of computerized marketing such as improved market information, operational efficiency, increased competition, improved market access, and higher grower prices. A survey of industry participants found positive attitudes towards computer aided marketing. The results were used to conceptualize a system that would complement existing marketing practices by facilitating information collection and dissemination.
Virtual clinical trials offer advantages over traditional trials such as improved patient comfort, convenience and confidentiality. They utilize technologies like apps and online platforms to remotely collect data from trial participants from start to finish. While offering benefits, virtual trials also carry risks regarding patient privacy, operational challenges, and technical or cultural barriers. Ideal virtual trials would generate necessary data with minimal burden, foster ongoing relationships to better understand conditions, and engage providers in a complementary way. Emerging technologies like social media, mobile devices, remote monitoring, and electronic patient reporting can help promote virtual trials by automating data collection and enabling remote participation. Physiologically-based modeling using software like GastroPlus can help predict food effects on drug absorption by simulating gastrointestinal conditions
Sensitivity analysis is the study of how uncertainty in the inputs of a mathematical model propagates to uncertainty in the model's outputs. It is useful for understanding relationships between inputs and outputs, identifying important inputs, and reducing uncertainty. Sensitivity analysis typically involves running the model many times while varying inputs, and calculating sensitivity measures from the resulting outputs to determine which inputs most influence uncertainty in the outputs. Common methods include variance-based approaches and screening methods.
Clinical Data Collection & Clinical Data Management Naveen BalajiNaveen Balaji
The document discusses clinical trial data collection and management. It covers 11 major sections including introduction, data collection vs management, communication tools used, pure paper-based systems, electronic-based systems, hybrid systems, acquiring software from vendors, and processes before, during, and after data collection. Communication tools discussed include meetings, telephone, fax, email, websites, and file transfer protocol. Pure paper-based systems do not require computers but have large data editing overhead at the central location.
The document discusses optimization in pharmaceutical formulation and processing. It defines optimization as choosing the best alternative from available options. Optimization in pharmacy involves formulating drug products using the best combination of ingredients and processing parameters. Experimental design techniques are used to optimize multiple variables. Response surface methodology and central composite designs are commonly used to model quadratic relationships between variables. The document outlines different types of experimental designs and their applications in pharmaceutical optimization.
Statistical modeling in Pharmaceutical research and development.pptxPawanDhamala1
The document discusses statistical modeling in pharmaceutical research and development. It begins with definitions of statistics and pharmaceutical statistics. It then discusses the history and concepts of statistical modeling, noting that models help reduce drug development costs and time while improving quality. Models can be descriptive, modeling real-world events, or mechanistic, based on natural science principles. The objective of models is to improve understanding of experiments and drugs through representation of reality.
This document discusses factorial design in pharmaceutical research. It defines key terms like factors, levels, and effects. Factorial design is used to study the effect of different factors and their interactions on a response. It presents examples of 2^2, 2^3, and 3^2 factorial designs and how to compute main effects and interactions. Data analysis methods like Yates' method and ANOVA are described. The design allows fitting of a polynomial equation to optimize a response based on factor levels. Advantages include efficiency in estimating effects and revealing interactions across factor levels.
Optimization technology and screening design sathish h tSatishHT1
This document discusses various design of experiment methodologies including screening designs and optimization designs. It provides examples of factorial designs, response surface designs like central composite designs and Box-Behnken designs, and three-level full factorial designs. It also gives an example of using a fractional factorial design to screen critical processing parameters in a wet granulation coating process and selecting a three-level full factorial design to optimize two factors, blending speed and time, in a dry mixing process to investigate their interactive and quadratic effects on the response.
Optimal design & Population mod pyn.pptxPawanDhamala1
This document discusses optimal design and population modeling. It begins with an introduction to optimal design, noting that it allows parameters to be estimated without bias and with minimum variance. The advantages of optimal design are that it reduces experimentation costs by allowing statistical models to be estimated with fewer runs. It then describes different types of optimal designs such as A, C, D, and E optimality. The document next discusses population modeling, explaining that it is a tool for integrating data to aid drug development decisions. It notes the key components of population models are structural models, stochastic models, and covariate models. Structural models describe the response over time using algebraic or differential equations, while stochastic models describe variability and covariate models influence factors like dem
This document discusses optimization techniques used in pharmaceutical formulations. It begins with defining optimization and describing how experimental design can be used to shorten experimentation time. It then covers various optimization parameters, classic optimization methods using calculus, and common optimization methods like factorial designs, response surface methodology, and simplex lattice designs. Applications mentioned include improving process yield, reducing costs and development time. Finally, some commonly used software for optimization is listed along with references.
computer aided formulation developmentSUJITHA MARY
The document discusses optimization techniques used in computer aided formulation development. It defines optimization as choosing the best alternative while considering all influencing factors. Optimization techniques help minimize experimental trials, reduce costs and save time compared to traditional trial and error methods. The document describes various experimental design approaches like factorial designs, response surface methodology and mixture designs that are used to optimize formulations. It also discusses simultaneous techniques like evolutionary operations and simplex method as well as sequential techniques like mathematical modeling and search methods. Optimization is important for developing formulations with desired performance and ensuring reproducible, large-scale manufacturing.
The document discusses automation in the pharmaceutical industry, noting that automation reduces human intervention and increases precision, quality, and production capacity. It describes different types of automatic control systems used in processes like heat exchange. Finally, it examines automation applications in tablet manufacturing, highlighting specific unit operations like mixing, compression, and coating that benefit from automation.
COMPUTER SIMULATIONS IN PHARMACOKINETICS & PHARMACODYNAMICSsagartrivedi14
Computer simulations in pharmacokinetics and pharmacodynamics can model the whole organism, isolated tissues, and individual organs. Whole organism simulations use lumped-parameter models that represent the body with a small number of differential equations, or physiological models that use more differential equations to describe organs in detail. Isolated tissue and organ simulations often use distributed blood tissue exchange models for organs like the heart and liver. These simulations aim to integrate organ-specific models with whole-body models to improve predictive capabilities in areas like pharmacokinetics.
This document discusses sensitivity analysis in drug development. Sensitivity analysis determines how changes in independent variables impact dependent variables. It allows decision-makers to identify areas for improvement. The document outlines methods of sensitivity analysis including local analysis of derivatives and global analysis using Monte Carlo techniques. Sensitivity analysis is useful for assessing risk, aiding decision making, and identifying errors in models. It provides insight into how sensitive outcomes are to changes in parameter values.
A Systems Approach to the Modeling and Control of Molecular, Microparticle, a...ejhukkanen
Processes with distributions are pervasive:
- Molecular: molecular weight distribution in polymerization
- Microparticle: particle size distribution in suspension polymerization
- Biological: rupture frequency distributions in single- molecule pulling experiments
This thesis presents a systematic approach to the modeling and control of these processes
Systematic approach applied to diverse processes
-Molecular distributions
-Microparticle distributions
-Biological distributions
Common approach
- Experiments/equipment
- Parameter estimation
- Sensitivity and uncertainty analysis
- Model selection
- Optimal control
Optimization is defined as choosing the best element from available alternatives to make a design, system, or decision as fully perfect as possible. In pharmaceutical formulation and process development, optimization determines the experimental conditions that result in optimal performance. It helps identify important variables, measure interactions between variables, and find the best solution within the domain studied. The process involves independent variables like formulation ingredients that are under the formulator's control and dependent variables like dissolution rate that are outcomes. Optimization has applications in formulation development, clinical chemistry, medicinal chemistry, and pharmacokinetic studies.
This document analyzes the potential for computer aided marketing in the produce industry. It discusses the benefits of computerized marketing such as improved market information, operational efficiency, increased competition, improved market access, and higher grower prices. A survey of industry participants found positive attitudes towards computer aided marketing. The results were used to conceptualize a system that would complement existing marketing practices by facilitating information collection and dissemination.
Virtual clinical trials offer advantages over traditional trials such as improved patient comfort, convenience and confidentiality. They utilize technologies like apps and online platforms to remotely collect data from trial participants from start to finish. While offering benefits, virtual trials also carry risks regarding patient privacy, operational challenges, and technical or cultural barriers. Ideal virtual trials would generate necessary data with minimal burden, foster ongoing relationships to better understand conditions, and engage providers in a complementary way. Emerging technologies like social media, mobile devices, remote monitoring, and electronic patient reporting can help promote virtual trials by automating data collection and enabling remote participation. Physiologically-based modeling using software like GastroPlus can help predict food effects on drug absorption by simulating gastrointestinal conditions
Sensitivity analysis is the study of how uncertainty in the inputs of a mathematical model propagates to uncertainty in the model's outputs. It is useful for understanding relationships between inputs and outputs, identifying important inputs, and reducing uncertainty. Sensitivity analysis typically involves running the model many times while varying inputs, and calculating sensitivity measures from the resulting outputs to determine which inputs most influence uncertainty in the outputs. Common methods include variance-based approaches and screening methods.
Clinical Data Collection & Clinical Data Management Naveen BalajiNaveen Balaji
The document discusses clinical trial data collection and management. It covers 11 major sections including introduction, data collection vs management, communication tools used, pure paper-based systems, electronic-based systems, hybrid systems, acquiring software from vendors, and processes before, during, and after data collection. Communication tools discussed include meetings, telephone, fax, email, websites, and file transfer protocol. Pure paper-based systems do not require computers but have large data editing overhead at the central location.
The document discusses optimization in pharmaceutical formulation and processing. It defines optimization as choosing the best alternative from available options. Optimization in pharmacy involves formulating drug products using the best combination of ingredients and processing parameters. Experimental design techniques are used to optimize multiple variables. Response surface methodology and central composite designs are commonly used to model quadratic relationships between variables. The document outlines different types of experimental designs and their applications in pharmaceutical optimization.
Statistical modeling in Pharmaceutical research and development.pptxPawanDhamala1
The document discusses statistical modeling in pharmaceutical research and development. It begins with definitions of statistics and pharmaceutical statistics. It then discusses the history and concepts of statistical modeling, noting that models help reduce drug development costs and time while improving quality. Models can be descriptive, modeling real-world events, or mechanistic, based on natural science principles. The objective of models is to improve understanding of experiments and drugs through representation of reality.
This document discusses factorial design in pharmaceutical research. It defines key terms like factors, levels, and effects. Factorial design is used to study the effect of different factors and their interactions on a response. It presents examples of 2^2, 2^3, and 3^2 factorial designs and how to compute main effects and interactions. Data analysis methods like Yates' method and ANOVA are described. The design allows fitting of a polynomial equation to optimize a response based on factor levels. Advantages include efficiency in estimating effects and revealing interactions across factor levels.
Optimization technology and screening design sathish h tSatishHT1
This document discusses various design of experiment methodologies including screening designs and optimization designs. It provides examples of factorial designs, response surface designs like central composite designs and Box-Behnken designs, and three-level full factorial designs. It also gives an example of using a fractional factorial design to screen critical processing parameters in a wet granulation coating process and selecting a three-level full factorial design to optimize two factors, blending speed and time, in a dry mixing process to investigate their interactive and quadratic effects on the response.
Optimal design & Population mod pyn.pptxPawanDhamala1
This document discusses optimal design and population modeling. It begins with an introduction to optimal design, noting that it allows parameters to be estimated without bias and with minimum variance. The advantages of optimal design are that it reduces experimentation costs by allowing statistical models to be estimated with fewer runs. It then describes different types of optimal designs such as A, C, D, and E optimality. The document next discusses population modeling, explaining that it is a tool for integrating data to aid drug development decisions. It notes the key components of population models are structural models, stochastic models, and covariate models. Structural models describe the response over time using algebraic or differential equations, while stochastic models describe variability and covariate models influence factors like dem
This document discusses optimization techniques used in pharmaceutical formulations. It begins with defining optimization and describing how experimental design can be used to shorten experimentation time. It then covers various optimization parameters, classic optimization methods using calculus, and common optimization methods like factorial designs, response surface methodology, and simplex lattice designs. Applications mentioned include improving process yield, reducing costs and development time. Finally, some commonly used software for optimization is listed along with references.
computer aided formulation developmentSUJITHA MARY
The document discusses optimization techniques used in computer aided formulation development. It defines optimization as choosing the best alternative while considering all influencing factors. Optimization techniques help minimize experimental trials, reduce costs and save time compared to traditional trial and error methods. The document describes various experimental design approaches like factorial designs, response surface methodology and mixture designs that are used to optimize formulations. It also discusses simultaneous techniques like evolutionary operations and simplex method as well as sequential techniques like mathematical modeling and search methods. Optimization is important for developing formulations with desired performance and ensuring reproducible, large-scale manufacturing.
The document discusses automation in the pharmaceutical industry, noting that automation reduces human intervention and increases precision, quality, and production capacity. It describes different types of automatic control systems used in processes like heat exchange. Finally, it examines automation applications in tablet manufacturing, highlighting specific unit operations like mixing, compression, and coating that benefit from automation.
COMPUTER SIMULATIONS IN PHARMACOKINETICS & PHARMACODYNAMICSsagartrivedi14
Computer simulations in pharmacokinetics and pharmacodynamics can model the whole organism, isolated tissues, and individual organs. Whole organism simulations use lumped-parameter models that represent the body with a small number of differential equations, or physiological models that use more differential equations to describe organs in detail. Isolated tissue and organ simulations often use distributed blood tissue exchange models for organs like the heart and liver. These simulations aim to integrate organ-specific models with whole-body models to improve predictive capabilities in areas like pharmacokinetics.
This document discusses sensitivity analysis in drug development. Sensitivity analysis determines how changes in independent variables impact dependent variables. It allows decision-makers to identify areas for improvement. The document outlines methods of sensitivity analysis including local analysis of derivatives and global analysis using Monte Carlo techniques. Sensitivity analysis is useful for assessing risk, aiding decision making, and identifying errors in models. It provides insight into how sensitive outcomes are to changes in parameter values.
A Systems Approach to the Modeling and Control of Molecular, Microparticle, a...ejhukkanen
Processes with distributions are pervasive:
- Molecular: molecular weight distribution in polymerization
- Microparticle: particle size distribution in suspension polymerization
- Biological: rupture frequency distributions in single- molecule pulling experiments
This thesis presents a systematic approach to the modeling and control of these processes
Systematic approach applied to diverse processes
-Molecular distributions
-Microparticle distributions
-Biological distributions
Common approach
- Experiments/equipment
- Parameter estimation
- Sensitivity and uncertainty analysis
- Model selection
- Optimal control
Metabolomic Data Analysis Workshop and Tutorials (2014)Dmitry Grapov
This document provides an introduction and overview of tutorials for metabolomic data analysis. It discusses downloading required files and software. The goals of the analysis include using statistical and multivariate analyses to identify differences between sample groups and impacted biochemical domains. It also discusses various data analysis techniques including data quality assessment, univariate and multivariate statistical analyses, clustering, principal component analysis, partial least squares modeling, functional enrichment analysis, and network mapping.
Predictive validation compares a model's predictions to actual observed data to determine how accurately it can predict real-world outcomes. This involves defining validation criteria, collecting real-world data to serve as a comparison, dividing the data into training and validation sets, using the model to make predictions on the validation data and calculating validation metrics to assess the model's performance. Parameter variability and sensitivity analysis are important techniques for understanding how sensitive a model's outputs are to changes in its parameters. This helps evaluate a model's robustness and identify influential parameters.
From sensor readings to prediction: on the process of developing practical so...Manuel Martín
Automatic data acquisition systems provide large amounts of streaming data generated by physical sensors. This data forms an input to computational models (soft sensors) routinely used for monitoring and control of industrial processes, traffic patterns, environment and natural hazards, and many more. The majority of these models assume that the data comes in a cleaned and pre-processed form, ready to be fed directly into a predictive model. In practice, to ensure appropriate data quality, most of the modelling efforts concentrate on preparing data from raw sensor readings to be used as model inputs. This study analyzes the process of data preparation for predictive models with streaming sensor data. We present the challenges of data preparation as a four-step process, identify the key challenges in each step, and provide recommendations for handling these issues. The discussion is focused on the approaches that are less commonly used, while, based on our experience, may contribute particularly well to solving practical soft sensor tasks. Our arguments are illustrated with a case study in the chemical production industry.
This paper advances the Domain Segmentation based on Uncertainty in the Surrogate (DSUS) framework which is a novel approach to characterize the uncertainty in surrogates. The leave-one-out cross-validation technique is adopted in the DSUS framework to measure local errors of a surrogate. A method is proposed in this paper to evaluate the performance of the leave-out-out cross-validation errors as local error measures. This method evaluates local errors by comparing: (i) the leave-one-out cross-validation error with (ii) the actual local error estimated within a local hypercube for each training point. The comparison results show that the leave-one-out cross-validation strategy can capture the local errors of a surrogate. The DSUS framework is then applied to key aspects of wind resource as- sessment and wind farm cost modeling. The uncertainties in the wind farm cost and the wind power potential are successfully characterized, which provides designers/users more confidence when using these models.
This document provides an overview of the course objectives and content for an experimental stress analysis course. The main objectives are:
1. To understand techniques for measuring displacements, stresses, and strains in structural components using strain gauges, photoelasticity, and non-destructive testing methods.
2. To familiarize students with different types of strain gauges, instrumentation systems for strain gauges, and photoelasticity stress analysis techniques.
3. To cover the basics of mechanical measurements, electrical resistance strain gauges, rosette strain gauges, and analyze experimental data through statistical methods.
The course will examine measurement systems, error analysis, contact and non-contact extensometers, electrical and optical
Survey methods have advantages like accommodating large sample sizes at low cost and collecting quantitative data suitable for statistical analysis, but also have disadvantages such as possible systematic errors, limited probing, and not knowing if responses are truthful. Different types of surveys include interviews that are person-administered, telephone-administered, or self-administered as well as factors to consider for selecting a survey method. There are also various types of errors in survey research like non-response errors and measurement errors.
This paper advances the Domain Segmentation based on Uncertainty in the Surrogate (DSUS) framework which is a novel approach to characterize the uncertainty in surrogates. The leave-one-out cross-validation technique is adopted in the DSUS framework to measure local errors of a surrogate. A method is proposed in this paper to evaluate the performance of the leave-out-out cross-validation errors as local error measures. This method evaluates local errors by comparing: (i) the leave-one-out cross-validation error with (ii) the actual local error estimated within a local hypercube for each training point. The comparison results show that the leave-one-out cross-validation strategy can capture the local errors of a surrogate. The DSUS framework is then applied to key aspects of wind resource as- sessment and wind farm cost modeling. The uncertainties in the wind farm cost and the wind power potential are successfully characterized, which provides designers/users more confidence when using these models
Surrogate-based design is an effective approach for modeling computationally expensive system behavior. In such application, it is often challenging to characterize the expected accuracy of the surrogate. In addition to global and local error measures, regional error measures can be used to understand and interpret the surrogate accuracy in the regions of interest. This paper develops the Regional Error Estimation of Surrogate (REES) method to quantify the level of the error in any given subspace (or region) of the entire domain, when all the available training points have been invested to build the surrogate. In this approach, the accuracy of the surrogate in each subspace is estimated by modeling the variations of the mean and the maximum error in that subspace with increasing number of training points (in an iterative process). A regression model is used for this purpose. At each iteration, the intermediate surrogate is constructed using a subset of the entire training data, and tested over the remaining points. The evaluated errors at the intermediate test points at each iteration are used for training the regression model that represents the error variation with sample points. The effectiveness of the proposed method is illustrated using standard test problems. To this end, the predicted regional errors of the surrogate constructed using all the training points are compared with the regional errors estimated over a large set of test points.
This document provides an overview of linear regression analysis. It discusses (1) why regression is used, including for description, adjustment for covariates, identifying predictors, and prediction; (2) the basics of linear regression in predicting an interval outcome variable based on predictor variables; and (3) how to conduct univariate linear regression in SPSS, including interpreting results and ensuring assumptions are met. Key assumptions include no outliers, independent data points, normally distributed residuals with constant variance.
What is MSA .
1. Why we Need MSA
2. How to use data.
3.Measurement Error Sources of Variation
• Precision (Resolution, Repeat ability, Reproducibility)
•Accuracy (Bias, Stability, Linearity)
4.What is Gage R&R?
5.Explain MSA Sheet
Measurement System Analysis is the first step of the Measure Phase of an improvement project. Before you can pass judgment on the process, you need to ensure that your measurement system is accurate, precise, capable and in control.
This document discusses types of errors, accuracy, sensitivity, resolution, and linearity in measurements. It defines random error, systematic error including environmental, instrumental and observational errors. Gross errors are discussed. Accuracy is defined as closeness to a true value. Sensitivity is a measure of output change for input change. Resolution is the ability to detect small changes. Linearity refers to how measurement bias is affected by the measurement range. First order response reaches steady state for a step input. Second order response can oscillate to a step input due to overshoot and damping effects.
Measurement Systems Analysis - Variable Gage R&R Study Metrics, Applications ...Gabor Szabo, CQE
This presentation walks you through the components of variation and the various metrics used in Variable Gage R&R Study. It also talks about the different root causes associated with a failing study, and how to perform root cause analysis using statistical tools.
1. The document discusses measurement systems analysis and different techniques for evaluating variable and attribute measurement systems.
2. Key aspects of measurement systems that can introduce variation are described, including bias, stability, repeatability, and reproducibility.
3. Three techniques are presented for analyzing variable gages: the average-range method, ANOVA method, and gauge R&R study which evaluates repeatability, reproducibility and overall measurement system accuracy.
The document provides an overview of measurement system analysis (MSA) techniques for both variable and attribute gages. It describes the average-range method and ANOVA method for analyzing variable gages, and the short method, hypothesis test analysis, and long method for attribute gages. Acceptability criteria are outlined for determining if a measurement system is capable of measuring process variation.
This document provides an overview of a course on measurements and instrumentation. It outlines the course outcomes, which include understanding different types of instruments, operating principles of common meters, transducers, and choosing suitable meters. It describes the exam format which tests knowledge across six modules. Module 1 covers general measurement principles, standards, errors, instrument classification, operating principles of moving coil and moving iron meters, and use of shunts and multipliers.
The document discusses different sampling techniques used in research. It describes probability sampling methods like simple random sampling, systematic sampling, stratified random sampling, and multistage cluster sampling which ensure that each population element has a known chance of selection. It also covers non-probability sampling which uses arbitrary selection. Key advantages of probability sampling include controlling for bias and representing the population, while non-probability sampling has lower costs. Sample size is based on desired precision, population variability, and confidence level.
The document discusses design of experiments (DOE) and Taguchi methods. It explains key concepts in Taguchi's approach such as quality robustness, quality loss function, and target specifications. Taguchi techniques use experimental design methods to identify important variables affecting a product or process and optimize the design. The document provides examples of full and fractional factorial experiments to study the effects of multiple factors and interactions. It emphasizes the importance of considering interactions between factors rather than just main effects.
Deriving likelihood functions is often perceived as a daunting task. This slides shows how the likelihood function is derived in a general case and demonstrate it for different models.
Part of the Eawag Summer School on System Analysis.
Recurrent Neuronal Network tailored for Weather Radar NowcastingAndreas Scheidegger
A Recurrent Neuronal Network (RNN) is used for short term prediction of weather radar images. The aim is to predict future rain fields.
The model structure has been carefully selected to guide the model and make learning more efficient.
Experimental design approach for optimal selection and placement of rain sensorsAndreas Scheidegger
1) The optimal placement and selection of rain sensors depends on the quantity of interest, sensor locations and properties, and rain field properties.
2) An approach called CAIRS (Continuous Assimilation of Integrating Rain Sensors) uses Bayesian assimilation to infer rain intensities at measured locations and extrapolate to other locations, using prior knowledge of temporal/spatial correlations.
3) CAIRS allows experimental design to evaluate sensor configurations and identify optimal combinations for estimating rain fields with minimum uncertainty.
Bayesian assimilation of rainfall sensors with fundamentally different integr...Andreas Scheidegger
Presents "CAIRS", a generic Bayesian method to assimilate signals from traditional and novel rain sensors. CAIRS is available for free as julia package: https://github.com/scheidan/CAIRS.jl
About the potential of novel, alternative rain sensors, such as microwave links (MWL) used for telecommunication, crowd sensing, or cheap ubiquitous sensors.
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
Authoring a personal GPT for your research and practice: How we created the Q...Leonel Morgado
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
and the revised UWWTD (Urban Waste Water Treatment Directive)”
Immersive Learning That Works: Research Grounding and Paths ForwardLeonel Morgado
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
The debris of the ‘last major merger’ is dynamically youngSérgio Sacani
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Sensitivity analysis
1. Eawag: Swiss Federal Institute of Aquatic Science and Technology
Sensitivity Analysis
9th EAWAG Summer School in Environmental System Analysis 2017
Andreas Scheidegger
12.06.2017
3. Sensitivity Analysis
Investigate how a model output responds to
changes in model parameters and/or model inputs.
Factors
(SA does not make a difference of inputs and parameters)
4. Goals of Sensitivity Analysis
• Better understanding of the model and its mechanisms
• Sanity check: does the model behave as expected?
• Identification of influential and non-influential model
parameters
The model is investigated, not the underlying system!
10. Local vs. Regional Sensitivity Analysis
Two approaches to sensitivity analysis:
Local Sensitivity Analysis
Regional (global) Sensitivity Analysis
Investigation of the sensitivity of model results on parameters at a given
reference point in parameter space
The results depend on the choice of the reference point and the
parameter ranges
The results do depend on the choice of the parameter distribution
Investigation of the sensitivity of model results to the parameters based
on a probability distribution of the model parameters
11. Local Sensitivity Analysis
Two approaches to sensitivity analysis:
Regional Sensitivity Analysis
The results do no longer depend on the choice of a single reference
point but on the choice of the parameter distribution
Investigation of the sensitivity of model results to the parameters based
on a probability distribution of the model parameters
Local Sensitivity Analysis
Investigation of the sensitivity of model results on parameters at a given
reference point in parameter space
The results depend on the choice of the reference point and the
parameter ranges
12. Local Sensitivity Analysis
Deterministic model function:
The sensitivity of a model result to a parameter depends on:
functional relationship provided by the model equations
selected ranges/distributions of parameters
13. Local Sensitivity Analysis
A “natural” measure: slope (= derivative) of the model function with
respect to the component of the parameter vector
14. Local Sensitivity Analysis
Sensitivity rankings: sensitivities for each model output can be difficult to evaluate. It can
be useful to average the squares of the sensitivity functions at
different values of the index i
average sensitivity of the
model for a given parameter j
15. Local Sensitivity Analysis
Local sensitivity analysis can provide useful insights into the
model mechanisms
It is computationally relatively inexpensive
Nonlinearities of the model are not taken into account
Parameter interactions are not observed
16. Regional Sensitivity Analysis
Two approaches to sensitivity analysis:
Local Sensitivity Analysis
Investigation of the sensitivity of model results on parameters at a given
reference point in parameter space
The results depend on the choice of the reference point and the
parameter ranges
Regional (global) Sensitivity Analysis
The results do no longer depend on the choice of a single reference
point but on the choice of the parameter distribution
Investigation of the sensitivity of model results to the parameters based
on a probability distribution of the model parameters
17. Regional Sensitivity Analysis – Variance decomposition
Variance-based techniques are based on a decomposition of the variance of the
model output into contributions due to different parameters.
A fraction of the variance of a model result i is due to the distribution of a parameter j
18. Regional Sensitivity Analysis– Variance decomposition
Variance-based sensitivity analysis is based on the comparison of the total variance
of the model output with a “reduced” variance when keeping one parameter fixed
The degree of variance reduction is a
measure of the contribution of the fixed
parameter to the total output variance
To remove the dependence of the conditional variance on where we fixed the
parameter, we take the expected value of these conditional variances with
respect to the marginal distribution of the selected parameter
19. Regional Sensitivity Analysis
Fourier amplitude sensitivity testing (FAST)
1. Change all inputs with in
different frequencies
2. Analyze frequency spectra of
outputs
Image source: https://homepages.thm.de/~hg54/mmk_2006/script/multimedia/multimedia.htm
21. Regional sensitivity analysis
• Change all parameter together
• Computationally more
expensive
• Considers interactions
• Describes model behavior
across a parameter region
Sensitivity analysis
• Learn about a model, not a system
• Gives hints which parameter can be identified well from data
Summary
Local sensitivity analysis
• Change one parameter at the time
• Computationally cheap
• Simple interpretation
• No interactions
• Results only valid for one point in
parameter space