you can know about the central composite design, historical design, optimisation techniques and also about the TYPES OF CENTRAL COMPOSITE DESIGN, BOX-BEHNKEN DESIGN, DATA COLLECTION, CRITICISM OF DATA, PRESENTATION OF FACTS, PURPOSE, OPTIMISATION PROCESS, DIFFERENT TYPES PRESENT IN IT AND THEIR CLASSIFICATION AND EXPLANATION.
you can know about the central composite design, historical design, optimisation techniques and also about the TYPES OF CENTRAL COMPOSITE DESIGN, BOX-BEHNKEN DESIGN, DATA COLLECTION, CRITICISM OF DATA, PRESENTATION OF FACTS, PURPOSE, OPTIMISATION PROCESS, DIFFERENT TYPES PRESENT IN IT AND THEIR CLASSIFICATION AND EXPLANATION.
optimization techniques in pharmaceutical product developmentDeepthiKolluru1
optimization techniques and factorial designs in pharmaceutical product development.its examples in pharmaceutics and formulation for both b.pharm, m.pharm and pharm.d students
Introduction & Basics of DoE
Terminologies
Key steps in DOE
Softwares used for DOE
Factorial Designs ( Full and Fractional)
Mixture Designs
Response Surface Methodology
Central Composite Design
Box -Behnken Design
Conclusion
References
Optimization techniques in formulation Development Response surface methodol...D.R. Chandravanshi
The term “optimize” is “to make as perfect”. It is defined as follows: choosing the best element from some set of variable alternatives.
An art ,process ,or methodology of making something (a design system or decision ) as perfect ,as functional, as effective as possible .
Various approaches to Targeted Drug Delivery Systems (TDDS) in its formuation and evaluation in a pharmaceutical industry and research is outlined in this presentation.
optimization techniques in pharmaceutical product developmentDeepthiKolluru1
optimization techniques and factorial designs in pharmaceutical product development.its examples in pharmaceutics and formulation for both b.pharm, m.pharm and pharm.d students
Introduction & Basics of DoE
Terminologies
Key steps in DOE
Softwares used for DOE
Factorial Designs ( Full and Fractional)
Mixture Designs
Response Surface Methodology
Central Composite Design
Box -Behnken Design
Conclusion
References
Optimization techniques in formulation Development Response surface methodol...D.R. Chandravanshi
The term “optimize” is “to make as perfect”. It is defined as follows: choosing the best element from some set of variable alternatives.
An art ,process ,or methodology of making something (a design system or decision ) as perfect ,as functional, as effective as possible .
Various approaches to Targeted Drug Delivery Systems (TDDS) in its formuation and evaluation in a pharmaceutical industry and research is outlined in this presentation.
How People Really Hold and Touch (their Phones)Steven Hoober
For the newest version of this presentation, always go to: 4ourth.com/tppt
For the latest video version, see: 4ourth.com/tvid
Presented at ConveyUX in Seattle, 7 Feb 2014
For the newest version of this presentation, always go to: 4ourth.com/tppt
For the latest video version, see: 4ourth.com/tvid
We are finally starting to think about how touchscreen devices really work, and design proper sized targets, think about touch as different from mouse selection, and to create common gesture libraries.
But despite this we still forget the user. Fingers and thumbs take up space, and cover the screen. Corners of screens have different accuracy than the center. It's time to re-evaluate what we think we know.
Steven reviews his ongoing research into how people actually interact with mobile devices, presents some new ideas on how we can design to avoid errors and take advantage of this new knowledge, and leaves you with 10 (relatively) simple steps to improve your touchscreen designs tomorrow.
What 33 Successful Entrepreneurs Learned From FailureReferralCandy
Entrepreneurs encounter failure often. Successful entrepreneurs overcome failure and emerge wiser. We've taken 33 lessons about failure from Brian Honigman's article "33 Entrepreneurs Share Their Biggest Lessons Learned from Failure", illustrated them with statistics and a little story about entrepreneurship... in space!
You are dumb at the internet. You don't know what will go viral. We don't either. But we are slighter less dumber. So here's a bunch of stuff we learned that will help you be less dumb too.
To help the curious class stay relevant, we’ve assembled an A-Z glossary of what we predict to be the 100 must-know terms and concepts for 2017.
We hope this cultural crib sheet will help prepare you for the year ahead.
Enjoy!
Digital Strategy 101 is an overview of the current state of digital strategy and an exploration of core concepts, deliverables, and thought-leaders relevant to young practitioners.
The What If Technique presented by Motivate DesignMotivate Design
Why "What If"...?
The What If Technique tackles the challenge of engaging a creative, disruptive mindset when it comes to design thinking and crafting innovative user experiences.
Thinking disruptively is a disruptive thing to do, which means it's a very hard thing to do, especially when you add in risk-averse business leaders and company cultures, who hold on tight to psychological blocks, corporate lore, and excuse personas that stifle creativity and possibilities (see www.motivatedesign.com/what-if for more details).
The What If Technique offers key steps, tools and examples to help you achieve incremental changes that promote disruptive thinking, overcome barriers to creativity, and lead to big, innovative differences for business leaders, companies, and ultimately user experiences and products.
Let's find out what's what together! Explore your "What Ifs" with us. See www.motivatedesign.com/what-if for details about the What If Technique, studio workshops, the book, case studies and more downloads--including a the sample chapter "Corporate Lore and Blocks to Creativity"
Connect with us @Motivate_Design
An impactful approach to the Seven Deadly Sins you and your Brand should avoid on Social Media! From a humoristic approach to a modern-life analogy for Social Media and including everything in between, this deck is a compelling resource that will provide you with more than a few take-aways for your Brand!
SEO has changed a lot over the last two decades. We all know about Google Panda & Penguin, but did you know there was a time when search engine results were returned by humans? Crazy right? We take a trip down memory lane to chart some of the biggest events in SEO that have helped shape the industry today.
Inside this guide, you'll learn an insiders tips and techniques to getting into the marketing industry - no job applications necessary.
You'll learn what marketing really is, why you'll find a job easily, what entry level marketing jobs look like and four actionable things you can try right now to help get you into the marketing industry.
Visit Inbound.org and the Inbound.org/jobs community jobs board to find opportunities and connect with professional marketers from all over.
Today we all live and work in the Internet Century, where technology is roiling the business landscape, and the pace of change is only accelerating.
In their new book How Google Works, Google Executive Chairman and ex-CEO Eric Schmidt and former SVP of Products Jonathan Rosenberg share the lessons they learned over the course of a decade running Google.
Covering topics including corporate culture, strategy, talent, decision-making, communication, innovation, and dealing with disruption, the authors illustrate management maxims with numerous insider anecdotes from Google’s history.
In an era when everything is speeding up, the best way for businesses to succeed is to attract smart-creative people and give them an environment where they can thrive at scale. How Google Works is a new book that explains how to do just that.
This is a visual preview of How Google Works. You can pick up a copy of the book at www.howgoogleworks.net
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Optimization techniques
1. S.R. College of Pharmacy
Optimization Techniques
in
Pharmaceutical Formulation
and Processing
P. Raja Abhilash, M.pharm
(Ph.D.)
Assistant professor,
S.R. college of pharmacy.
2. Contents
• Introduction
• Optimization Parameters
• Classic Optimization
• Statistical Design
• Applied Optimization Methods
• Use of Computers for Optimization
• Applications
• Conclusion
• References
3. INTRODUCTION
OPTIMIZATION
It is defined as follows: choosing the best element from some set of available
alternatives.
• In Pharmacy word “optimization” is found in the literature referring to any study of
formula.
• In development projects pharmacist generally experiments by a series of logical steps,
carefully controlling the variables and changing one at a time until satisfactory results are
obtained. This is how the optimization done in pharmaceutical industry.
• OPTIMIZATION is an act, process, or methodology of making design, system or decision as
fully perfect, functional or as effective as possible.
• Optimization of a product or process is the determination of the experimental conditions
resulting in its optimal performance.
3
5. Problem types in
optimization
Unconstrained Constrained
no restrictions are restrictions are placed
placed on the system on the system
eg: preparation of hardest eg: preparation of hardest
tablet without any disintegration tablet which has the ability of
or dissolution parameters. disintegrate in less than 15min
6. variables in optimization
Independent Dependent
variables variables
directly under the control responses that are developed
of formulator due to the independent
variables
eg: eg:
disintegrant level disintegration time
compression force hardness
binder level weight
uniformity
lubricant level thickness
7. response surface curve
• Once the relationship between the variable and the response
is known, it gives the response surface as represented in the
Fig. 1. Surface is to be evaluated to get the independent
variables, X1 and X2, which gave the response, Y. Any number
of variables can be considered, it is impossible to represent
graphically, but mathematically it can be evaluated.
Fig I; response surface curve
8. Classic Optimization
•Classical optimization is done by using the calculus to basic problem to find the
maximum and the minimum of a function.
•The curve in the Fig. 2. represents the relationship between the response Y and the
single independent variable X and we can obtain the maximum and the minimum. By
using the calculus the graphical represented can be avoided. If the relationship, the
equation for Y as a function of X, is available [Eq. (1)]:
Y = f(X) ---eqn (1)
Figure 2. Graphic location of optimum (maximum or minimum)
9. Classic Optimization
• When the relationship for the response Y is given as the function of two independent
variables, X1 and X2 ,
Y = f(X1, X2)
•Graphically, there are contour plots (Fig. 3.) on which the axes represents the two
independent variables, X1 and X2, and contours represents the response Y.
Here the contours are showing the response. (contour represents the connecting point
showing the peak level of response)
Figure 3. Contour plot. Contour represents values of the dependent
variable Y
9
10. Optimization Techniques
• The techniques for optimization are broadly divided into two categories:
(A) simultaneous method: Experimentation continues as optimization study
proceeds.
E.g.: a. Evolutionary Operations Method
b. Simplex Method
(B) sequential method: Experimentation is completed before optimization takes
place.
E.g.: a. Mathematical Method
b. Search Method
• In case (B), the formulator has to obtain the relationship between the response and
one or more independent variables.
• This includes two approaches: Theoretical Approach & Empirical Approach.
11. Optimization Strategy:
Problem definition
Selection of factors and levels
Design of experimental protocol
Formulating and evaluating the dosage form
Prediction of optimum formula
Validation of optimization
12. Factorial Designs
Full factorial designs: Involve study of the effect of all
factors(n) at various levels(x) including the interactions among
them with total number of experiments as Xn .
SYMMETRIC
ASYMMETRIC
Fractional factorial designs: It is a fraction ( 1/xp ) of a
complete or full factorial design, where ‘p’ is the degree of
fractionation and the total number of experiments required
is given as xn-p .
14. Applied optimization methods
A. Evolutionary Operations (EVOP)
B. Simplex Method
C. Lagrangian Method
D. Search Method
A. canonical analysis
15. A. Evolutionary operations (EVOP)
• Most widely used method of experimental optimization in
fields other than pharmaceutical technology..
• Experimenter makes very small changes in formulation
repeatedly.
• The result of changes are statistically analyzed. If there is
improvement, the same step is repeated until further change
doesn’t improve the product.
• Can be used only in industries and not on lab scale.
16. B. Simplex Method
• It was introduced by Spendley et.al, which has been applied
more widely to pharmaceutical systems.
• A simplex is a geometric figure, that has one more point
than the no. of factors. so, for two factors ,the simplex is a
triangle.
1
• It is of two types:
A. Basic Simplex Method
B. Modified Simplex Method
2 3
• Simplex methods are governed by certain rules.
17. Basic Simplex Method
9 10
Rule 1 :
s8
s7 s9
7 11
The new simplex is formed
s6 8 s10 by keeping the two vertices
s5 from preceding simplex with
5
6
12 best results, and replacing
s4
s3 the rejected vertex (W) with
(N) 1 4 its mirror image across the
s2 (R) line defined by remaining
s1 two vertices.
2 3
(W) (B)
18. Basic Simplex Method
(W) 9 10 (W)
Rule 2 :
s8
s7 s9
7 11
When the new vertex in a
s6 8 s10 simplex is the worst
s5 response, the second lowest
5
6
12 response in the simplex is
s4
s3
(W) eliminated and its mirror
(N) 1 4 image across the line; is
s2 (R) defined as new vertices to
s1 form the new simplex.
2 3
(W) (B)
19. Basic Simplex Method
(W) 9 10 (W) Rule 3 :
s8
When a certain point is
s7 s9 retained in three successive
7 11
s6 8 s10 simplexes, the response at
s5 this point or vertex is re
5
6
12 determined and if same
s4
s3
(W) results are obtained, the
(N) 1 4
point is considered to be the
s2 (R) best optimum that can be
s1 obtained.
2 3
(W) (B)
20. Basic Simplex Method
(W) 9 10 (W) Rule 4 :
s8
If a point falls outside the
s7 s9 boundaries of the chosen
7 11
s6 8 s10 range of factors, an
s5 artificially worse response
5
6
12 should be assigned to it and
s4
s3
(W) one proceeds further with
(N) 1 4
rules 1 to 3. This will force
s2 (R) the simplex back into the
s1 boundaries.
2 3
(W) (B)
21. Modified Simplex Method
•It was introduced by Nelder-Mead in 1965.
•This method should not be confused with the simplex
algorithm of Dantzig for linear programming.
•Nelder-Mead method is popular in chemistry, chemical engg.,
pharmacy etc.
•This method involves the expansion or contraction of the
simplex formed in order to determine the optimum value more
effectively.
22. Modified Simplex Method
E1
• If response at R1 > B,
R1 expansion of simplex to E1.
N
•If response at N<= R1<=B,
C1 no expansion or contraction
is done.
•If response at R1<N,
contraction of the simplex is
B done.
W
23. C. Lagrangian Method
• It represents mathematical method of optimization.
• Steps involved:
1.Determine the objective function.
2. Determine the constraints.
3. Introduce the Lagrange Multiplier (λ) for each constraint.
4. Partially differentiate Lagrange Function (F).
5. Solve the set of simultaneous equations.
6. Substitute the resulting values into objective function.
24. Lagrangian Method (polynomial model)
Total Cost = 3x2 + 6y2 – xy ------ objective function determined!
Subject to: x+y = 20 ------------- constraints determined!
We can rewrite the condition as,
0 = 20-x-y ------- This has to be embedded in objective function
LTC = 3x2 + 6y2 – xy + λ ( 20 -x - y) ---------- Lagrange multiplier (λ) introduced
LTC = 3x2 + 6y2 – xy + 20 λ - x λ - y λ --------- Lagrange function (F)
Partial differentiation done! Now
solve the simultaneous equations
25. Lagrangian Method
6x – y - λ = 0
x – 12y + λ = 0
7x - 13y = 0
i.e. 7x = 13y
so Insert in any of the
simultaneous
equations
26. Lagrangian Method
Total Cost = 3x2 + 6y2 – xy ------ objective function
We have determined using Lagrange function, x= 13 and y= 7
Substituting these values in the objective function,
Total Cost = 3x2 + 6y2 – xy
Total Cost = 3(13)2 + 6(7)2 – (13)(7)
Total Cost = 507 + 294 – 91
Hence the total cost to produce 20 units is $ 710
27. Example for the Lagrangian Method
• The active ingredient , phenyl- propanolamine HCl,
was kept at a constant level, and the level of the
levels of disintegrant (corn starch) and lubricant
(stearic acid) were selected as the independent
variables. X1 and X2. the dependent variables include
tablet hardness, friability,invitro release rate, and
urinary excretion rate in human subject.
• A graphic technique may be obtained from the
polynomial equations, as follows:
29. D. Search methods
• Unlike the Lagrangian method, do not require differentiability of
the objective function.
• It can be used for more than two independent variables.
• The response surface is searched by various methods to find the
combination of independent variables yielding an optimum.
• select a system
• select variables: independent and dependent
• Perform experiments and test product
• Submit data for statististical and regressional analysis
• Set specifications for feasibility program
• Select constraints for grid research
• Evaluate grid search printout as contour plots
30. Example for the Search methods
Independent Variables Dependent Variables
X1 = Diluent ratio Y1 = Disintegration time
X2= Compressional force Y2= Hardness
X3= Disintegrant levels Y3 = Dissolution
X4= Binder levels Y4 = Friability
X5 = Lubricant levels Y5 = Porosity
31. Search methods
• The first 16 trials are represented
by +1 and -1.
• The remaining trials are
represented by a -1.547, zero or
1.547
• The type of predictor equation
used in this example is :
32. Search methods
The output includes plots of a given responses as a function of all
five variables.
32
33. Search methods
Contour plots for (a) disintegration time (b) tablet hardness (c)
dissolution response (d) tablet friability.
33
34. E. Canonical Analysis
Canonical analysis, or canonical reduction, is a technique used to reduce a
second-order regression equation, to an equation consisting of a constant
and squared terms, as follows:
Y = Y0+λ1W12+λ2W22+…….
35. Canonical Analysis
. In canonical analysis or canonical
reduction, second-order regression
equations are reduced to a simpler
form by a rigid rotation and translation
of the response surface axes in
multidimensional space, as shown in
Fig.14 for a two dimension system.
35
36. Use of Computers for optimization
• Statistical Analysis Systems (SAS)
• RS/Discover
• eCHIP
• Xstat
• JMP
• Design Expert
• FICO Xpress Optimization Suite
• Multisimplex
37. Applications
• Formulation and Processing
• Clinical Chemistry
• HPLC Analysis
• Medicinal Chemistry
• Studying pharmacokinetic parameters
• Formulation of culture medium in microbiology studies.
38. Conclusion
• Optimization techniques are a part of development process.
• The levels of variables for getting optimum response is
evaluated.
• Different optimization methods are used for different
optimization problems.
• Optimization helps in getting optimum product with desired
bioavailability criteria as well as mass production.
• More optimum the product = More $$ the company earns
in profits!!!
39. References
• Joseph B. Schwartz. Optimization techniques in product formulation. Journal of the Society of
Cosmetic Chemists. (1981) Vol 32; p: 287-301.
• Gilbert S. Banker, Christopher T. Rhodes. Modern Pharmaceutics. 4th edition. CRC Press.
(2002); p: 900-928.
• Optimization. 2012. In Merriam-Webster Online Dictionary. Retrieved March 07, 2012, from
http://www.merriam-webster.com/dictionary/optimization
• N. Arulsudar, N. Subramanian & R.S.R. Murthy. Comparison of artificial neural network and
multiple linear regressions in the optimization of formulation parameters of leuprolide
acetate loaded liposomes. Journal of Pharmacy & Pharmaceutical Sciences. (2005) Vol. 8(2);
p: 243-258.
• Roma Tauler, Steven D. Brown, Beata Walczak. Comprehensive Chemometrics: Chemical and
Biochemical data analysis. Elsevier. (2009); p: 555-560.
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Editor's Notes
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING