Rubella is a viral disease. occurrence in pregnancy can result in congenital rubella syndrome having catastrophic consequences in the newborn child. it is a vaccine preventable disease
Rubella, also known as German measles, is a contagious viral infection caused by the rubella virus. It presents with flu-like symptoms including a rash and swollen lymph nodes. While usually mild, rubella infection during pregnancy can cause congenital rubella syndrome in the fetus, resulting in deafness, eye abnormalities, and heart defects. The rubella virus is transmitted through the air via coughs or sneezes and can be prevented through vaccination with the MMR vaccine.
Rubella (German measles) is a disease caused by the rubella virus. Rubella is usually a mild illness. Most people who have had rubella or the vaccine are protected against the virus for the rest of their life. Because of routine vaccination against rubella since 1970 , rubella is now rarely reported.
This document discusses the epidemiology of rubella, also known as German measles. It is caused by the rubella virus, which is transmitted through respiratory droplets. Rubella usually causes a mild infection in children under 10 years old, characterized by low fever and a rash. However, infection during early pregnancy can lead to serious birth defects in the fetus known as congenital rubella syndrome. Vaccination with the MMR vaccine is recommended to prevent rubella infection and protect pregnant women.
This document provides an outline and overview of measles. It discusses the history, etiology, signs and symptoms, epidemiology, transmission, vaccine development and global elimination efforts. Measles is a highly contagious viral disease that was once common in children but has been largely eliminated through widespread vaccination programs. While outbreaks can still occur, global strategies aim to fully eradicate the disease by 2020 through continued immunization efforts.
Rubella ( german measles or three days measlsesJoseph164
Rubella, also known as German measles, is usually a mild disease that often presents with a rash. Congenital rubella syndrome can occur if a pregnant woman is infected and can cause fetal death or abnormalities. Vaccination has nearly eliminated rubella in many countries through routine childhood immunization programs. Management of an outbreak involves confirmation of cases, investigating contacts, immunizing at-risk groups, and communication to increase public awareness.
Rubella, also known as German measles, is a contagious viral infection spread through respiratory droplets from infected individuals. It causes a distinctive red rash and swollen lymph nodes. While usually mild, rubella infection during pregnancy can cause fetal death or congenital defects known as congenital rubella syndrome. There is no specific treatment for rubella, but it is preventable through vaccination.
The document discusses HIV/AIDS, providing details on:
- What HIV/AIDS is, how it is caused by the HIV virus, and how it progresses by weakening the immune system.
- The global history of HIV/AIDS, including its origins and key developments such as the identification of the virus and development of blood tests.
- Global statistics on people living with HIV/AIDS and new infections as of 2019.
- Modes of HIV transmission including unprotected sex, contaminated blood transfusions, and mother-to-child transmission.
The document describes the first reported case of 2019 novel coronavirus (2019-nCoV) in the United States. A 35-year old man from Washington state presented with cough and fever after returning from a trip to visit family in Wuhan, China. Nasopharyngeal swabs tested positive for 2019-nCoV by RT-PCR. He was treated supportively in isolation and showed clinical improvement after a course of intravenous remdesivir.
Rubella, also known as German measles, is a contagious viral infection caused by the rubella virus. It presents with flu-like symptoms including a rash and swollen lymph nodes. While usually mild, rubella infection during pregnancy can cause congenital rubella syndrome in the fetus, resulting in deafness, eye abnormalities, and heart defects. The rubella virus is transmitted through the air via coughs or sneezes and can be prevented through vaccination with the MMR vaccine.
Rubella (German measles) is a disease caused by the rubella virus. Rubella is usually a mild illness. Most people who have had rubella or the vaccine are protected against the virus for the rest of their life. Because of routine vaccination against rubella since 1970 , rubella is now rarely reported.
This document discusses the epidemiology of rubella, also known as German measles. It is caused by the rubella virus, which is transmitted through respiratory droplets. Rubella usually causes a mild infection in children under 10 years old, characterized by low fever and a rash. However, infection during early pregnancy can lead to serious birth defects in the fetus known as congenital rubella syndrome. Vaccination with the MMR vaccine is recommended to prevent rubella infection and protect pregnant women.
This document provides an outline and overview of measles. It discusses the history, etiology, signs and symptoms, epidemiology, transmission, vaccine development and global elimination efforts. Measles is a highly contagious viral disease that was once common in children but has been largely eliminated through widespread vaccination programs. While outbreaks can still occur, global strategies aim to fully eradicate the disease by 2020 through continued immunization efforts.
Rubella ( german measles or three days measlsesJoseph164
Rubella, also known as German measles, is usually a mild disease that often presents with a rash. Congenital rubella syndrome can occur if a pregnant woman is infected and can cause fetal death or abnormalities. Vaccination has nearly eliminated rubella in many countries through routine childhood immunization programs. Management of an outbreak involves confirmation of cases, investigating contacts, immunizing at-risk groups, and communication to increase public awareness.
Rubella, also known as German measles, is a contagious viral infection spread through respiratory droplets from infected individuals. It causes a distinctive red rash and swollen lymph nodes. While usually mild, rubella infection during pregnancy can cause fetal death or congenital defects known as congenital rubella syndrome. There is no specific treatment for rubella, but it is preventable through vaccination.
The document discusses HIV/AIDS, providing details on:
- What HIV/AIDS is, how it is caused by the HIV virus, and how it progresses by weakening the immune system.
- The global history of HIV/AIDS, including its origins and key developments such as the identification of the virus and development of blood tests.
- Global statistics on people living with HIV/AIDS and new infections as of 2019.
- Modes of HIV transmission including unprotected sex, contaminated blood transfusions, and mother-to-child transmission.
The document describes the first reported case of 2019 novel coronavirus (2019-nCoV) in the United States. A 35-year old man from Washington state presented with cough and fever after returning from a trip to visit family in Wuhan, China. Nasopharyngeal swabs tested positive for 2019-nCoV by RT-PCR. He was treated supportively in isolation and showed clinical improvement after a course of intravenous remdesivir.
Rubella, also known as German measles, is a mild viral illness caused by the rubella virus. It was first described as a distinct clinical entity in the 18th century. In 1941, an Australian ophthalmologist documented the virus's ability to cause birth defects when a pregnant woman is infected. An attenuated vaccine was developed in 1967 that provides lifelong immunity. The virus is transmitted through respiratory droplets and causes a maculopapular rash. If a pregnant woman is infected it can lead to congenital rubella syndrome in the fetus, resulting in defects like deafness, cataracts and heart disease. Diagnosis involves virus isolation or serology to detect antibodies. There is no specific treatment but the live attenuated M
This document provides information on rubella (German measles), including:
- It is a viral disease that mainly affects children and causes a rash and lymph node swelling.
- The virus was isolated in the 1960s and a live attenuated vaccine was developed in 1967.
- Infection during pregnancy can cause congenital rubella syndrome in the baby.
- Transmission is via respiratory droplets and the infection is usually mild but can cause birth defects if a woman is infected during pregnancy.
- Rubella vaccination is recommended to control the disease.
Rubella, also known as German measles, is generally a mild viral illness that is often asymptomatic in children but can cause serious birth defects if contracted during pregnancy. It spreads through respiratory droplets. While rubella itself is usually not serious, infection during the first trimester of pregnancy can lead to congenital rubella syndrome in the fetus, causing defects such as deafness, heart problems, and cataracts. The rubella virus was isolated in 1962. An attenuated vaccine was developed in 1967 and is included in the routine MMR vaccine for children, helping to control outbreaks and prevent congenital rubella syndrome through herd immunity.
This document provides information about poliomyelitis (polio) including its history, epidemiology, clinical features, diagnosis, treatment, vaccination, and global eradication efforts. It notes that polio cases have declined globally from over 350,000 cases in more than 125 endemic countries in 1985 to just 22 cases in Afghanistan and Pakistan in 2019. India was declared polio-free in 2014 and key milestones in India's polio eradication program are highlighted. Oral polio vaccine and inactivated polio vaccine are discussed.
Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus. This disease is often mild with half of the people not realizing that they are infected. A rash may start around two weeks after exposure and last for three days.
- Rubella, also known as German measles, is a viral infection that can cause birth defects if a pregnant woman is infected.
- It is caused by the rubella virus and spreads through respiratory droplets. While it usually causes a mild illness in children, it poses risks during pregnancy.
- If a pregnant woman is infected during the first trimester, the virus can cross the placenta and infect the fetus, possibly resulting in congenital rubella syndrome which can affect multiple organs and body systems in the baby.
Mumps is a contagious viral infection that causes swelling of the salivary glands. It is transmitted through saliva or respiratory droplets from infected individuals. Common symptoms include fever, headache, swelling and tenderness of the parotid salivary glands. Complications can include meningitis, pancreatitis, orchitis and deafness. Mumps is preventable through vaccination with the MMR vaccine, which provides lifelong immunity for most people.
Influenza, or seasonal flu, is caused by influenza viruses type A, B, or C. Type A viruses can cause pandemics when new subtypes emerge that humans have little immunity against. Influenza spreads easily through droplets and contact. Common symptoms include fever, cough, and sore throat. Young children, elderly adults, and those with underlying health conditions are at highest risk of complications like pneumonia. Seasonal flu epidemics typically occur in winter. Vaccination is recommended for at-risk groups. Antiviral drugs can treat influenza if started early. Good hygiene and avoiding sick people can help prevent spread.
This ppt is About Rabies epidemiology and treatment .
This is done by using Park book 24th edition of PSM .
This presentation is presented in academics of Master of public health in Christian medical college .
One more Important thing is that that zareb regime (intramuscular ) is not practiced . We try to make this ppt lucid. and the statistics is used in the presentation is upto 27 june 2018
This document provides information on Rubella (German measles) including its history, epidemiology, clinical manifestations, diagnosis, and treatment. Some key points:
- Rubella is a mild viral illness that was first described in the 18th century. It can cause birth defects if a pregnant woman is infected.
- A large rubella epidemic in the US in 1964-1965 resulted in over 20,000 cases of congenital rubella syndrome.
- Rubella is generally a mild childhood disease but infection during early pregnancy can cause severe birth defects collectively called congenital rubella syndrome.
- Diagnosis is made through virus isolation, serologic testing for IgM antibodies or IgG seroconversion between acute
Tuberculosis infection is very common in the world and the disease manifest when ever either the virulence of the organism increases or the resistance of the host goes down.it can affect any part of the body.the best method of control of tuberculosis is early diagnosis and treatment.despite international cooperation the problem of resistance in tuberculosis is increasing and great efforts are being made to tackle this problem both in diagnostic tools as well as in treatment modalities. the social factors also play a big role in the causation as well as emergence of resistance is concerned . a participatory approach is required to combat the problem.
Measles is a highly contagious viral illness that spreads through the air. It begins with fever, runny nose, cough, red eyes, and small white spots inside the mouth. A rash develops 3-7 days later that spreads from the face to the rest of the body. While most people recover without complications, measles can sometimes cause pneumonia, brain swelling, or even death. The measles virus is preventable through vaccination with the measles, mumps, and rubella (MMR) vaccine.
Measles is a highly infectious disease that affects children. It is caused by a virus and causes fever, runny nose, cough, and a red rash. While measles vaccination has reduced deaths, it remains a major cause of death in developing countries. The measles virus is transmitted through the air via coughing and sneezing. Complications from measles can include blindness, encephalitis, and pneumonia. Prevention relies on achieving high vaccination rates of at least 95% through routine childhood immunization.
This document discusses measles, an acute viral infection characterized by a maculopapular rash and high fever. It is caused by measles virus, an RNA virus that is highly contagious and spreads through respiratory droplets. Common symptoms include fever, cough, runny nose, and a red rash that starts on the face and spreads to the rest of the body. Complications can include pneumonia, encephalitis, and death in malnourished or immunocompromised patients. Diagnosis is based on clinical presentation and can be confirmed through virus detection or serologic testing.
Chickenpox is caused by the varicella-zoster virus. It causes a red, itchy rash that looks like blisters all over the body, and is most common in children ages 4-12. The virus is highly contagious from two days before the rash appears until the blisters crust over. While the rash is present, infected individuals are asked to stay home to prevent spreading the virus. There is an effective vaccine that provides immunity from the virus.
This document provides information on leprosy (Hansen's disease), including:
- It is caused by Mycobacterium leprae and mainly involves the skin and peripheral nerves.
- It has a worldwide distribution but is more common in developing countries. Global prevalence has dropped 90% since 1985.
- India has achieved the goal of leprosy elimination at the national level with a prevalence rate of less than 1 per 10,000 people.
- Classification systems include Ridley-Jopling (based on immunology) and WHO (for chemotherapy, divides into paucibacillary and multibacillary). Clinical features vary depending on classification from single well-defined lesions to numerous, diffuse infiltr
The document summarizes key information about several vaccine-preventable diseases including measles, rubella, mumps, diphtheria, tetanus, and chickenpox. It provides details on the infectious agents, reservoirs, modes of transmission, incubation periods, typical clinical manifestations, and potential complications for each disease. Vaccine recommendations for children and adolescents are also listed for measles, mumps, rubella, varicella, and diphtheria-tetanus-pertussis combinations.
This document discusses HIV and TB co-infection. It notes that HIV increases the risk of developing active TB due to immunosuppression. Diagnosing TB is more difficult in HIV patients as sputum smears can be negative and symptoms are atypical. WHO recommends treating TB first before beginning antiretroviral therapy for co-infected patients, and directly observed treatment to ensure adherence. Clinical trials are exploring optimal antiretroviral regimens for co-infected patients.
Rubella, also known as German measles, is caused by the rubella virus. It is usually a mild disease but can have serious complications if contracted during pregnancy, as it can cause birth defects known as congenital rubella syndrome. The virus is transmitted through the air via coughs or sneezes. While rubella infection itself is typically mild, featuring a rash and mild fever, infection during the first trimester of pregnancy carries a risk of harming the fetus, resulting in conditions like deafness, heart defects, or cataracts. The MMR vaccine, given in two doses to children, provides effective protection against rubella.
Rubella, also known as German measles, is a mild viral illness caused by the rubella virus. It can cause serious birth defects if a pregnant woman is infected. Norman McAlister Gregg first documented the teratogenic effects of rubella in 1941. The rubella virus is transmitted through respiratory droplets and causes a rash that usually lasts less than a week. Congenital rubella syndrome occurs if an infant is infected in utero and can cause deafness, heart defects, cataracts and other issues. Vaccination with the MMR vaccine is the best way to prevent rubella infection and congenital rubella syndrome.
Rubella, also known as German measles, is a mild viral illness caused by the rubella virus. It was first described as a distinct clinical entity in the 18th century. In 1941, an Australian ophthalmologist documented the virus's ability to cause birth defects when a pregnant woman is infected. An attenuated vaccine was developed in 1967 that provides lifelong immunity. The virus is transmitted through respiratory droplets and causes a maculopapular rash. If a pregnant woman is infected it can lead to congenital rubella syndrome in the fetus, resulting in defects like deafness, cataracts and heart disease. Diagnosis involves virus isolation or serology to detect antibodies. There is no specific treatment but the live attenuated M
This document provides information on rubella (German measles), including:
- It is a viral disease that mainly affects children and causes a rash and lymph node swelling.
- The virus was isolated in the 1960s and a live attenuated vaccine was developed in 1967.
- Infection during pregnancy can cause congenital rubella syndrome in the baby.
- Transmission is via respiratory droplets and the infection is usually mild but can cause birth defects if a woman is infected during pregnancy.
- Rubella vaccination is recommended to control the disease.
Rubella, also known as German measles, is generally a mild viral illness that is often asymptomatic in children but can cause serious birth defects if contracted during pregnancy. It spreads through respiratory droplets. While rubella itself is usually not serious, infection during the first trimester of pregnancy can lead to congenital rubella syndrome in the fetus, causing defects such as deafness, heart problems, and cataracts. The rubella virus was isolated in 1962. An attenuated vaccine was developed in 1967 and is included in the routine MMR vaccine for children, helping to control outbreaks and prevent congenital rubella syndrome through herd immunity.
This document provides information about poliomyelitis (polio) including its history, epidemiology, clinical features, diagnosis, treatment, vaccination, and global eradication efforts. It notes that polio cases have declined globally from over 350,000 cases in more than 125 endemic countries in 1985 to just 22 cases in Afghanistan and Pakistan in 2019. India was declared polio-free in 2014 and key milestones in India's polio eradication program are highlighted. Oral polio vaccine and inactivated polio vaccine are discussed.
Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus. This disease is often mild with half of the people not realizing that they are infected. A rash may start around two weeks after exposure and last for three days.
- Rubella, also known as German measles, is a viral infection that can cause birth defects if a pregnant woman is infected.
- It is caused by the rubella virus and spreads through respiratory droplets. While it usually causes a mild illness in children, it poses risks during pregnancy.
- If a pregnant woman is infected during the first trimester, the virus can cross the placenta and infect the fetus, possibly resulting in congenital rubella syndrome which can affect multiple organs and body systems in the baby.
Mumps is a contagious viral infection that causes swelling of the salivary glands. It is transmitted through saliva or respiratory droplets from infected individuals. Common symptoms include fever, headache, swelling and tenderness of the parotid salivary glands. Complications can include meningitis, pancreatitis, orchitis and deafness. Mumps is preventable through vaccination with the MMR vaccine, which provides lifelong immunity for most people.
Influenza, or seasonal flu, is caused by influenza viruses type A, B, or C. Type A viruses can cause pandemics when new subtypes emerge that humans have little immunity against. Influenza spreads easily through droplets and contact. Common symptoms include fever, cough, and sore throat. Young children, elderly adults, and those with underlying health conditions are at highest risk of complications like pneumonia. Seasonal flu epidemics typically occur in winter. Vaccination is recommended for at-risk groups. Antiviral drugs can treat influenza if started early. Good hygiene and avoiding sick people can help prevent spread.
This ppt is About Rabies epidemiology and treatment .
This is done by using Park book 24th edition of PSM .
This presentation is presented in academics of Master of public health in Christian medical college .
One more Important thing is that that zareb regime (intramuscular ) is not practiced . We try to make this ppt lucid. and the statistics is used in the presentation is upto 27 june 2018
This document provides information on Rubella (German measles) including its history, epidemiology, clinical manifestations, diagnosis, and treatment. Some key points:
- Rubella is a mild viral illness that was first described in the 18th century. It can cause birth defects if a pregnant woman is infected.
- A large rubella epidemic in the US in 1964-1965 resulted in over 20,000 cases of congenital rubella syndrome.
- Rubella is generally a mild childhood disease but infection during early pregnancy can cause severe birth defects collectively called congenital rubella syndrome.
- Diagnosis is made through virus isolation, serologic testing for IgM antibodies or IgG seroconversion between acute
Tuberculosis infection is very common in the world and the disease manifest when ever either the virulence of the organism increases or the resistance of the host goes down.it can affect any part of the body.the best method of control of tuberculosis is early diagnosis and treatment.despite international cooperation the problem of resistance in tuberculosis is increasing and great efforts are being made to tackle this problem both in diagnostic tools as well as in treatment modalities. the social factors also play a big role in the causation as well as emergence of resistance is concerned . a participatory approach is required to combat the problem.
Measles is a highly contagious viral illness that spreads through the air. It begins with fever, runny nose, cough, red eyes, and small white spots inside the mouth. A rash develops 3-7 days later that spreads from the face to the rest of the body. While most people recover without complications, measles can sometimes cause pneumonia, brain swelling, or even death. The measles virus is preventable through vaccination with the measles, mumps, and rubella (MMR) vaccine.
Measles is a highly infectious disease that affects children. It is caused by a virus and causes fever, runny nose, cough, and a red rash. While measles vaccination has reduced deaths, it remains a major cause of death in developing countries. The measles virus is transmitted through the air via coughing and sneezing. Complications from measles can include blindness, encephalitis, and pneumonia. Prevention relies on achieving high vaccination rates of at least 95% through routine childhood immunization.
This document discusses measles, an acute viral infection characterized by a maculopapular rash and high fever. It is caused by measles virus, an RNA virus that is highly contagious and spreads through respiratory droplets. Common symptoms include fever, cough, runny nose, and a red rash that starts on the face and spreads to the rest of the body. Complications can include pneumonia, encephalitis, and death in malnourished or immunocompromised patients. Diagnosis is based on clinical presentation and can be confirmed through virus detection or serologic testing.
Chickenpox is caused by the varicella-zoster virus. It causes a red, itchy rash that looks like blisters all over the body, and is most common in children ages 4-12. The virus is highly contagious from two days before the rash appears until the blisters crust over. While the rash is present, infected individuals are asked to stay home to prevent spreading the virus. There is an effective vaccine that provides immunity from the virus.
This document provides information on leprosy (Hansen's disease), including:
- It is caused by Mycobacterium leprae and mainly involves the skin and peripheral nerves.
- It has a worldwide distribution but is more common in developing countries. Global prevalence has dropped 90% since 1985.
- India has achieved the goal of leprosy elimination at the national level with a prevalence rate of less than 1 per 10,000 people.
- Classification systems include Ridley-Jopling (based on immunology) and WHO (for chemotherapy, divides into paucibacillary and multibacillary). Clinical features vary depending on classification from single well-defined lesions to numerous, diffuse infiltr
The document summarizes key information about several vaccine-preventable diseases including measles, rubella, mumps, diphtheria, tetanus, and chickenpox. It provides details on the infectious agents, reservoirs, modes of transmission, incubation periods, typical clinical manifestations, and potential complications for each disease. Vaccine recommendations for children and adolescents are also listed for measles, mumps, rubella, varicella, and diphtheria-tetanus-pertussis combinations.
This document discusses HIV and TB co-infection. It notes that HIV increases the risk of developing active TB due to immunosuppression. Diagnosing TB is more difficult in HIV patients as sputum smears can be negative and symptoms are atypical. WHO recommends treating TB first before beginning antiretroviral therapy for co-infected patients, and directly observed treatment to ensure adherence. Clinical trials are exploring optimal antiretroviral regimens for co-infected patients.
Rubella, also known as German measles, is caused by the rubella virus. It is usually a mild disease but can have serious complications if contracted during pregnancy, as it can cause birth defects known as congenital rubella syndrome. The virus is transmitted through the air via coughs or sneezes. While rubella infection itself is typically mild, featuring a rash and mild fever, infection during the first trimester of pregnancy carries a risk of harming the fetus, resulting in conditions like deafness, heart defects, or cataracts. The MMR vaccine, given in two doses to children, provides effective protection against rubella.
Rubella, also known as German measles, is a mild viral illness caused by the rubella virus. It can cause serious birth defects if a pregnant woman is infected. Norman McAlister Gregg first documented the teratogenic effects of rubella in 1941. The rubella virus is transmitted through respiratory droplets and causes a rash that usually lasts less than a week. Congenital rubella syndrome occurs if an infant is infected in utero and can cause deafness, heart defects, cataracts and other issues. Vaccination with the MMR vaccine is the best way to prevent rubella infection and congenital rubella syndrome.
Measles, mumps, and rubella are viral infections that are prevented through the MMR vaccine. Measles causes an infectious rash and can lead to pneumonia or encephalitis. Mumps causes swelling of the parotid glands and can cause meningitis. Rubella during pregnancy can lead to congenital defects known as congenital rubella syndrome. The live, attenuated MMR vaccine provides protection against all three viruses and is recommended in two doses for children.
This document discusses rubella (German measles). It provides information on:
- Rubella is caused by the rubivirus and affects both sexes equally, usually occurring in children aged 5-9.
- The virus enters through the respiratory tract and spreads to lymph nodes, causing a rash after 7-9 days.
- Infection confers lifelong immunity. Contracting rubella while pregnant can cause congenital rubella syndrome in the baby.
- Treatment focuses on rest, symptoms, isolation during infection period, and vaccination to prevent spread.
Primary maternal syphilis infection can infect the fetus in utero. Without treatment, fetal infection risks include stillbirth, premature birth, low birthweight, and neonatal death. Fetal infection may also cause deformities of the nose, long bones, and teeth. Diagnosis involves maternal and fetal serology, with treatment of pregnant women and neonates with penicillin to prevent transmission and morbidity.
Torch infections in pregnancy presentationAashissh Shah
The document provides an overview of TORCH infections, which are a group of perinatal infections that can be passed from a pregnant woman to her fetus. The TORCH acronym stands for Toxoplasmosis, Other (syphilis, varicella, parvovirus B19, listeriosis, coxsackie virus), Rubella, Cytomegalovirus, and Herpes simplex virus. Each infection is described in terms of transmission, clinical features, diagnosis, and treatment. Congenital infections can cause severe fetal anomalies or loss. Screening and treatment are important for preventing adverse effects in pregnancy.
Measles is a highly contagious viral infection that is transmitted through respiratory droplets. It causes a rash and fever and can lead to severe complications or death, especially in malnourished children. Before the widespread use of the measles vaccine in the 1960s, nearly all children contracted measles by age 10. Through vaccination campaigns and increased immunization rates, global measles deaths have declined significantly. However, ongoing efforts are still needed to achieve regional elimination goals and protect susceptible populations.
Measles is a highly contagious viral infection that is transmitted through respiratory droplets. It causes a rash and fever and can lead to severe complications without vaccination. Before widespread vaccination, measles killed millions of children globally each year. Two doses of the measles vaccine, usually combined in the MMR vaccine, are effective at preventing the disease and its complications. Public health efforts aim to achieve at least 90% vaccination coverage to eliminate measles through both routine immunization and supplemental catch-up campaigns.
1. The document discusses several enveloped RNA viruses including paramyxoviruses, orthomyxoviruses, and togaviruses. Paramyxoviruses covered include human parainfluenza viruses, mumps virus, measles virus, and respiratory syncytial virus.
2. Paramyxoviruses have a non-segmented negative-sense RNA genome and cause diseases like croup, pneumonia, and measles. They are transmitted through respiratory droplets and cause infections in the respiratory tract.
3. Rubella virus is a togavirus that can cause mild fever and rash after infection but can have serious complications if a pregnant woman is infected, potentially resulting in congen
This document discusses TORCH infections that can affect pregnancy. It covers Toxoplasmosis, Rubella, CMV, and Herpes infections. For each infection, it describes transmission, clinical manifestations, effects on pregnancy like risk of transmission and fetal anomalies, diagnosis, and treatment approaches. For toxoplasmosis, it highlights risks increase with gestational age and treatments include pyrimethamine and spiramycin. For rubella, congenital rubella syndrome can cause fetal defects if acquired early in pregnancy. CMV and herpes infections also pose risks of fetal transmission and growth restriction. Diagnosis involves serology and PCR testing of amniotic fluid. Treatment may include antivirals and monitoring for complications.
Rubella, also known as German measles, is caused by the rubella virus. It is transmitted through airborne droplets or direct contact. A person is contagious from one week before the rash appears until one week after. Clinical manifestations in children include fever, swollen lymph nodes, and a rash lasting 3 days. In adults, arthritis is common. Infection during pregnancy can cause miscarriage or congenital rubella syndrome in the baby, affecting growth, vision, hearing, and development. Diagnosis is clinical and treatment focuses on symptoms. Prevention involves vaccination with two doses of the MMR vaccine.
This document discusses various perinatal and congenital infections including TORCH infections. It provides details on the causative organisms, modes of transmission, clinical features, diagnosis, and management of toxoplasmosis, rubella, CMV, herpes, HIV, hepatitis B, tuberculosis, varicella zoster virus, syphilis, malaria, and parvovirus infections. Timely diagnosis and treatment of perinatally acquired infections is important. Prevention strategies include maternal screening, vaccination, treatment of infected mothers, and avoiding risk factors during pregnancy and delivery.
Rubella is a viral infection transmitted through respiratory droplets. It causes a rash and fever lasting less than a week. While usually mild, rubella infection during pregnancy can cause congenital rubella syndrome in the fetus, resulting in deafness, eye problems, and heart defects. Rubella virus is diagnosed through serologic tests detecting antibodies. Rubella vaccination helps prevent infection and congenital rubella syndrome.
Rubella, also known as German measles, is a mild childhood infection caused by the rubella virus. It is typically a mild disease lasting 1-3 days, though infection during pregnancy can cause serious complications for the fetus. The virus is transmitted through respiratory droplets. Diagnosis is made through virus isolation or serological tests. There is no specific treatment, though vaccination provides effective prevention.
Measles is a highly contagious viral infection that spreads through the air. It typically causes a rash, fever, and other symptoms. While a safe and effective vaccine exists, measles cases have risen globally due to undervaccination. Treatment focuses on relieving symptoms, while complications can include secondary infections of the lungs, brain, or eyes. Vaccination has significantly reduced measles deaths worldwide.
Smallest known DNA viruses.
Structure
Non-enveloped
18-26 nm diameter
Single-stranded DNA, 5.6 kb
Icosahedral
Parvovirinae (vertebrates)
Parvovirus
Erythrovirus
Dependovirus (requires helper virus, such as an adenovirus)
Bocavirus
Amdovirus
Densovirinae (invertebrates)`
B19 virus most common.
Diseases
Erythema infectiosum (cutaneous rash)
Polyarthropathy syndrome (acute or chronic)
Transient aplastic crisis (severe acute anemia)
Pure red cell aplasia (chronic anemia)
Hydrops fetalis (fetal anemia)
Simplest animal viruses infecting humans, responsible for - childhood exanthema - erythema infectiosum (fifth disease).
Smallest viruses (18–26 nm size)
Non-enveloped with icosahedral symmetry
Only DNA viruses - possess single-stranded DNA
Depend upon the host cell enzymes for replication
Transmission - Respiratory route, followed by blood transfusion and transplacental route.
Infects precursors of RBCs: Parvovirus B19 has a special tropism for erythroid progenitor cells present in adult bone marrow and foetal liver as it binds to blood group P antigen as receptors; which are present on the RBC surface.
This results in red cell destruction and inhibition of erythropoiesis
Erythema infectiosum (or fifth disease)
Transient aplastic crisis
Pure red cell aplasia
Non-immune hydrops fetalis
Papular-purpuric gloves and socks syndrome
Known to cause foetal loss through hydrops fetalis; severe anaemia, congestive heart failure, generalized oedema and foetal death
No evidence of teratogenicity.
Risk of foetal death highest when infection occurs during the second trimester of pregnancy (12%).
Molecular methods:
PCR - detects viral DNA (e.g. genes coding for VP1 and VP2) from serum, tissue or respiratory secretions.
Real time PCR - used for quantification of viral load in blood, during acute infections
Antibody detection: ELISA – detecting antibodies against VP1 and VP2 antigens. IgM appears early - recent infection and remains elevated for 2–3 months
Antigen detection: Immunohistochemistry - detect viral antigens in fetal tissues and bone marrow.
No antiviral drug is available
Symptomatic treatment is given
Immunoglobulins containing neutralizing antibodies to human parvovirus are available commercially
No antiviral drug is available
Symptomatic treatment is given
Immunoglobulins containing neutralizing antibodies to human parvovirus are available commercially
Measles is an acute, highly contagious childhood disease characterized by fever & respiratory symptoms, followed by typical maculopapular rash.
Transmission
Droplets inhalation over short distances and, less commonly,
Small-particle aerosols - remain suspended especially in schools, hospitals, and enclosed public places in the air for longer period.
Spread-The virus multiplies locally in the respiratory tract; then spreads to the regional lymph nodes → enter into the bloodstream in infected monocytes (primary viremia)→further multiply in reticuloendothelial system → spills over into blo
The rubella virus causes German measles and belongs to the Togaviridae family. It is a small, enveloped RNA virus that is highly contagious and spreads through respiratory droplets. Rubella infection typically causes a mild illness in children and adults characterized by fever, rash, and lymphadenopathy. However, infection during pregnancy can lead to congenital rubella syndrome in the fetus, resulting in birth defects. Rubella is diagnosed through clinical evaluation, patient history, and serological tests. It can be prevented through vaccination with the MMR or MMRV vaccines.
Rubella is caused by a togavirus that spreads through respiratory droplets. It typically causes a maculopapular rash and lymphadenopathy. While usually mild, rubella infection during the first trimester of pregnancy can cause congenital rubella syndrome in the fetus, leading to deafness, cataracts, heart defects, and intellectual disabilities. Prevention is through immunization with the MMR vaccine.
Can the health system sustain population explosion in indiaHarivansh Chopra
The health system in India faces challenges in sustaining the country's growing population. There are shortfalls across primary health centers, community health centers, and specialist doctors in rural areas. Literacy and access to family planning have improved but fertility rates, child mortality, and unmet need for family planning remain high. Uttar Pradesh has a very large population that stresses its health resources. The document argues that population control laws and strong implementation are needed to help address these issues.
Lesson learned and not learned in COVID -19 PANDEMICHarivansh Chopra
The document discusses lessons learned and not learned from the COVID-19 pandemic. It notes that disease was treated as a disaster rather than understood transmission dynamics. Guidelines changed frequently. Preparations only focused on approved hospitals. The private sector and community participation were not involved. Effective implementation of masks, distancing, and hygiene was lacking. It argues the vaccination strategy should consider demand, waste, hesitancy, access, trust, and supply at the city, state, ward and family levels. Community participation and inter-sectoral coordination are needed, along with primary healthcare development, to manage pandemics.
Bio psycho social and spiritual dimension and chdHarivansh Chopra
This presentation is a part of webinar on prevention and reversal of chd and type 2 diabetes mellitus . in this presentation prof rahul bansal has emphasised the role of mind body connection and role of stress in causation as well its removal in prevention and reversal of chd.he has given ample evidence of use of meditation, yoga, as well as of prayers and diet in the reversal of chd
This document discusses coronary artery disease (CAD) and its epidemiology in India. It provides three real stories about myocardial infarctions occurring in young individuals to illustrate the severity of the issue. It then presents statistics on the leading causes of death in India, showing that cardiovascular diseases are becoming more common, now accounting for over a third of deaths and occurring at younger ages compared to developed countries. The document discusses the traditional risk factors for CAD, including diabetes, hypertension, smoking, dyslipidemia, obesity, lack of exercise, and family history. It provides data on the prevalence of these risk factors in India. The document emphasizes that risk factor assessment is not prevalent in India's public health system. It concludes by describing clinical features of
Promotion of child survival -Experiences, innovations and opportunitiesHarivansh Chopra
In this presentation, i have discussed the normal growth in children. the focus of attention must be an infant as it is the time of maximum growth and chances of growth faltering are also high. if one has to reduce underfive mortality and promote child survival than aBIGWIN APPROACH is to be followed. i have also shared few success stories of low birth weight babies attaining the target at one year of age.causes of malnutrition are also discussed and what type of opportunities are there for public health professional in the community settings.focus from under six has to be shifted to ist year of life
crying in infant is a normal phenomenon but can be troublesome when an infant cry excessively. colic is an acronym and it is important to rule out every physiological and pathological cause before making a diagnosis of colic.this presentation will help you in doing so . happy viewing.
Success stories & innovative approach for prevention of childhood malnutr...Harivansh Chopra
in this presentation i have shown few success stories of low birth weight children attaining normal weight by the end of first year by implementing an innovative BIGWIN APPROACH. Bigwin is an acronym for the best practices described aptly in this presentation.if we can shift the strategy to prevent malnutrition in children from under six to under one than we can overcome malnutrition in five years time provided if we are able to reach every pregnant women and newborn child.
This is a most basic presentation on balanced diet and RDA. Unfortunately the basic requirements are easily forgotten and right kind of nutrition education is thus not provided to population. Remembering the right requirement in vulnerable periods is of utmost important to prevent the occurrence of deficiency and its deleterious effects
Vitamin C is an essential water-soluble nutrient that functions as an antioxidant. It is required in the diet since humans cannot produce it internally. Vitamin C deficiency can result in scurvy, with symptoms of bleeding gums, slow wound healing, and bone pain. Cooking, storage, and processing can reduce vitamin C content in foods. Good dietary sources include amla, guava, and citrus fruits. The recommended daily intake is 40 mg for adults.
This document discusses the role of diet in coronary heart disease (CHD). It identifies major modifiable risk factors for CHD like diabetes, obesity, elevated cholesterol, and homocysteinemia that can be influenced by diet. It provides dietary recommendations for individuals with CHD risk factors or existing CHD, focusing on limiting saturated fats, cholesterol and refined carbohydrates while emphasizing plant-based foods, fiber and antioxidants. The document also describes reversal diets for CHD that restrict animal products and emphasize polyunsaturated and monounsaturated fats to potentially reverse the effects of CHD.
Nutrition assessment in children- dr harivansh chopraHarivansh Chopra
Assessment of nutritional status especially in vulnerable population is important for taking prompt action. young children are the most affected proportion of the population in the world.In community settings, rapid methods of assessment are important tools to identify children suffering from both macro and micro deficiencies .This is pictorial presentation showing various methods as well as pictures of deficiencies
Nutritional deficiencies are very common in india as well as in other developing countries.both macro and micro nutrients are not eaten in adequate quantities in india due to poverty and ignorance. A number of national program are there to combat these deficiencies.But unfortunately effective implementation is lacking due to which nutritional deficiency is not being overcome in our country. Now due to covid -19 these are bound to increase
Stress is the gift of modern society which has got a lot of bearing on the mental and physical health of the people . the stress can't be eliminated in totality but can be minimised by using this simple presentation and applying it in day to day life .the answer of stress is in the word stress only.kindly view and use and share it further.
Medicine is considered as one of the best profession in the world and Doctors are still considered next to GOD because they save human life. now a days doctors in developing countries are under tremendous stress. lot of changes are happening in medical education and recently national medical commission has started a new initiative to to change the teaching learning practices medical colleges. Now the upcoming doctors are to be trained keeping in mind the necessary attributes and skills which are required to fulfil their responsibility in fitting manner in future.
This presentation is based upon my more than 3 decades of experience in medical college.
Immunization is one of the best public health intervention to reduce mortality and morbidity caused by vaccine preventable diseases. in this part i am going to describe regarding cold chain ,frequently ask questions regarding vaccines and how to manage acute and life threatening adverse reactions at most peripheral level
Immunization is one of the best public health intervention to prevent morbidity as well as mortality. it also help in prevention of malnutrition in young children.still developing countries are trying hard to make it universal. in india lot of changes have taken place in the immunization schedule and number of newer vaccines have been incorporated. still the awareness as well as acceptability is not universal . this presentation is very basic and will help students as well as teachers. we all have to join hands to make it universal
japenese encephalitis is an important vector borne disease which carries a high mortality as well as high disability. it is a preventable disease and an effective vaccine is available for it.the vaccine is an important part of universal immunization program in india. Environmental modification and control of vector will go long way in the control of this disease.
Enhancing child survival means keeping the normal child as normal as well as bringing low birth weight child to normal.this presentation describe four real stories of low birth weight children attaining normal weight by the end of first year. for this intensive child caring practices are to be implemented. in fact a BIGWIN APPROACH is applied. if this strategy is scaled up then we can make india and other developing countries free of malnutrition in five years thereby giving a big boost to child survival.videotalk can be seen at https://youtu.be/7Ey07cV2clw
meningococcal meningitis is a very serious and fatal disease if not treated in time. the case fatality rate can go upto 50% in untreated cases .there are many strains which are responsible for its occurrence .it tend to occur both in endemic as well as in epidemic form. a qudrivalent vaccine is available for protection. recipient of this vaccine are to be given chemo prophylaxis .recently a vaccine against type b strain has been made avialable in canada for use in routine immunization
This presentation describes the Evolution of Community Medicine from the word hygiene to public health to preventive and social medicine to community medicine . It is a very simple presentation which describes difference between doctor ,good doctor and a very good doctor. It also includes recent IAPSM ( INDIAN ASSOCIATION OF PREVENTIVE AND SOCIAL MEDICINE) definition of Community Medicine and what are the key functions of Community Medicine Specialist. it also describes concept of Socialized Medicine.
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
1. Rubella –
German Measles
Dr. Harivansh Chopra,
DCH., MD
Professor
Community Medicine,
LLRM Medical College,
Meerut.
harichop@gmail.com
2. DR. HARIVANSH CHOPRA
Objectives of Lecture
1. To study the epidemiology of Rubella.
2. To study Rubella in pregnancy and its
management.
3. Understanding the manifestations of
Congenital Rubella.
4. Prevention of Rubella and strategies
for Rubella vaccination.
3. DR. HARIVANSH CHOPRA
Why Rubella is k/a
“German Measles”?
The word "German" in the name of this
disease has nothing to do with the
country. The name likely comes from
the Latin term "germanus" meaning
"similar." And indeed, rubella and
measles (rubeola) share some
characteristics, but they're caused by
different viruses.
4. DR. HARIVANSH CHOPRA
Etiology Pleomorphic RNA virus.
Family Togaviridae;
Genus Rubivirus.
RUBELLA
(GERMAN / 3-DAY MEASLES)
5. DR. HARIVANSH CHOPRA
Epidemiology
1. Spread by oral droplet or
transplacentally through
congenital infection.
RUBELLA
(GERMAN / 3-DAY MEASLES)
6. DR. HARIVANSH CHOPRA
Epidemiology
2. The period of infectivity is 7 days
prior to onset of rash and 7 days
after disappearance of rash.
3. The incubation period ranges
from 14 days to 21 days (average
= 18 days).
RUBELLA
(GERMAN / 3-DAY MEASLES)
7. DR. HARIVANSH CHOPRA
Epidemiology
4. Peak incidence of disease in
children 3-10 yrs. of age
(> 70% of cases in developed
countries occur in > 15 yrs.
old).
5. Many infections are sub
clinical with a ratio of 2:1;
inapparent to overt disease.
RUBELLA
(GERMAN / 3-DAY MEASLES)
8. DR. HARIVANSH CHOPRA
Epidemology
6. In closed population, almost
100% of susceptible individuals
may become infected. In family
setting spread of virus is less –
50-60%.
RUBELLA
(GERMAN / 3-DAY MEASLES)
9. DR. HARIVANSH CHOPRA
RUBELLA
(GERMAN / 3-DAY MEASLES)
Epidemiology
7. A single attack usually confers
permanent immunity.
8. Epidemics occurred every 6-9 years
before vaccine was available.
9. Infants with rubella are a source of
infection for older children who are
not immune & for non-immune
adults, including pregnant women
& nursery personnel.
10. DR. HARIVANSH CHOPRA
RUBELLA
(GERMAN / 3-DAY MEASLES)
Epidemiology
10. Disease occurs in seasonal
pattern i.e. during the later
winter and spring, with
epidemics repeating every
4 – 9 years.
11. DR. HARIVANSH CHOPRA
1. Prodromal phase – Mild catarrhal symptoms;
shorter than measles; may be so mild as to go
unnoticed.
2. Most characteristic sign is Retroauricular,
Posterior Cervical & Post-Occipital adenopathy
which is tender.
3. Lymphadenopathy is evident at least 24 hrs.
before rash appears & remains for 1 week or
more.
CLINICAL MANIFESTATIONS
OF RUBELLA
12. DR. HARIVANSH CHOPRA
3. An enanthem may appear just before the
onset of skin rash. It is discrete rose spots
on soft palate that may coalesce into a red
bluish & extend over the fauces.
(Forchheimer spots)
4. Rash begins on face & spread quickly; rash
may be fading on face by the time it appears
on the trunk.
CLINICAL MANIFESTATIONS
OF RUBELLA
13. DR. HARIVANSH CHOPRA
CLINICAL MANIFESTATIONS
OF RUBELLA
5. Rash is discrete maculo-papular with large
areas of flushing; spreads rapidly over the
entire body within 24 hrs.
6. Rubella without a rash has been described.
7. Fever is slight or absent during the rash &
persists for 1-2 or occasionally 3 days.
14. DR. HARIVANSH CHOPRA
8. Anorexia, Headache & Malaise are
not common.
9. Spleen is often slightly enlarged.
10. Thrombocytopenia is rare.
11. Paraesthesia.
CLINICAL MANIFESTATIONS
OF RUBELLA
15. DR. HARIVANSH CHOPRA
12. In older children Polyarthritis may with
Arthralgia & Swelling, Tenderness &
Effusion but without Residuum; Small
joints of hands are affected most
frequently. Duration is usually several days
to 2 weeks rarely for months.
13. Orchidalgia also reported.
CLINICAL MANIFESTATIONS
OF RUBELLA
16. DR. HARIVANSH CHOPRA
Viral Others
Measles. Meningococcemia.
Roseola Infantum. Typhoid fever.
Erythema Infectiosum. Scarlet fever.
Infectious
Mononucleosis.
Live viral vaccine.
Drug eruption.
DIFFERENTIAL DIAGNOSIS
17. DR. HARIVANSH CHOPRA
Stage of
Gestation
(weeks)
when mother
is infected
Percentage
of fetus
infected
Percentage
of infected
fetus
damaged
Overall risk
damages to
fetus (in
percent)
< 11 90 100 90
11-16 55 37 20
17-26 33 0 0
27-36 53 0 0
Risk of damage to fetus by Maternal Rubella
during pregnancy
18. DR. HARIVANSH CHOPRA
Latex agglutination, enzyme immunoassay,
passive hemagglutination,
and fluorescent immunoassay appear
to be equal or superior to the HI test in
sensitivity.
Immunoglobulin (Ig) M antibodies are
detectable in the first few days of illness
and are considered diagnostic.
DIAGNOSIS
19. DR. HARIVANSH CHOPRA
Detection of IgM antibodies, which do not
cross the placenta, in the newborn is
especially useful for the diagnosis of
congenital rubella syndrome.
Seroconversion, or a fourfold increase in
IgG titer, is diagnostic.
DIAGNOSIS
21. DR. HARIVANSH CHOPRA
COMPLICATIONS
Complications are relatively
uncommon in childhood.
Encephalitis similar to that seen with
measles occurs in about 1 in 6,000
cases. The severity is highly
variable, and there is an overall
mortality rate of 20%
Thrombocytopenic purpura occurs
at an overall rate of 1 in 3,000
cases.
22. DR. HARIVANSH CHOPRA
PREGNANCY & RUBELLA
Pregnant Female with unknown immune status
exposed to Rubella
ANTIBODY TESTING
SUSCEPTIBLE NOT SUSCEPTIBLE
Abortion advised Reassurance
23. DR. HARIVANSH CHOPRA
PREGNANCY & RUBELLA
Female susceptible but
Abortion unacceptable
Rubella Immunoglobulin
0.55 ml/kg body weight given IM
Under no condition in pregnancy should an Active
Immunisation against Rubella be performed in
pregnancy.
24. DR. HARIVANSH CHOPRA
1. IUGR is most common.
2. Cataract B/L or U/L; Associated
with micro-ophthalmia.
3. Blueberry skin lesion, similar to
CMV infection.
CONGENITAL RUBELLA SYNDROME
25. DR. HARIVANSH CHOPRA
4. Myocarditis & structural cardiac
defects – PDA or Pulmonary Artery
Stenosis.
5. Hearing loss from Sensorineural
deafness.
6. May have active meningo-
encephalitis at birth; Later motor &
mental retardation.
CONGENITAL RUBELLA SYNDROME
27. DR. HARIVANSH CHOPRA
10. Pancreatitis.
11. Syndactyly.
12. Retinal lesions –
Salt and Pepper retinitis.
CONGENITAL RUBELLA SYNDROME
28. DR. HARIVANSH CHOPRA
Prevention against Rubella
• Rubella Vaccine – RA 27/3
1. Produced in human diploid fibroblast.
2. Produces an immune response more
closely paralleling natural infection & largely
prevents sub clinical infection.
3. Single dose of 0.5 ml subcutaneously
4. Seroconversion in >95% vaccinees.
5. Immunity persists for at least 14 – 16 years
and probably lifelong.
29. DR. HARIVANSH CHOPRA
MMR Vaccine
• Composition –
1. Live hyperattenuated Measles virus
(Schwartz strain) – 1000 TCID50
2. Live attenuated Mumps virus (Urabe AM 9
strain) – 5000 TCID50
3. Live attenuated Rubella virus (Wistar RA
27/3M strain) – 1000 TCID50
4. Stabilizer excipient (containing human
albumin)
30. DR. HARIVANSH CHOPRA
MMR Vaccine
• Route and Dose –
1. 0.5 ml Subcutaneous or Intramuscular.
2. Single dose between 12 and 15 months of
age (Recommended age).
3. Second dose recommended 6 months later
in children vaccinated below 12 months of
age, particularly in collective environment.
31. DR. HARIVANSH CHOPRA
MMR Vaccine
1.It is freezed dried
vaccine
2.Has to be
reconstituted with
distilled water
3.Reconstituted
vaccine must be
used as early as
possible
32. DR. HARIVANSH CHOPRA
MMR Vaccine
1. It has shell life for
2 years
2. Must be stored
between
2-8 degree
centirgade
34. DR. HARIVANSH CHOPRA
Contraindications to Rubella
1. Congenital or Acquired
immunodepressions. (An infection
with HIV should not be
contraindication to MMR vaccination,
but advised only under specialised
paediatric team).
2. True allergy to egg proteins.
35. DR. HARIVANSH CHOPRA
Contraindications to Rubella
3. Recent injection of Immunoglobulins
(Vaccine must not be given till 3 months
after Immunoglobulin transfusion, or
Immunoglobulins must not be given 2
weeks after vaccination).
4. Pregnancy (Recipients of vaccine must
not be advised to become pregnant over
next 3 months).
36. DR. HARIVANSH CHOPRA
Vaccination Strategy – Rubella
1. First protect women of
childbearing age (15 – 34 or
39 years of age).
2. Then interrupt transmission
of Rubella by vaccinating
children 1 – 14 years of age.
3. Subsequently vaccinating all
children at 1 year of age.
37. DR. HARIVANSH CHOPRA
Conclusion
1. Rubella is a vaccine preventable
disease, which is very similar to
Measles in its presentation.
2. A relatively mild clinical manifestation
but hazardous to developing foetus if
contracted in pregnancy.
3. Affected foetus presents with a variety
of signs grouped under “Congenital
Rubella Syndrome”.
39. DR. HARIVANSH CHOPRA
MCQ
1. Which of the following disease can
result in congenital anomaly in the
newborn child
1. HIV.
2. Hepatitis B.
3. Rubella.
4. All of the above.
Answer – 3.
40. DR. HARIVANSH CHOPRA
MCQ
2. “Three day measles” is another
name for
1. Roseola Infantum.
2. Erythema Infectiosum.
3. Scarlet fever.
4. None of the above.
Answer – 4.
41. DR. HARIVANSH CHOPRA
MCQ
3. The most characteristic
differentiating feature between
measles and rubella is
1. Type of rash.
2. Prodromal period.
3. Tender enlargement of cervical group of
glands.
4. Degree of fever.
Answer – 3.
43. DR. HARIVANSH CHOPRA
MCQ
5. The pregnancy should be deferred
in the recipient of Rubella vaccine
for a period of
1. Next 1 month
2. Next 2 months
3. Next 3 months
4. Next 6 months
Answer – 3.
44. DR. HARIVANSH CHOPRA
MCQ
• Q-6 Incubation period of rubella is
1. 1 – 7 days
2. 7 – 14 days
3. 14 – 21 days
4. 21 – 28 days
Ans 3