direct route of drug administration. Parenteral methods like manual injection and automatic injectors can be used for small numbers of valuable fish. Drugs are typically injected intramuscularly into the epaxial musculature, intraperitoneally just below the vent, or into the dorso-median sinus of salmonids. Parenteral administration requires anesthetizing the fish first to prevent injury. It is suitable for vaccination or treatment of limited numbers of valuable fish when other administration routes cannot be used.