Vasculitis
pathology
Define and classify vasculitis.
Describe the cause, pathogenesis, morphology, and clinical presentation of various types of vasculitis.
Vasculitis
pathology
Define and classify vasculitis.
Describe the cause, pathogenesis, morphology, and clinical presentation of various types of vasculitis.
non-skeletal mesodermal tissues: adipose tissue, fibrous tissue, muscle, blood vessels and peripheral nerves (despite neuroectodermal origin)
benign, malignant and intermediate (low-grade malignant – locally aggressive, can recur, no metastatic potential)
originate from primitive mesenchymal stem cells
classification according to differentiation lines (e.g. liposarcoma is not a tumor arising from adipose tissue but exhibiting lipoblastic differentiation)
non-skeletal mesodermal tissues: adipose tissue, fibrous tissue, muscle, blood vessels and peripheral nerves (despite neuroectodermal origin)
benign, malignant and intermediate (low-grade malignant – locally aggressive, can recur, no metastatic potential)
originate from primitive mesenchymal stem cells
classification according to differentiation lines (e.g. liposarcoma is not a tumor arising from adipose tissue but exhibiting lipoblastic differentiation)
Acute rheumatic fever-definition,pathophysiology,clinical presentation and ma...onlinefreelancer1
A detailed approach to ACUTE RHEUMATIC FEVER,based on Harrison Principles of internal medicine and Braunwald Textbook of Cardiology.Useful for post graduate seminars.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
2. •Rheumatic fever (RF) is an acute, immunologically
mediated, multisystem inflammatory disease that occurs a
few weeks following an episode of group A streptococcal
pharyngitis.
•Major involvement of systemic connective tissue, it often
violate connective tissue of heart, joint, skin, and
subcutaneous and vascular connective tissue. Key
pathologic features is Rheumatic Granuloma.
•It occurs in children in age 5 to 15 years, 20% -adults
•The clinical course of rheumatic fever involves a
childhood infection with complications in adulthood
(cardiac defect).
Rheumatic Fever
3. Etiology and pathogenesis
It is an immune response associated with
streptococcal infection, but it is not caused
by bacteria directly effects.
4. 1. There is a streptococcus infection history before
the onset of RF.
2. A variety of antibodies of the streptococcus and
its products can be detected in the onset phase.
serous "O" antibody in 95% patients is high, >
500 units.
3. Regional distribution consistent with area of
streptococcal infection.
4. Antibiotic prophylaxis treatment is effective.
The evidence related with group A β-hemolytic
streptococcus infection including:
5. The evidence which is not directly caused by
streptococcus infection including:
1. The disease is not appeared in infected at the
time, but in 2-3 weeks later, it is in line with
emergence period of the general immune
response.
• No evidence of direct invasion of organ by
streptococcus.
• Streptococcus has never been found in the RF
patient's blood .
• Not purulent inflammation, but the fibrinoid
necrosis.
6. Antigen and antibody cross-reactivity:
The antigens of streptococcus may stimulate
the immunological cross-reactivity in
patients.
7. M antibody+Vascular
smooth muscle
C antibody+Cardiovascular
connective tissue
Pathogenesis
Antigen antibody complex
Local deposition
alexin platelet
activation of
coagulation
system Embolism,
bleeding
Neutrophil infiltration
Release of lysosomal enzymes(Neutral, acid hydrolases, elastase,
collagenase and so on
Blood vessel, tissue injury
9. Exudative and degenerative phase
It is characterized by serofibrinous exudate, with deposits of
immune precipitate on collagen fibers that lead to fibrinoid
necrosis. About 1 months.
10. The proliferative phase (Granulomatous period)
Aschoff Body:
Structure:
center: fibrinoid necrosis
around the center:Anitschkow cells , lymphocytes,
occasional plasma cells
Distribution:
Myocardial interstitial, subendocardial and subcutaneous
connective tissue. Epicardial, joints and blood vessels is
rare.
pathognomonic for RF
11. Anitschkow cells:
These distinctive cells have abundant cytoplasm
and central round-to-ovoid nuclei in which the
chromatin is disposed in a central, slender, wavy
ribbon (hence the designation "caterpillar cells“--
cross section named Owl 's eye cells).
Some of the larger macrophages become
multinucleated to form Aschoff cells(inflammatory
giant cells).
12.
13.
14. The myocardial interstitium has a circumscribed collection of
mononuclear inflammatory cells, including some large histiocytes
with prominent nucleoli and a prominent binuclear histiocyte, and
central necrosis
17. Scar phase
Emergence of fibroblasts and collagen
production, formation of small spindle scar, 2-3
months or so.
The above three stages repeated attacks, the
old and new lesions coexist.
The whole course about 4-6 months.
18. RF involves various organs
Rheumatic heart disease
Rheumatic arthritis
Rheumatic arteritis
Rheumatic disease of skin
Rheumatic disease of brain
19. Rheumatic heart disease
Divided into rheumatic endocarditis,
rheumatic myocarditis and rheumatic
pericarditis, often for rheumatic
pancarditis.
60% to 80% children associated with
pancarditis。
21. rheumatic endocarditis
Lesions were most often involved: mitral valve
Secondly: both mitral and aortic valve
The most important lesions caused by rheumatism,
valvular deformity and dysfunction
22. Pathological changes:
early stage: serous endocarditis , valve swelling,translucent
Microscopically: valve become loose due to serous
exudate , accompanied by macrophages entering and
fibrinoid necrosis of collagen fiber.
Concomitant involvement of the endocardium and the left-
sided valves by inflammatory foci typically results the
small (diameter 1- to 2-mm) vegetations .
Vegetations: White thrombus consist of platelet and
cellulose.
23. Acute rheumatic endocarditis: small (diameter 1- to 2-mm)
vegetations along the mitral valve margin, insufficient to cause
valvular deformation.
25. Advanced: vegetations organization, recurrent organization cause
chronic heart valve disease ( valvular stenosis and / or valvular
insufficiency )
26. Mitral stenosis with diffuse fibrous thickening and distortion of
the valve leaflets, commissural fusion (arrows), and thickening
and shortening of the chordae tendineae.
32. Adhesive pericardit is in
cardiac surface of patients.
From the epicardial surface
to the pericardial sac visible
fibrinous exudate, which is
typical for a fibrinous
pericarditis.
33. trichocardia
Can lead to
precordial pain,
pericardial friction
sound, serious
cause constrictive
pericarditis,
influence on
cardiac function.
34. Rheumatoid arthritis
predilection age: Adults
predilection site: involving the large joints, most
commonly in the knee and ankle joint, followed
by the shoulder, wrist, elbow and other joints
Lesion characteristics: migratory polyarthritis.
Local serous exudate, appear red, swelling, heat,
pain and dysfunction. As the heals , serous
exudate is absorbed, generally no sequela.
Microscopic lesions mainly for serous
inflammation.
lick the knee but bite the heart.
35. Involving the coronary arteries, renal artery, brain
artery etc, small arteries see more.
Vascular wall connective tissue myxoid degeneration
and fibrinoid necrosis. There can see Rheumatic
Granuloma, and later wall narrow even block, with
thrombosis.
Rheumatoid coronary artery inflammation.
rheumatic arteritis
36. Mainly in acute period
1 subcutaneous nodules ( hyperplasia ):
2 The annular erythema (exudative lesions) :
Appear on the extremities and the trunk skin.
1-2 days. Hyperemia, edema changes of the
superficial layer of dermis. (pathognomonic )
Rheumatic disease of skin
39. Mainly involving the cerebral cortex, basal
ganglia, thalamus and cerebellum cortex.
Lesions to rheumatic arteritis and
subcortical encephalitis.
In 5-12 years old children, girls see more.
Rheumatic disease of brain
40. Infective endocarditis, one of the most serious of all
infections, is characterized by colonization or
invasion of the heart valves or the mural
endocardium by a microbe, leading to the formation
of bulky, friable vegetations composed of thrombotic
debris and organisms, often associated with
destruction of the underlying cardiac tissues.
Infective endocarditis
(IE)
41. Traditionally, IE has been classified on
clinical grounds into acute and subacute forms.
1. Acute IE
2. Subacute IE
42. 1Acute IE :The strong pathogenic pyogenic bacteria
(carbuncle, puerperal fever, osteomyelitis )---
resistance down---bacteria into the blood---sepsis---
normal endocardium ---invasion of mitral valve,
aortic valve---acute septic endocarditis---bacterial
vegetations
2Subacute IE: Streptococcus viridans (localized
infection focus in vivo or iatrogenic infection)----
bacteria into the blood---the mitral valve or/and
aortic valve with original lesions ( 80%,
congenital heart disease, RHD or valve repair)--
Subacute IE--bacterial vegetations
43. Pathological change
In both the subacute and acute forms of the disease,
friable, bulky, and potentially destructive vegetations
containing fibrin, inflammatory cells, and bacteria or
other organisms are present on the heart valves.
45. In the aortic opening a larger, irregular red vegetations, this
mostly by Staphylococcus aureus infection.
46. Acute IE :Caused the distant organ septic infarction and abscess.
Valve rupture, perforation, rupture of chordae tendineae, leading
to chronic valvular heart disease. 50% died in days or weeks.
48. End and complications:
1.Fever: it is the most consistent sign of IE. However, with
subacute disease, particularly in the elderly, fever
may be slight or absent, and the only manifestations
are sometimes nonspecific fatigue, loss of weight, and
a flulike syndrome. In contrast, acute endocarditis
has a stormy onset with rapidly developing fever,
chills, weakness, and lassitude.
2.Arterial embolization ( 20%-40% ): embolism of
brain ,heart, kidney, spleen, mesenteric, limbs and
pulmonary.
53. Janeway lesions: are small erythematous or hemorrhagic,
macular, nontender lesions on the palms and soles and are the
consequence of septic embolic events.
54. Osler nodes: are small, tender subcutaneous nodules that
develop in the pulp of the digits or occasionally more
proximally in the fingers and persist for hours to several days.
56. Subacute IE Acute IE
bacterial
virulence
weak strong
valve Have lesions normal
Dry, crisp A larger, soft
vegetation Bacteria are less, little
or no necrosis
Many bacteria,
much necrosis
final result the vast majority of
people heal
50% died in days or
weeks.
Bacteria
into the
blood
ichorrhemia Sepsis
embolism Non-infectious
infarction
Multiple embolic
microabscesses
57. rheumatic
endocarditis
Subacute IE
Etiology immunologically
mediated
bacterial infection
grossly White, small, compact
vegetations
gray red, large, loose
vegetations, fall off
easily
microscopically white thrombus White thrombus with
necrosis, colony etc.
clinical feature Valvular Disease Valvular heart disease,
thromboembolism,
infarction, Septicemia
connection SIE often occurs on
the basis of RE