Rheumatic heart disease is a chronic condition that results from damage to the heart valves caused by rheumatic fever. Rheumatic fever is an inflammatory reaction that typically affects the heart, joints, brain and skin and is triggered by a prior streptococcal throat infection. It can cause scarring and deformity of the heart valves over time due to recurrent attacks. Treatment involves controlling streptococcal infections with antibiotics like penicillin to prevent recurrence of rheumatic fever and further heart damage. Patients are also at risk for developing valvular heart disease long-term.
Rheumatic heart disease is a condition in which the heart valves have been permanently damaged by rheumatic fever. The heart valve damage may start shortly after untreated or under-treated streptococcal infection such as strep throat or scarlet fever.
Rheumatic heart disease is a condition in which the heart valves have been permanently damaged by rheumatic fever. The heart valve damage may start shortly after untreated or under-treated streptococcal infection such as strep throat or scarlet fever.
Bronchiectasis is a chronic, irreversible dilation of the bronchi and bronchioles. Or •Bronchiectasis is characterized by permanent, abnormal dilation of one or more large bronchBronchiectasis.
Rheumatic fever (acute rheumatic fever) is a disease that can affect the heart, joints, brain, and skin.
Rheumatic fever can develop if strep throat and scarlet fever infections are not treated properly.
Early diagnosis of these infections and treatment with antibiotics is key to preventing rheumatic fever.
Acute respiratory distress syndrome (ARDS) is a sudden, progressive form of respiratory failure characterized by severe dyspnea, refractory hypoxemia, and diffuse bilateral infiltrates.
Bronchiectasis is a chronic, irreversible dilation of the bronchi and bronchioles. Or •Bronchiectasis is characterized by permanent, abnormal dilation of one or more large bronchBronchiectasis.
Rheumatic fever (acute rheumatic fever) is a disease that can affect the heart, joints, brain, and skin.
Rheumatic fever can develop if strep throat and scarlet fever infections are not treated properly.
Early diagnosis of these infections and treatment with antibiotics is key to preventing rheumatic fever.
Acute respiratory distress syndrome (ARDS) is a sudden, progressive form of respiratory failure characterized by severe dyspnea, refractory hypoxemia, and diffuse bilateral infiltrates.
Acute Rheumatic Fever and Rheumatic Heart Disease, are two common conditions in children between 3-15 years of age following a Group B Streptococcal throat infection. We discuss these two conditions in the slides above, as well as their management.
RHEUMATIC FEVER AND RHEUMATIC HEART DISEASEANILKUMAR BR
Rheumatic heart disease (RHD) is damage to one or more heart valves that remains after an episode of acute rheumatic fever (ARF) is resolved.
It is caused by an episode or recurrent episodes of ARF, where the heart has become inflamed.
The heart valves can remain stretched and/or scarred, and normal blood flow through damaged valves is interrupted.
Untreated, RHD causes heart failure and those affected are at risk of arrhythmias, stroke, endocarditis and complications of pregnancy.
These conditions cause progressive disability, reduce quality of life and can cause premature death in young adults.
Heart surgery can manage some of these problems and prolong life but does not cure RHD.
RHD is the a chronic condition characterized by scarring and deformity of the heart valves following rheumatic fever infection.
Rheumatic fever is an inflammatory disease that may affect many connective tissues of the body, especially those of the heart, joints, brain or skin. It usually starts out as a strep throat (streptococcal) infection.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Rheumatic fever (RF) is generally classified
as a connective tissue or collagen-vascular
disease
It is an inflammatory reaction that causes
damage to collagen fibrils and to the ground
substance of connective tissue
Rheumatic fever principally involves the
heart, joints, CNS (Central Nervous
System), skin, subcutaneous tissues.
3. • Recurrent attacks of RF may cause
fibrosis of heart valves, leading to
chronic valvular heart disease
• The term Rheumatic heart disease refers
to the cardiac involvement develops to
50% of patients and may affect the
endocardium, myocardium or pericardium.
It may later affect the heart valves,
causing chronic valvular disease.
• The extent of damage to the heart
depends on where the disorder strikes.
4. DEFINITION
• Rheumatic heart disease is a chronic
condition resulting from rheumatic
fever that is characterized by
scarring and deformity of the heart
valves
5. Epidemiology
•Peak incidence ages 5~15 years
•Rare before age 4 years and after age 40 years
•The incidence of RF and prevalence of rheumatic
heart disease (RHD) are markedly variable in
different countries:
•In developed country, such as the united states,
the incidence of RF < 2/100,000
•In many developing countries, the incidence of
acute RF approaches or exceeds 100/100,000
11. Risk Factors
• 5-15 years old
• Family history of RF
• Low socioeconomic status (poverty,
poor hygiene, medical deprivation)
• Untreated strepthroat
12. CLINICAL MANIFESTATION
Jones Criteria for Diagnosis of
Rheumatic Feve
MAJOR CRITERIA
• carditis
• Poly arthritis- sharp, sudden pain starts over sternum
and radiates to neck, shoulders, back and arms.
• Erythema marginatum- Erythema marginatum: A long-
lasting reddish rash that begins on the trunk or arms
as macules, which spread outward.
13. • Subcutaneous nodules- a firm,
movable, nontender collagen fibers
over bones or tendons and about 3
mm-2 cm in diameter.
• Transient chorea- involuntary
grimace and an inability to use skeletal
muscles in a coordinated manner.
15. •Supporting evidence of an
antecedent group A
•streptococcal infection:
① Positive throat culture or rapid
streptococcal antigen test
② Elevated or rising titers of
antistreptococcal antibodies
(anti-streptolysin O and anti-DNase B)
16. Daignostic Evaluation
•Modified Jones criteria were first published in 1944
by T. Duckett Jones, MD.They have been periodically
revised by the American Heart Association in
collaboration with other groups.
•Guidelines for the diagnosis of initial attacks of
RF (Jones criteria, updated 1992)
•If supported by evidence of preceding group A
streptococcal infection, the presence of two major
manifestations or of one major and two minor
manifestations establishes the diagnosis of acute RF
17. WBC count and ESR is elevated
C- reactive protein is positive.
Cardiac enzmes levels may increase in
severe carditis.
Anti streptolysin- O titser is elevated 95% of
patients with in 2 months onset.
Throat cultures continue to presence of
GABS; however they usually occur in small
numbers. Isolating them is difficult.
ECG reveals no diagnostic changes, but
20% of patient show a prolonged PR
interval.
18. Treatment
General Measures
Strict bed rest
Medical Measures
1. Control streptococcal infection
Penicillin is of choice
benzathine penicillin, 1.2 million
units im once,
or procaine penicillin, 600,000
units im daily, 10 days
If allergic to penicillin, erythromycin be given
19. 2. Antirheumatic therapy
(1) Salicylates
Of choice in patients with little or no
cardiac involvement;
Particularly effective in reducing
fever and relieving joint pain and
swelling
Aspirin 0.6~0.9 g / 4h in adults;
lower doses in children
(2) Corticosteroids
Used in patients who do not respond
well to adequate doses of salicylates
Prednisone 40~60 mg orally daily,
tapering over 2 weeks
20. 3. Treatment of symptoms and complications
If heart failure is present, digitalis
preparations should be used cautiously because
cardiac toxicity may occur with conventional
dosages
Prevention
Primary prevention
Early treatment of streptococcal pharyngitis
Penicillin or erythromycin
Secondary prevention
To prevent recurrence of rheumatic activity
Long-acting penicillin (benzathine
penicillin)
1.2 million units im, every 4 weeks
Sulfonamides or erythromycin may be
substituted
21. Nursing Daignosis
• Activity intolorence related to
arthralgia secondry to joint pain
• Decreased cardiac output related to
valve dysfuntion,HF
• Ineffective therapuetic regimen
related to lack of knowledge
24. 1) ALL ARE FEATURES OF ACUTE RHEUMATIC FEVER
EXCEPT:
a) Pancarditis
b) Carey Coombs murmur
c) Chorea
d) Always causes residual joint damage
2) What heart problem may be caused, ironically, by the
body's attempt to protect itself from a streptococcal
throat infection?
A)Cardiomyopathy
B)rheumatic heart disease
C)coronary atherosclerosis
D)infectious endocarditis
25. 3) When teaching a patient about the long-term consequences
of rheumatic fever, the nurse should discuss the possibility
of
a. valvular heart disease
b. pulmonary hypertension
c. superior vena cava syndrome
d. hypertrophy of the right ventricle
4) Which is a priority nursing intervention for a patient during
the acute phase of rheumatic fever?
a. administration of antibiotics as ordered
b. management of pain with opioid analgesics
c. encouragement of fluid intake for hydration
d. performance of frequent, active range-of motion
exercises
26. 5) Which of the following nursing actions should the nurse
prioritize during the care of a patient who has recently
recovered from rheumatic fever?
a. Teach the patient how to manage his or her physical
activity.
b. Teach the patient about the need for ongoing
anticoagulation.
c. Teach the patient about his or her need for continuous
antibiotic prophylaxis.
d. Teach the patient about the need to maintain standard
infection control procedures.