The document describes a case of a patient who developed septic shock from Methicillin-Resistant Staphylococcus epidermidis (MRSE) infection of a vascular graft, who was successfully treated with Daptomycin and Doxycycline. It then discusses resistant gram positive bacteria and newer antimicrobial options for treating such infections, noting Daptomycin and Linezolid as effective alternatives to Vancomycin in some cases.