Presentation in Kiev Oblast State Administration, for the "Centre for training and advanced education of employees, public authorities, local governments, public enterprises, institutions and organizations in Kyiv Oblast State Administration". The presentation deals with regional development of smaller non capital cities, with a best practice of the restructuring of the economy of the city of Enschede in the eastern part of The Netherlands, from mono-industrial city to a more diversified innovation driven economy. The second half of the presentation deal with the necessary political and economic preconditions for Ukraine to get real and sustainable economic development in its regions (based on the theory from Why nations fail of Acemoglu & Robinson).