1) The document discusses complete response rates for patients with advanced rectal cancer receiving pre-operative chemoradiotherapy. It reports a complete pathological response rate of 17.5% in its study. 2) Patients who had a complete pathological response were found to have excellent long-term survival and no recurrence of cancer, with a median follow-up time of over 5 years. 3) A complete clinical response seen before surgery does not guarantee there is no remaining cancer, as viable tumor cells may still be present. The nature of the surgery should not be determined based on clinical response alone.

1. Rectal Cancer and Radiotherapy: What is the Clinical Implication of a Complete Response Nick Rieger Ciccocioppo A, Hewett P, Rodda D, Stephens J. Adelaide No Disclosures

14. Endorectal Ultrasound: T3 Tumour

15. Treatment Regimens 1 (3%) 0 Total Procto-colectomy 1 (3%) 0 Recto-sigmoid Resection 0 1 (14%) Low Hartmann Procedure 4 (12%) 1 (14%) Anterior Resection 6 (18%) 1 (14%) Low Anterior Resection 13(39%) 2 (28%) Ultra-low Anterior Resection 8 (24%) 2 (28%) Abdomino-perineal Resection Non-CpR CpR Procedures Performed

16. 20 (60.6%) 0 Disease Recurrence 7 (21%) 1 (14%) Mortality 3.8 (2.05-5.92) 6.0 (1.42-7.02) Median F/U Time (yrs) 21M : 12F 5M : 2F Male:Female 33 7 No. of Patients Non-CpR CpR STATISTIC

19. At Diagnostic Colonoscopy Following Pre-operative Long Course Radiotherapy Ulcer-like Scar remains A COMPLETE RESPONDER- COLONOSCOPY