In our latest SlideShare, we discuss the exciting new field of stem cells in regenerative medicine. These slides cover briefly the sources and types of stem cells, as well as the recent figures and growing interest in this sector. Recent R&D highlights would focus on the vast potential of stem cells; for blood disorders, multiple sclerosis, diabetes as well as brain injury.

1. Recent Development in Regenerative Medicine
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Stem Cell Therapy
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2. Stem Cell Therapy
Content Overview
• What is Stem Cell Therapy?
• What are Stem Cells?
• Sources & Types of Stem Cells
• Recent Interest in Stem Cells
• Key Market Figures
• Potential Applications
• Recent Stem Cell R&D
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3. What is Stem Cell Therapy?
Stem cell therapy is a non-
invasive form of regenerative
medicine that utilizes the
body's natural healing
mechanism to treat or
prevent a disease or
condition.
Stem cells can renew and repair
diseased or damaged tissues and
have shown promising results in
treatments of various orthopedic,
cardiovascular, neuromuscular
and autoimmune conditions.
Source: https://www.dvcstem.com/post/stem-cell-therapy
Credit: Morsa/Getty Images
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4. Recap: What are Stem Cells?
Stem cells are the body's raw
materials — cells from which
all other cells with specialized
functions are generated.
Under specific conditions, stem
cells divide to form more cells
called daughter cells. These
daughter cells become either new
stem cells or specialized cells with
a more specific function.
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Credit: Genome Research Ltd.
Source: https://www.mayoclinic.org/tests-procedures/bone-marrow-transplant/
in-depth/stem-cells/art-20048117
- Bone Cells
- Muscle Cells
- Blood Cells
- Skin Cells
- Neurons

5. Sources of Stem Cells
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Source: https://www.medicalnewstoday.com/articles/323343
Embryonic Stem
Cells
Found in earliest
stage of pregnancy,
3-5 days after egg is
fertilized by sperm,
within the inner cell
mass of blastocyst.
Adult Stem Cells
AKA somatic stem
cells, more
specialized than
embryonic. Found
within brain, bone
marrow, blood
vessels, skeletal
muscles, skin, liver,
etc.
Mesenchymal Stem
Cells (MSCs)
Comes from
connective tissue or
stroma that
surrounds the body’s
organs and other
tissues. Can be used
to create bone,
cartilage & fat cells.
Induced Pluripotent
Stem Cells (iPS)
Created in labs using
tissue-specific cells
like the skin.
Extracted stem cells
are placed in
controlled cell
cultures for
therapeutic R&D.

6. Types of Stem Cells
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Source: https://www.medicalnewstoday.com/articles/323343
TOTIPOTENT
Can differentiate
into all possible
cell types.
Appears as the
zygote starts to
divide.
PLURIPOTENT
Can turn into
almost any type
of cell.
Found in early
embryo.
MULTIPOTENT
Can differentiate
into closely
related family of
cells.
Example:
hematopoietic
stem cells turn
into red and
white blood cells.
OLIGOPOTENT
Can differentiate
into a few
different cell
types.
Examples: adult
lymphoid or
myeloid stem
cells.
UNIPOTENT
Can only turn
into one kind of
specific cell.
Example: adult
muscle stem
cells.
Stem cells are categorized according to their
potential to differentiate into other types of
cells. Embryonic stem cells are the most potent.

7. Interest in Stem Cells
Tapping Into the Potential of Stem Cells
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8. Interest in Stem Cell Therapy
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8 Source: https://www.mayoclinic.org/tests-procedures/bone-marrow-transplant/
in-depth/stem-cells/art-20048117
REGENERATE
Stem cells can be guided
into becoming specific cells,
and then used in transplant
or regenerative medicine
STUDY
Researchers may better
understand how diseases or
conditions develop by
watching how stem cells
grow
DEVELOP
Drug developers can use
programmed stem cells to
test drugs during pre-clinical
stages for safety & quality.

9. Key Figures in the Stem Cells market
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Stem Cell Market
Value projected at
USD 18.51 billion in
2026
- Increase from USD 11.6
billion in 2021
- CAGR of 9.8%
(2021-2026)
- Increased prevalence
of chronic diseases
worldwide driving
stem cell development
ResearchAndMarkets
USD 12.72 billion in
2022
Forecasted market value
by end of 2022 (based
on revenue of USD 9.38b
in 2020).
Regenerative
Medicine has largest
revenue share
Market share of 89.1%
due to increasing
approvals for use of
blood-forming cells.
Source: Grand View Research, ResearchAndMarkets.com
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Key Insights:
- North America
dominates with 52.1%
in 2020 due to
presence of key
players
- Asia Pacific expanding
with fastest CAGR of
9% due to regional
policies
- Products are skewed
towards adult stem
cells (85.7%) to
minimize controversy
Grand View Research

10. Stem Cell Research
Tapping into the Potential of Regenerative Medicine
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11. Potential Applications of Stem Cells
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Neuro-
degeneration
Spinal Cord
injury
Frailty
syndrome
Heart
disease
Blindness
Blood
Disorder
Source: https://www.nature.com/articles/s41392-019-0089-y
At time of writing, the only stem cell products that are FDA-approved
are blood-forming cells (also known as hematopoietic progenitor cells)
that are derived from umbilical cord blood.

12. HPC Cord Blood Transplantation (FDA Approved)
Intravenous infusion of
hematopoietic progenitor cells
helps to reestablish blood cell
production in patients whose
bone marrow or immune
system is damaged or
defective.
Progenitor cells are descendants of
stem cells that can further
differentiate to create specialized
cell types.
Source: https://hemacord.info/patients/
Credit: TheOklahoman.com
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HPC, Cord Blood has been used to treat patients
with certain leukemias and some inherited
metabolic and immune system disorders.

13. Treatment of Type 1 Diabetes (Phase 1/2)
Vertex Pharmaceuticals is
conducting phase 1/2 clinical
trial for VX-880.
VX-880 is an investigational
allogeneic stem cell-derived, fully
differentiated, insulin-producing
islet cell therapy for people with
type 1 diabetes.
Approximately 17 patients will be
enrolled in this 3-part study.
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Credit: Getty Images
Source: https://www.healio.com/news/endocrinology/20220711/fda-lifts-clinical-
hold-on-trial-for-novel-stem-cellderived-therapy-for-type-1-diabetes
Vertex Pharmaceuticals recently bought
ViaCyte (also developing stem cell-based
treatment for T1D) for USD 320 million.

14. Treatment of Multiple Sclerosis (Phase 2)
The Tisch MS Research
Center of New York
conducted an FDA-approved
study to improve disability
status for multiple sclerosis
patients using stem cell
treatments (first-ever).
A total of 50 patients were
involved, 36 of which have
completed 6x stem cell treatments.
Source: https://www.tischms.org/news/new-research-finds-first-time-
ever-stem-cell-treatments-improve-disability-status-multiple
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Following the stem cell treatments, upper limb
dexterity and walking speed improved for 36%
of patients, while 30% realized improved muscle
strength.

15. Repair of Traumatic Brain Injury (Research)
Patients who suffer a stroke
or brain injury risk long-term
impairment of crucial motor
or cognitive (language &
memory) functions due to
loss of neurons.
Scientists in Portugal discovered a
novel mechanism by which
neurons and glia collaborate to
drive the process of neural
regeneration.
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Credit: Rhiner Lab, The Champalimaud Foundation
Source: https://www.eurekalert.org/news-releases/955923
Glial cells secrete transporter proteins
(‘Swim’) when oxygen levels drop. These
proteins encapsulate and carry ‘Wg/Wnt’
molecules to nearby neural stem cells,
activating them to begin the process of neural
regeneration.

16. • Researchers have recently shown interest in using stem cells
in the field of regenerative medicine.
• Stem cell-based therapy has shown promising results in
treating various diseases and conditions.
• Despite the vast potential of stem cells in regenerative
medicine, only less than a dozen therapies have been
approved by the FDA (even then they are hematopoietic
progenitor cells and not stem cells per se).
• With the recent advances already made within the past
decade, new regulatory framework and policy support is
needed to further drive the use of stem cells in regenerative
medicine.
Conclusion
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17. By xeraya capital
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Follow us: @xerayacapital
www.xeraya.com
July 2022. © Xeraya Capital.
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