Potential therapeutic applications of stem cells include treating many diseases. Stem cells can differentiate into other cell types and can self-renew. Embryonic stem cells are pluripotent and can differentiate into all germ layers but have ethical issues. Adult stem cells are multipotent and are found in tissues but are limited in differentiation. Stem cell therapies show promise for diseases like Parkinson's, diabetes, and heart disease. Challenges include controlling differentiation and reducing tumor risks. The stem cell market is growing rapidly with applications in regenerative medicine and drug development.

1. Potential Therapeutic Applications of Stem Cells Dr. Boenjamin Setiawan, Ph.D. Dr.Virgi Saputra

2. Definition of stem cells: stem cells are unspecialized cells that have two defining properties: the ability to differentiate into other cells and the ability to self-regenerate /self-renew

5. Differentiation of Human Tissue

7. Inner cell mass Day 5 after conception

8. Deriving Umbilical Cord Blood Stem Cells

9. Adult Stem Cells: Bone Marrow

10. Plasticity of Adult Stem Cells

13. Cell-based Regenerative Therapy

25. Cell-based therapy for Parkinson’s Disease

26. Dopamine-Neuron Transplantation

28. Stem Cells for Diabetes

29. Commercialization and Utilization of Stem Cells

42. Potential US Patient Populations for Cell-based Therapies 2005 0.15 Birth defects 0.25 Spinal-cord injuries 1.0 Parkinson’s disease 1.1 Burns (severe) 4.5 Alzheimer’s disease 10.0 Cancer 10.0 Osteoporosis 18.0 Diabetes 50.0 Autoimmune disease 70.0 Cardiovascular disease Patients (millions) Medical Condition

43. Annual Direct Expenditures in the US for Selected Diseases 2005 216.5 Total 6.5 Parkinson’s disease 10.0 Spinal cord injury 25.0 Chronic liver disease 30.0 Stroke 45.0 Diabetes mellitus 100.0 Alzheimer’s disease Expenditure ($bn) Medical Condition

44. Stem Cell Market Forecasts by Technology and Product Type 2005 - 2010 22.9 100.0 68,851 100.0 24,560 Total 0.0 - 30.0 40.0 22.0 45.0 38.0 53.0 0.0 0.1 1.6 0.8 92.6 1.5 2.2 1.2 0 50 1,114 538 63,784 1,026 1,501 838 0.0 0.0 1.2 0.4 96.1 0.7 1.2 0.4 0 0 300 100 23,600 160 300 100 hESCs hFSCs hHSCs hMSCs/Other Adult SCs Mobilization/Activation (cytokines) Expansion/Differentiation (in vitro) SC Banking (in vitro) Drug Screening (in vitro) Market share (%) Sales ($m) Market share (%) Sales ($m) CAGR 2005 – 2010 (%) 2010 2005 Technology/Product Type

45. Stem Cell Market Forecasts by Region 2005 – 2010 22.9 100.0 68,851 100.0 24,560 Total 18.6 26.1 39.2 5.1 41.1 42.4 23.6 7.0 37.7 29.7 3.0 4.8 14.5 7.2 97.1 2.9 25,986 20,478 2,097 3,328 9,990 4,968 66,847 2,004 45.1 26.2 1.6 10.5 7.3 3.5 94.2 5.8 11,074 6,430 402 2,590 1,786 848 23,131 1,429 US & Canada European Union Rest of Europe Japan Asia (excl Jpn), Africa & Australia Latin America Sub-Total Others Market share (%) Sales ($m) Market share (%) Sales ($m) CAGR 2005 – 2010 (%) 2010 2005 Region

46. Commercial Focus of 106 Stem Cell Companies by Type of Stem Cell Program

47. Geographic location of 106 specialized stem cell companies

48. Cord blood banks by region

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