The endocrine system is comprised of glands that secrete hormones directly into the bloodstream to regulate bodily functions. Key glands include the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, adrenal glands, pancreas, and gonads. The hypothalamus controls the pituitary gland, which is the "master gland" that regulates most other endocrine glands. Hormones function via negative feedback loops to maintain homeostasis and influence growth, metabolism, fluid balance, mood, and reproduction. Imbalances can result in hypo- or hyperthyroidism, influencing factors like heart rate, weight, and digestion.