Chronic illness can cause psychological stress and impact coping abilities. It involves a cognitive appraisal of the illness in relation to one's resources. While it may cause anxiety, depression, guilt or anger, social support and personality can mediate these effects. Common emotional reactions include denial, anger, depression, and acceptance through various stages. Multimodal interventions aim to help patients adjust, manage stress and pain, learn coping skills, and strengthen family communication. Chronic illness strongly impacts social and emotional well-being, and better coping is linked to improved prognosis and health outcomes.