Hormones regulate the structure and function of target organs and tissues. They circulate in the bloodstream and act in very small amounts on target cells. This document discusses the principles of hormonal regulation including the classification, mechanisms, and regulation of hormone secretion for various hormones like thyroid hormones, sex hormones, and parathyroid hormone. It also covers diseases related to abnormal hormone levels such as hyperparathyroidism, hypoparathyroidism, and Cushing's syndrome.
GENERAL MECHANISM OF PEPTIDE AND STEROID HORMONE ACTION.pdfApoorva Rajagopal
Hormones are a type of signaling molecules that are produced by the endocrine glands. They are natural organic substance produced in minute quantity to regulate growth, metabolism and other functions.
GENERAL MECHANISM OF PEPTIDE AND STEROID HORMONE ACTION.pdfApoorva Rajagopal
Hormones are a type of signaling molecules that are produced by the endocrine glands. They are natural organic substance produced in minute quantity to regulate growth, metabolism and other functions.
organic biologically active compounds of different chemical nature that are produced by the endocrine glands, enter directly into blood and accomplish humoral regulation of the metabolism of compounds and functions on the organism level.
As a component of the endocrine system, both male and female gonads produce sex hormones. Male and female sex hormones are steroid hormones and as such, can pass through the cell membrane of their target cells to influence gene expression within cells. Gonadal hormone production is regulated by hormones secreted by the anterior pituitary in the brain. Hormones that stimulate the gonads to produce sex hormones are known as gonadotropins. The pituitary secretes the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These protein hormones influence reproductive organs in various ways. LH stimulates the testes to secrete the sex hormone testosterone and the ovaries to secrete progesterone and estrogens. FSH aids in the maturation of ovarian follicles (sacs containing ova) in females and sperm production in males.
Basic Introduction to the vast science of the endocrine glands and their interactions. A brief review into the physiological processes that result in endocrine disorders.
organic biologically active compounds of different chemical nature that are produced by the endocrine glands, enter directly into blood and accomplish humoral regulation of the metabolism of compounds and functions on the organism level.
As a component of the endocrine system, both male and female gonads produce sex hormones. Male and female sex hormones are steroid hormones and as such, can pass through the cell membrane of their target cells to influence gene expression within cells. Gonadal hormone production is regulated by hormones secreted by the anterior pituitary in the brain. Hormones that stimulate the gonads to produce sex hormones are known as gonadotropins. The pituitary secretes the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These protein hormones influence reproductive organs in various ways. LH stimulates the testes to secrete the sex hormone testosterone and the ovaries to secrete progesterone and estrogens. FSH aids in the maturation of ovarian follicles (sacs containing ova) in females and sperm production in males.
Basic Introduction to the vast science of the endocrine glands and their interactions. A brief review into the physiological processes that result in endocrine disorders.
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IEM comprise a group of disorders in which a single gene defect causes a clinically significant block in a metabolic pathway resulting either in accumulation of substrate behind the block or deficiency of the product.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
In mammals, the adrenal glands (also known as suprarenal glands) are endocrine glands that sit at the top of the kidneys. They are chiefly responsible for releasing hormones in response to stress through the synthesis of corticosteroids such as cortisol and catecholamines such as adrenaline (epinephrine) and noradrenaline. They also produce androgens in their innermost cortical layer. The adrenal glands affect kidney function through the secretion of aldosterone, and recent data (1998) suggest that adrenocortical cells under pathological as well as under physiological conditions show neuroendocrine properties; within normal adrenal glands, this neuroendocrine differentiation seems to be restricted to cells of the zona glomerulosa and might be important for an autocrine regulation of adrenocortical function.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Principles of hormonal regulation
Hormones are substances which can change
the status, function, metabolism and structure
of body organs and tissues.
True hormones are released into blood stream
Act only on target cells
Active in very low doses
May stay active for months
9. 1. The hormones combine with their receptors on the
outer surface of target cell membranes.
2. Activation of adenylate cyclase on the cytoplasmic side
of the membranes.
3. Conversion of ATP to cyclic AMP (cAMP) within the
cytoplasm.
4. cAMP activates protein kinase.
5. Protein kinase phosphorylates enzymes.
6. The activity of specific enzymes is either increased or
inhibited by phosphorylation.
7. Changes in cell metabolism, permeability or functions.
SEQUENCE OF EVENTS INVOLVING CYCLIC
AMP AS A SECOND MESSENGER
10. Mechanism of action of lipid solvableMechanism of action of lipid solvable
hormoneshormones
17. Thyroid gland hormones’ effects
Increase metabolism by activating enzymes &
increasing oxygen consumption
As the result increase heat production and
body temperature
Morphogenic influence (especially CNS &
bone tissue)
Activate protein synthesis by increasing
membrane permeability for amino acids
Activate lipids breakdown
18. Thyroid gland hormones’ effects
Increase glucose level in blood plasma by intensifying
glucose absorbtion in the intestines
Activate gluconeogenesis and glucogenolysis
Inactivate insuline by activation of liver insulinase
Increase heart rate and cardiac output by increasing
adrenoreceptors sensitivity to adrenalin and
increasing the number of receptors
Activate erythropoesis
20. Disease States
Both increased and decreased secretion of parathyroid hormone are
recognized as causes of serious disease in man and animals.
Excessive secretion of parathyroid hormone is seen in two forms:
Primary hyperparathyroidism is the result of parathyroid gland disease,
most commonly due to a parathyroid tumor (adenoma) which secretes the
hormone without proper regulation. Common manifestations of this
disorder are chronic elevations of blood calcium concentration
(hypercalcemia), kidney stones and decalcification of bone.
Secondary hyperparathyroidism is the situation where disease outside
of the parathyroid gland leads to excessive secretion of parathyroid
hormone. A common cause of this disorder is kidney disease - if the
kidneys are unable to reabsorb calcium, blood calcium levels will fall,
stimulating continual secretion of parathyroid hormone to maintain normal
calcium levels in blood. Secondary hyperparathyroidism can also result
from inadequate nutrition - for example, diets that are deficient in calcium
or vitamin D, or which contain excessive phosphorus (e.g. all meat diets
for carnivores). A prominent effect of secondary hyperparathyroidism is
decalcification of bone, leading to pathologic fractures or "rubber bones".
21. There is no doubt that chronic secretion or continuous
infusion of parathyroid hormone leads to decalcification
of bone and loss of bone mass. However, in certain
situations, treatment with parathyroid hormone can
actually stimulate an increase in bone mass and bone
strength. This seemingly paradoxical effect occurs
when the hormone is administered in pulses (e.g. by
once daily injection), and such treatment appears to be
an effective therapy for diseases such as osteoporosis.
Inadequate production of parathyroid hormone -
hypoparathyroidism - typically results in decreased
concentrations of calcium and increased concentrations
of phosphorus in blood. Common causes of this
disorder include surgical removal of the parathyroid
glands and disease processes that lead to destruction
of parathyroid glands. The resulting hypocalcemia often
leads to tetany and convulsions, and can be acutely
life-threatening. Treatment focuses on restoring normal
blood calcium concentrations by calcium infusions, oral
calcium supplements and vitamin D therapy.
22. The effect of somatotropic hormone on
protein metabolism:
1. stimulates the passing of amino acids into the cells;
2. activates the synthesis of proteins, DNA, RNA.
carbohydrate metabolism:
1. activates the insulinase of liver;
2. inhibits the conversion of lipids to carbohydrates;
3. activates the exit of glucose from liver;
4. inhibits the entry of glucose into the cells.
lipid metabolism:
1. stimulates lipolysis;
2. stimulates the oxidation of fatty acids.
The deficiency of somatotropic hormone in children
age causes nanism. Nanism - proportional
underdevelopment of all body.
26. Hormones of pancreas
Insulin. Chemical structure: protein
Effect of insulin on carbohydrate metabolism:
increases the permeability of cell membranes of skeletal
muscles, adipose tissue and liver for glucose;
activates the first enzyme of glycolysis - glucokinase and prevent
the inactivation of hexokinase;
activates some enzymes of Krebs cycle (citrate synthase);
activates the pentose phosphate cycle;
activates glycogen synthetase;
activates pyruvate dehydrogenase and α-ketoglutarate
dehydrogenase;
inhibits the gluconeogenesis;
inhibits the decomposition of glycogen.
27. Effect of insulin on protein metabolism:
increases the permeability of cell membranes for amino acids;
activates synthesis of proteins and nucleic acids;
inhibits the gluconeogenesis.
Effect of insulin on lipid metabolism:
enhances the synthesis of lipids;
promotes the lipid storage activating the carbohydrate
decomposition;
inhibits the gluconeogenesis.
Effect of insulin on mineral metabolism:
activates Na+, K+-ATP-ase (transition of K into the cells and Na
from the cells).
The deficiency of insulin causes diabetes mellitus.
29. Somatostatine.
Somatostatine is produced by hypothalamus, intestine and δ-cells
of pancreas).
Functions:
inhibits the secretion of insulin and glucagon;
inhibits secretion of somatotropic and thyrotropic hormones;
inhibits secretion of tissue hormones of alimentary tract.
Lipocain.
Lipocain is produced in the epithelium cells of pancreatic ducts.
Functions:
activates the formation of phospholipids in liver and stimulates
the action of lipotropic alimentary factors;
activates the oxidation of fatty acids in liver.
30.
31.
32.
33. Typical findings in Cushing’s
syndrome
Caused by prolonged decrease in plasma
corticoids
Increased protein catabolism results in :
Thin skin
Poor muscle development
Poor wound healing
Bruisability with ecchymoses
Thin and scraggy hair
34. Typical findings in Cushing’s
syndrome
Redistribution of body fat : thin extremities, fat
collects in the abdominal wall, face, upper
back
Purple striae (subdermal tissue rapture due to
increased subcutaneous fat depots)
osteoporosis