Slide 35
References
Tornetta P. Rockwood and Green's fractures in adults. Philadelphia: Wolters Kluwer; 2020.
Buckley R, Moran C, Apivatthakakul T. AO principles of fracture management. Davos Platz, Switzerland: AO Foundation; 2017.
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
An orthopedic operative procedure which stabilizes and aligns the fractured segment with the help of externally placed mechanical devices holding up the intact bone.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
2. Outline
1. Indications of Ex-fix
2. Components, Principles and Biomechanincs of Ex-fix
3. Construct designs
4. Anatomical Considerations
5. Pin-site Care/Pin-site Infection
6. Ex-fix Reuse
3. External Fixator is a surgical device used to
stabilize bone and soft tissues at a distance from
the operative or injury focus.
4. History
• The concept of Ex-fixation dates back to 2400 years.
• Use of Ex-fix mentioned before the invention of POP cast.
• Earliest recognizable ex-fix by Malgaigne 1840.
• Ex-fix has being evolving over time and gained acceptance because of
improving pin design and frame biomechanics.
• the first AO fixator was designed by M.E. Muller in 1952.
5. Indications
• Open fractures
• Closed fractures with severe soft tissue injury
• polytrauma - DCO
• Articular fractures
• Bone or Soft tissue loss
6. Advantages
• Less damage to the bone blood supply
• Rapid application
• Stabilization of open and contaminated fractures
• Adjustment of fracture reduction and stability without surgery
• Minimal foreign body in the presence of infection
• Less experience and surgical skill required than ORIF
• Bone transport and deformity correction possible
7.
8. Component, Principles AND Biomechanics
PINS
Types
• Schanz screws (half pins)
• Steinman pins (Transosseos/Transfixation pins)
Biomechanics And Principles
• Pin bending strength is increased to the 4th power of the increase in
the pin’s radius.
• Decreased pin stiffness causes increased stress at the pin-bone
interface, leading to micromotion and ultimate pin failure.
9. Component, Principles AND Biomechanics
PINS
• The pin <1/3 diameter to avoid
substantial stress riser that leads
to a possible fracture.
• hydroxyapatite-coated pins
provide a significantly improved
pin bone interface and a greater
extraction torque.
10. PINS
• The weakest point of a pin is the
thread-shank junction, which
forms a large stress riser.
• The shank should be buried into
the proximal cortex, doubling
the pin’s stiffness. In addition,
soft tissues become less irritated
.
11. Component, Principles AND Biomechanics
PINS
• Two pins must be inserted into each main fragment through an
anatomical safe zone.
• Pins should be spread as wide apart as possible.
• If the soft-tissue allows, pins are inserted as close to the fracture
focus as possible. avioid hematoma or degloved areas.
• If delayed internal fixation is planned, the pins should avoid potential
incisions and surgical approaches (the zone of surgery).
12.
13. PINS
Insertion Techniques
• Know the anatomy and avoid nerves, vessels, and tendons
• Avoid the fracture focus, hematoma, degloved, contused skin and
joints.
• Insert a Schanz screw of the correct length to allow appropriate frame
construction.
• Adequate skin incision, spreading tissues to bone, using cannulation
during drill/pin insertion with the use of protective sleeves, and
stabilizing soft tissues around the pin to prevent motion (results local
infa/infe).
14. PINS
Insertion Techniques
• Predrill the cortex to avoid burning the bone (ring sequestrum is produced)
• predrilling before manual pin insertion lowered temperatures by more than
half (Mathews et al)
• Thermal damage to bone play a potential role in pin loosening.
• Irreversible changes, including osteocyte death and alkaline phosphatase
inactivation, are seen at temp of 50C.
• Methods to decrease temperatures during pin insertion include predrilling,
irrigation, and power insertion of the pin.
15. PINS
Insertion Techniques
• Self-drilling, self-tapping pins allows for the advancement speed of
the pin. However, 22% reduction in bone purchase of self-drilling pins
compared with predrilled pins has been observed. (Seitz et al)
{ stripping of the near cortex when the cutting tip hits the far cortex}
16. Component, Principles AND Biomechanics
BARS
• Sidebars, or rods, form the link between bony fragments
Types
• Aluminum alloy
• Stainless steel
• Carbon fiber rods
Biomechanics And Principles
• Carbon fiber rods are 15% stiffer in loading to failure.
• However, 85% stiff when used in ex-fix compared to stainless steel.
• Reason; Clamp tightening to carbon rods is less effective.
17. BARS
Biomechanics And Principles
• Distance of the longitudinal connecting tube/bar from the bone:
closer means stiffer
• Number of bars/tubes: two are stiffer than one.
18. Component, Principles AND Biomechanics
CLAMPS
Types
• Simple (ie, single) clamps connect one pin to a rod
• Modular (ie, universal) clamps allow multiple pins to be connected to a rod.
Biomechanics
• Modular clamps, there is the possibility of uneven holding strength on
multiple pins within the clamp, thus interfering with the rigidity of the
fixation.
• This problem is avoided with the use of simple clamps.
20. Circular Frames
• Allows controlled dynamic axial loading.
• Utilizes tensioned thin wires, half pins,clamps, rods and rings.
• Ring frames resist axial and bending deformation better than any
hybrid modification.
• Useful in management of bone loss, corrective osteotomies,
infections and peri-articular fractures.
• Technically demanding.
21. Hybrid Fixator
• Combines the advantages of ring fixators in periarticular areas
with simplicity of planar half pin fixators in diaphyseal bone.
• Biomechanically superior to monolateral frame.
• This is accomplished with a minimum of three tensioned wires
and if possible, an additional level of periarticular fixation using
adjunctive halfpins.
22. LCPs as External Fixator
• Mechanical studies
demonstrated slightly higher
torsional stiffness with similar
axial rigidity as the external
fixator for both titanium and
stainless LCPs.
23. LCPs as External Fixator
• In a series of seven patients LCP external fixators;
• Facilitated mobilization - Low profile
• More manageable
• Aesthetically acceptable
• Disadvantages;
• higher costs
• plates andscrews cannot be reused
• Small screws for adults (only 4.5mm available for LCP)
(Rockwood ed 9)
26. Conversion to DefinitiveTreatment
Factors to consider in the timing of conversion;
1. condition of the soft tissues
2. the initial injury
3. the need for further surgical débridement
4. fasciotomy wounds
5. the condition of external fixator pins
6. external fixator stability
7. bone or soft-tissue loss
8. vascular injury
9. infection
10. the physiologic state of the patient.
27. Conversion to DefinitiveTreatment
• For femoral shaft fractures, early definitive stabilization is thought to reduce
the risks of;
• decubitus ulcers,
• pneumonia,
• venous thromboembolic disease
• Conversion to IMN is most frequently performed as a;
• single procedure,
• staged conversion, or “pin holiday,” before definitive fixation is sometimes warranted.
• Timing of conversion to Internal fixation; remarkable reduction of
complications reported when converted with in 2 weeks.
28. Postop management
Pin-site Care
• No consensus in the literature as to the appropriate regimen for pin-
tract care and infection prevention.
• RCT compared daily pin-tract care vs no pin-tract care - No significant
difference
• The author suggested that specific routine pin-tract care is
unnecessary as long as daily hygiene for the patient and frame is
maintained.
(Camathias C 2012)
29. Pin-site Infection
• A recent metaanalysis from 1980 through 2014 documented an
overall rate of 27.4% for risk of at least one pin-tract infection.
• hybrid external fixators demonstrated a similar risk of pin-tract
infection as unilateral fixator. but lower infection rate in the ring
fixator group. (Horst K 2015)
• pin-tract infection for limb-lengthening procedures;
• rate of half-pin site infection 100%
• rate of hybrid fixators infection (78%)
• rate of ring fixator infection (33%)
(Antoki V 2008)
30. Pin-site Infection
• Trauma patients had the lowest risk for infection at 24%.
• Reconstructive and limb-lengthening frames had the highest risk at
46%.
• This was probably related to frame duration.
• fixators removed at average 88 days and
• reconstructive frame removed on average at 198 days
(Iobista CA 2016)
31. General recommendations for Pin-site Care
• Use normal saline as the cleansing agent in concert with dilute
hydrogen peroxide.
• One RCT has shown 9% lower pin-site infection with half-strength hydrogen
peroxide and application of Xeroform dressing (Lethaby A 2008)
• LLRS authors agreed there is insufficient evidence for a single particular
strategy of pin-site care.
• Ointments are not recommended for post cleansing - inhibit normal
skin flora
• Occasional removal of a serous crust around the pins using dilute
hydrogen peroxide and saline.
32. General recommendations for Pin-site Care
• Immediate postoperative compressive dressing - stabilize pin-skin
interface.
• Compressive dressings can be removed within 10 days to 2 weeks
once the pin sites are healed.
• If pin drainage does develop,
• providing pin care three times per day
• compressive dressing
33. Ex-fix reuse
• Components showing no signs of wear can be reused.
• No differences in the rates of reoperation or complications before and
after institution of the reuse.
• No mechanical failure reported of a reused component.
• Recycling of external fixator components is safe and effective.
• In one of the studies, no component used more than three
times/Local policy.
(Dirschl DR 2002) (Mahapatra 2017)
35. References
1. Tornetta P. Rockwood and Green's fractures in adults. Philadelphia:
Wolters Kluwer; 2020.
2. Buckley R, Moran C, Apivatthakakul T. AO principles of fracture
management. Davos Platz, Switzerland: AO Foundation; 2017.
Editor's Notes
The pins used were not threaded until 1917, Humphry was the first man to use threaded pins.
M.E. Muller in 1952. He set forth the concept by which stable fixation could be achieved, only if one applied axial compression through the fixator.
External fixation can be used for almost every long bone and large joint fracture. The main advantage of this approach is the rapid achievement of relative stability that helps to control pain, decrease bleeding, lessen systemic inflammatory response syndrome [3], and facilitate nursing care.
Anatomical reduction, interfragmentary compression and absolute stability is the treatment goal for articular fractures.
Ex-fix is thus used to protect delicate soft-tissues associated with an unstable or complex articular fracture, or to cope with joint dislocations that do not permit primary definitive internal fixation or ligament repair. Any major joint can be bridged in this way. but it is most common in the wrist, knee and ankle.
provide the surgeon with the unique
opportunity to manage major soft tissue and bone loss by primary shortening of the limb followed by secondary distraction osteogenesis to restore limb length.
The weakest point of a pin is the thread-shank junction, which forms a large stress riser. Therefore, placing the pin’s junction at the pin-bone interface, at the site of the highest stress, should be avoided. If possible, the shank should be buried into the proximal cortex, doubling the pin’s stiffness. In addition, soft tissues become less irritated and inflamed when only the smooth shank is exposed.
The most common method of reducing motion is the use of a gentle compressive dressing around the pin to create a bolster between the skin and the clamp, such as a roll of gauze wrapped around the pin.
The authors also observed a visible“wobble factor” when predrilled pins were inserted by hand. This wobble leads to conical deformation
and subsequent instability of the near cortex, causing increased stress in the far cortex.
Although bilateral frames (ie,placed on both sides of the bone) arestiffer, they can be cumbersome toapply and hold a higher potential for
pin infection compared with unilateral frames. Similarly, uniplanarframes are less obstructive for soft_x0002_tissue access but are four to seven
times weaker when stressed in the plane orthogonal to the pins.