POAG and PACG are two major types of glaucoma. POAG is caused by increased intraocular pressure due to improper drainage of fluid from the eye. It progresses slowly and causes damage to the optic nerve and visual field loss over time. PACG occurs when the iris blocks the drainage angle, often in hyperopic eyes, and can progress more rapidly. Treatment options include medications, laser therapy, and surgery to lower pressure and prevent further vision loss. Regular eye exams are important for early detection and management of glaucoma.
www.ophthalclass.blogspot.com has the complete class and MCQs on uveitis for undergraduate medical students. Class 5 in the series of classes on uveitis deals with the common causes of panuveitis and briefly discusses their management. The clinical feature of each of the disease entities is explained with the help of case studies.
www.ophthalclass.blogspot.com has the complete class and MCQs on uveitis for undergraduate medical students. Class 5 in the series of classes on uveitis deals with the common causes of panuveitis and briefly discusses their management. The clinical feature of each of the disease entities is explained with the help of case studies.
Glaucoma is not a single disease process but a group of disorders characterized by a progressive optic neuropathy resulting in a irreversible visual field defects that are associated frequently raised intraocular pressure (IOP).
IOP is the most common risk factor but not the only risk factor for development of glaucoma.
A common eye condition in which the fluid pressure inside the eye rises to a level higher than healthy for that eye.
If untreated, it may damage the optic nerve, causing the loss of vision or even blindness
Glaucoma: the “silent thief of sight”
Glaucoma is a leading cause of preventable sight loss. Vision can often be preserved with early identification, good adherence to treatment and long-term monitoring.
Glaucoma presentation for ophthalmology course, presented as a student seminar. Class location: ophthalmology unit, An-Najah National University Hospital.
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Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
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CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
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VERIFICATION AND VALIDATION TOOLKIT Determining Performance Characteristics o...
POAG AND PACG
1. POAG AND PACG
AN INTRODUCTION
JAYENDRA JHA
OPTOMETRIST
C.L GUPTA EYE INSTITUTE
MORADABAD
2. HISTORICAL ASPECTS
• The glaucoma term is derived from the old greek
word “glaukos” which means “greyish-blue”
• Hippocrates defined glaucoma as “a disease of
the elderly patients in which the pupilla becomes
blue”.
– A person with a swollen cornea and a rapidly
developing cataract and chronic (long-term)
elevated pressure inside the eye
c. 460 BC–c. 380 BC
3. WHAT IS THE INTRAOCULAR PRESSURE
• Pressure insıde the eye is termed ”intraocular pressure (IOP)”
• Eye pressure is measured in millimeters of mercury (mmHg)
• “Normal eye pressure” is not a stable number(s), it ranges from 10
to 21 mmHg
• Elevated IOP is an eye pressure of “greater than 21 mmHg”
4. WHAT IS GLAUCOMA
• Currently, glaucoma is defined as “a progressive optic
neuropathy which causes permanent blindness by damaging
the optic nerve and the periferal visual field”.
• Glaucoma affects 3% of the society and the second frequent
reason of permanent blindness (especially in developed
countries).
• The prevalance is higher in elderly population.
5. RISK FACTORS
• IOP
• AGE
• RACE
• FAMILY HISTORY
• DIABETES MELLITUS
• REFRACTIVE ERROR
• VASCULAR DISEASE
6. CLASSIFICATION OF GLAUCOMA
• Various classifıcations are available.
• Many classifications are based on etiology, anatomy and clinical
presentation.
• CLASSIFICATION BY THE TIME OF ONSET IS AS;
– Congenital glaucoma
– Acquired glaucoma
• Primary glaucoma
• Secondary glaucoma
7. CLASSIFICATION OF THE ACQUIRED
GLAUCOMAS
PRIMARY OPEN ANGLE
GLAUCOMA
•Normal pressure glaucoma
•Ocular hypertensıon
SECONDARY OPEN ANGLE
GLAUCOMAS
•Pseudoexfoliatıon glaucoma
•Pigmentary glaucoma
•Phacolytic glaucoma
•Secondary to ocular inflammation
•Secondary to high episcleral venous
pressure
•Secondary to steroid therapy
PRIMARY ANGLE CLOSURE
GLAUCOMA
•Acute angle closure glaucoma
•Subacute angle closure glaucoma
SECONDARY ANGLE CLOSURE
GLAUCOMAS
•Due to peripheral anterior synechiae
•Swollen lens or pupillary seclusion anterior
movement of the iris-lens diaphragm
•Neovascular glaucoma
• Plateau iris syndrome
8. PRIMARY OPEN ANGLE GLAUCOMA
• POAG is described as optic nerve damage from multiple possible
causes that is chronic and progresses over time
• A loss of optic nerve fibers is characteristic of the disease
• POAG characteristics are open anterior chamber angle, high
intraocular pressure in the eye ,visual field abnormalities and
cupping and atrophy of the optic disc
9. • The exact cause of POAG is unknown
• The most important (and well known) cause of POAG is increased
IOP
• The cause of the high IOP is generally accepted to be because of an
imbalance in the productıon and drainage of fluid in the eye
(aqueous humor)
• The fluid is continually being produced but cannot be drained
because of the improperly functioning drainage channels (called
trabecular meshwork)
POAG CAUSES ?
RAISING THE IOP!!
10. PRIMARY ANGLE CLOSURE GLAUCOMA
• PACG is characterised by apposition of peripheral iris against the
trabecular meshwork obstructing aqueous outflow
• Generally seen in hyperopic eyes than myopic eyes
• PACG is typically associated with greater speed of progresssion and
visual morbidity than POAG
12. GLAUCOMATOUS DAMAGE
• The basis of the glaucomatous damage
is the loss of retinal ganglion cells.
• The ganglion cells constituting the
retinal nerve fiber layer and their axons
dies during the glaucomatous damage
process.
13. SYMPTOMS
• Most cases are asymptomatic until the visual field abnormalities
become prominent and affect central vision.
• Thus, annual routine examinatıon is essential for early
diagnosis.
• In PACG, some patient present acute pain and headache
14. SIGNS
CHRONIC PRESENTATION
• VA is normal unless advanced stages
• Anterior chamber is shallow
• IOP elevation may be only intermittent
ACUTE ANGLE CLOSURE
• VA is usually 20/200 or HM
• IOP is usually very high (50-100 mmHg)
• Conjunctival hyperaemia, corneal oedema
• Unreactive mid- dilated oval pupil
• Fellow eye generally shows an occludable angle
15. THE EVALUATION OF GLAUCOMA PATIENTS
• Visual acuity (best corrected)
• Biomicroscopy (clues to specific diagnosis...)
• Measurement of intraocular pressure
– Applanation tonometry
– Noncontact tonometry
• Pachymetry
• Evaluation of the anterior chamber angle
• Perimetry
• Funduscopy
16. TONOMETRY
• Tonometry is a method used to measure the pressure inside the eye
• Because IOP varies from hour to hour in any individual (diurnal
variation), measurements may be taken at different times of day
(morning and night)
– A difference in pressure between morning and night of 5 mmHg
or more may suggest glaucoma
• A difference in pressure between the two eyes of 3 mmHg or more
may suggest glaucoma
17. THE TECHNIQUES OF
IOP MEASUREMENTS
APPLANATION TONOMETRY
SCHIOTZ
TONOMETER
PERRKINS HAND
HELD TONOMETER
TONOPEN XLNON CONTACT TONOMETER
18. PACHYMETRY
Normal central corneal thickness is variable
500-520 microns
Thinner cornea (CCT < 500 µm) can give
falsely low pressure readings
Severe glaucoma patients may be failed
diagnose
A thick cornea (>600 µm) can give falsely
high pressure readings
Unnecessary treatments !!
19. GONIOSCOPY
SL:Schwalbe’s lıne
TM:Trabecular Meshwork
SS:Scleral Spur
CBB:Ciliary Body Band
•Gonioscopy is performed to check
the drainage angle of an eye
•A special contact lens(goniolens)
is placed on the eye
•This test is important to
determine if the angles are open,
narrowed, or closed
•Open angle: long term,slowly,
insidious disease
•Close (narrow): risk of PACG.
20. VISUAL FIELD TESTING
• VF testing to check the patients peripheral vision
• Typically by using an automated visual field machine
• This test is done to rule out any visual defects due to glaucoma
• VF defects may not be apperent until over 40% of the optic nerve
fiber layer has been lost
• VF testıng may need to be repeated
– A low risk of glaucomatous damage, the test may be performed
once a year
– A high risk of glaucomatous damage, test may be performed as
frequently as every 2 months
21. NORMAL VF
AUTOMATED VISUAL FIELD ANALYZER
STAGES OF GLAUCOMATOUS VISUAL FIELD
DEFECTS
EARLY STAGE MODERATE STAGE END STAGE
22. OPTIC NERVE HEAD EXAMINATION
• Each optic nerve head is examined for any damage or
abnormalities
• This may require dilation of the pupils to ensure an adequate
examination of the optic nerves
• Fundus photographs,which are pictures of optic disc are taken
for future reference and comparison
• Different imagıing studies may be conducted to document the
status of optic nerve and to detect changes over time
25. NORMAL TENSION
GLAUCOMA
• People can have optic nerve
damage without having
elevated IOP
• The main reason of this
condition is vascular
insufficiency (ocular
ischemia)
• People can have elevated
pressures without signs of
optic nerve damage or visual
field loss
• They are considered as a
risk for glaucoma
• These people are known as
glaucoma suspect
OCULAR HYPERTENSION
TWO DIFFERENT SITUATION
26. GENERAL TREATMENT OPTIONS FOR
GLAUCOMA
• MEDICAL THERAPY
• LASER THERAPY
• SURGICAL THERAPY
THE GOAL OF GLAUCOMA TREATMENT IS
REDUCE THE PRESSURE BEFORE IT CAUSES
GLAUCOMATOUS LOSS OF VISION
30. KEY POINTS
• Glaucoma is progressive Optic neuropathy causes irreversible
vision loss.
• Glaucoma is not treatable entity, only further progression is
restricted by timely intervention.
• Awareness about glaucoma is only the major action to restrict the
progression entity.
• Medical or surgical therapy can only restrict its progression speed.
31. REFRENCES
• Comprehensive ophthalmology – A K Khurana Sixth Edition
The Health Sciences Publishers
• Clinical Ophthalmology – Jack J Kanski &Brad Bowling Seventh
Edition, Elsevier Saunders
• Shields Textbook of Glaucoma – R. Rand Allingham Sixth Edition
• Educational Sites (Wikipedia, Webmd.com….)
• The Glaucoma Book
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