PLGA is a biodegradable and biocompatible copolymer of PLA and PGA that is widely used for controlled drug delivery. It can be synthesized via melt polycondensation or ring opening polymerization to produce copolymers of varying molecular weight and properties. PLGA nanoparticles are effectively used to encapsulate drugs and provide sustained release over time. The drug release kinetics from PLGA nanoparticles are dependent on factors like polymer composition, drug loading, particle size and shape. PLGA degrades via hydrolysis of its ester linkages into biocompatible monomers. Alpha-1 antitrypsin encapsulated in PLGA nanoparticles is a promising approach for pulmonary delivery to treat lung diseases.
The document discusses poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer. It provides details on the synthesis of PLGA from lactide and glycolide monomers, its properties such as solubility and glass transition temperature, and its biodegradation process. Applications of PLGA include drug delivery systems, medical implants, and tissue engineering scaffolds. Case studies show that modifying PLGA with other polymers or peptides can improve drug permeability and distribution in tissues.
PLGA is a biodegradable and FDA-approved copolymer of poly lactic acid and poly glycolic acid. It is commonly used as a carrier for drug delivery due to its biodegradability and ability to tune degradation kinetics by adjusting the lactic acid to glycolic acid ratio. The document discusses the types of biodegradable polymers including synthetic polymers like PLGA and natural polymers. It explains that PLGA degradation is dependent on hydrolysis and factors like crystallinity and molecular weight that influence properties. The pharmacokinetics of PLGA is non-linear and dose-dependent, and PLGA has been shown to accumulate in organs like the liver and spleen. Surface modification with polymers like PEG can
PLGA is a biodegradable synthetic polymer commonly used for tissue engineering scaffolds. It consists of lactic acid and glycolic acid monomers linked together. PLGA degrades through hydrolysis of its ester linkages into lactic acid and glycolic acid, which can be metabolized by the body. It has properties suitable for bone tissue engineering like biocompatibility and ability to be tuned to degrade at different rates depending on monomer ratios. PLGA has applications as sutures, fixation devices, and drug delivery systems due to its biodegradability and tunable properties. Future areas of research include modifying PLGA scaffold surfaces and adding hydroxyapatite to improve osteoconductivity and mechanical properties for load-
Hydrogels are water-swollen polymer networks that can absorb large amounts of water. They have numerous pharmaceutical and biomedical applications due to their unique bulk and surface properties. Hydrogels can be designed to respond to environmental stimuli like pH, temperature, and ionic strength. This allows for controlled drug release in response to changes in the surrounding conditions. Hydrogels find use in various drug delivery applications like oral, ocular, and subcutaneous delivery due to their biocompatibility and ability to encapsulate and release bioactive compounds.
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers.
Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European
Medicine Agency approval in drug delivery systems for parenteral administration, (iii) well-described formulations and methods of production adapted to various types of drugs e.g. hydrophilic or hydrophobic small
molecules or macromolecules, (iv) protection of the drug from degradation, (v) possibility of sustained release,
(vi) possibility to modify surface properties to provide stealthiness and/or better interaction with biological
materials and (vii) the possibility to target nanoparticles to specific organs or cells.
This document discusses characterization methods for hydrogels. Hydrogels are crosslinked polymeric networks that can absorb large amounts of water due to hydrophilic functional groups. The document outlines various physical and chemical characterization techniques to determine a hydrogel's structure, mechanical properties, porosity, water content, and chemical composition. Physical techniques include stress-strain tests, microscopy, atomic force microscopy, and mercury intrusion. Chemical techniques involve Fourier transform infrared spectroscopy, nuclear magnetic resonance, and differential scanning calorimetry. These characterization methods provide insights into a hydrogel's properties and structure-property relationships.
The document discusses biodegradable polymers and their medical applications. It defines polymer degradation as the process where properties and performance deteriorate over time. For medical uses, biodegradable polymers are desirable as they do not require removal surgery and can provide controlled drug delivery. Common biodegradable polymers discussed include PLA, PGA and PLGA. The mechanisms of degradation include hydrolysis and enzymatic processes. Medical applications discussed include sutures, implants, stents and drug delivery systems.
This document provides an overview of biodegradation of polymers. It begins with definitions of key terms like biodegradable polymer and discusses various factors that affect biodegradation like chemical structure, morphology, and physical properties. It then classifies polymers as natural or synthetic and lists examples of commonly used biodegradable polymers like poly(lactic acid), poly(glycolic acid), and poly(caprolactone). The mechanisms of biodegradation and bioerosion are described. Applications of biodegradable polymers in medical devices and advantages of using biodegradable polymers are highlighted. The document concludes with a glossary of terms.
The document discusses poly(lactic-co-glycolic acid) (PLGA), a biodegradable polymer. It provides details on the synthesis of PLGA from lactide and glycolide monomers, its properties such as solubility and glass transition temperature, and its biodegradation process. Applications of PLGA include drug delivery systems, medical implants, and tissue engineering scaffolds. Case studies show that modifying PLGA with other polymers or peptides can improve drug permeability and distribution in tissues.
PLGA is a biodegradable and FDA-approved copolymer of poly lactic acid and poly glycolic acid. It is commonly used as a carrier for drug delivery due to its biodegradability and ability to tune degradation kinetics by adjusting the lactic acid to glycolic acid ratio. The document discusses the types of biodegradable polymers including synthetic polymers like PLGA and natural polymers. It explains that PLGA degradation is dependent on hydrolysis and factors like crystallinity and molecular weight that influence properties. The pharmacokinetics of PLGA is non-linear and dose-dependent, and PLGA has been shown to accumulate in organs like the liver and spleen. Surface modification with polymers like PEG can
PLGA is a biodegradable synthetic polymer commonly used for tissue engineering scaffolds. It consists of lactic acid and glycolic acid monomers linked together. PLGA degrades through hydrolysis of its ester linkages into lactic acid and glycolic acid, which can be metabolized by the body. It has properties suitable for bone tissue engineering like biocompatibility and ability to be tuned to degrade at different rates depending on monomer ratios. PLGA has applications as sutures, fixation devices, and drug delivery systems due to its biodegradability and tunable properties. Future areas of research include modifying PLGA scaffold surfaces and adding hydroxyapatite to improve osteoconductivity and mechanical properties for load-
Hydrogels are water-swollen polymer networks that can absorb large amounts of water. They have numerous pharmaceutical and biomedical applications due to their unique bulk and surface properties. Hydrogels can be designed to respond to environmental stimuli like pH, temperature, and ionic strength. This allows for controlled drug release in response to changes in the surrounding conditions. Hydrogels find use in various drug delivery applications like oral, ocular, and subcutaneous delivery due to their biocompatibility and ability to encapsulate and release bioactive compounds.
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers.
Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European
Medicine Agency approval in drug delivery systems for parenteral administration, (iii) well-described formulations and methods of production adapted to various types of drugs e.g. hydrophilic or hydrophobic small
molecules or macromolecules, (iv) protection of the drug from degradation, (v) possibility of sustained release,
(vi) possibility to modify surface properties to provide stealthiness and/or better interaction with biological
materials and (vii) the possibility to target nanoparticles to specific organs or cells.
This document discusses characterization methods for hydrogels. Hydrogels are crosslinked polymeric networks that can absorb large amounts of water due to hydrophilic functional groups. The document outlines various physical and chemical characterization techniques to determine a hydrogel's structure, mechanical properties, porosity, water content, and chemical composition. Physical techniques include stress-strain tests, microscopy, atomic force microscopy, and mercury intrusion. Chemical techniques involve Fourier transform infrared spectroscopy, nuclear magnetic resonance, and differential scanning calorimetry. These characterization methods provide insights into a hydrogel's properties and structure-property relationships.
The document discusses biodegradable polymers and their medical applications. It defines polymer degradation as the process where properties and performance deteriorate over time. For medical uses, biodegradable polymers are desirable as they do not require removal surgery and can provide controlled drug delivery. Common biodegradable polymers discussed include PLA, PGA and PLGA. The mechanisms of degradation include hydrolysis and enzymatic processes. Medical applications discussed include sutures, implants, stents and drug delivery systems.
This document provides an overview of biodegradation of polymers. It begins with definitions of key terms like biodegradable polymer and discusses various factors that affect biodegradation like chemical structure, morphology, and physical properties. It then classifies polymers as natural or synthetic and lists examples of commonly used biodegradable polymers like poly(lactic acid), poly(glycolic acid), and poly(caprolactone). The mechanisms of biodegradation and bioerosion are described. Applications of biodegradable polymers in medical devices and advantages of using biodegradable polymers are highlighted. The document concludes with a glossary of terms.
1) Biodegradable polymers are polymers that break down into non-toxic molecules via biological processes such as hydrolysis or enzymatic degradation. They are used for applications such as drug delivery where degradation is beneficial.
2) There are several types of biodegradable polymers including synthetic aliphatic polyesters like polylactic acid and polyglycolic acid, polyanhydrides, and natural polymers like collagen and gelatin. These polymers degrade via hydrolysis, surface erosion, or enzymatic degradation.
3) Biodegradable polymers have advantages for drug delivery such as localized and sustained release as well as reduced dosing requirements. However, challenges remain in controlling degradation rates and maintaining drug stability
The document discusses hydrogels, including their classification, advantages, disadvantages, types, monomers used in synthesis, methods of preparation, characterization, uses, and pharmaceutical applications. Hydrogels are crosslinked polymer networks that can absorb large amounts of water. They are biocompatible and can be used for controlled drug release in applications such as contact lenses, wound dressings, and tissue engineering scaffolds.
Hydrogels are cross-linked polymer networks that can absorb large amounts of water. They come in natural and synthetic varieties. Hydrogels can be classified based on their synthesis method (homopolymer, copolymer, multipolymer), structure (amorphous, semi-crystalline, hydrogen-bonded), or electric charge (non-ionic, ionic, amphoteric, zwitterionic). Hydrogels have properties like high absorption capacity and biodegradability. They have a wide range of applications including use in contact lenses, hygiene products, wound dressings, and drug delivery.
hydro gels compositions and applicationsAli Al-Rufaye
Hydrogels are three-dimensional polymer networks that can absorb large amounts of water but do not dissolve. They have properties similar to natural tissue and are biocompatible. Hydrogels can be classified based on their degree of swelling, porosity, biodegradability, and type of crosslinking. They are used in a variety of biomedical applications including drug delivery, contact lenses, and tissue engineering due to their water retention and flexibility. Hydrogels can be designed to respond to environmental stimuli like temperature or pH changes to control drug release. Current research is developing self-healing hydrogels for uses like medical sutures and targeted drug delivery.
Biodegradable polymers break down in the body through natural biological processes. They degrade into non-toxic molecules that are metabolized and removed. Common mechanisms of biodegradation include enzymatic degradation, hydrolysis, and bulk or surface erosion. Some polymers suitable for drug delivery systems include poly(lactic acid), poly(glycolic acid), poly(caprolactone), albumin, collagen, chitosan, and dextran. These polymers can be engineered to control drug release kinetics and degradation rates.
This document discusses biodegradable polymers. It defines biodegradable polymers as plastics capable of being decomposed by microorganisms into carbon dioxide and water. The four major commercially available biodegradable polymers are starch-based polymers, poly lactic acid, polyhydroxyalkanoates, and aliphatic/aromatic copolyesters. These polymers are often synthesized through condensation reactions, ring opening polymerization, or with metal catalysts. Biodegradable polymers have applications in medicine due to their biocompatibility and ability to degrade at controlled rates, as well as in packaging to reduce waste.
Hydrogels are three-dimensional polymer networks that swell in water but do not dissolve. They have existed for over half a century and were first used commercially in contact lenses in the 1950s. Hydrogels can be classified based on their degree of swelling, porosity, biodegradability, and electrical charge. They are stimuli-responsive and have a wide range of applications including drug delivery, wound healing, tissue engineering, and more. Hydrogels are prepared using various polymerization techniques and their properties can be tuned by modifying factors like monomer composition, crosslinking, and environmental conditions. Newer "intelligent" hydrogels are being developed that are DNA-based and can undergo phase transitions or actuation in
IMPORTANCE OF BIO-POLYMERS AND POLYMERS Lini Cleetus
This document discusses polymers and biopolymers. It defines polymers as large molecules composed of repeated subunits and explains that polymerization combines monomers into covalently bonded chains. It outlines various applications of polymers in automotive, medical, and aerospace fields. Both positives like strength and weight and negatives like improper disposal are noted. Solutions proposed include reuse, recycling like Levi's jeans containing recycled PET bottles, plastic roads in India containing waste plastic, and converting plastics to fuels. Biopolymers derived from renewable resources are highlighted as alternatives that are biodegradable, carbon neutral, and help reduce fossil fuel dependence.
Polymer-drug conjugates are a novel class of nanocarriers for drug delivery, which can protect the drug from premature degradation, prevent the drug from premature interaction with the biological environment and enhance the absorption of the drugs into tissues (by enhanced permeability and retention effect or active targeting).
Polymer-drug conjugates are often considered as new chemical entities (NCEs) owing to a distinct pharmacokinetic profile from that of the parent drug.
Conjugation of a drug with a polymer forms so-called ‘Polymeric Prodrug’.
This document summarizes hydrogel drug delivery systems. Hydrogels are hydrophilic polymer networks similar to natural tissue that can encapsulate drugs for targeted release. Drugs are released from the hydrogel matrix upon contact with specific organ or tumor molecules. Hydrogels offer adaptable targeting, more precise drug placement, and fewer side effects. Drug loading methods include multiphase encapsulation in microparticles and in situ entrapment during hydrogel formation. Drug release is affected by hydrogel composition and properties. Hydrogels show potential for delivering drugs to bone and cartilage and may enable non-invasive cartilage repair using embedded stem cells.
Synthetic polymers have many applications in biomedical fields such as bone fracture repair, hip joint replacements, ligaments, tendons, contact lenses, sutures, and burn treatments. Polymers are used where biostability is needed for long-term implants, as biodegradable temporary implants, or as water soluble components of blood substitutes. Common polymers used include PMMA, PGA, PCL, silicone, PUs, nylon and polyacrylates which are chosen based on their mechanical properties, biocompatibility and degradation time frame needed for the application. The variety of polymers and their applications in biomedicine has grown tremendously and is expected to continue expanding to improve medical treatments.
This document discusses hydrogels, which are cross-linked polymer networks that can absorb large amounts of water. It classifies hydrogels based on their structure, charge, and mechanism of drug release. It also outlines common monomers used to synthesize hydrogels and various preparation methods like crosslinking. The document notes advantages like biocompatibility and ability to inject hydrogels, as well as disadvantages such as low mechanical strength. It concludes that hydrogels can be used for targeted drug delivery, as biosensors, and in wound healing and tissue regeneration due to their responsiveness to stimuli.
The following slides contain introduction to biomedical polymers, their properties and classification. These polymers are classified in the basis of their sources as natural and synthetic polymers. synthetic polymers are classified on the basis of their functionality. Selection parameter and applications of biomedical polymers are also included.
This document discusses hydrogels, which are 3D polymer networks that can absorb large amounts of water while maintaining their shape. It provides a brief history of hydrogels and classifications based on generation. Stimuli-responsive or "smart" hydrogels that change properties in response to environmental stimuli are highlighted. Characterization techniques and applications of hydrogels in biomedical areas like drug delivery, cell encapsulation, and tissue engineering scaffolds are summarized.
Hydrogels introduction and applications in biology and enAndrew Simoi
Hydrogels are water-swollen, crosslinked polymers that can absorb large amounts of water. They have a variety of applications including in soft contact lenses, drug delivery, wound healing, and tissue engineering. Hydrogels are advantageous for tissue engineering and cell culture as they can mimic extracellular matrix, provide structural support, and allow for nutrient transport. They are also useful for drug delivery as they allow controlled release of molecules. The document discusses the properties, types, advantages and uses of hydrogels.
This document discusses biodegradable polymers. It begins by defining biodegradation as the process of converting polymers into harmless gaseous products via microorganisms and enzymes. It then notes that biodegradable polymers eliminate the need for disposal systems by degrading through natural biological processes. The document outlines the need for biodegradable polymers due to the large amount of non-biodegradable plastic waste produced annually. It proceeds to discuss various biodegradable polymers like biopol, polycaprolactone, polylactic acid, polyglycolic acid, and their characteristics, production processes, uses, and degradation mechanisms.
The document discusses biodegradable polymers and their classification. It covers the history of biodegradable polymers and defines biodegradation. Biodegradable polymers are classified into categories including those derived from biomass, microorganisms, biotechnology, and petrochemical products. The mechanisms of biodegradation and various types of biodegradable polymers like photolytic, peroxidisable, and hydro-biodegradable polymers are also explained. Agricultural applications of biodegradable mulch films are highlighted.
This document discusses key concepts related to polymers and their biomedical applications. It defines thermoplastics and thermosets, and lists some common biomedical uses of polymers like PMMA, UHMWPE, PET, and silicones. It also summarizes polymer synthesis methods, including addition and condensation polymerization. Finally, it covers structural properties of polymers like crystallinity and morphology, as well as models for polymer behavior like reptation theory.
Biodegradable polymers are materials that can break down over time through biological processes like hydrolysis or enzymatic degradation. Some key biodegradable polymers discussed include polylactic acid (PLA), polyglycolic acid (PGA), and poly(lactide-co-glycolide) (PLGA). These polymers find applications in drug delivery, medical implants, and tissue engineering due to their biodegradability and biocompatibility. Factors like chemical structure, morphology, and environmental conditions influence the degradation behavior of these polymers. Common medical uses include sutures, drug delivery micro/nanoparticles, and orthopedic devices.
degradable polymeric carriers for parenteral controlled drug deliveryOmer Mustapha
This document provides an overview of degradable polymeric carriers for controlled drug delivery. It discusses the factors that influence drug release from degradable polymer matrices, including environmental conditions, drug properties, and osmotically mediated mechanisms. It also describes the principles of polymer degradation and erosion, and different strategies to achieve near zero-order drug release profiles from degradable polymers. Commercial parenteral drug delivery products often use microparticles or preformed/in situ forming implants made of poly(lactic-co-glycolic acid) (PLGA) polymer. Drug release from these systems is complex and governed by the polymer's degradation and the drug's diffusion properties.
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsSuraj Choudhary
This document discusses factors affecting the design of controlled release drug delivery systems (CRDDS). It outlines several key considerations for CRDDS design including selection of the drug candidate, medical and biological rationale, and physicochemical properties. It also discusses important physicochemical factors such as solubility, partition coefficient, molecular size and diffusivity, dose size, complexation, ionization constant, drug stability, and protein binding that influence CRDDS design. Finally, it briefly describes dissolution-controlled and diffusion-controlled release approaches for developing CRDDS.
1) Biodegradable polymers are polymers that break down into non-toxic molecules via biological processes such as hydrolysis or enzymatic degradation. They are used for applications such as drug delivery where degradation is beneficial.
2) There are several types of biodegradable polymers including synthetic aliphatic polyesters like polylactic acid and polyglycolic acid, polyanhydrides, and natural polymers like collagen and gelatin. These polymers degrade via hydrolysis, surface erosion, or enzymatic degradation.
3) Biodegradable polymers have advantages for drug delivery such as localized and sustained release as well as reduced dosing requirements. However, challenges remain in controlling degradation rates and maintaining drug stability
The document discusses hydrogels, including their classification, advantages, disadvantages, types, monomers used in synthesis, methods of preparation, characterization, uses, and pharmaceutical applications. Hydrogels are crosslinked polymer networks that can absorb large amounts of water. They are biocompatible and can be used for controlled drug release in applications such as contact lenses, wound dressings, and tissue engineering scaffolds.
Hydrogels are cross-linked polymer networks that can absorb large amounts of water. They come in natural and synthetic varieties. Hydrogels can be classified based on their synthesis method (homopolymer, copolymer, multipolymer), structure (amorphous, semi-crystalline, hydrogen-bonded), or electric charge (non-ionic, ionic, amphoteric, zwitterionic). Hydrogels have properties like high absorption capacity and biodegradability. They have a wide range of applications including use in contact lenses, hygiene products, wound dressings, and drug delivery.
hydro gels compositions and applicationsAli Al-Rufaye
Hydrogels are three-dimensional polymer networks that can absorb large amounts of water but do not dissolve. They have properties similar to natural tissue and are biocompatible. Hydrogels can be classified based on their degree of swelling, porosity, biodegradability, and type of crosslinking. They are used in a variety of biomedical applications including drug delivery, contact lenses, and tissue engineering due to their water retention and flexibility. Hydrogels can be designed to respond to environmental stimuli like temperature or pH changes to control drug release. Current research is developing self-healing hydrogels for uses like medical sutures and targeted drug delivery.
Biodegradable polymers break down in the body through natural biological processes. They degrade into non-toxic molecules that are metabolized and removed. Common mechanisms of biodegradation include enzymatic degradation, hydrolysis, and bulk or surface erosion. Some polymers suitable for drug delivery systems include poly(lactic acid), poly(glycolic acid), poly(caprolactone), albumin, collagen, chitosan, and dextran. These polymers can be engineered to control drug release kinetics and degradation rates.
This document discusses biodegradable polymers. It defines biodegradable polymers as plastics capable of being decomposed by microorganisms into carbon dioxide and water. The four major commercially available biodegradable polymers are starch-based polymers, poly lactic acid, polyhydroxyalkanoates, and aliphatic/aromatic copolyesters. These polymers are often synthesized through condensation reactions, ring opening polymerization, or with metal catalysts. Biodegradable polymers have applications in medicine due to their biocompatibility and ability to degrade at controlled rates, as well as in packaging to reduce waste.
Hydrogels are three-dimensional polymer networks that swell in water but do not dissolve. They have existed for over half a century and were first used commercially in contact lenses in the 1950s. Hydrogels can be classified based on their degree of swelling, porosity, biodegradability, and electrical charge. They are stimuli-responsive and have a wide range of applications including drug delivery, wound healing, tissue engineering, and more. Hydrogels are prepared using various polymerization techniques and their properties can be tuned by modifying factors like monomer composition, crosslinking, and environmental conditions. Newer "intelligent" hydrogels are being developed that are DNA-based and can undergo phase transitions or actuation in
IMPORTANCE OF BIO-POLYMERS AND POLYMERS Lini Cleetus
This document discusses polymers and biopolymers. It defines polymers as large molecules composed of repeated subunits and explains that polymerization combines monomers into covalently bonded chains. It outlines various applications of polymers in automotive, medical, and aerospace fields. Both positives like strength and weight and negatives like improper disposal are noted. Solutions proposed include reuse, recycling like Levi's jeans containing recycled PET bottles, plastic roads in India containing waste plastic, and converting plastics to fuels. Biopolymers derived from renewable resources are highlighted as alternatives that are biodegradable, carbon neutral, and help reduce fossil fuel dependence.
Polymer-drug conjugates are a novel class of nanocarriers for drug delivery, which can protect the drug from premature degradation, prevent the drug from premature interaction with the biological environment and enhance the absorption of the drugs into tissues (by enhanced permeability and retention effect or active targeting).
Polymer-drug conjugates are often considered as new chemical entities (NCEs) owing to a distinct pharmacokinetic profile from that of the parent drug.
Conjugation of a drug with a polymer forms so-called ‘Polymeric Prodrug’.
This document summarizes hydrogel drug delivery systems. Hydrogels are hydrophilic polymer networks similar to natural tissue that can encapsulate drugs for targeted release. Drugs are released from the hydrogel matrix upon contact with specific organ or tumor molecules. Hydrogels offer adaptable targeting, more precise drug placement, and fewer side effects. Drug loading methods include multiphase encapsulation in microparticles and in situ entrapment during hydrogel formation. Drug release is affected by hydrogel composition and properties. Hydrogels show potential for delivering drugs to bone and cartilage and may enable non-invasive cartilage repair using embedded stem cells.
Synthetic polymers have many applications in biomedical fields such as bone fracture repair, hip joint replacements, ligaments, tendons, contact lenses, sutures, and burn treatments. Polymers are used where biostability is needed for long-term implants, as biodegradable temporary implants, or as water soluble components of blood substitutes. Common polymers used include PMMA, PGA, PCL, silicone, PUs, nylon and polyacrylates which are chosen based on their mechanical properties, biocompatibility and degradation time frame needed for the application. The variety of polymers and their applications in biomedicine has grown tremendously and is expected to continue expanding to improve medical treatments.
This document discusses hydrogels, which are cross-linked polymer networks that can absorb large amounts of water. It classifies hydrogels based on their structure, charge, and mechanism of drug release. It also outlines common monomers used to synthesize hydrogels and various preparation methods like crosslinking. The document notes advantages like biocompatibility and ability to inject hydrogels, as well as disadvantages such as low mechanical strength. It concludes that hydrogels can be used for targeted drug delivery, as biosensors, and in wound healing and tissue regeneration due to their responsiveness to stimuli.
The following slides contain introduction to biomedical polymers, their properties and classification. These polymers are classified in the basis of their sources as natural and synthetic polymers. synthetic polymers are classified on the basis of their functionality. Selection parameter and applications of biomedical polymers are also included.
This document discusses hydrogels, which are 3D polymer networks that can absorb large amounts of water while maintaining their shape. It provides a brief history of hydrogels and classifications based on generation. Stimuli-responsive or "smart" hydrogels that change properties in response to environmental stimuli are highlighted. Characterization techniques and applications of hydrogels in biomedical areas like drug delivery, cell encapsulation, and tissue engineering scaffolds are summarized.
Hydrogels introduction and applications in biology and enAndrew Simoi
Hydrogels are water-swollen, crosslinked polymers that can absorb large amounts of water. They have a variety of applications including in soft contact lenses, drug delivery, wound healing, and tissue engineering. Hydrogels are advantageous for tissue engineering and cell culture as they can mimic extracellular matrix, provide structural support, and allow for nutrient transport. They are also useful for drug delivery as they allow controlled release of molecules. The document discusses the properties, types, advantages and uses of hydrogels.
This document discusses biodegradable polymers. It begins by defining biodegradation as the process of converting polymers into harmless gaseous products via microorganisms and enzymes. It then notes that biodegradable polymers eliminate the need for disposal systems by degrading through natural biological processes. The document outlines the need for biodegradable polymers due to the large amount of non-biodegradable plastic waste produced annually. It proceeds to discuss various biodegradable polymers like biopol, polycaprolactone, polylactic acid, polyglycolic acid, and their characteristics, production processes, uses, and degradation mechanisms.
The document discusses biodegradable polymers and their classification. It covers the history of biodegradable polymers and defines biodegradation. Biodegradable polymers are classified into categories including those derived from biomass, microorganisms, biotechnology, and petrochemical products. The mechanisms of biodegradation and various types of biodegradable polymers like photolytic, peroxidisable, and hydro-biodegradable polymers are also explained. Agricultural applications of biodegradable mulch films are highlighted.
This document discusses key concepts related to polymers and their biomedical applications. It defines thermoplastics and thermosets, and lists some common biomedical uses of polymers like PMMA, UHMWPE, PET, and silicones. It also summarizes polymer synthesis methods, including addition and condensation polymerization. Finally, it covers structural properties of polymers like crystallinity and morphology, as well as models for polymer behavior like reptation theory.
Biodegradable polymers are materials that can break down over time through biological processes like hydrolysis or enzymatic degradation. Some key biodegradable polymers discussed include polylactic acid (PLA), polyglycolic acid (PGA), and poly(lactide-co-glycolide) (PLGA). These polymers find applications in drug delivery, medical implants, and tissue engineering due to their biodegradability and biocompatibility. Factors like chemical structure, morphology, and environmental conditions influence the degradation behavior of these polymers. Common medical uses include sutures, drug delivery micro/nanoparticles, and orthopedic devices.
degradable polymeric carriers for parenteral controlled drug deliveryOmer Mustapha
This document provides an overview of degradable polymeric carriers for controlled drug delivery. It discusses the factors that influence drug release from degradable polymer matrices, including environmental conditions, drug properties, and osmotically mediated mechanisms. It also describes the principles of polymer degradation and erosion, and different strategies to achieve near zero-order drug release profiles from degradable polymers. Commercial parenteral drug delivery products often use microparticles or preformed/in situ forming implants made of poly(lactic-co-glycolic acid) (PLGA) polymer. Drug release from these systems is complex and governed by the polymer's degradation and the drug's diffusion properties.
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsSuraj Choudhary
This document discusses factors affecting the design of controlled release drug delivery systems (CRDDS). It outlines several key considerations for CRDDS design including selection of the drug candidate, medical and biological rationale, and physicochemical properties. It also discusses important physicochemical factors such as solubility, partition coefficient, molecular size and diffusivity, dose size, complexation, ionization constant, drug stability, and protein binding that influence CRDDS design. Finally, it briefly describes dissolution-controlled and diffusion-controlled release approaches for developing CRDDS.
Application of polymers in oral sustained drug delivery systemprashant bhamare
This document discusses polymers used in oral sustained drug delivery systems. It defines polymers and sustained drug delivery systems. Some key advantages of sustained release systems are reduced dosing frequency and more consistent drug levels. Matrix and reservoir systems are two formulation approaches that use insoluble or erodible polymers to control drug dissolution or diffusion rates. Examples of polymers commonly used include cellulose derivatives, waxes, and acrylic acid copolymers. Matrix tablets containing carbopol, HPMC or EC can provide extended release of drugs like zidovudine or diclofenac sodium. Sustained release drug delivery systems aim to prolong the therapeutic effects of drugs over time.
This document summarizes a seminar on oral controlled drug delivery systems presented by Sonam M. Gandhi. It discusses advantages and disadvantages of controlled delivery systems. Key types discussed include dissolution controlled, diffusion controlled, and combined dissolution/diffusion controlled systems using coatings or matrices. Other methods covered are ion exchange resins, pH dependent formulations, osmotic pressure controlled systems, and hydrodynamically balanced systems. Specific examples and equations are provided to explain the drug release mechanisms and rate determinations for several of these approaches.
This document discusses the use of polymer micelles for targeted drug delivery. Polymer micelles are nano-sized particles composed of amphiphilic block copolymers with both hydrophobic and hydrophilic blocks that can self-assemble in water. They are promising drug carriers as they can solubilize hydrophobic drugs and extend circulation time. Two common preparation methods are direct dissolution and solvent evaporation. Drug release can be triggered by internal factors like pH or temperature changes at the target site. Important parameters for characterization include encapsulation efficiency and loading capacity. Polymer micelles show potential for applications in cancer therapy and other diseases.
This document discusses hydrogel polymers for use in drug delivery. It begins by explaining how hydrogels can be used to control drug dosage by swelling at target sites to release drugs in a controlled manner. It then classifies hydrogels based on their synthesis route, configuration, cross-linking type, and ionic charges. Key properties that make hydrogels suitable for drug delivery, such as biocompatibility and environment sensitivity, are also outlined. Examples of hydrogel materials commonly used for drug delivery, such as sodium alginate, chitosan, and gelatin, are provided along with challenges to improving their applicability.
This document discusses biodegradable polymers for drug delivery applications. It provides background on limitations of non-degradable systems and advantages of biodegradable polymers, which degrade into non-toxic components and avoid need for device removal. Common biodegradable polymers used are poly(lactic acid), poly(glycolic acid) and their copolymer poly(lactide-co-glycolide), which degrade via hydrolysis of bonds between monomers. These polymers were first developed as degradable sutures and have since been widely used to provide controlled release in applications like contraception and cancer treatment.
NOVEL DRUG
1.INTRODUCTION: Novel Drug delivery system is the advance drug delivery system which improve drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue.
2.ADVANTAGES
3.DISADVANTAGES
4.SELECTION OF DRUG CANDIDATES FOR CONTROL RELEASE DOSAGE FORM
5.APPROACHES TO DESIGN CONTROLLED RELEASE FORMULATIONS
6.FACTORS INFLUENCING THE DESIGN AND ACT OF CONTROLLED RELEASE PRODUCTS
DELIVERY SYSTEM
This document provides information on factors affecting the design of controlled release drug delivery systems (CRDDS). It discusses selection of drug candidates, medical and biological rationales, physicochemical properties, in vitro and in vivo evaluation, and regulatory considerations. Dissolution-controlled and diffusion-controlled delivery systems are described. Key factors like solubility, partition coefficient, molecular size, dose size, and stability are explained. Different approaches for controlled release like matrix systems, encapsulation, reservoir devices are summarized.
This document discusses different types of rate controlled drug delivery systems. It begins by introducing controlled release drug delivery and distinguishing it from sustained release. It then classifies controlled release systems into three main categories: rate programmed, activation modulated, and feedback regulated systems. Within each category it describes several examples of systems, identifying how drug release is controlled in each case. Key factors that can affect controlled release are also listed. The document aims to provide an overview of controlled drug delivery technologies with classifications and examples.
In our final webinar of the MDC Connects Series 2021 | A Guide to Complex Medicines.
This slide deck takes a closer look at the advantages of good formulation.
Claire Patterson, Seda Pharmaceutical Development Services
The document discusses various techniques for enhancing the solubility of poorly soluble drugs. It begins by explaining the importance of drug solubility for bioavailability and effectiveness. The main techniques discussed include reducing particle size through methods like micronization and nanosuspensions. It also covers modifying the crystal structure of drugs through polymorphism, amorphism, and changing hydration states. The document provides details on methods like sonocrystallization and supercritical fluid processing for size reduction.
The document discusses various techniques for enhancing the solubility of poorly soluble drugs. It begins by explaining the importance of drug solubility for bioavailability and outlines several techniques, including physical modifications like reducing particle size and modifying crystal forms, chemical modifications like changing pH, and forming complexes with agents. A key technique is using surfactants to create microemulsions that can solubilize drugs and enhance permeability across biological membranes. Overall, the techniques aim to increase surface area, modify crystal energy states, or alter a drug's chemistry to improve its solubility.
This document discusses release kinetics and various drug release mechanisms and models. It begins by outlining the objectives of studying release kinetics, including predicting in vitro release and release profiles. It then covers key topics like modified Noyes-Whitney equation, drug release mechanisms, and theoretical models for diffusion, swelling, and erosion controlled systems. Specific models discussed in detail include zero order, first order, Hixson-Crowell, and various swelling and erosion models. The document provides information on interpreting release kinetics data using these mathematical models.
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Nanocrystals are pure drug particles in the nanometer size range that can increase drug solubility and bioavailability without using surfactants. Various "bottom up" and "top down" methods are used to produce drug nanocrystals including precipitation, cryo-vacuum processing, wet milling, and high pressure homogenization. Drug nanocrystals have potential applications for oral, transdermal, and targeted cancer delivery and imaging. Further research is still needed to reduce nanocrystal toxicity before clinical use.
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2. Polylactic glycolic acid
• Polyester poly(lactic-co-glycolide) (PLGA) is a copolymer of PLA and
polyglycolic acid (PGA).
• PLGA is the most well known and widely applied polymer in controlled
release systems. This synthetic polymer has found great success due to
its biocompatibility, biodegradability, and favorable release
kinetics.
• PLGA nanoparticles can be used safely for oral, nasal, pulmonary,
parenteral, transdermaland intra-ocular routes of administrationthe.
3. Synthesis of PLGA
• Melt Polycondensation:resulting in copolymers of low molecular
weight.
4. Synthesis of PLGA
• Ring opening polymerization: resulting in copolymers with high
molecular weight and therefore with better mechanical properties
5. Synthesis of PLGA
• Biodegradable polymeric nanoparticles are highly
preferred because they show promise in drug delivery
system.
• Such nanoparticles provide controlled/sustained release
property, subcellular size and biocompatibility with
tissue and cells.
• Lactide is more hydrophobic than glycolide, therefore
PLGA copolymers rich in lactide are less hydrophilic
and absorb less water, leading to a slower degradation
of the polymer chains
6. Synthesis of PLGA
• The PLGA nanoparticles can be prepared by different techniques.
• The most common technique is the emulsification solvent
evaporation technique because of its simplicity and high encapsulation
efficiency.
• The single emulsion method is only suitable for hydrophobic drugs and
leads to very poor encapsulation efficiency with regard to protein or
peptide drugs.
• The oil-in-oil (o/o) emulsification technique which is known as the
nonaqueous emulsion method is a new and efficient method for
encapsulation of hydrophilic drugs.
7. Synthesis of PLGA
• Monomer ratios of 70/30 and 50/50 (D,L-lactide/gly- colide)
have been used in the syntheses, these are the most commonly
used ratios in controlled drug delivery systems.
• If lactic acid is used in a higher ratio than glycolic acid, a more
hydrophobic copolymer is formed due to the higher
hydrophobicity of lactic acid. Such a change can be used to
reduce the rate of water penetration into a device.
• An increase in the ratio of glycolic acid in the copolymer
composition can be used to produce a more crystalline polymer
matrix
8. Lactide
Lactide has asymmetric carbons, which means that the
levorotatory (L-PLA), dextrorotatory (D-PLA) and ra-cemic
(D,L-PLA) polymeric forms may be obtained.
The levorotatory and dextrorotatory forms are semi-crystalline,
while the racemic form is amorphous due to the irregularities in
the polymer chain.
This is because the use of the racemic mixture yields a polymer
product that exhibits more amorphous features in its structure
to improve the homogeneous dispersion of drugs throughout
the PLGA polymer matrix when fabricating delivery devices
9. Figure Effect of Lactic Acid (LA) and Glycolic Acid (GA)
composition on degradation rate of poly(lactide-co-glycolic acid) in
an in vivo.
10. Fig. Type of biodegradable nanoparticles: According to the structural organization
biodegradable nanoparticles are classified as nanocapsule, and nanosphere.
The drug molecules are either entrapped inside or adsorbed on the surface.
11. MECHANISMS OF RELEASE
The mechanism of release is the rate limiting step or series of rate
limiting steps that control the rate of drug release from a device until
release is exhausted.
The major release mechanisms include:
1. Diffusion, solvent penetration/device swelling.
2. Degradation and erosion of the polymer matrix.
3. A combination of these mechanisms occurring on different time
scales that leads to a more complex release process.
13. • The most desirable case is zero order release kinetics. In such a case the
rate of drug release is independent of its dissolved concentration in the
release medium and is delivered at a constant rate over time.This type of
release is unachievable by current polymeric release systems.
• Diffusion (2a) is the most common release mechanism and is
dependent on the concentration of the dissolved drug as described by
Fick’s second Law.
• Erodible delivery systems (2b) are also non-zero ordered and the
rate of release is dependent on the degradation kinetics of the polymer
used.
• Solvent penetration systems (2c) are also non-zero ordered and
their rate is dependent upon the permeability of the polymer used.
14. Schematic of processes that contribute to PLGA device release mechanism:
a) Initial drug loaded device
b) Water penetration and drug diffusion
c) Bulk degradation and erosion
d) Autocatalytic PLGA degradation and accelerated drug diffusion
e) Total degradation and exhaustion of drug release
15. MECHANISMS OF RELEASE
• A biphasic curve for drug release as a result of PLGA
biodegradation has been shown to display following pattern:
• Initial burst of drug release is related to drug type, drug
concentration and polymer hydrophobicity.
• Drug on the surface, in contact with the medium, is released as a
function of solubility as well as penetration of water into
polymer matrix. Random scission of PLGA decreases molecular
weight of polymer significantly, but no appreciable weight loss
and no soluble monomer product are formed in this phase.
16. MECHANISMS OF RELEASE
• In the second phase, drug is released progressively through
the thicker drug depleted layer. The water inside the matrix
hydrolyzes the polymer into soluble oligomeric and monomeric
products.
• This creates a passage for drug to be released by diffusion and
erosion until complete polymer solubilization. Drug type also
plays an important role here in attracting the aqueous phase
into the matrix.
18. MATHEMATICAL MODELING OF
PLGA RELEASE SYSTEMS
• The classic Higuchi equation;
QtQ∞=1L2Cw*A∫0tP(t)dt
Where Qt is the cumulative mass of drug release per unit release
area at time t.
C* w is the solubility of the drug in the release medium.
P is the time dependent permeability.
A is the drug loading, L is the half thickness of the matrix.
Qinf is the drug loading per unit release area
19. MATHEMATICAL MODELING OF PLGA
RELEASE SYSTEMS
• A release model based on Fick’s second law for a spherical
geometry depends on a changing polymer molecular weight:
Mt=4πr2[2(C0−Cs)CsDt+4CsDt9r(Cs2C0−Cs−3)]
• Where Mt is the cumulative mass released at time t.
• r is the radius of the micro particle.
• C0 is the initial drug concentration within the polymer matrix.
• Cs is the solubility of the drug in the medium.
• D is the diffusion coefficient
21. Degredation Equation
ln(X) = intercept − kdt
X is the number of bond cleavages per initial number-average
molecule.
kd is the copolymer degradation rate constant.
t is time.
X is calculated by the measurements of the initial number
average molecular weight and the number average molecular
weight at degradation time t via size exclusion chromatography.
22. Factors Affecting Degradation
• Effect of Composition:PLGA 50:50 (PLA/PGA) exhibited a faster degradation
than PLGA 65:35 due to preferential degradation of glycolic acid proportion
assigned by higher hydrophilicity.
• Effect of Crystallinity: the crystallinity of lactic acid (PLLA) increases the
degradation rate because the degradation of semi-crystalline polymer is
accelerated due to an increase in hydrophilicity.
• Effect of Weight Average Molecular Weight (Mw): Polymers having higher
molecular weight have longer polymer chains, which require more time to degrade
than small polymer chains.
• Effect of Drug Type: one must seriously consider the effect of the chemical
properties of the drug to explain the drug-release mechanisms of a particular
system using biodegradable polymers.
23. Factors Affecting Degradation
• Effect of Size and Shape of the Matrix: The ratio of surface area to
volume has shown to be a significant factor for degradation of large devices.
Higher surface area ratio leads to higher degradation of the matrix.
• Effect of pH: The in vitro biodegradation/hydrolysis of PLGA showed that
both alkaline and strongly acidic media accelerate polymer degradation.
• Effect of Enzymes: It has been proposed that PLGA degrades primarily
through hydrolytic degradation but it has also been suggested that enzymatic
degradation may play a role in the process.
• Effect of Drug Load: Matrices having higher drug content possess a larger
initial burst release than those having lower content because of their smaller
polymer to drug ratio.
24. ADVANTAGES
• Less toxic compared to non-biodegradable polymers
• Much higher doses of the drug can be delivered locally
• Controlled drug release from the formulation
• Stabilization of drug
• Localized delivery of drug
• Decrease in dosing frequency
• Reduce side effects
• Improved patient compliance
• Polymer retain its characteristics till the depletion of drug
25. CONSIDERATIONS IN THE EVALUATION
OF MODIFIEDRELEASE PRODUCTS
The development of a modified-release formulation has to be
based on a well-defined clinical need and on an integration of
physiological, pharmacodynamic (PD), and pharmacokinetic (PK)
considerations.
The two important requirements in the development of extended-
release products are
(1) demonstration of safety and efficacy and
(2) demonstration of controlled drug release.
26. Pharmacodynamic and Safety Considerations
• The most critical issue is to consider whether the modified-
release dosage form truly offers an advantage over the same
drug in an immediate-release (conventional) form. This
advantage may be related to better efficacy, reduced toxicity, or
better patient compliance.
• Ideally, the extended-release dosage form should provide a
more prolonged pharmacodynamic effect compared to the same
drug given in the immediate-release form. However, an
extended-release dosage form of a drug may have a different
pharmacodynamic activity profile compared to the same drug
given in an acute, intermittent, rapid-release dosage form.
27. Alpha-1 antitrypsin
• Alpha 1- antitrypsin (α1AT) is a 54 kDa glycoprotein which belongs to the
superfamily of serpin. The protein inhibits serine protease and a broad group of
other proteases.
• It protects the lungs from cellular inflammatory enzymes, especially elastase,
therefore it is known as the human neutrophil elastase inhibitor.
• In the absence of α1AT, the neutrophil elastase released by lung macrophages, is not
inhibited, thus leading to elastin breakdown and the loss of lung elasticity. This
causes degradation of the lung tissue resulting in pulmonary complications, such as
emphysema or chronic obstructive pulmonary disease COPD in adults.
• The commercially available plasma derived product of α1AT is administered
intravenously. Such an intravenous augmentation therapy has disadvantages, such
as high costs, viral contaminations and immune reactions because of prolonged
retention of the drug in circulation.
28. Encapsulation of Alpha-1 antitrypsin in
PLGA nanoparticles
• The pulmonary route is an alternative, potent and noninvasive route
for systemic and local delivery of macromolecules. The aerosolized
α1AT not only affects locally the lung, its main site of action, but also
avoid remaining and circulation for a long time in peripheral blood.
• prepare a wide range of particle size as a carrier of protein-loaded
nanoparticles to deposit in different parts of the respiratory system
especially in the deep lung.
• The lactic acid to glycolic acid ratio affects the release profile of α1AT.
Hence, PLGA with a 50:50 ratios exhibited the ability to release %60
of the drug within 8, but the polymer with a ratio of 75:25 had a
continuous and longer release profile.
29.
30. Particle sizes and Distribution
• Preparation method affects particle size and distribution.
• Particles produced by nonaqueous emulsion technique have smaller
size and wider size distribution.
• Nanoparticles obtained by double w/o/w technique have slightly
bigger size and narrower distribution.
35. Refrences
• Synthesis and Characterization of Poly(D,L-Lactide-co-Glycolide) Copolymer,
Cynthia D’Avila Carvalho Erbetta1, Ricardo José Alves2, Jarbas Magalhães
Resende3, Roberto Fernando de Souza Freitas1, Ricardo Geraldo de Sousa1
• Science and Principles of Biodegradable and Bioresorbable Medical Polymers by
Xiang Zhang 2017.
• Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery
Carrier Hirenkumar K. Makadia 1 and Steven J. Siegel 2;2011.
• Poly (lactic-co-glycolic acid) controlled release systems: experimental and
modeling insights Daniel J. Hines and David L. Kaplan, 2013.
• Encapsulation of Alpha-1 antitrypsin in PLGA nanoparticles: In Vitro
characterization as an effective aerosol formulation in pulmonary diseases,
Nazanin Pirooznia, 2012.