Platinum-based drugs have been used to treat cancer since the 1960s. Three major platinum drugs are currently used: cisplatin, carboplatin, and oxaliplatin. While effective, they have limitations like nephrotoxicity and neurotoxicity. Researchers continue developing new platinum complexes to reduce toxicity and overcome resistance. Recent progress includes developing orally administered and light-activated platinum drugs, and identifying genes involved in platinum transport and DNA repair pathways. Clinical trials of new drugs like satraplatin and picoplatin continue seeking FDA approval to expand treatment options.

1. PLATINUM DRUG
SUDESHNA SAHA ~ Chem.3 Yr

2. INTRODUCTION
Platina del pinto - Pt - 78

3.  Cis Pt (NH3)2 discovered by M.PEYRON, 1845.
 In 1965, BARNETT ROSERBERG discovered,
Electrolysis of Platinum electrode produce CISPLATIN.
 Cis Pt gets approval for clinical use in 1978.

4. CARBOPLATIN was discovered
in1889 at CANCER RESEARCH
CENTRE, London.

5. OXAPLATIN was
discovered in 1976 at
Nagoya City UniversIty by
Professor Yoshinori Kidani.

6. PROGRESS : 1992
 Corelation of increased nucleotide – excision
repair with lower response Platinum based
chemotherapy in patients with Ovarian Cancer
was observed, in 1992.
 It was also in 1992, that the first clinical study
showed the promising result of OXAPLATIN
when used in combination with 5- fluorouracil in
patients with Colorectal Cancer.

7. PROGRESS : 1993 & 97
 1993 : It was in 1993, the first patient
treated with an orally administered
PLATINUM drug, SATRAPLATIN
(JM216).
 1997 : It was in 1997, the first patient
was treated with PICOPLATIN
(JM473).

8. PROGRESS : 1999 & 2002
 1999 : Molecular defect in nucleotide - excision
Repair, was identified that causes hypersensitivity
of some testicular Cancer to CISPLATIN.
 2002 : OXAPLATIN gets initial approval from US
FDA for Colorectal Cancer treatment.
 2002 : Identification of the role of COPPER
TRANSPORTER CTR1 in transporting CISPLATIN
into cells, was also in 2002.

9. PROGRESS : 2006 & 2007
 2006 : BEVACIZUMAB got approved for
treatment in non-cell lung cancer used in
combination with CARBOPLATIN &
PACLITAXEL.
 2007 : It was in 2007, that SATRAPLATIN
was taken into consideration for approval by
the US FDA for Prostate Cancer.

10. PROGRESS : 2009
 Researchers have now identified a way to
enhance the in vitro anticancer effects of the
commonly used platinum-based drug Cisplatin
and hope that it might be possible to translate
these data into the development of a clinical
strategy to enhance the anti-cancer effects of
platinum-based drugs.

11. PROGRESS : 2009
 Researchers in the Department of Chemistry at
Wake Forest University in collaboration with
colleagues at the Wake Forest University Health
Sciences Comprehensive Cancer Center have
developed a new class of platinum-based anti-
tumor drugs that animal studies have shown to
be 10 times more effective than current
treatments in destroying certain types of lung
cancer cells.

12. PROGRESS
2010
 A new light activate
Platinum based complex
compound known as trans,
trans, trans – [ Pt (N3)2
(OH)2 (Py)2 ], was
discovered, that can be
activated by normal visible
Blue or even Green light,
which can used as `light
activation` to kill Cancer
cells in a much more targeted way. It is 80 times more
powerful, it is easy to work & stable & it can be flushed
out of the body after use as it is water soluble.

13. LIMITATIONS
CISPLATIN CARBOPLATIN
 MYELOSUPRESSION
 NEPHROTOXICITY
 NEURO-TOXICITY
 OTOTOXICITY

14. NEPHROTOXICITY
~ The property of
harming kidney cells
or causing kidney
failure.

15. NEUROTOXICITY
BEFORE AFTER

16. OTOTOXICITY
~ Ototoxicity is
drug or chemical
damage to the
inner ear.

17. MYELOSUPPRESSION
~ Inhibition of bone
marrow activity, resulting
in decreased production of
blood cells and platelets.

18. CISPLATIN RESISTANCE
 It is a disease in which patients becomes
non responsive to Cisplatin.

19. FUTURE ~ BNP 7787
Overcomes Cisplatin resistance.
Overcomes Cisplatin resistance.

20. SOME OTHER PT DRUGS ~ APROVED FOR MARKETING
 NEDAPLATIN -------------------
 LOBAPLATIN -----------------
 HEPTAPLATIN ----------------

21. DRUGS UNDER CLINICAL TRIAL
 SATRAPLATIN ----------------
 PICOPLATIN ------------------
 And ot s…
her

22. Conclusion…
Precious metals are not only precious as wealth
but far more precious for health also.

23. Thank
Thank
You