Cisplatin based metal complexes

1. Cisplatin as anti-cancer
activity

2. Cisplatin was explored in 1845 by ‘Michele
Peyrone’ but in 1965 Dr. Barnett
Rosenberg discovered its inhibiting cell
division property. It gets approval for clinical
use in 1978.
Cisplatin, or cis-diamminedichloroplatinum
(II), is a well-known chemotherapeutic drug.
It has been used for treatment of numerous
human cancers, including bladder, head,
neck, lung, ovarian, and testicular cancers

3. K2[PtCl4] K2[PtI4]
KI NH4OH
cis-[Pt(NH3)2I2]
2AgNO3
Aqueous sol.
[Pt (NH3)2(H2O)2] 2+
Excess KCl
Yellow solid Cisplatin

4.  Cisplatin was first metal based anticancer drug, It is used for
wide range of solid cancers such as testicular, ovarian, bladder,
lung, cervical, head and neck cancer, gastric cancer and some
other cancers. Studies confirmed that cisplatin exerts
its anticancer activity by attacking more than one place. It
generally binds with genomic DNA (gDNA) or mitochondrial
DNA (mtDNA) to create DNA lesions.
 Cisplatin coordinates to DNA and that this coordination
complex not only inhibits replication and transcription of DNA,
but also leads to programmed cell death (apoptosis).

5. Nuclear DNA damage Mitochondrial DNA damage
Block of nDNA
transcription and replication
Block of mtDNA
transcription and replication
DNA damage response ROS production
Cell Death
Glucose
oxidation
Aerobic
glycolysis
Increased
ROS scavenging
ability
Increased
DNA repair
ability

6.  Carboplatin anti-cancer Drug
 Carboplatin is used to treat various types of cancer. It is
a chemotherapy drug that contains platinum. It is used to
slow or stop cancer cell growth.

8.  Carboplatin is used for the treatment of ovarian
cancer, head and neck cancer, and also small cell lung
cancer. Because cisplatin and carboplatin have similar
efficacy, the most appropriate use of carboplatin is in
those with impaired renal function, those who are unable
to tolerate high-volume hydration, or who are at high risk
for neurotoxicity or ototoxicity.

9.  The side effects of carboplatin is much reduced as compared
to cicplatin, so it is more preferred. Although it has
drawback is that it causes blood cell and platelet output of
bone marrow to reduce significantly.

10.  Oxaliplatin is a chemotherapy drug. It’s a treatment for a
number of different types of cancer. It pronounce oxaliplatin as
ox-ali-pla-tin.usually have oxaliplatin in combination with other
cancer drugs.
 Oxaliplatin Drug

11. Oxaliplatin

12.  Oxaliplatin is a platinum group metal complex, which is a new
generation of platinum antineoplastic drugs after cisplatin and
carboplatin. Oxaliplatin, also known as platinum oxalate.