This document discusses platinum-based drugs used for cancer therapy. It provides a history of platinum complexes starting with cisplatin in 1844. Key platinum complexes discussed are cisplatin, carboplatin, and oxaliplatin. The document outlines advantages such as charge variations and apoptosis induction, and disadvantages like kidney damage and neurotoxicity. It also discusses future updates to complexes and market availability of platinum drugs. In conclusion, cisplatin can target cancer cells without toxic side effects, and modifying complexes may lead to less ototoxicity while maintaining anti-cancer activity.

2. CONTENT
• History
• Platinum complexes
• Cancer therapy
• Advantages
• Disadvantages
• Future updates
• Market availability
• Conclusions
• References

3. HISTORY
(cis platin)
• 1844 it was first created by Italian chemist Michele
Peyrone
• Barnett Rosenberg 1965
(carboplatin)
• 1971 by Bristol-Myers Squibb
(Oxaliplatin)
• 1976 World Health Organization's List of Essential
Medicines

4. PLATINUM COMPLEXES
 Cis-platinum
 Carbo-platinum
 Oxaliplatin
oxaliplatin
corboplatin

5. Cancer therapy

8. Advantages
 Charge variations
 Structure and bonding
 Matel ligind interaction
 Lewis acid properties
 Partially field d-orbital
 Redox activity
 Maximum survival rate
 Apoptosis
 Selective targets

9. Disadvantages
 Kidney damage
 Anemia
 Cough
 Platelet disorders
 Drug resistance
 Neurotoxicity
 Alimentary canal toxicity
 Hair lose

10. Future updates
 Dicycloplatin is a reformulation of the drug
carboplatin by Sopo-Xingda Pharmaceutical and
Bioplatin AG and is currently under clinical trial
evaluation in China.

11. Market availability
Platinum based Cancer Drug Market Segment by Type
covers:
 Cisplatin (Platino)
 Oxaliplatin (Paraplatin)
 Carboplatin (Eloxatin)
 Other

12. Conclusion
 Anti-cancer drug cisplatin and could be able to target cancer cells
without producing the ototoxic side-effects commonly
associated with this chemotherapy compound.
 Addition of steric bulk cis to the coordinating center of a
monofunctional DNA compound is one strategy that has
emerged in the development of new chemotherapy drug
candidates.
 Our results suggest that triamine-ligated complexes with this
form of steric bulk can exhibit nuclear compartmental targeting
and anti-cancer cell effects competitive with their heterocyclic
ligated counterparts.
 Further, although the triamine- and heterocyclic ligated
complexes produce auditory threshold shifts similar to cisplatin,
unlike cisplatin, the monofunctional compounds produce
virtually no effect on auditory hair cell density.

13. References
 1.Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J,
Zolk O. Understanding platinum-induced ototoxicity.
Trends Pharmacol Sci. 2013;34: 458–69. pmid:23769626
 2.Karasawa T, Steyger PS. An integrated view of cisplatin-
induced nephrotoxicity and ototoxicity. Toxicol Lett.
2015;237: 219–27. pmid:26101797
 And Cancer Therapy. Cancer. 2016;122: 1647–58.
pmid:26859792
 4.Lanvers-Kaminsky C, Zehnhoff-Dinnesen AA, Parfitt R,
Ciarimboli G. Drug-induced ototoxicity: Mechanisms,
Pharmacogenetics, and protective strategies. Clin
Pharmacol Ther. 2017;101: 491–500. pmid:28002638