The document discusses lactation and breastfeeding. It begins by defining lactation as the production and secretion of breast milk after delivery. It then describes the structure of the breast and the five stages of lactation: mammogenesis, lactogenesis, galactokinesis, galactopoiesis, and involution. Key hormones involved in each stage are prolactin, estrogen, progesterone, oxytocin, and human placental lactogen. Factors that can affect lactation and medications that increase or decrease milk production are also reviewed. The document concludes with advice to mothers to improve lactation such as frequent breastfeeding and adequate nutrition.
This topic contains detailed description about labour, its definition, date of onset of labour, calculations of date of delivery, causes of onset of labour, physiology of normal labour, and events, clinical course and management of each stages of labour.
This topic contains detailed description about labour, its definition, date of onset of labour, calculations of date of delivery, causes of onset of labour, physiology of normal labour, and events, clinical course and management of each stages of labour.
Series of events that takes place in the genital organ in an effort to expel the viable products of conception out of the womb through the vagina into the outer world is called labour.
there are four stages of labour.
It explains the mechanism of normal labour to medical and para-medical staff.It also puts light on principle movements underlying mechanism of normal labour with pictures.Thank You Like an share it to the maximum.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Series of events that takes place in the genital organ in an effort to expel the viable products of conception out of the womb through the vagina into the outer world is called labour.
there are four stages of labour.
It explains the mechanism of normal labour to medical and para-medical staff.It also puts light on principle movements underlying mechanism of normal labour with pictures.Thank You Like an share it to the maximum.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Puerperium is the period following childbirth during which the body tissues, specially the pelvic organs revert back approximately to the pre-pregnant state both anatomically and physiologically. puerperium begins as soon as the placenta is expelled and lasts for approximately 6 weeks when the uterus becomes regressed almost to the non-pregnant size.
This slide share revolves around the anatomy and physiology of an udder including the mechanism of milk production in cows and the hormones involved with their role in milk synthesis.Hope its helpful.
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
Factor Causing low production and physiology of mamary GlandRcvets
Low production in the mammary glands, particularly in dairy animals, can be influenced by several factors, ranging from genetics to environmental conditions. Understanding these factors is crucial for improving milk yield and overall animal health. Here are some key factors affecting the production and physiology of the mammary glands
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. OBJECTIVES:
Understand the structure of the breast
Describe the stages of lactation
Composition of breast milk
Factors affecting lactation
Medications that affect lactation
2
3. Definition of lactation
Lactation describes the production of breast
milk and its secretion from the mammary
gland after delivery
3
4. Structure of the breast
Parenchyma consists of 10-15 ducts extending from
the nipple to terminate in grape-like clusters known as
alveoli (basic unit) via ductules from lobules
There are 15-20 pyramid shaped lobes separated by
cooper ligament and each contains lobules which are
further separated by fat and connective
tissue(stroma)
Nipple surrounded by area of hyperpigmented skin –
areola
4
6. Physiology of Lactation.
Lactation can be divided into 5 stages:
1. Mammogenesis-Development of breasts to
a functional state
2. Lactogenesis-Synthesis and secretion of milk
from the breast alveoli
3. Galactokinesis-Ejection of milk outside the
breast
4. Galactopoiesis-Maintenance of lactation
5. Involution-regression and atrophy post
lactation
6
8. 1.Mammogenesis
Growth of ducts and lobuloalveolar systems
This starts from birth to puberty and continues in
pregnancy
Ductal sprouting predominates in 1st trimester and
lobular sprouting occurs more in 2nd trimester
hence the breast will contain more glandular
epithelial cells than stroma
Just before and during parturition there is a new
wave of mitotic activity causing growth growth and
maturation
8
9. Hormonal influence during
mammogenesis
Prepubertal growth-
depends on estrogen and progesterone.
Secretion of prolactin and somatotropin by the
pituatory gland results in mammary growth.
Adrenocorticotrophic hormone(ACTH) and thyroid
stimulating hormone(TSH) acting on the adrenal
gland and thyroid gland also play a minor role in
growth of the mammary gland
9
10. Pubertal growth-
When the hypophyseal-ovarian –uterine cycle is
established, there is extensive branching of the duct
system and parenchymal proliferation and canalization
of the lobuloalveolar units controlled by estrogen and
progesterone
10
Hormonal influence during
mammogenesis…
11. 11
During pregnancy
In early pregnancy a marked increase in ductular
sprouting, branching and lobular formation is evoked
by luteal and placental hormones.
Progesterone:causes increased growth of alveoli size
and lobes,
Estrogen:Stimulates milk duct system to grow and
differentiate, deposition of fat.
Prolactin:contributes to increased growth and
differentiation of the alveoli and ductal structures
12. Types of lobules
Type 1- (virginal lobule) when an average of 11 alveolar
buds/ductules cluster around a terminal duct, this is
apparent within 1 to 2 years after onset ofmenses
Type 2 - changing levels of estrogen and progesteron
during menstrual cycle stimulates type 1 lobules to
sprout new alveolar buds and evolve to mature
structures, type 2-47 lobules
Type 3- in pregnancy, 80 lobules
Type 4-attained in late pregnancy with breast milk
12
14. 2. LACTOGENESIS(stage 1)
Stage 1: occurs in mid pregnancy
There is initiation of milk synthesis,
alveoli differentiates into secretory cells and prolactin
stimulates mammary secretory cells to produce milk.
insulin and serum growth factor induced cell
division of stem cells of the gland and presence of
cortisol for formation of alveoli is required for
induction of milk synthesis .
Further differentiation is inhibited by high levels of
progesterone from the placenta and loss of
progesterone receptors in the lactating breast
14
15. Prolactin:
exerts its effects through receptors for initiation of milk
secretion located on the alveolar surfaces.
stabilizes and promotes transcription of mRNA and
stimulates synthesis of lactoalbumin, which is a
regulatory protein of the lactose synthetase enzyme system
Increases lipoprotein activity in the mammary gland
In conjunction with estrogen and progetserone it attracts
and retain Ig-A immunoblasts
estrogen enhances prolactin production by 10-20 fold. This
is regulated by human placental lactogen which has an
inhibitory effect
Its inhibited by prolactin inhibiting factor under control
of catecholamines in the hypothalamus.
15
16. LACTOGENESIS-stage 2
Stage 2: from late pregnancy to day 8.
This is triggered by rapid drop in progesterone
levels after placental delivery
requires the presence of elevated levels of prolactin
and cortisol , insulin, growth hormone and
parathyroid hormone to facilitate mobilization of
nutrients and minerals
there is a switch from endocrine to autocrine
control
16
17. 2. Lactogenesis. Pathways for milk secretion
by the mammary epithelial cell
I - Exocytosis : milk protein and lactose are
transported in Golgi-derived secretory
vesicles, with water and electrolytes in to the
alveolar lumen
II – Reverse Pinocytosis: lipid formed in
smooth ER forms droplets and covered by
phospholipid membrane transported as milk-fat
globule
III – Apical transport: Direct movement of
monovalent ions, water, and glucose across
the apical membrane of the cell.
17
18. Lactogenesis……
IV – Transcytosis. sodium, potassium,
chlorides, some monosaccharides, and
water
V - The paracellular pathway for some
interstitial fluid components and
leukocytes to pass by diapedesis through
the tight junctions.
18
19. Pathways for milk secretion by the
mammary epithelial cell
I. Exocytosis
II. Reverse
pinocytosis
III.Apical transport
IV.Transcytosis
V. Paracellular
pathways
19
21. galactokinesis
• Depends on the suckling mechanism of the
baby and the contractile action which will
express milk from the alveoli into the ducts.
• This contraction is brought about by the
action of Oxytocin
• Milk let down reflex/milk ejection reflex
• Inhibited by psychic condition /pain /breast
engorgement
21
22. oxytocin:
Released from posterior lobe of the pituatory gland
during nipple stimulation or sensory stimulation(
visual, tactile , olfactory or auditary)
Causes ejection of milk from the alveoli gland by
contraction of the myoepithelial cells into ductules
and ducts
22
23. During suckling, a conditioned reflex is set up:
Ascending impulses from the nipple and areola
thoracic sensory (4, 5 and 6) afferent neural arc
paraventricular and supra optic nuclei of the hypothalamus
Oxytocin from the posterior pituitary produces contraction of
the myoepithelial cells of the alveoli and the ducts containing
milk. ("milk ejection" or "milk let down" reflex)
Milk is forced down into the ampulla of lactiferous ducts,
wherefrom it can be expressed by the mother or sucked by
The baby. This occurs between 30sec. to 60sec.
23
25. Galactopoiesis.
Prolactin is the hormone for maintenance of
lactation
And suckling is essential for maintenance of
milk secretion
Periodic breast feeding relieves pressure in
the ducts and promotes more secretion
Controlled by autocrine system(supply-demand)
25
26. 5. Involution
Apoptotic cell death and tissue remodelling
post lactation
Requires a combination of lactogenic
hormone deprivation and local signals to
undergo regression and atrophy
26
27. Variations in composition :
Colostrum(1-5 days) – is reacher in proteins ,minerals,
immunoglobulins , anti inflammatory factors(PGE1 and
PGE2, cytokines), phagocytes and lymphocytes.
Mature milk(>30 days)-larger quantity than colostrum,
Foremilk –thin, proteins, lactose, water and other
nutrients.
Hindmilk –more fat therefore whiter, provides much of
the energy of a feed.
Other components include human growth factors, cortisol,
insulin, thyroxine and prolactin
27
29. FACTORS AFFECTING LACTATION
Maternal problems:
stress(post c/s,stressful vaginal delivery or other psychosocial
stresses) opiates and beta-endorphins are released that block
the stimulus-secretion coupling thus reducing oxytocin release
polycystic ovarian syndrome,
theca lutein cysts,
obesity,
labour analgesia,
dm type 1,
placental retention-increased circulating progesterone
Alcohol dependence
12/7/2014 6:49 PM 29
30. FACTORS AFFECTING LACTATION..
Infrequent suckling/failure to empty breast
causes Elevated intrammary pressure also disrupts
connections between cells and their attachment to
the basement membrane disrupting synthesis and
secretion of milk components.
Premature infants-prolactin may not be
sufficient
30
31. MEDICATIONS AND LACTATION
Medications that increase lactation-
metoclopramide
domperidone
phenothiazine neuroleptics -chlorpromazine
risperine
Hypoglycemics
H2 antagonists-cimetidine
Antihypertensives-methyl dopa, b blockers
31
33. Advise to the mother to improve
lactation
Good health;
Early and sufficient
treatment of illnesses;
Proper balance between
rest and exercise;
Freedom from worry
Care of the breast
/nipples during
pregnancy
Post natally frequent
breast feeding
Avoid breast
engorgement
Plenty of fluids
Adequate nutrition.
33
36. References
E-medicine – Human milk and lactation.
Breastfeeding and human lactation-Jones and Bartlett
Series.
Breast feeding, guide for medical proffesion by Ruth
Lawrence.