The presentation discusses physical methods of drug degradation, which involve changes to a drug's physical properties rather than its chemical structure. There are two main types of drug degradation: physical and chemical. Physical degradation can occur through processes like loss or absorption of water, polymorphic changes, crystal growth, and color changes. Examples are provided like iodine losing volatile compounds through vaporization or glycerol absorbing water from the atmosphere.

2. PRESENTATION ON
Physical Method of Drug Degradation

3. DEGRADATION
The change of a
chemical compound
into a less complex
compound.

4. PHARMACEUTICAL DEGRADATION
Pharmaceutical degradation is a type of organic reaction in which a compound is converted into a simple
compound

5. TYPE OF DRUG DEGRADATION
Drug degradation are two type:
1.Physical drug degradation
2.Chemical drug degradation

6. PHYSICAL DRUG DEGRADATION
It is the degradation which result into the change of physical nature of drug. Or physical degradation
involves change to materials resulting from ambient conditions like sunlight, heat, humidity

7. TYPES: TYPES OF PHYSICAL DEGRADATION ARE AS UNDER
Many kind of cause are responsible for physical drug degradation
 Loss of water
 Absorption of water
 Polymorphic change
 Color change
 Crystal growth
 Loss of volatile compound

8. LOSS OF VOLATILE COMPOUND
Many drug and excipient may be lost from pharmaceutical product at ambient temperature through
vaporization. They escape from the formulations rendering them degraded
Example:
Iodine , Menthol , Corpus , Chloroform

9. LOSS OF WATER
Loss of water may decrease the product stability that’s why product loss its weight. Product such as
emulsion exhibit cracking.
Example:
Water loss from oil

10. ABSORPTION OF WATER
Hygroscopic drug absorb the water from atmosphere causing the physical degradation
Example:
Glycerol

11. CRYSTAL GROWTH
Drug when lose water, become saturated and crystal growth occurs, molecule in crystal are not static, they
can grow in size move when there is a medium to travel.
Example:
Carbamazepine tablets

12. COLOR CHANGE
Color change indicates some kind of chemical decomposition of active ingredient
Example:
aspirin tablets, phenolphthalein