Sites of the highest risk are the duodenum, for adenocarcinomas, and the ileum, for carcinoids and lymphomas.
In industrialized countries, small bowel cancers are predominantly adenocarcinomas;
In developing countries, lymphomas are much more common.
The incidence of small bowel cancer rises with age and has generally been higher among males than among females.
The risk factors for small bowel cancer include
Dietary factor
Cigarette smoking,
Alcohol intake,
Medical conditions -Crohn's disease, familial adenomatous polyposis, cholecystectomy, peptic ulcer disease, and cystic fibrosis.
The protective factors may include rapid cell turnover, a general absence of bacteria, an alkaline environment, and low levels of activating enzymes of precarcinogens.
Sites of the highest risk are the duodenum, for adenocarcinomas, and the ileum, for carcinoids and lymphomas.
In industrialized countries, small bowel cancers are predominantly adenocarcinomas;
In developing countries, lymphomas are much more common.
The incidence of small bowel cancer rises with age and has generally been higher among males than among females.
The risk factors for small bowel cancer include
Dietary factor
Cigarette smoking,
Alcohol intake,
Medical conditions -Crohn's disease, familial adenomatous polyposis, cholecystectomy, peptic ulcer disease, and cystic fibrosis.
The protective factors may include rapid cell turnover, a general absence of bacteria, an alkaline environment, and low levels of activating enzymes of precarcinogens.
Right iliac fossa mass is a common clinical presentation and has a range of differentials that need to be excluded.
In this presentation will discuss RIF masses in briefly.
contact me / dr.3shaq@gmail.com
Right iliac fossa mass is a common clinical presentation and has a range of differentials that need to be excluded.
In this presentation will discuss RIF masses in briefly.
contact me / dr.3shaq@gmail.com
Appendicular Mucinous Neoplasms are rare pathologies of the appendix that can lead to rupture and the development of Pseudomyxoma Peritonei. In this lecture we present the difference between 4 cases of appendicular Mucinous Neoplasm in which the proper management and early surgical intervention prevented the development of Pseudomyxoma Peritonei
RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS VADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS VRADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS
RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS
RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS VADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS VRADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS
RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS RADIOKOGY PRESENTATION OF GIT AND GUT SYSTEM FOR PGRS
Ovarian tumors are abnormal growths on the ovaries, the female reproductive organs that produce eggs. Ovarian tumors can be noncancerous (benign) or cancerous (malignant). Many things can make you more likely to develop an ovarian tumor.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Surgical Anatomy of the Peritoneum
The peritoneum is the largest serous membrane in the
body, with a surface area of about 22,000 cm2.
It can be divided into parietal and visceral portions:
The parietal layer lines the abdominal and pelvic
cavities and the abdominal surface of the diaphragm.
The visceral layer covers the abdominal and pelvic
viscera and includes the mesenteries.
3. Surgical Anatomy of the Peritoneum
The parietal peritoneum is only loosely connected with
the body wall, separated from it by an adipose layer, the
tela subserosa;
Whereas the visceral peritoneum is usually tightly
attached to the organs it covers.
The peritoneum consists of a fibrous layer (the tunica
subserosa) and a surface layer of mesothelium (the
tunica serosa).
4. Surgical Anatomy of the Peritoneum
The peritoneal cavity is a potential space.
It normally contains only a thin film of fluid which
lubricates the surfaces, allowing frictionless movements
of the gastrointestinal tract.
Under the effects of certain pathologic conditions, great
quantities of fluid can occupy the peritoneal cavity.
5. Surgical Anatomy of the Peritoneum
Peritoneum does not line the entirety of the abdominopelvic cavity.
It is lifted from the body wall, especially posteriorly, by organs
located against the wall during embryologic development.
This chain of events causes the formation of a retroperitoneal space
between the peritoneum and the body wall, with organs situated
within the space.
An organ that is covered only in part by the peritoneum is referred
to as a retroperitoneal organ. An organ that is covered by
peritoneum essentially everywhere except for the site of entrance of
vessels is referred to as an intraperitoneal organ.
6. NEOPLASMS OF THE PERITONEUM
Primary malignancies Secondary malignancies
Rare
Include malignant mesothelioma
and sarcomas
Most of the cases
Due to transperitoneal metastases
from a carcinoma of the GIT
(especially the stomach, colon, and
pancreas), the genitourinary tract
(most commonly, ovarian), or more
rarely, an extra-abdominal site (e.g.,
breast).
When metastatic cancer deposits
diffusely coat the visceral and
parietal peritoneum, these
peritoneal metastases are referred to
as carcinomatosis.
Malignant neoplasms of the peritoneum may be classified as primary or
secondary depending on the site of origin of the tumor.
7. NEOPLASMS OF THE PERITONEUM
Primary peritoneal tumors Classification
Defined as tumors with
primary manifestation in the
peritoneum in the absence of
a visceral site of origin.
They arise from mesothelial
cells, submesothelial
mesenchymal cells, and
uncommitted stem cells
Mesothelial tumors
Peritoneal malignant mesothelioma
Well-differentiated papillary mesothelioma
Multicystic mesothelioma
Adenomatoid tumor
Epithelial tumors
Primary peritoneal serous carcinoma
Primary peritoneal serous borderline tumor
Smooth muscle tumor
Leiomyomatosis peritonealis disseminata
Tumors of uncertain origin
Desmoplastic small round cell tumor
Solitary fibrous tumor
8. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
The most common primary malignant peritoneal
neoplasm.
The median survival rate for patients with this rare
tumor is 4 to 12 months.
At least in part, this poor prognosis is due to the very
advanced stage of the disease at the time of
presentation.
9. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
Classifying malignant mesotheliomas into diffuse and
localized subtypes has prognostic significance.
Diffuse malignant mesotheliomas are highly aggressive and,
with a few exceptions such as well-differentiated papillary
mesotheliomas that occur in women, are incurable.
In contrast, patients with localized malignant
mesotheliomas usually have a good prognosis following
complete surgical excision of the lesions
10. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
Clinical picture:
.
Fifty to 70 percent of patients have a history of asbestos exposure.
Other etiologic factors implicated in the development of malignant
mesothelioma include exposure to erionite (a mineral fiber found in
Turkey), therapeutic irradiation, exposure to simian virus 40, and, in rare
cases, chronic pleural or peritoneal irritation. Occasionally,
malignant mesothelioma is seen in young patients with no exposure
history.
The majority of all malignant mesotheliomas occur in men, with a median
age at presentation of 60 years.
In women, peritoneal malignant mesothelioma occurs in a slightly younger
age group (mean age, 50 years) and, in general, has a better prognosis.
11. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
Clinical picture:
.
Abdominal pain, ascites, and weight loss
Gastrointestinal complications such as bowel obstruction may
occur with advanced disease.
Patients with localized peritoneal malignant mesotheliomas
may complain of localized abdominal pain or a palpable
abdominal or pelvic mass.
The omentum may be diffusely involved with tumor and
present as an epigastric mass.
12. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
CT demonstrates mesenteric thickening, peritoneal
studding, hemorrhage within the tumor, and ascites.
At laparotomy, the ascitic fluid ranges from a serous
transudate to a viscous fluid rich in mucopolysaccharides.
The neoplasm tends to involve all peritoneal surfaces,
producing large masses of tumor.
In contrast to pseudomyxoma peritonei, local invasion of
intra-abdominal organs, such as the liver, intestine, bladder,
and abdominal wall, is common.
14. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
It may be difficult to differentiate a malignant peritoneal
mesothelioma from diffuse peritoneal carcinomatosis arising from an
intra-abdominal organ such as the stomach, pancreas, colon, or ovary.
Careful intraoperative examination of the pattern of spread and
biopsy with histologic examination allow this distinction to be made.
Furthermore, malignant peritoneal mesothelioma generally
remains confined to the abdomen, whereas advanced-stage intra-
abdominal carcinomas frequently have pulmonary and other extra-
abdominal metastases.
Extension of the mesothelioma into one or both pleural cavities is
more likely than hematogenous dissemination.
15. NEOPLASMS OF THE PERITONEUM
Malignant Peritoneal Mesothelioma
Complete surgical resection is technically challenging
and requires peritonectomy with resection of involved
organs.
Combined-modality approaches using surgery and
chemotherapy hint of a brighter future.
16. NEOPLASMS OF THE PERITONEUM
Well-differentiated Papillary Mesothelioma
It occurs predominantly in women and most often
arises from the peritoneal surfaces of the pelvis, but it
has been reported to occur in the pleura, pericardium,
and tunica vaginalis.
17. NEOPLASMS OF THE PERITONEUM
Multicystic Mesothelioma
Multicystic mesothelioma is an unusual, multilocular
cystic tumor that most commonly arises from the pelvic
surfaces of the peritoneum.
It has benign or indolent biologic behavior in the
majority of patients.
Some authors consider it to be a mesothelial neoplasm
because it may recur locally and in rare cases may show
malignant transformation . Other authors believe that
it is a non-neoplastic, reactive mesothelial proliferation
18. NEOPLASMS OF THE PERITONEUM
Primary Peritoneal Serous Carcinoma
Primary peritoneal serous carcinoma is an epithelial tumor
that arises from the peritoneum.
At histopathologic analysis, it resembles a malignant
ovarian surface epithelial stromal tumor.
Primary peritoneal serous carcinoma is thought to arise
from extraovarian mesothelium that has mullerian potential,
making it a unique clinicopathologic entity distinct from its
ovarian counterpart.
19. NEOPLASMS OF THE PERITONEUM
Primary Peritoneal Serous Carcinoma
Patients typically present with complaints of abdominal
distention, pain, and fullness; increasing abdominal girth;
and gastrointestinal symptoms such as nausea and
vomiting.
Clinically, the majority of patients have ascites and
elevation of serum levels of cancer antigen CA- 125.
20. NEOPLASMS OF THE PERITONEUM
Secondary Tumors and Tumorlike Lesions of the Peritoneum
Tumors and tumor-like lesions that secondarily involve the
mesothelial or submesothelial layers of the peritoneum are a
diverse group of disorders that range in biologic behavior from
benign to highly malignant.
The anatomy of peritoneal ligaments and mesenteries and the
normal circulation of peritoneal fluid dictate location and
distribution of these diseases within the peritoneal cavity.
21. NEOPLASMS OF THE PERITONEUM
Classification of Secondary Tumors and Tumorlike Lesions of the Peritoneum
I. Metastatic neoplasms
Carcinomatosis
Pseudomyxoma peritonei
Lymphomatosis
Sarcomatosis
II. Infectious and inflammatory lesions
Granulomatous peritonitis
Inflammatory pseudotumor
Sclerosing encapsulating peritonitis
III. Miscellaneous tumors and tumorl-ike lesions
Endometriosis
Gliomatosis peritonei
Osseous metaplasia
Cartilagenous metaplasia
Melanosis
Splenosis
22. NEOPLASMS OF THE PERITONEUM
Peritoneal carcinomatosis:
This is a common terminal event in many cases of
carcinoma of the stomach, colon, ovary or other
abdominal organs and also of the breast and bronchus.
The peritoneum, both parietal and visceral, is studded
with secondary growths and the peritoneal cavity
becomes filled with clear, straw-colored or blood-stained
ascitic fluid.
23. NEOPLASMS OF THE PERITONEUM
Peritoneal carcinomatosis:
The main forms of peritoneal metastases are:
Discrete nodules – by far the most common variety;
Plaques varying in size and colour;
Diffuse adhesions – this form occurs at a late stage of
the disease and gives rise, sometimes, to a ‘frozen
pelvis’.
24. NEOPLASMS OF THE PERITONEUM
Peritoneal carcinomatosis:
Differential diagnosis
Early discrete tubercles common in tuberculous peritonitis
are greyish and translucent and closely resemble the discrete
nodules of peritoneal carcinomatosis.
Fat necrosis can usually be distinguished from a
carcinomatous nodule by its opacity.
Peritoneal hydatids can also simulate malignant disease
after rupture of a hydatid cyst, with seeding of daughter cysts.
25. NEOPLASMS OF THE PERITONEUM
Peritoneal carcinomatosis:
Treatment
Ascites caused by carcinomatosis of the peritoneum
may respond to systemic or intraperitoneal
chemotherapy or to endocrine therapy in the case of
hormone receptor-positive tumours.
26. NEOPLASMS OF THE PERITONEUM
Pseudomyxoma Peritonei
A rare malignant process of the peritoneal cavity that
characteristically arises from a ruptured ovarian or
appendiceal adenocarcinoma.
The peritoneum becomes coated with a mucus-secreting
tumor that fills the peritoneal cavity with tenacious,
semisolid mucus and large loculated cystic masses.
27. NEOPLASMS OF THE PERITONEUM
Pseudomyxoma Peritonei
Pseudomyxoma peritonei is most prevalent in
women between 50 and 70 years of age.
It is often asymptomatic until very late in its course,
and patients often experience a global deterioration
in their health long before the diagnosis of
pseudomyxoma peritonei is made.
28. NEOPLASMS OF THE PERITONEUM
Pseudomyxoma Peritonei
Symptoms include abdominal pain and distention as
well as numerous nonspecific symptoms.
Physical examination reveals a distended abdomen
with non-shifting dullness.
On occasion, a palpable abdominal mass may be
present, especially in tumors of appendiceal origin.
30. NEOPLASMS OF THE PERITONEUM
Pseudomyxoma Peritonei
CT may demonstrate posterior
displacement of the small
intestine, loculated collections of
fluid-density material, and
scalloping of intra-abdominal
organs due to extrinsic
compression by adjacent
peritoneal implants.
31. NEOPLASMS OF THE PERITONEUM
Pseudomyxoma Peritonei
The management of these patients includes drainage of
the mucus and intraperitoneal fluid and cytoreduction
of the primary and secondary tumor implants, including
peritonectomy and omentectomy.
For those tumors originating from an appendiceal
adenocarcinoma, a right colectomy is also performed.
Ovarian malignancies are treated with total abdominal
hysterectomy and bilateral salpingo-oophorectomy as
well as cytoreduction.
32. NEOPLASMS OF THE PERITONEUM
Pseudomyxoma Peritonei
In the setting of an indeterminate site of origin, a
right colectomy and resection of the omentum along
with bilateral oophorectomy and cytoreduction
surgery are performed.
Postoperative adjuvant therapy has included the use
of intraperitoneal 5-fluorouracil, mitomycin C, and
oxiliplatin, as well as intraperitoneal mucolytics,
33. Tumors of the omentum
Omental cysts
Pathology
Most cysts of the omentum are of lymphatic
mesothelioma origin.
All are rare.
34. Tumors of the omentum
Omental cysts
Cystic lymphangioma
In childhood, omental cysts are usually caused by developmental abnormalities of
the lymphoid tissue, such as obstruction of the lymphatic channels or by growth
of congenitally misplaced lymphatic tissue.
They are variously called chylous cysts, cystic hygromas, or cystic lymphangiomas,
and are benign.
They vary greatly in size, and can be unilocular or multilocular.
Histologically each cyst has an endothelial lining similar to cystic hygroma of the
neck, and contains many foamy macrophages, giving the fluid a milky
appearance.
35. Tumors of the omentum
Omental cysts
Cystic mesothelioma
Omental cysts of mesothelial origin occur almost exclusively in adult life, usually
in women under the age of 50 years.
Although they are benign, local recurrence often occurs after surgical excision.
They appear as large multicystic masses similar to cystic lymphangiomas, but
histologically they are lined by flattened or cuboidal mesothelial cells and the cyst
fluid is clear, containing mucopolysaccharides.
Although the aetiology is unknown there is no association with asbestos exposure.
36. Tumors of the omentum
Omental cysts
Dermoid cysts
As with dermoid cysts elsewhere in the body, omental dermoid cysts are lined
with squamous epithelium and may contain epithelial structures such as hair and
teeth.
Pseudocysts
Omental pseudocysts are caused by fat necrosis or abdominal trauma with
haematoma formation. They are lined with fibrous tissue and contain blood-
stained fluid.
37. Tumors of the omentum
Omental cysts
Clinical features and treatment
Many omental cysts are small and asymptomatic and may only be discovered
incidentally at laparotomy or autopsy.
Large cysts may present with diffuse abdominal distension or as asmooth, mobile,
palpable mass in the lower midline. Characteristically they are non-tender unless
complicated by torsion of the omentum or intestinal obstruction.
Plain radiographs of the abdomen may demonstrate a soft tissue shadow and
barium studies may show displacement of bowel.
The differential diagnosis includes mesenteric, peritoneal, or retroperitoneal cysts
and tumours but the diagnosis is usually made at laparotomy.
Treatment consists of surgical excision of the cyst.
38. Tumors of the omentum
Solid tumors of the omentum
Pathology
Secondary tumor
The vast majority of omental neoplasms are metastatic carcinomas
arising from ovary, bowel, or pancreas and these are often associated with
abdominal ascites.
The rare, diffuse, malignant mesothelioma of the peritoneum which is
associated with the exposure to fibrous minerals such as asbestos also
consistently involves the omentum.
39. Tumors of the omentum
Solid tumors of the omentum
Pathology
Primary tumor
Primary solid tumors of the omentum are exceptionally rare and may
be benign or malignant.
The majority are of smooth muscle origin.
Malignant potential is difficult to predict from the histology but
approximately one-third are frankly malignant.
Before making a diagnosis of primary smooth muscle tumour of the
omentum, leiomyosarcoma of the uterus or gastrointestinal tract giving
rise to omental metastases must be carefully excluded.
Other rare primary omental tumors include fibroma, fibrosarcoma,
lipoma, and liposarcoma.
Infantile myxoid hamartomas, found in infants under 1 year old, consist
of multiple nodular lesions which show histological resemblance to
myxoid liposarcoma; the clinical course is invariably benign.
40. Tumors of the omentum
Solid tumors of the omentum
Clinical features and treatment
Benign primary tumours of the omentum, when sufficiently large,
present with a palpable abdominal mass or diffuse distension and require
surgical excision.
Malignant primary omental tumours are highly invasive and often present
late with involvement of adjacent organs. Radical surgical excision of both
the omentum and the involved organs may be required, but often
palliative surgery is the only treatment option.
41. Retroperitoneal neoplasms
The retroperitoneum is a large potential space bounded
anteriorly by the posterior peritoneum, posteriorly by
the spine and back muscles, superiorly by the
diaphragm, inferiorly by the levators, and laterally by the
flank muscles at the level of the anterior superior spine
of the iliac crest to the tip of the twelfth rib.
42. Retroperitoneal neoplasms
In this vast potential space, retroperitoneal masses tend
to become very large before producing signs or
symptoms, thus accounting for the poor prognosis for
most malignant tumors arising there.
Although the pancreas, kidneys, ureters, and adrenals
are retroperitoneal structures, neoplasms of these
organs are not generally included in the analysis of
retroperitoneal neoplasms.
43. Retroperitoneal neoplasms
With rare exceptions, retroperitoneal neoplasms are
sarcomas, lymphomas, or benign lesions.
Retroperitoneal sarcomas are rare, representing only about
0.1 to 0.2 per cent of all malignancies overall and only about
10 to 15 per cent of all soft-tissue sarcomas. They form
approximately 40 per cent of all retroperitoneal masses.
44.
45. Retro-peritoneal sarcoma
Sarcomas constitute a heterogeneous group of rare solid
tumors of mesenchymal cell origin with distinct
clinical and pathological features.
They are divided into two broad categories:
Soft tissue sarcomas
Bone sarcomas
46. Retro-peritoneal sarcoma
Sarcomas collectively account for approximately 1% of all
adult malignancies and 15% of pediatric malignancies.
The true incidence of STS is underestimated, especially
because a large proportion of patients with
gastrointestinal stromal tumors (GISTs) may not have
been included in tumor registry database before 2001.
47. Retro-peritoneal sarcoma
The most common subtypes of STS are undifferentiated
pleomorphic sarcoma, GISTs, liposarcoma,
leomyosarcoma, synovial sarcoma and malignant
peripheral nerve sheath tumors.
The anatomic site of the primary disease represents an
important variable that influences treatment and
outcome. Extremities (43%), trunk (10%),
visceral(19%), retroperitoneal (15%) and head and
neck (9%) are the most common primary sites.
48. Retro-peritoneal sarcoma
Approximately 80 percent of the neoplasms that arise
within the retroperitoneal space are malignant.
Furthermore, the majority of patients who present with
a primary retroperitoneal, extravisceral, unifocal soft
tissue mass will be found to have a sarcoma.
49. Retro-peritoneal sarcoma
In adults, the most common histologic types of
retroperitoneal STS are liposarcomas and
leiomyosarcomas, followed by pleomorphic
undifferentiated sarcoma/malignant fibrous
histiocytoma.
A variety of other histologic types may be observed, but
they are much less common in the retroperitoneum
than in other primary sites.
50. Retro-peritoneal sarcoma
Among children, the most common histologic types of
retroperitoneal STS are extraskeletal Ewing
sarcoma/primitive neuroectodermal tumors [PNET],
alveolar rhabdomyosarcoma, and fibrosarcoma
Approximately one-half of all retroperitoneal sarcomas
are high-grade tumors, although this varies according
to histology. The majority of retroperitoneal
liposarcomas are low- to intermediate-grade lesions.
51. Retro-peritoneal sarcoma
STS most commonly metastasize to the lungs ; tumors
arising in the abdominal cavity more commonly
metastasize to the liver and peritoneum.
Management of STS in adult patients is addressed from
the perspective of the following disease subtypes:
STS of extremity, superficial/ trunk, or head and neck.
Retroperitoneal or intra-abdominal STS.
GISTs
Desmoid tumors
Rabdomyosarcoma.
52. Retro-peritoneal sarcoma
Genetic cancer syndromes with predisposition to
STS:
Li-Faumeni syndrome (TP53 germline mutation).
Associated with RMS, fibrosarcoma and
undifferentiated pleomorphic sarcoma.
Gardner syndrome (desmoid tumors)
Carney-Stratakis syndrome (GISTs and
paragangliomas)
53. Retro-peritoneal sarcoma
WORKUP:
Prior to the initiation of therapy, all patients should be
evaluated and managed by multidisciplinary team.
History and physical examination.
Chest, abdomen and pelvis CT with contrast
MRI may add some data
54. Retro-peritoneal sarcoma
WORKUP:
Criteria for unresectability — Radiographic findings that indicate
unresectability include:
Extensive vascular involvement (aorta, vena cava and/or iliac vessels), although
involvement of the vena cava and iliac veins is a relative rather than absolute
contraindication, as these vessels can often be replaced with interposition
grafts
Peritoneal implants
Distant metastases
Involvement of the root of the mesentery (specifically, the superior mesenteric
vessels)
Spinal cord involvement
55. Retro-peritoneal sarcoma
WORKUP:
Biopsy:
Pre-resection biopsy is not necessarily required ; consider
biopsy if there is suspicion of malignancy other than
sarcoma.
Image-guided (U/s or CT) core needle biopsy is preferred
Patients with personal/family history suggestive of Li-
Fraumeni syndrome should be considered for further
genetic assessment.
56. Retro-peritoneal sarcoma
Staging:
Retroperitoneal sarcomas are staged using the same TNM system
as is used for extremity STS. However, the ability of the TNM
staging system to discriminate outcomes is limited.
Several studies have found no prognostic role for tumor size in
retroperitoneal sarcoma.
Given the importance of histologic grade and resection margins
in the prognosis of retroperitoneal STS, an alternative staging
system has been proposed that incorporates these features as
well as the presence or absence of metastatic disease. However,
this staging system is not in widespread use.
57. Retro-peritoneal sarcoma
Staging:
The Dutch/Memorial Sloan-Kettering cancer center
classification system for retroperitoneal soft
tissue sarcomas
Classification Definition
Stage I Low-grade, complete resection, no metastases
Stage II High-grade, complete resection, no metastases
Stage III Any grade, incomplete resection, no metastases
Stage IV Any grade, any resection, distant metastases
58. Retro-peritoneal sarcoma
TREATMENT
Surgical resection:
Surgical resection has traditionally been the only potentially
curative treatment for a localized retroperitoneal STS.
The ability to perform a complete surgical resection at the
time of initial presentation is the most important
prognostic factor for survival.
The usual reasons for unresectability are extensive vascular
involvement or the presence of multiple peritoneal
implants.
59. Retro-peritoneal sarcoma
TREATMENT
Surgical resection:
The primary oncologic goal is complete resection with
microscopically negative margins (R0 resection).
However, the large size of most retroperitoneal tumors,
coupled with the inability to obtain wide margins due to
anatomic constraints make this goal difficult to achieve.
In clinical practice, many resections are grossly complete but
with microscopically positive margins (R1 resection)
60. Retro-peritoneal sarcoma
TREATMENT
Surgical resection:
Resection of adjacent organs such as the small bowel, colon
or kidney is often required to achieve a complete resection
and bowel preparation and evaluation of kidney function
should be performed prior to exploration.
Liberal en-bloc resection of adjacent viscera may allow a
subset of patients to achieve wide, macroscopically
negative surgical margins who might otherwise have been
considered unresectable.
62. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
In contrast to extremity STS in which the most common site
of first recurrence is a distant site, the primary pattern of
treatment failure after resection of a retroperitoneal STS is
local.
Adjunctive radiation therapy (RT) can be administered
following resection (adjuvant RT). However, increasingly,
preoperative RT is being chosen for large high-grade or
intermediate-grade STS.
63. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
Adjuvant RT
It is often difficult to deliver postoperative radiation therapy
because the bowel and other organs fall into the resection cavity;
however, newer techniques such as intensity-modulated RT
(IMRT) and proton beam irradiation make it more feasible but
the therapeutic ratio is probably still more favorable with
preoperative RT.
Nevertheless, it is reasonable to consider the use of postoperative
RT if it can be delivered safely.
64. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
Adjuvant RT
In the postoperative setting, radiation doses to the tumor bed are often
limited by the large field size and the proximity and tolerance of
surrounding radiosensitive normal structures, such as the liver and
bowel.
In fact, many multidisciplinary sarcoma groups do not routinely offer
postoperative RT to patients with resected retroperitoneal sarcomas
because of significant concerns about the narrow therapeutic ratio.
65. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
Preoperative RT
The delivery of RT prior to surgery, with or without
intraoperative RT (IORT) at the time of resection, may
permit the safe delivery of higher RT doses than are
possible in the postoperative setting
66. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
Preoperative RT
There are several theoretical advantages for preoperative as compared to
postoperative RT for retroperitoneal STS :
The main advantage of preoperative RT is that the gross tumor volume
can be precisely defined for radiation treatment planning, allowing
accurate targeting of the radiation volume around the tumor.
The tumor itself can act to displace small bowel from the high-dose
radiation field, resulting in safer and less toxic treatment.
67. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
Preoperative RT
There are several theoretical advantages for preoperative as
compared to postoperative RT for retroperitoneal STS :
Higher RT doses can be delivered to the actual tumor field, since
bowel adhesions to tumor are less likely compared to the
postoperative setting.
The risk of intraperitoneal tumor dissemination at the time of
the operation may be reduced by preoperative RT.
68. Retro-peritoneal sarcoma
TREATMENT
Adjunctive RT:
Preoperative RT
There are several theoretical advantages for preoperative as compared to
postoperative RT for retroperitoneal STS :
Radiation is considered to be biologically more effective in the
preoperative setting.
It is possible that an initially unresectable tumor may be converted to
one that is potentially resectable for cure.
These advantages may result in an improvement in the therapeutic
ratio when RT is administered preoperatively.
69. Retro-peritoneal sarcoma
Outcomes and prognostic factors
Retroperitoneal sarcomas have a substantially less satisfactory
outcome than soft tissue sarcomas (STS) at other sites, such as
the extremities or trunk.
Several factors contribute to poor outcome and a high rate of
recurrence:
Retroperitoneal STS are often large at diagnosis and anatomically
situated such that wide resection is often not achievable.
Even with complete resection, retroperitoneal liposarcomas tend
to do worse than extremity liposarcomas, independent of tumor
size, grade, or surgical margin.
70. Retro-peritoneal sarcoma
Outcomes and prognostic factors
Retroperitoneal sarcomas have a substantially less satisfactory
outcome than soft tissue sarcomas (STS) at other sites, such as
the extremities or trunk.
Several factors contribute to poor outcome and a high rate of
recurrence:
The surrounding normal tissues (liver, kidney, gastrointestinal
tract, spinal cord) have relatively low tolerance for radiation
therapy (RT). As a result, radiation dose levels must be kept
below those typically employed for extremity sarcomas.
71. Retro-peritoneal sarcoma
Outcomes and prognostic factors
In contrast to extremity sarcomas, 90 percent of first recurrences
are local. Eventually, distant metastases develop in 20 to 30
percent . The main sites of distant metastases are liver and lungs.
Local recurrence rates are higher with high-grade (poorly
differentiated) tumors, liposarcoma histology, and in patients
with positive resection margins.
72. Retro-peritoneal sarcoma
Outcomes and prognostic factors
In contrast to extremity sarcomas, 90 percent of first recurrences
are local. Eventually, distant metastases develop in 20 to 30
percent . The main sites of distant metastases are liver and lungs.
Local recurrence rates are higher with high-grade (poorly
differentiated) tumors, liposarcoma histology, and in patients
with positive resection margins.