This document analyzes the performance of a 4x4 Vertical Bell Labs Layered Space-Time (V-Blast) multiple-input multiple-output multi-carrier code division multiple access (MIMO MC-CDMA) wireless communication system using different digital modulation schemes. The system uses minimum mean square error (MMSE) signal detection and 1/2-rated convolution and cyclic redundancy check (CRC) channel encoding. Simulation results show that binary phase-shift keying (BPSK) modulation outperforms differential phase-shift keying (DPSK), quadrature phase-shift keying (QPSK), and 16-quadrature amplitude modulation (QAM), achieving the lowest bit error rate (BER) especially at