The document discusses three pathogenic gram-positive bacilli: Corynebacterium, Listeria monocytogenes, and Erysipelothrix rhusopathiae. Corynebacterium includes the species C. diphtheriae, which causes respiratory diphtheria, and C. urealyticum, which can cause urinary tract infections. L. monocytogenes is an intracellular pathogen that can cause listeriosis, especially in immunocompromised individuals. E. rhusopathiae causes erysipeloid skin lesions in those exposed through meat/fish handling and can potentially spread systemically.
Rickettsia: The rickettssia are a diverse collection of obligate intracellular Gram-negative bacteria found in ticks, lice, fleas, mites, chiggers, and mammals.
Spirochetes: Spirochetes are long and slender bacteria, usually only a fraction of a micron in diameter but 5 to 250 microns long.
Rickettsia: The rickettssia are a diverse collection of obligate intracellular Gram-negative bacteria found in ticks, lice, fleas, mites, chiggers, and mammals.
Spirochetes: Spirochetes are long and slender bacteria, usually only a fraction of a micron in diameter but 5 to 250 microns long.
The rickettsiae are a diverse collection of obligately intracellular bacteria. These zoonotic pathogens cause infections that disseminate in the blood to many organs.
The rickettsiae are a diverse collection of obligately intracellular bacteria. These zoonotic pathogens cause infections that disseminate in the blood to many organs.
Aerobic Non-Spore-Forming Gram-Positive BacilliSijo A
Disease: listeriosis.
L. monocytogenes causes a variety of infections in neonates, pregnant women, and immunosuppressed patients.
CNS infections: meningitis, encephalitis, brain abscess, spinal cord infections.
Neonatal:
Early onset: Granulomatosis infantisepticum—in utero infection disseminated systemically that causes stillbirth.
Late onset: Bacterial meningitis.
Food poisoning, bacteremia.
Mode of transmission:
Direct contact: Human gastrointestinal tract, ingestion of contaminated food, such as meat and dairy products.
Endogenous strain: Colonized mothers may pass organism to fetus. Portal of entry is probably from gastrointestinal tract to blood and in some instances from blood to meninges.
Cryptosporidium exhibits a monoxenous lifecycle and affects both humans and animals. Infected domestic animals are reservoirs for susceptible humans. in the lifecycle of the cryptosporidium, Thin-wall oocyst (used for autoinfection) and Thick wall oocyst are (thrown into the environment for infecting another host). Invaginate cell membrane and forming #bi-layered membranous vacuole (parasitophorous vacuolar membrane) creates a conducive environment for the parasite for escaping the host immune system.
Similar to Pathogenic anaerobe gram positive bls 206 (20)
In his public lecture, Christian Timmerer provides insights into the fascinating history of video streaming, starting from its humble beginnings before YouTube to the groundbreaking technologies that now dominate platforms like Netflix and ORF ON. Timmerer also presents provocative contributions of his own that have significantly influenced the industry. He concludes by looking at future challenges and invites the audience to join in a discussion.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Welcome to the first live UiPath Community Day Dubai! Join us for this unique occasion to meet our local and global UiPath Community and leaders. You will get a full view of the MEA region's automation landscape and the AI Powered automation technology capabilities of UiPath. Also, hosted by our local partners Marc Ellis, you will enjoy a half-day packed with industry insights and automation peers networking.
📕 Curious on our agenda? Wait no more!
10:00 Welcome note - UiPath Community in Dubai
Lovely Sinha, UiPath Community Chapter Leader, UiPath MVPx3, Hyper-automation Consultant, First Abu Dhabi Bank
10:20 A UiPath cross-region MEA overview
Ashraf El Zarka, VP and Managing Director MEA, UiPath
10:35: Customer Success Journey
Deepthi Deepak, Head of Intelligent Automation CoE, First Abu Dhabi Bank
11:15 The UiPath approach to GenAI with our three principles: improve accuracy, supercharge productivity, and automate more
Boris Krumrey, Global VP, Automation Innovation, UiPath
12:15 To discover how Marc Ellis leverages tech-driven solutions in recruitment and managed services.
Brendan Lingam, Director of Sales and Business Development, Marc Ellis
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Le nuove frontiere dell'AI nell'RPA con UiPath Autopilot™UiPathCommunity
In questo evento online gratuito, organizzato dalla Community Italiana di UiPath, potrai esplorare le nuove funzionalità di Autopilot, il tool che integra l'Intelligenza Artificiale nei processi di sviluppo e utilizzo delle Automazioni.
📕 Vedremo insieme alcuni esempi dell'utilizzo di Autopilot in diversi tool della Suite UiPath:
Autopilot per Studio Web
Autopilot per Studio
Autopilot per Apps
Clipboard AI
GenAI applicata alla Document Understanding
👨🏫👨💻 Speakers:
Stefano Negro, UiPath MVPx3, RPA Tech Lead @ BSP Consultant
Flavio Martinelli, UiPath MVP 2023, Technical Account Manager @UiPath
Andrei Tasca, RPA Solutions Team Lead @NTT Data
Climate Impact of Software Testing at Nordic Testing DaysKari Kakkonen
My slides at Nordic Testing Days 6.6.2024
Climate impact / sustainability of software testing discussed on the talk. ICT and testing must carry their part of global responsibility to help with the climat warming. We can minimize the carbon footprint but we can also have a carbon handprint, a positive impact on the climate. Quality characteristics can be added with sustainability, and then measured continuously. Test environments can be used less, and in smaller scale and on demand. Test techniques can be used in optimizing or minimizing number of tests. Test automation can be used to speed up testing.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
Generative AI Deep Dive: Advancing from Proof of Concept to ProductionAggregage
Join Maher Hanafi, VP of Engineering at Betterworks, in this new session where he'll share a practical framework to transform Gen AI prototypes into impactful products! He'll delve into the complexities of data collection and management, model selection and optimization, and ensuring security, scalability, and responsible use.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
The Metaverse and AI: how can decision-makers harness the Metaverse for their...Jen Stirrup
The Metaverse is popularized in science fiction, and now it is becoming closer to being a part of our daily lives through the use of social media and shopping companies. How can businesses survive in a world where Artificial Intelligence is becoming the present as well as the future of technology, and how does the Metaverse fit into business strategy when futurist ideas are developing into reality at accelerated rates? How do we do this when our data isn't up to scratch? How can we move towards success with our data so we are set up for the Metaverse when it arrives?
How can you help your company evolve, adapt, and succeed using Artificial Intelligence and the Metaverse to stay ahead of the competition? What are the potential issues, complications, and benefits that these technologies could bring to us and our organizations? In this session, Jen Stirrup will explain how to start thinking about these technologies as an organisation.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Enhancing Performance with Globus and the Science DMZGlobus
ESnet has led the way in helping national facilities—and many other institutions in the research community—configure Science DMZs and troubleshoot network issues to maximize data transfer performance. In this talk we will present a summary of approaches and tips for getting the most out of your network infrastructure using Globus Connect Server.
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Removing Uninteresting Bytes in Software FuzzingAftab Hussain
Imagine a world where software fuzzing, the process of mutating bytes in test seeds to uncover hidden and erroneous program behaviors, becomes faster and more effective. A lot depends on the initial seeds, which can significantly dictate the trajectory of a fuzzing campaign, particularly in terms of how long it takes to uncover interesting behaviour in your code. We introduce DIAR, a technique designed to speedup fuzzing campaigns by pinpointing and eliminating those uninteresting bytes in the seeds. Picture this: instead of wasting valuable resources on meaningless mutations in large, bloated seeds, DIAR removes the unnecessary bytes, streamlining the entire process.
In this work, we equipped AFL, a popular fuzzer, with DIAR and examined two critical Linux libraries -- Libxml's xmllint, a tool for parsing xml documents, and Binutil's readelf, an essential debugging and security analysis command-line tool used to display detailed information about ELF (Executable and Linkable Format). Our preliminary results show that AFL+DIAR does not only discover new paths more quickly but also achieves higher coverage overall. This work thus showcases how starting with lean and optimized seeds can lead to faster, more comprehensive fuzzing campaigns -- and DIAR helps you find such seeds.
- These are slides of the talk given at IEEE International Conference on Software Testing Verification and Validation Workshop, ICSTW 2022.
3. 1. Corynebacteria (Genus Corynebacterium)
Aerobic or facultatively anaerobic
Small, pleomorphic (club-shaped), gram-positive
bacilli that appear in short chains (“V” or “Y”
configurations) or in clumps resembling “Chinese
letters”
Cells contain metachromatic granules (visualize
with methylene blue stain)
Lipid-rich cell wall contains meso-
diaminopimelic acid, arabino-galactan polymers,
and short-chain mycolic acids
Lysogenic bacteriophage encodes for potent
exotoxin in virulent strains
19. 2.Listeria monocytogenes
• Small, Gram +, nonsporing rod
• End-over-end tumbling motility when grown at
20-25°C, not at 37°C
• Facultative anaerobe, ß-hemolytic
• CAMP Test positive (like Group B Streptococcus)
20. Listeriosis
• Humans, domestic animals
described in ≥ 40 species of animals
usually follows ingestion
outbreaks, sporadic cases related to food
asymptomatic fecal carriage common,
especially for those in contact with domestic
animals
Incidence increases in summer, when
outbreaks of food-borne disease are more
common.
21. Listeriosis
Neonates, elderly & immunocompromised
Granulomatosis infantiseptica
• Transmitted to fetus transplacentally
• Early septicemic form: 1-5 days post-partum
• Delayed meningitic form: 10-20 days following birth
Intracellular pathogen
• Cell-mediated and humoral immunity develop
• Only cell-mediated immunity is protective
22. Distribution of Listeria?
Intestinal tract of mammals & birds (especially chickens)
Persists in soil
Soft cheeses & unwashed raw vegetables
Raw or undercooked food of animal origin
Luncheon meats
Hot dogs
Large scale food recalls have become common
23. Epidemiology of Listeria Infections
Natural Common Routes for Population at
Reservoirs Human Exposure Greatest Risk
24. Virulence Factors and Pathogenesis -
Motility
• Actin-mediated motility (ActA)
host cell actin polymerized
growth of tail by actin polymerization at end of
bacterium propels it through cytoplasm
• Uptake: induced phagocytosis
internalin
similar to M protein of S. pyogenes
(antiphagocytic), dissimilar functions
25. Virulence Factors and Pathogenesis
• After entry to epithelial
cells
escapes phagosome,
multiplies in cytoplasm
exocytosis from epithelial
cell followed by
phagocytosis by MØ, PMN
multiplication followed by
death of phagocytes,
secondary phagocytosis
systemic spread
26. Virulence Factors and Pathogenesis -
Listeriolysin
• Major virulence factor: listeriolysin
thiol-activated cytolysin, hemolysin
mediates escape from phagocytic vesicle
• LLO mutants: LD50 5 logs higher than WT,
do not survive in MØ
27. Virulence Factors and Pathogenesis
• Bacteria encountering plasma
membrane continue to move
forward
produce protrusions extending
into adjacent cell: listeriopods
escape listeriopod in double-
membrane vesicle, enter
cytoplasm of adjacent cell
• Mediated by phospholipase
28. Virulence Factors and Pathogenesis -
Actin-based Motility
• Bacteria in cytoplasm
polymerize actin, form
tails
hollow mesh forms on
surface, left behind as
bacterium moves forward
invade adjacent cells
• Actin nucleating factor: ActA
ActA localized at one end of the
bacterium, not found in tail
29.
30. Intracellular Survival & Replication of Listeria
Phagocytosis
Macrophag
e
Listeriolysin O?
Macrophag
e
Intracellula
Actin
r
Filaments
Replication
31. Immune Response
• In infected mice, bacteria first appear in MØ, then
invade hepatocytes
most replication probably occurs in liver
infection of MØ leads to presentation of antigens with
MHC class I, stimulating cytotoxic T cell response
cytotoxic T cells (and NK cells) kill infected hepatocytes
32. bacteria released from lysed host cells killed
bv activated MØ
T cell-deficient mice survive infection:
cytotoxic T-cell response helps clear
hepatocytes, not essential
increased susceptibility in mice unable to
produce IFN-: suggests importance of
activated MØ
33. Erysipelothrix rhusopathiae
Gram-positive non-motile bacillus; forms filaments
Occupational disease of meat and fish handlers,
hunters, veterinarians
Preventable with protective gloves & clothing
Erysipeloid in humans; erysipelas in swine & turkeys
Organisms enter through break in skin
Nonsuppurative, self-limiting skin lesions with erythema
and eruption
Peripheral spread may lead to generalized infection,
septicemia and/or endocarditis
Organisms can be isolated from skin biopsy
39. 3. Erysipelothrix rhusopathiae
Gram-positive non-motile bacillus; forms filaments
Occupational disease of meat and fish handlers,
hunters, veterinarians
Preventable with protective gloves & clothing
Erysipeloid in humans; erysipelas in swine & turkeys
Organisms enter through break in skin
Nonsuppurative, self-limiting skin lesions with erythema
and eruption
Peripheral spread may lead to generalized infection,
septicemia and/or endocarditis
Organisms can be isolated from skin biopsy