The document discusses various topics related to immunization including:
- The goals of immunization are disease prevention in individuals and eventually worldwide disease eradication.
- Immunization involves administering vaccines to stimulate immunity against infectious diseases. There are active, passive, and herd types of immunization.
- Pakistan's Expanded Program on Immunization (EPI) recommends vaccines for BCG, polio, diphtheria, pertussis, tetanus, hepatitis B, Hib, and measles to be given from birth through age 15 months. Some non-EPI recommended vaccines include rotavirus, influenza, varicella, meningococcal, and pneumococcal vaccines.
It includes the five most common immunization vaccines for the infant and these are the BCG, DPT, OPV, Hep B and Measles and also the Tetanus Toxoid for both infant and mother.
Universal Programme Immunization as per World Health Organisation in India with Cold Chain and Vaccine Storage in Overall Health Management for Children under 5 years of age
Bcg opv ipv vaccines and catchup vaccination (immunization)Praveen RK
This document provides information on BCG, OPV, IPV, and catch-up vaccination schedules. It discusses the vaccines' composition, administration procedures, immunization schedules, effectiveness, adverse reactions, contraindications and storage requirements. BCG protects against tuberculosis and is given at birth. OPV provides polio immunity orally while IPV is administered via injection. Catch-up vaccination allows children who missed scheduled doses to be protected as quickly as possible through accelerated schedules.
This document discusses immunization in children. It begins by defining key terms like immunization, vaccination, immunity, antigen, and antibody. It then lists the objectives of the lecture. The introduction states that the lecture will increase knowledge about immunizing infants and children. Various types of vaccines are described like attenuated, antitoxin, and immunoglobulin vaccines. Active and passive immunity is explained. Common vaccines given like BCG, DPT, polio, MMR and their administration routes are outlined. The importance of cold chain storage and transportation of vaccines is emphasized to maintain their effectiveness. The nurse's role in immunization programs is also reviewed.
This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
This document discusses immunization and communicable diseases. It defines vaccination as a method of stimulating the immune response through active immunization. It outlines different types of vaccines including live, attenuated, inactivated, toxoids, and polysaccharide/polypeptide vaccines. Common side effects and nursing management are described for various vaccines. Communicable diseases are defined as illnesses transmitted directly or indirectly between humans, animals, or the environment. Common communicable diseases like the common cold and influenza are explained along with their symptoms, diagnosis, and treatment.
This document provides statistics on the global HIV epidemic in 2018 from UNAIDS as well as information on HIV in India. Some key points:
- 37.9 million people globally were living with HIV in 2018. 1.7 million became newly infected that year while 23.3 million were accessing antiretroviral therapy.
- India has the third largest HIV epidemic in the world. In 2015, the national adult prevalence was 0.26%. Prevalence is highest in certain states like Mizoram (2.04%) and Manipur (1.43%).
- Children account for 6.54% of total PLHIV in India. Early infant diagnosis, appropriate infant feeding and prophylaxis
It includes the five most common immunization vaccines for the infant and these are the BCG, DPT, OPV, Hep B and Measles and also the Tetanus Toxoid for both infant and mother.
Universal Programme Immunization as per World Health Organisation in India with Cold Chain and Vaccine Storage in Overall Health Management for Children under 5 years of age
Bcg opv ipv vaccines and catchup vaccination (immunization)Praveen RK
This document provides information on BCG, OPV, IPV, and catch-up vaccination schedules. It discusses the vaccines' composition, administration procedures, immunization schedules, effectiveness, adverse reactions, contraindications and storage requirements. BCG protects against tuberculosis and is given at birth. OPV provides polio immunity orally while IPV is administered via injection. Catch-up vaccination allows children who missed scheduled doses to be protected as quickly as possible through accelerated schedules.
This document discusses immunization in children. It begins by defining key terms like immunization, vaccination, immunity, antigen, and antibody. It then lists the objectives of the lecture. The introduction states that the lecture will increase knowledge about immunizing infants and children. Various types of vaccines are described like attenuated, antitoxin, and immunoglobulin vaccines. Active and passive immunity is explained. Common vaccines given like BCG, DPT, polio, MMR and their administration routes are outlined. The importance of cold chain storage and transportation of vaccines is emphasized to maintain their effectiveness. The nurse's role in immunization programs is also reviewed.
This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
This document discusses immunization and communicable diseases. It defines vaccination as a method of stimulating the immune response through active immunization. It outlines different types of vaccines including live, attenuated, inactivated, toxoids, and polysaccharide/polypeptide vaccines. Common side effects and nursing management are described for various vaccines. Communicable diseases are defined as illnesses transmitted directly or indirectly between humans, animals, or the environment. Common communicable diseases like the common cold and influenza are explained along with their symptoms, diagnosis, and treatment.
This document provides statistics on the global HIV epidemic in 2018 from UNAIDS as well as information on HIV in India. Some key points:
- 37.9 million people globally were living with HIV in 2018. 1.7 million became newly infected that year while 23.3 million were accessing antiretroviral therapy.
- India has the third largest HIV epidemic in the world. In 2015, the national adult prevalence was 0.26%. Prevalence is highest in certain states like Mizoram (2.04%) and Manipur (1.43%).
- Children account for 6.54% of total PLHIV in India. Early infant diagnosis, appropriate infant feeding and prophylaxis
This document discusses special situations and adverse events following immunization. It provides guidance on vaccinating preterm/low birth weight infants, those receiving corticosteroids or immunosuppressive therapy, children with malignancies, congenital immunodeficiencies, chronic diseases, allergies, bleeding disorders, or acute illness. It recommends that most vaccines can be administered according to chronological age for preterm/low birth weight infants. It also provides specific guidance on contraindications and precautions for different groups.
the ppt describes the pentavalent and trivalent according to the national immunisation program,india in an easy to understand and interactive form.useful for students and tutors.
also has a FAQ section.
This document discusses paediatric HIV, including:
1) Over 2 million children under 15 were living with HIV by 2006, most acquiring it vertically from their mothers. Prevention of mother-to-child transmission focuses on antiretroviral prophylaxis and treatment.
2) HIV infected children can receive routine immunizations which are generally safe and effective, though antibody response may be impaired. Live attenuated vaccines require additional precautions for immunosuppressed children.
3) Clinical monitoring of perinatally exposed infants includes growth, development, and screening for opportunistic infections. HIV testing is done via PCR and serology. Antiretroviral therapy aims to suppress viral load and improve CD4 counts.
This document discusses immunization and provides information on key terms, schedules, coverage rates, and barriers. It defines immunization as stimulating the immune system through antigens to induce immunity. The national immunization schedule in India is outlined which recommends vaccines for pregnant women, infants, and children at specific ages and doses. Coverage rates from 1985 to 2008 show improvements. Barriers to immunization mentioned include physical barriers like waiting time as well as socio-cultural factors. Herd immunity is described as resistance to disease spread when few members are susceptible.
The document discusses the Expanded Program on Immunization (EPI) which aims to make vaccines available to all children worldwide. It was launched by the WHO in 1974 to immunize against six preventable diseases. The EPI schedule in Pakistan aims to reduce mortality from seven target diseases by vaccinating children aged 0-11 months and women of childbearing age. Vaccines included in the schedule are BCG, OPV, DPT, measles, and more recently pneumococcal vaccine. The goals of EPI in Pakistan include achieving 100% coverage with all vaccines, eliminating polio and measles, and reducing disease incidence. Progress has been made through improved routine immunization, campaigns, and strengthening of surveillance, cold chain
Immunization is a process of protecting an individual from a disease through introduction of live attenuated, killed or organisms or antibodies in the individual system.
Immunization is the process of protecting an individual by active or passive method.
The immunizing agents are
Vaccines, Immunoglobulins and antisera
Why vaccination?
Prevention of deadly and debilitating diseases.
Keeps child from suffering through a preventable illness.
Less doctor visits
No hospitalization
This presentation is a part 2/4 of series of presentation on Paediatric immunization.This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
The document discusses India's national immunization program and schedule, outlining the vaccines provided including BCG, OPV, DPT, measles, and others. It describes important milestones over the decades in expanding coverage as well as recent changes like the introduction of new vaccines IPV, Rota, and PCV. The national schedule provides the recommended ages, doses, and routes of administration for different vaccines to both children and pregnant women.
Immunization is single most important step towards control and elimination of infectious disease.
With regards to epidemiology and population demographics, various changes are made from time to time in Immunization Schedule of the National Health Programme.
This slide show encompasses the recent changes made by National Health Commission with regards to Immunization Schedule.
The document discusses the history and science of immunization and vaccination. It begins by describing how Edward Jenner used cowpox to provide immunity against smallpox. Later, Louis Pasteur further developed vaccination principles. In 1974, the WHO organized the Expanded Program on Immunization and in 1985 India introduced the Universal Immunization Program. The document then defines key vaccination terms and describes various types of immunizing agents and vaccines including live, killed, toxoids, and subunit vaccines. It provides details on vaccination schedules, administration routes, contraindications and the importance of cold chain storage.
1. HIV attacks T-cells in the immune system, leading to AIDS in advanced stages.
2. Clinical manifestations in children vary widely and can include failure to thrive, respiratory issues, gastrointestinal diseases, and neurological problems.
3. Diagnosis is made through HIV antibody testing after 18 months or virological testing before 18 months, and management includes prophylaxis, antiretroviral therapy, treating opportunistic infections, adequate nutrition, and immunization.
Immunization is the most effective way of protecting the human body from infectious disease. Immunization is a process by which an individual’s immune system become fortified by vaccine against an agent.
Immunization program are an Integral and important part of the health activities of every country in the world.
Immunization is the process whereby person is made immune or resistant to an infectious disease, typically by the administration of a vaccine.
This document discusses immunization and different types of vaccines. It describes passive and active immunization. Passive immunization provides immediate short-term protection from antibodies without immune system activation, while active immunization activates the immune system to produce long-lasting immunity. The document outlines various vaccine types including live attenuated, inactivated, toxoid, and subunit vaccines. It provides details on vaccine administration, schedules, and contraindications.
Hepatitis B and BCG vaccines are given to newborns to prevent transmission of diseases. Hepatitis B can be transmitted from mother to baby during birth, so the WHO recommends giving the Hepatitis B vaccine within 24 hours of birth. The National Immunization Program in the country also recommends giving the Hepatitis B vaccine within 24 hours or up to 7 days. BCG vaccine prevents tuberculosis and is given as an intramuscular injection in the upper arm to babies under 1 year old. Both vaccines have minimal side effects but can occasionally cause local reactions or mild fever.
This document discusses newer vaccines and an MR vaccination campaign. It provides background on vaccine history and types. Recent developments include vaccines for pneumococcal, influenza, meningococcal, HPV, and rotavirus. Future vaccines discussed include ones for HIV. The document also outlines the need for vaccination, recently added vaccines in India's national program, and details of vaccination schedules and target groups for campaigns like one for MR in 2017.
The document summarizes information about various vaccines including BCG, DPT, oral polio vaccine, and inactivated polio vaccine. It discusses details like the epidemiology of the diseases they protect against, how the vaccines are produced and administered, their efficacy and safety, recommended schedules, storage requirements, and contraindications. The vaccines protect against tuberculosis, diphtheria, pertussis, tetanus, and poliomyelitis, and reducing the burden of these diseases has been a priority for global immunization programs.
This document provides information on the national immunization schedules for infants and children in India. It includes the vaccines recommended, the ages at which they should be administered, dosage, route of administration, maximum age limits, and storage requirements. Key details provided for individual vaccines include dose, administration route and site, adverse reactions, contraindications, schedules, and cold chain storage temperatures. The schedules outline the vaccines recommended by the national program as well as by the Indian Academy of Pediatrics.
This document discusses rotavirus disease and the rotavirus vaccine. It begins with an introduction about rotavirus, which causes severe diarrhea in young children globally. It then discusses the epidemiology of rotavirus including the viral agent, those affected, and transmission through the fecal-oral route. Four types of rotavirus vaccines available in India are described along with their composition, dosage, administration, and efficacy. Storage requirements are outlined, and vaccine stock management including early expiry, first out is advised. The document concludes with recommendations for phasing in the vaccine and estimating annual vaccine requirements based on the target population and doses.
This document summarizes key information about vaccines and immunity:
1. It describes active and passive immunity and how vaccines work to stimulate active immunity through antibody production.
2. It explains herd immunity and how widespread vaccination benefits unvaccinated individuals by making disease transmission unlikely.
3. It provides an overview of different types of vaccines including live attenuated, killed/inactivated, toxoid/subunit, and recombinant vaccines.
4. Examples are given of specific vaccines for diseases like tuberculosis, typhoid, cholera, pertussis, polio, rabies, hepatitis B, and measles/mumps/rubella.
The document discusses various types of immunization including their goals, definitions, and details. It covers:
- Passive and active immunity from natural and artificial sources
- Types of vaccines including live attenuated, inactivated, subunit, toxoid, and conjugate
- Details on specific vaccines like BCG, polio, diphtheria, hepatitis B, pneumococcal, rotavirus, and measles
- Schedules, efficacy, advantages, side effects and contraindications of different vaccines
- The importance of vaccination programs in reducing disease prevalence globally
This document discusses special situations and adverse events following immunization. It provides guidance on vaccinating preterm/low birth weight infants, those receiving corticosteroids or immunosuppressive therapy, children with malignancies, congenital immunodeficiencies, chronic diseases, allergies, bleeding disorders, or acute illness. It recommends that most vaccines can be administered according to chronological age for preterm/low birth weight infants. It also provides specific guidance on contraindications and precautions for different groups.
the ppt describes the pentavalent and trivalent according to the national immunisation program,india in an easy to understand and interactive form.useful for students and tutors.
also has a FAQ section.
This document discusses paediatric HIV, including:
1) Over 2 million children under 15 were living with HIV by 2006, most acquiring it vertically from their mothers. Prevention of mother-to-child transmission focuses on antiretroviral prophylaxis and treatment.
2) HIV infected children can receive routine immunizations which are generally safe and effective, though antibody response may be impaired. Live attenuated vaccines require additional precautions for immunosuppressed children.
3) Clinical monitoring of perinatally exposed infants includes growth, development, and screening for opportunistic infections. HIV testing is done via PCR and serology. Antiretroviral therapy aims to suppress viral load and improve CD4 counts.
This document discusses immunization and provides information on key terms, schedules, coverage rates, and barriers. It defines immunization as stimulating the immune system through antigens to induce immunity. The national immunization schedule in India is outlined which recommends vaccines for pregnant women, infants, and children at specific ages and doses. Coverage rates from 1985 to 2008 show improvements. Barriers to immunization mentioned include physical barriers like waiting time as well as socio-cultural factors. Herd immunity is described as resistance to disease spread when few members are susceptible.
The document discusses the Expanded Program on Immunization (EPI) which aims to make vaccines available to all children worldwide. It was launched by the WHO in 1974 to immunize against six preventable diseases. The EPI schedule in Pakistan aims to reduce mortality from seven target diseases by vaccinating children aged 0-11 months and women of childbearing age. Vaccines included in the schedule are BCG, OPV, DPT, measles, and more recently pneumococcal vaccine. The goals of EPI in Pakistan include achieving 100% coverage with all vaccines, eliminating polio and measles, and reducing disease incidence. Progress has been made through improved routine immunization, campaigns, and strengthening of surveillance, cold chain
Immunization is a process of protecting an individual from a disease through introduction of live attenuated, killed or organisms or antibodies in the individual system.
Immunization is the process of protecting an individual by active or passive method.
The immunizing agents are
Vaccines, Immunoglobulins and antisera
Why vaccination?
Prevention of deadly and debilitating diseases.
Keeps child from suffering through a preventable illness.
Less doctor visits
No hospitalization
This presentation is a part 2/4 of series of presentation on Paediatric immunization.This presentation aims at helping the pediatric trainees and practitioners to brush up their knowledge in Immunization. The schedule is based on the Universal Immunisation Programme. I have tried to cover as much as possible in terms of individual vaccines and hope it is beneficial to the reader.
The document discusses India's national immunization program and schedule, outlining the vaccines provided including BCG, OPV, DPT, measles, and others. It describes important milestones over the decades in expanding coverage as well as recent changes like the introduction of new vaccines IPV, Rota, and PCV. The national schedule provides the recommended ages, doses, and routes of administration for different vaccines to both children and pregnant women.
Immunization is single most important step towards control and elimination of infectious disease.
With regards to epidemiology and population demographics, various changes are made from time to time in Immunization Schedule of the National Health Programme.
This slide show encompasses the recent changes made by National Health Commission with regards to Immunization Schedule.
The document discusses the history and science of immunization and vaccination. It begins by describing how Edward Jenner used cowpox to provide immunity against smallpox. Later, Louis Pasteur further developed vaccination principles. In 1974, the WHO organized the Expanded Program on Immunization and in 1985 India introduced the Universal Immunization Program. The document then defines key vaccination terms and describes various types of immunizing agents and vaccines including live, killed, toxoids, and subunit vaccines. It provides details on vaccination schedules, administration routes, contraindications and the importance of cold chain storage.
1. HIV attacks T-cells in the immune system, leading to AIDS in advanced stages.
2. Clinical manifestations in children vary widely and can include failure to thrive, respiratory issues, gastrointestinal diseases, and neurological problems.
3. Diagnosis is made through HIV antibody testing after 18 months or virological testing before 18 months, and management includes prophylaxis, antiretroviral therapy, treating opportunistic infections, adequate nutrition, and immunization.
Immunization is the most effective way of protecting the human body from infectious disease. Immunization is a process by which an individual’s immune system become fortified by vaccine against an agent.
Immunization program are an Integral and important part of the health activities of every country in the world.
Immunization is the process whereby person is made immune or resistant to an infectious disease, typically by the administration of a vaccine.
This document discusses immunization and different types of vaccines. It describes passive and active immunization. Passive immunization provides immediate short-term protection from antibodies without immune system activation, while active immunization activates the immune system to produce long-lasting immunity. The document outlines various vaccine types including live attenuated, inactivated, toxoid, and subunit vaccines. It provides details on vaccine administration, schedules, and contraindications.
Hepatitis B and BCG vaccines are given to newborns to prevent transmission of diseases. Hepatitis B can be transmitted from mother to baby during birth, so the WHO recommends giving the Hepatitis B vaccine within 24 hours of birth. The National Immunization Program in the country also recommends giving the Hepatitis B vaccine within 24 hours or up to 7 days. BCG vaccine prevents tuberculosis and is given as an intramuscular injection in the upper arm to babies under 1 year old. Both vaccines have minimal side effects but can occasionally cause local reactions or mild fever.
This document discusses newer vaccines and an MR vaccination campaign. It provides background on vaccine history and types. Recent developments include vaccines for pneumococcal, influenza, meningococcal, HPV, and rotavirus. Future vaccines discussed include ones for HIV. The document also outlines the need for vaccination, recently added vaccines in India's national program, and details of vaccination schedules and target groups for campaigns like one for MR in 2017.
The document summarizes information about various vaccines including BCG, DPT, oral polio vaccine, and inactivated polio vaccine. It discusses details like the epidemiology of the diseases they protect against, how the vaccines are produced and administered, their efficacy and safety, recommended schedules, storage requirements, and contraindications. The vaccines protect against tuberculosis, diphtheria, pertussis, tetanus, and poliomyelitis, and reducing the burden of these diseases has been a priority for global immunization programs.
This document provides information on the national immunization schedules for infants and children in India. It includes the vaccines recommended, the ages at which they should be administered, dosage, route of administration, maximum age limits, and storage requirements. Key details provided for individual vaccines include dose, administration route and site, adverse reactions, contraindications, schedules, and cold chain storage temperatures. The schedules outline the vaccines recommended by the national program as well as by the Indian Academy of Pediatrics.
This document discusses rotavirus disease and the rotavirus vaccine. It begins with an introduction about rotavirus, which causes severe diarrhea in young children globally. It then discusses the epidemiology of rotavirus including the viral agent, those affected, and transmission through the fecal-oral route. Four types of rotavirus vaccines available in India are described along with their composition, dosage, administration, and efficacy. Storage requirements are outlined, and vaccine stock management including early expiry, first out is advised. The document concludes with recommendations for phasing in the vaccine and estimating annual vaccine requirements based on the target population and doses.
This document summarizes key information about vaccines and immunity:
1. It describes active and passive immunity and how vaccines work to stimulate active immunity through antibody production.
2. It explains herd immunity and how widespread vaccination benefits unvaccinated individuals by making disease transmission unlikely.
3. It provides an overview of different types of vaccines including live attenuated, killed/inactivated, toxoid/subunit, and recombinant vaccines.
4. Examples are given of specific vaccines for diseases like tuberculosis, typhoid, cholera, pertussis, polio, rabies, hepatitis B, and measles/mumps/rubella.
The document discusses various types of immunization including their goals, definitions, and details. It covers:
- Passive and active immunity from natural and artificial sources
- Types of vaccines including live attenuated, inactivated, subunit, toxoid, and conjugate
- Details on specific vaccines like BCG, polio, diphtheria, hepatitis B, pneumococcal, rotavirus, and measles
- Schedules, efficacy, advantages, side effects and contraindications of different vaccines
- The importance of vaccination programs in reducing disease prevalence globally
Vaccines help the body develop immunity to diseases without having to get the disease. They work by exposing the immune system to parts of disease-causing germs, which triggers antibody production. There are two types of vaccines - live attenuated vaccines which use weakened germs, and inactivated vaccines which use killed germs. Common childhood vaccines provide protection against diseases like polio, diphtheria, pertussis, tetanus, measles, and more. Vaccines are administered through injections or orally according to recommended schedules to be most effective.
Update on Vaccine Issues & WSAVA Guidelines (2015-2017)Yotam Copelovitz
Dr. Jean Dodds opens her presentation with an explanation on how animals obtain immunity. She continues it by discussing some key points on vaccine issues and their relationship to memory cell immunity. The presentation is concluded with suggested alternatives to current vaccine practices, such as titer testing.
This document summarizes recent advancements in immunization. It discusses the goals of immunization as preventing disease in individuals and ultimately eradicating diseases worldwide. Data from the US shows significant decreases in morbidity from diseases like smallpox, polio, measles, and haemophilus influenza type B due to immunization programs. It also discusses common concerns parents have about immunization and ways to address those concerns. The document then describes the different types of immunization including active and passive immunization. It provides guidelines for many common vaccines and discusses considerations around vaccine handling, scheduling, and specific diseases.
It commonly institutes activities that limit risk exposure or increase the immunity of individuals at risk to prevent a disease from progressing in a susceptible individual to subclinical disease. For example, immunizations are a form of primary prevention.
mmunization currently prevents 3.5-5 million deaths every year from diseases like diphtheria, tetanus, pertussis, influenza and measles. Immunization is a key component of primary health care and an indisputable human right. It's also one of the best health investments money can buy.
This document contains an expert lecture on immunization and vaccines. It defines key terms like vaccines, immunization, active and passive immunity. It describes different types of vaccines including live attenuated, conjugated, and toxoid vaccines. Specific details are provided on various vaccines like BCG, polio, tetanus, diphtheria, pertussis, measles and hepatitis B. It addresses contraindications, dosage, efficacy and complications of different vaccines. Multiple choice questions at the end assess understanding of vaccine details like appropriate age for rotavirus vaccination and disease eradicated by vaccination.
Immunity and vaccine (community medicine )Niko439610
This document discusses immunity, types of immunity (active and passive), antigens, antibodies, humoral immunity, cellular immunity, how active immunity is developed, how passive immunity is acquired, immune response, herd immunity, immunizing agents (vaccines, immunoglobulins, antiserum), EPI schedule, cold chain, complications of vaccination, contraindications to vaccination, adverse events following immunization (AEFI), and coincidental events. The key points are that immunity protects the body from foreign antigens, there are two types of immunity (active and passive), and vaccines help develop active immunity while immunoglobulins provide passive immunity.
This document discusses adult immunization and vaccination. It covers the basics of immunity and the immune system. It describes the different types of vaccines including live, inactivated, conjugate, and combination vaccines. It discusses the various routes of administration including oral, intranasal, subcutaneous, intramuscular, and intradermal. Recommendations are provided for various adult vaccines including Tdap, MMR, varicella, HPV, hepatitis A and B, pneumococcal, influenza, and meningococcal vaccines. A table outlines the recommended vaccines for different adult age groups.
The document discusses immunity and principles of vaccination. It covers innate immunity, which is non-specific and present from birth, and adaptive immunity, which is acquired after exposure and leads to immunological memory. Vaccination works by exposing individuals to weakened or killed pathogens to artificially increase immunity. The goals of vaccination are to provide protective immunity through memory responses and to ultimately eradicate diseases. Vaccines can provide active immunity by inducing antibody or cellular responses, or passive immunity by administering preformed antibodies.
Passive immunity is temporary protection transferred from another individual, such as maternal antibodies. Active immunity is stimulated through natural infection or vaccination and results in the formation of memory cells that provide long-lasting protection. Vaccines work by mimicking natural infections and stimulating the immune system to develop antibodies and memory cells against targeted pathogens. Widespread vaccination benefits both individuals and communities through herd immunity.
This document provides an overview of immunization and vaccination. It discusses the basics of active and passive immunization. It describes different types of vaccines including live attenuated, inactivated, toxoid, polysaccharide, conjugate, recombinant, and subunit vaccines. Key concepts in vaccinology like herd immunity, vaccine efficacy, and vaccine failure are explained. The principles, technique, and schedule of immunization administration are outlined. Adverse events following immunization and vaccine storage requirements are also summarized.
This document discusses different types of traditional vaccines, including inactivated, live attenuated, toxoid, and subunit vaccines. It provides details on how each type is prepared, such as using heat or chemicals to kill pathogens for inactivated vaccines and weakening live viruses for live attenuated vaccines. Both advantages and disadvantages are described for each approach. Specific examples like the polio, diphtheria, tetanus, and influenza vaccines are examined in more depth. The history of vaccine development from Lady Mary Wortley Montagu's variolation technique to Louis Pasteur's first live attenuated vaccine for chicken cholera is also reviewed.
This document provides an overview of vaccines and immunization. It defines immunization as the process of making a person immune or resistant to an infectious disease, typically through vaccine administration. The document discusses the history of vaccines, types of vaccines, immunization schedules, special populations, adverse reactions, and the importance of immunization in preventing disease outbreaks and saving lives. It concludes that vaccinations reduce global child mortality and allow individuals to live healthier lives while being economically sensible.
Vaccination: how vaccination helps to prevent diseasesLekhan Lodhi
The document discusses vaccination and immunization. It defines vaccination as stimulating protective immune responses through exposure to non-pathogenic forms of microbes. A vaccine produces specific protection against a disease by being antigenic but not pathogenic. Immunization makes a person immune or resistant to an infectious disease typically through vaccine administration. The first empirical proof of protective immunity was provided by Edward Jenner through vaccinating against smallpox using cowpox. Smallpox was possible to eradicate due to unique biological factors and the effectiveness of the smallpox vaccine. The document also discusses vaccine design, mechanisms of protection, types of vaccines including live, inactivated, toxoids, cellular fraction and recombinant vaccines, and routes and schemes of immun
basic imunization and immunization in sepecal situation.pptssuser2dcad1
This document provides information on basic immunization and immunization in special situations. It discusses different types of immunity including active and passive immunity. It describes various immunizing agents such as immunoglobulins, antisera, and different types of vaccines including live, attenuated, inactivated, toxoids, and recombinant vaccines. It also discusses vaccination schedules, adverse reactions to immunization, maintaining the cold chain, and provides guidance on immunization for special populations such as preterm infants, immunocompromised individuals, and hepatitis B-positive mothers and their newborns.
This document discusses immunization and immunity. It covers different types of immunity including active and passive immunity. It also discusses different immunizing agents such as antisera, immunoglobulins, and vaccines including live, attenuated, inactivated, toxoid, polysaccharide, and recombinant vaccines. It provides details on vaccination coverage, maintaining the cold chain for vaccine storage and transport, potential adverse reactions to immunization, and precautions that should be taken.
This document provides information on basic immunization and immunization in special situations. It discusses different types of immunity, immunizing agents like vaccines, immunoglobulins, and antisera. It describes various types of vaccines including live, attenuated, inactivated, toxoids, and recombinant vaccines. It also discusses vaccination schedules, potential adverse reactions to vaccination, maintaining the cold chain, and precautions that should be taken with vaccination. Finally, it covers special considerations for vaccination in situations like immunocompromised individuals, preterm infants, hepatitis B-positive mothers, and adult females.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
2. OBJECTIVES:-
Classification
What are the goals of immunization?
What is immunization and its types?
Barriers to Immunization in Pakistan
Vaccination Programs in Pakistan
EPI and Non EPI programs
5. Immunization
“Immunization is the process whereby a person
is made immune or resistant to an infectious
disease, typically by the administration of a
vaccine.
Vaccines stimulate the body's own immune
system to protect the person against subsequent
infection or disease.” - WHO
7. Active Immunization:
• The administration of all or part of a micro-organism
or a modified product of that organism(toxoid or
purified antigen) to evoke an immunologic
response that mimics that of the natural infection
but usually presents little or no risk for the
recipient.
• It may provide life long protection ,partial protection
or may require administration at regular intervals.
8. Passive Immunization
It is the administration of preformed antibodies to
recipients.
It is available as:
• Human Immunoglobulin (Ig):
• Intravenous Immunoglobulin (IVIG)
• Subcutaneous Immunoglobulin (SCIG)
• Hyperimmune globulin
• Monoclonal antibodies
9. • It is a concentrated antibody-containing
solution prepared from plasma obtained
from normal donors. Primarily consists of
Ig G.
Human
Immunoglobulin (IG)
• Prophylaxis for:
• Hepatitis A
• Measles
• Immunoglobulin deficiency
• Varicella (in immunocompromised patients when
varicella-zoster IG is unavailable)
• Rubella exposure during the 1st trimester of pregnancy
Indications
• Anaphylaxis
• Local inflammatory reactionSide Effects
10. • To provide larger and repeated doses of
human immune globulin in treating severe
bacterial and viral infections as well as immune
deficiency disorders.
Intravenous
Immunoglobulin
(IVIG)
• Kawasaki disease
• HIV infection in children
• Chronic B-cell lymphocytic leukemia
• Primary immunodeficiencies
• Immune thrombocytopenia
• Prevention of graft-vs-host disease
Indications
• Hypersensitivity
• Anaphylactic reactions
• Coughing
• Volume overload
Side Effects
11. • For home use in patients with a primary immunodeficiency.
• Can Local Inflammatory reactions.
Subcutaneous
Immunoglobulin
(SCIG)
• Prepared from the plasma of people with high titers of
antibody against a specific organism or antigen.
• Available for
Hepatitis B
Infant botulism
Rabies
Tetanus
CMV
Varicella-zoster
• Can cause Anaphylactic reactions.
Hyperimmune
globulin
12. • Antibodies produced by a
single clone of cells or cell
line and consisting of
identical antibody molecules.
• Mostly experimental role so
far.
Monoclonal
Antibodies
• Prophylaxis against RSV
infection in certain high-risk
children.
Indications
13. Herd Immunity
• It exists if a number of people in the community
who have active immunity against an infection
exceeds a critical level.
• If this level is achieved, then, non-vaccinated
individuals are protected from the disease. In
this way, transmission fails or stops without
universal immunity.
15. What is a Vaccine?
• A vaccine is usually a protein similar to part of a
virulent infectious organism, that can be
recognized by an individual’s immune system.
• It produces antibodies or cell-mediated
immunity against the antigen in the vaccine.
16. Types of Vaccines
Live Attenuated
Vaccines
Killed/
Inactivated
Vaccines
Toxoids
Polysaccharides:
Pure &
Conjugated
Genetically
engineered
Vaccines
17. Live Vaccines
• Live vaccines produce active immunity by
causing a mild infection.
• A virulent organism is weakened so that it
produces an antigenic response without serious
consequences.
Vaccines included:
• BCG
• Oral Polio
• MMR
18. Killed/Inactivated Vaccines
• They are prepared from virulent organisms or
pre-formed antigens inactivated by heat,phenol,
formaldehyde or any other means.
Vaccines included:
• Pertussis
• Cholera
• Influenza
• Injectable Polio
• Rabies
19. Toxoids
• They are based on the toxin (poison) produced
by certain bacteria that has been made harmless
but elicits an immune response. (e.g. tetanus or
diphtheria).
20. Polysaccharide Vaccines:
Pure & Conjugated
• They are a unique type of inactivated subunit vaccine
composed of long chains of sugar molecules that make
up the surface capsule of certain bacteria.
• The response to polysaccharide vaccines is incomplete
and unreliable and are sometimes conjugated with
other antigens to improve immunological response.
21. Recombinant Vaccines(GE)
• Vaccine antigens may also be produced by
genetic engineering technology. These products
are sometimes referred to as recombinant
vaccines.
• Eg:Hepatitis B, HPV
22. Principles of handling and storing
Vaccines
• Vaccines are temperature sensitive.
Strict temperature monitoring should be done to
ensure a maintained cold chain*.
• FEFO- “first expiry and first out”
*Cold chain includes all of the materials, equipment and procedures used to maintain
vaccines in the required temperature range of +2 °C to +8 °C from the time of
manufacture until the vaccines are administered to individuals.
23. Recommended temperatures
Type Storage temp.
Most sensitive to
heat
•Oral polio(live
attenuated)
•Measles (freeze
dried)
-15 °C to -25 °C (at
the freezer)
15°C to -15 °C (at
the freezer)
Least sensitive to
heat
•DPT/Hep B
•BCG (freeze
dried)
•Tetanus Toxoid
+2 °C to +8 °C (in
the body of the
refrigerator)
24. Vaccination Programs in Pakistan
• There are currently two programs being followed in
Pakistan:
• Expanded Program of Immunization(EPI)-
Commonly followed
• American Academy of Pediatrics (AAP)
25. Expanded Program on
Immunization(EPI)
Age Name of Vaccine
At Birth BCG, OPV-0
6 weeks OPV-1, Pentavalent, Pneumococcal-1
10 weeks OPV-2,Pentavalent-2, Pneumococcal-2
14 weeks OPV-3,Pentavalent-3, Pneumococcal-3
9 months Measles
15 months Measles
26. BCG(Bacille Calmette Guerin)
• It is made up of a live, weakened strain of
mycobacterium bovis.
• R.O.A: Intradermal
• Dose: 0.05ml<12 mo
0.01ml>12 mo
• Site: The recommended site of injection (all age
groups) is the deltoid region of the arm, about one
third down the upper arm over the insertion of the
deltoid muscle.
• Efficacy: 0-80% for lung TB.
75-86% for Meningitis and Miliary TB.
• Duration of Immunity: 10-15yrs
28. Contraindications
• Neonates with an immuno-deficiency.
• Neonates receiving cortico-steroids.
• Neonates born to a mother with HIV or suspected HIV
infection.
• Neonates with a significant fever.
• Neonates with a generalised septic skin condition.
• Preterm infants. There is some evidence of decreased
effectiveness.
29. Polio Vaccine
• They are divided into:
Live Attenuated Oral Polio Vaccine(OPV-Sabin)
Injectable Polio Vaccine (IPV-Salk)
Both vaccines contain type I,II and III strains.
• Efficacy: 95-99%
• Duration of Immunity: Lifelong if boosted.
30.
31.
32. DPT( Diptheria,Pertussis,Tetanus)
• The vaccine contains toxoid of diphteria and tetatnus
with a suspension of killed whole bacillus pertussis.
• 3 doses of 0.5ml given I/M at 4-8 weeks interval
starting at 6 weeks.
• Booster given 1 yr after 3rd dose and another between
4-6 yrs of age.
33. Diptheria Toxoid
• It is prepared by formaldehyde inactivation of
diptheria toxin adsorbed onto aluminum salts to
increase its antigenicity.
Protects against diptheria toxin.
• Dose: 0.5ml
Site: I/M
• Efficacy: 87%
• Duration of Immunity: 5 yrs.
• Complications: Nil
34. Special Considerations
• Diptheria Toxoid is only used when Tetanus
and Pertussis vaccines are contra-indicated.
• Diptheria-Tetanus(DT) is used when Pertussis
vaccine is contraindicated.
• Td(Tetanus-Diptheria) is used in persons 7
years of age or older.
35. Pertussis
• It is used against Bordatella Pertussis.
• Dose:0.5ml
• Site: I/M
• Efficacy: 80%
• Duration of Immunity: Decreases with time
• Complications:
Acute Encephalopathy ( 1 in 110,000 )
Permanent neurological sequelae( 1 in 310,000)
• Contra-indications:
Family history of convulsions.
Family history of Sudden Infant Death syndrome
Family history of adverse events following DPT administration
36. Comparison between aP and wP
Whole cell vaccine Acellular vaccine
Local reaction more Much less
Systemic More Much less
Anaphylaxis 2 per million Much less
Seizures 1:1750 doses Much less
HHE 1:1750 Much less
Temp 105F In 0.3%reciepients Much less
crying for more than 3 hrs 1% Much less
37. Tetanus Toxoid(TT)
• It is prepared by inactivating the toxin by
formaldehyde. TT is stable at room temperature and
can survive for few weeks at 37 degrees.
• Dose: 0.5ml
• R.O.A: I/M
• Efficacy: 95%>
• Duration of Immunity: 5 years
41. Special Considerations
• If mother is HBsAg +ve
First dose: 0.5ml Hep B Ig within 12 hrs after birth
& Hep B vaccine at a separate site.
Second dose: 1-2 months
Third dose: 6 months
Infants should be tested for Anti-HBs.
If +ve If -ve
Vaccination effective
Test for
HbsAg
Infant is chronic carrier
If +ve
If -ve
Repeat tests at 0,1 &
6months followed by
anti-HBS 1 month
after 3rd dose.
42. Hemophilus Influenza Type B(Hib)
• It is a conjugated vaccine developed against
Hemophilus influenza type B bacteria.
• Given in combination with DPT at 6,10 and 14
weeks.
Booster given at 18 months.
• Dose: 0.5ml
R.O.A: I/M
• Efficacy: 95-100%
• S.E: Temporary local inflammatory reaction
• C.I: Anaphylaxis
43. Pneumococcal Vaccine
• It is the current vaccine against Strep Pneumoniae.
• Composed of capsular antigens 7,9 & 23 serotypes.
• Types:
1)Conjugated –PCV10(Prevenar) & PCV13(Synflorix)
2)Polysaccharide- PPSV 23
• Dose: 0.5ml
• R.O.A: I/M or S/C
• Efficacy: 55-57%
• C.I: Severe allergic reaction to previous dose.
44. PCV10 & 13 PPSV23
Conjugated Polysaccharide
Immunogenic from
6 weeks -5 years of age
Immunogenic after the age of
2 years
S.E:
Drowsiness
Fever
Loss of appetite
Muscular pain
Inflammatory reaction
Herd immunity +ve No herd immunity
Comparison between PCV and PPSV
45. Measles
• It is a live, attenuated vaccine prepared from multiple measles
strains. It is available as:
-Monovalent and in combinations (MMR , MMRV).
• Dose: 0.5ml
R.O.A: S/C
• Efficacy:>85% at 9 months of age
>90% at 12 months of age
• Duration of Immunity: Lifelong
• S.E: Mild febrile illness
Morbiliform rashes
Encephalitis
• C.I:
Immunodeficiency
Pregnancy
Neomycin Resistance
46. MMR(Measles, Mumps, Rubella)
• It is a live, attenuated (weakened), combination vaccine
that protects against all three viruses.
• R.O.A: S/C
• Dose: 0.5ml
Two doses are recommended, at 1 yr and 4-6yrs of age
respectively.
Minimum dose interval : 28 days
• Efficacy: 75-90%
• Duration of Immunity: 95% after the first dose, life long
long after the second.
47. Complications
• 10% of children will develop fever, malaise &
rashes 5-21 days after vaccination.
• 3% develop joint pain lasting 18 days on average.
• Aseptic meningitis is a rare complication.
51. Rotavirus
• Rotavirus accounts for 35% of all diarrheal disease in
Pakistan. It is a two-dose live attenuated oral vaccine.
• Min age for 1st dose: 6wks--14wks & 6 days
Dose Interval : 4 weeks.
• Max age for 2nd dose: 8 months
• R.O.A: Oral
• Efficacy: 61.2%
• Available as Rotarix and Rotateq
• Complications: Hypersensitivity to previous dose
• C.I: Intussusseption
52. Influenza vaccine
• Available as a shot or nasal spray.
• Two types:
-Seasonal inactivated flu vaccine
-Seasonal live attenuated intra-nasal vaccine
Min age: 6 months
2 doses in a 4 wk interval for first time vaccinators under 9
yrs of age, followed by 1 dose each year.
• Efficacy: 60%
• S.E: Local inflammatory reaction
Rhinorrhea, wheezing (for Nasal spray)
Dyspnea
Weakness
54. Meningococcal vaccine
• Composed of quadrivalent A,C,W-135 and Y capsular
polysaccharides.
• Given after the age of 2 years*.
• Dose: 0.5ml
• R.O.A: S/C
• Duration of Immunity: 5 years
• S.E: pain , redness , swelling
• Fever for 1-2 days
*Can be given as 2 doses 3 months
apart at 3 months of age in endemic areas.
56. Varicella Vaccine
• It is a live attenuated virus administered to protect against
Chicken Pox caused by Varicella Zoster virus.
• 1st dose at 12-15 months and 2nd dose 4-6 years
• Dose: 0.5ml
• R.O.A: S/C
• Efficacy: 98% after 2 doses.
• S.E: Inflammatory Reaction
Mild Rash
• C.I: Pregnancy
Gelatin allergy
High dose steroid users
Chemotherapy
57. Rabies
• It is a killed inactivated vaccine used to control Rabies.
• Dose: 3 doses of 1ml each.
1st dose: Stat
2nd dose: 7 days after dose 1
3rd dose: 21-28 days after dose 1
• R.O.A: I/M
• Efficacy: 97%
• S.E:
Inflammatory Reaction
Abdominal and joint pain
GBS
59. HEPATITIS A VACCINE
• Inactivated Hep A
• Doses: At 1 year and 2nd dose 6 months after 1st dose
• Doses are 720 ELU 1 -18 year of age
• And 1440 ELU 19 years and older
• For post exposure prophylaxis(contact with near and
dear ones)
• IG(0.02ml/kg) given within 2 weeks after exposure and
is effective upto 85% in preventing Hep-A upto 3
months
Available as Twinrix (Hep A+Hep B) for age 18 years
and above
60.
61.
62.
63. References
• Nelsons Essential
• Merck Manuals
• Pakistan Pediatrics Association
• WHO
• CDC
• Advisory Committee on Immunization
Practices (ACIP)
Editor's Notes
Koch's phenomenon is well known as an adverse skin reaction that appears within a few days at the BCG vaccination site if the vaccination is given to a person infected with tuberculosis.
Vaccine-derived polioviruses (VDPVs) are rare strains of poliovirus that have genetically mutated from the strain contained in the oral polio vaccine
Overall risk for VAPP =1:2.4 million doses
Contact immunity is the property of some vaccines, where a vaccinated individual can confer immunity upon unimmunized individuals throughcontact with bodily fluids or excrement