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OUTBREAK – MANAGEMENT
DR.M.JANE ESTHER
II YR MD(Micro) POST GRADUATE
CMCHRC, Trichy
Tamilnadu
Contents
• Definition of an outbreak
• History of worst outbreaks
• Investigations
• Management
• Institutional outbreak
OUTBREAK - DEFINITION
• The occurrence in a community or region
of cases of an illness with a frequency
clearly in excess of normal expectancy.
Worst outbreaks - history
• Ebola – 2014-2015
Plague – black death
400 BC
Small pox – 1492 to 1900
Yellow fever epidemic
• 1793
Cholera pandemic
• 1817-1823
Influenza
• 1918
Typhus
• 1918-1922
Malaria
• 2800 children – die each day
AIDS
• From 1981
INVESTIGATIONS
• Regardless of the communicable disease, the
procedure for the investigation of a
suspected outbreak is the same
• 10 Steps
1.Establish the existence of an outbreak
• Compare current information with previous
incidence in the community during the same
time of year to determine if the observed
number of cases exceeds the expected.
• Compare available information about new
cases with a predetermined definition of an
outbreak.
1.Establish the existence of an outbreak
• Public health surveillance.
• Gather reports of illnessess
• Doctors and microbiologists – notify
• Public health officials – look at reports
• Astute clinician
• Specimens collected – organism identified
• Serotyping / DNA fingerprinting/ PFGE
2.Confirm the diagnosis
• Analyze clinical histories of cases
• Have standard laboratory tests performed to confirm or
reject the suspected diagnosis
• To determinethe type of agent associated with the illness
(e.g.,bacterial, viral, other).
3.Establish the case definition and count
cases
Case definition
• Features of the illness
• The pathogen or toxin, if known
• Certain typical symptoms
• Time range
• Geographic range,
Case count
• The number of cases that meet the case
definition is called the case count.
4.Relate the outbreak to time, place and
person
• Characterize the outbreak
according to person, place or time
by interviewing known or selected
cases
• When they became ill (time)
• Where they became infected
(place)
• Who they are (person).
5.Formulate a tentative hypothesis
To explain the most likely
• Cause
• Source – Mode of transmission
• Distribution – Location, age
• Example : Food borne illness 
what they ate? Where ? – before
they became ill
• Time after intake
• Challenge : Memory
6.Testing the hypothesis
• Analytical studies – compare ill with healthy
• H/O sickness – particular food – association
• Frequencies of exposure to a specific food
item
• Strength of the statistical association
• The food’s production, preparation and service
• The food’s distribution
Testing a hypothesis
• Food studies (in food borne outbreak)
• Finding bacteria with the same DNA fingerprint in an
unopened package of food and in the stool samples of
people in the outbreak can be convincing evidence of a
source of illness
7.Finding the Point of Contamination
• Environmental assessment
• Who cooked?
• Ingredients
• Steps followed
• Temperature
• Health status of workers
8.Epidemiologic investigations & Report
writing
• Summarize and interpret all of the
information that has been
collected
• Examine the results of laboratory
tests that have been conducted.
• Construct epidemic curves, tables
and charts.
• On the basis of the available data
and the appropriate calculations-
accept or reject the hypothesis.
9.Controlling an Outbreak
• Once the source of illness is found – control
measures
• Isolating the source (patient)
• Discarding the food
• Temporary closure of restaurant
• Disinfection of the room/ ward
• Inform public
10.Deciding an Outbreak is Over
• An outbreak ends when the number
of new illnesses reported drops back
to the number normally expected.
• The epidemic curve helps
investigators see that illnesses are
declining.
• Public health officials - continue
surveillance for a few weeks
• Continue or restart
their investigation – if cases start
occuring again
Practical Considerations
• Regional Health Authority (RHA)- routine surveillance –
early identification of outbreaks
• A plan for the investigation of outbreaks
• Each RHA- establish direct contact with Laboratory
• A line-listing of cases and contacts – should be maintained
electronically
• Outbreaks be reported to the Director of Communicable
Disease Control
Management of Outbreaks in Institutions
• Each facility should have a plan in place for routine
surveillance and for outbreak investigation – RHA
should be aware of it
• Team approach by the facility staff and Regional
Health Authority (usually the Medical Officer of
Health or delegate)
• Provincial Infection Control Nurse should be informed
of and involved in the outbreak investigation.
• It may be difficult to recognize an outbreak in a health-
care facility
• The Regional Health Authority - should establish
circumstances under which they are to be notified.
• Those where public health intervention or expertise may
be required (e.g., foodborne illness, influenza).
• Food-borne outbreaks  potential to spread
• Early consultation with a public health inspector/
Provincial Infection Control Nurse responsible for
communicable diseases is strongly recommended
summary
• Definition
• Recent and remote outbreaks
• 10 steps of management
• Investigations to be carried out
• Management of institutional
outbreaks
References
• Epidemiological investigation of an outbreak –
communicable disease management protocol
manual
• Outbreak management – CDC guidelines
Outbreak – management

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Outbreak – management

  • 1. OUTBREAK – MANAGEMENT DR.M.JANE ESTHER II YR MD(Micro) POST GRADUATE CMCHRC, Trichy Tamilnadu
  • 2. Contents • Definition of an outbreak • History of worst outbreaks • Investigations • Management • Institutional outbreak
  • 3. OUTBREAK - DEFINITION • The occurrence in a community or region of cases of an illness with a frequency clearly in excess of normal expectancy.
  • 4. Worst outbreaks - history • Ebola – 2014-2015
  • 5. Plague – black death 400 BC
  • 6. Small pox – 1492 to 1900
  • 11. Malaria • 2800 children – die each day
  • 13. INVESTIGATIONS • Regardless of the communicable disease, the procedure for the investigation of a suspected outbreak is the same • 10 Steps
  • 14.
  • 15. 1.Establish the existence of an outbreak • Compare current information with previous incidence in the community during the same time of year to determine if the observed number of cases exceeds the expected. • Compare available information about new cases with a predetermined definition of an outbreak.
  • 16. 1.Establish the existence of an outbreak • Public health surveillance. • Gather reports of illnessess • Doctors and microbiologists – notify • Public health officials – look at reports • Astute clinician • Specimens collected – organism identified • Serotyping / DNA fingerprinting/ PFGE
  • 17. 2.Confirm the diagnosis • Analyze clinical histories of cases • Have standard laboratory tests performed to confirm or reject the suspected diagnosis • To determinethe type of agent associated with the illness (e.g.,bacterial, viral, other).
  • 18. 3.Establish the case definition and count cases Case definition • Features of the illness • The pathogen or toxin, if known • Certain typical symptoms • Time range • Geographic range,
  • 19. Case count • The number of cases that meet the case definition is called the case count.
  • 20. 4.Relate the outbreak to time, place and person • Characterize the outbreak according to person, place or time by interviewing known or selected cases • When they became ill (time) • Where they became infected (place) • Who they are (person).
  • 21. 5.Formulate a tentative hypothesis To explain the most likely • Cause • Source – Mode of transmission • Distribution – Location, age • Example : Food borne illness  what they ate? Where ? – before they became ill • Time after intake • Challenge : Memory
  • 22. 6.Testing the hypothesis • Analytical studies – compare ill with healthy • H/O sickness – particular food – association • Frequencies of exposure to a specific food item • Strength of the statistical association • The food’s production, preparation and service • The food’s distribution
  • 23. Testing a hypothesis • Food studies (in food borne outbreak) • Finding bacteria with the same DNA fingerprint in an unopened package of food and in the stool samples of people in the outbreak can be convincing evidence of a source of illness
  • 24. 7.Finding the Point of Contamination • Environmental assessment • Who cooked? • Ingredients • Steps followed • Temperature • Health status of workers
  • 25. 8.Epidemiologic investigations & Report writing • Summarize and interpret all of the information that has been collected • Examine the results of laboratory tests that have been conducted. • Construct epidemic curves, tables and charts. • On the basis of the available data and the appropriate calculations- accept or reject the hypothesis.
  • 26. 9.Controlling an Outbreak • Once the source of illness is found – control measures • Isolating the source (patient) • Discarding the food • Temporary closure of restaurant • Disinfection of the room/ ward • Inform public
  • 27. 10.Deciding an Outbreak is Over • An outbreak ends when the number of new illnesses reported drops back to the number normally expected. • The epidemic curve helps investigators see that illnesses are declining. • Public health officials - continue surveillance for a few weeks • Continue or restart their investigation – if cases start occuring again
  • 28.
  • 29. Practical Considerations • Regional Health Authority (RHA)- routine surveillance – early identification of outbreaks • A plan for the investigation of outbreaks • Each RHA- establish direct contact with Laboratory • A line-listing of cases and contacts – should be maintained electronically • Outbreaks be reported to the Director of Communicable Disease Control
  • 30. Management of Outbreaks in Institutions • Each facility should have a plan in place for routine surveillance and for outbreak investigation – RHA should be aware of it • Team approach by the facility staff and Regional Health Authority (usually the Medical Officer of Health or delegate) • Provincial Infection Control Nurse should be informed of and involved in the outbreak investigation.
  • 31. • It may be difficult to recognize an outbreak in a health- care facility • The Regional Health Authority - should establish circumstances under which they are to be notified. • Those where public health intervention or expertise may be required (e.g., foodborne illness, influenza).
  • 32. • Food-borne outbreaks  potential to spread • Early consultation with a public health inspector/ Provincial Infection Control Nurse responsible for communicable diseases is strongly recommended
  • 33. summary • Definition • Recent and remote outbreaks • 10 steps of management • Investigations to be carried out • Management of institutional outbreaks
  • 34. References • Epidemiological investigation of an outbreak – communicable disease management protocol manual • Outbreak management – CDC guidelines