Osteosarcoma is a malignant bone tumor that produces bone or osteoid. It most commonly occurs in the long bones of adolescents and young adults. The tumor arises from mesenchymal stem cells and develops most often in areas of rapid bone growth. Histologically, osteosarcoma is defined by the presence of malignant osteoid produced by the tumor cells. There are several subtypes including conventional, telangiectatic, small cell and epithelioid osteosarcoma, which can be difficult to diagnose. Prognosis depends on tumor grade and response to chemotherapy.
Presentation on bone tumors for undergraduate 2nd year MBBS medical students. The information for this presentation has been taken from texbook of Robbins & Cotran Pathologic Basis of Disease 8th ed.
In this presentation, radiological characteristics of different bone tumors has been explained in detail including MRI, CT scan, Bone scan, and plain radiography.
Malignant Bone Tumours - A lecture for undergraduate students and demonstrators / Tutors featuring general aspects and three common malignant bone tumours viz. Osteosarcoma, Ewing's Sarcoma and Multiple Myeloma
Presentation on bone tumors for undergraduate 2nd year MBBS medical students. The information for this presentation has been taken from texbook of Robbins & Cotran Pathologic Basis of Disease 8th ed.
In this presentation, radiological characteristics of different bone tumors has been explained in detail including MRI, CT scan, Bone scan, and plain radiography.
Malignant Bone Tumours - A lecture for undergraduate students and demonstrators / Tutors featuring general aspects and three common malignant bone tumours viz. Osteosarcoma, Ewing's Sarcoma and Multiple Myeloma
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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The prostate is an exocrine gland of the male mammalian reproductive system
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Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. DEFINITION
It is a malignant mesenchymal tumor in which the tumor cells
produce bone matrix or osteoid.
3. OSTEOSARCOMA
It is m/c non-hematologic primary malignancy of bone
the second most common primary malignancy of bone behind multiple
myeloma
m/c radiation associated sarcoma
Lungs are m/c site of metastases in OS
.
4. EPIDEMIOLOGY
incidence is 2 cases per million persons per year
peak incidence is in 2nd – 3rd decades.
It is more frequent in tall people than in short people.
Bones having the fastest rates of growth have the highest frequency of occurrence
Slightly more common in males
5. Associated syndromes
o Hereditary form of retinoblastoma
o Li-Fraumeni syndrome (p53)
o Rothmund-Thomson syndrome (8q24)
o Beckman-Wiederman syndrome
o Paget disease or fibrous dysplasia
5
7. Arise from multipotent mesenchymal cells
usually in the medullary cavity of the metaphysis of a growing long tubular bone,
it may also arise on the surface of a bone, or from an extra-skeletal site.
the majority of medullary origin are high grade, whereas surfaces OS are of lower
grade.
Origin
8. PATHOGENESIS
The tumor arise in the metaphysis where
the growth is more active.
The tumor originate beneath the
periosteum
After originating tumor may extend in
two directions
1 towards medulla or 2. towards sub-
periosteal area
9. This triangular area is known as codmans triangle.
In the medulla the bone trabeculae are destroyed
Tumor appear as irregular mass permeating
along medullary canal
At first the periosteum offers impenetrable barrier
and is only raised off the bone.
On diaphyseal side of tumor the periosteum is
often stripped for a short distance
There may be deposition of layers of new bone
parallel to shaft
10. GROSS PATHOLOGY
OS are bulky tumors that are gritty,
grayish-white in color
areas of hemorrhage and cystic
denegation
Destruction of cortex
spread in medullary canal, infiltrating and
replacing marrow
Rarely , they penetrate epiphyseal plate
or enter the joint
There is Reactive periosteal new bone
formation
10
12. MICROSCOPICALLY
High grade spindle cell tumor that
produces osteoid matrix unconnected
by cartilage
Tumor cells produce neoplastic bone -
basophilic thin trabeculae resembling
fungal hyphae or
neoplastic osteoid - eosinophilic,
homogenous, glassy with irregular
contours and osteoblastic rimming
Vascular invasion and areas of necrosis
common
13. MICROSCOPICALLY
May have osteoblastic, fibroblastic or
chondroblastic predominance
Osteoid in variable amount
stroma contain bizarre giant cells or acellular
Tumor cells may be spindle, oval or round of
variable size
25% of os have osteoclast-like multinucleated
giant cells
Cartilage may be mineralized, immature, myxoid
14. TYPES OF OSTEOSARCOMA
1. Central
a. High-grade
Conventional
Telangiectatic
Small cell
Epithelioid
Osteoblastoma-like
Chondroblastoma-like
Fibrohistiocytic
Giant cell–rich
b. Low-grade
Low-grade central
Fibrous dysplasia–like
2. Surface
a. Low-grade
Parosteal
b. Intermediate-grade
Periosteal
c. High-grade
Dedifferentiated parosteal
High-grade surface
3. Intracortical
4. Gnathic
5. Extraskeletal
High-grade
Low-grade
15. CONVENTIONAL OSTEOSARCOMA
The tumor cells vary from spindle to
polyhedral;
their nuclei are pleomorphic and
hyperchromatic.
Mitotic figures are easily demonstrable.
extracellular matrix that may be osseous,
cartilaginous, or fibrous in various proportions.
The production of bone directly by tumor
cells at least somewhere in the tumor is the
absolute requirement for diagnosis
high-grade tumors and need chemotherapy
abundant production of osteoid and bone matrix
in a lacy pattern into which the malignant cells
are incorporated.
16. TELANGIECTATIC OSTEOSARCOMA
It resembles aneurysmal bone cyst
radiographically and histologically.
there is asymmetric expansion of the
involved bone with radiolucent bone
destruction
but in ABC, a thin shell of periosteal
neocortex IS not seen.
17. telangiectatic OS ABC
an enhancing thin peripheral rim and septa without nodularity
or osteoid matrix mineralization.
the growth is less aggressive, with expansile well-defined
encapsulated margin,
asymmetric expansion, geographic lysis of bone,
and an aggressive growth pattern with cortical
destruction and minimal peripheral sclerosis
and infiltrative margins
18. An eccentric radiolucent destructive lesion.
Curetting was done & histopathology showed features of ABC. but
One month later, the patient returned with pain and increasing size of mass with destruction and expansion
of the entire metaphyseal region of the right humerus.
Retrospectively, first radiograph showed a medial interrupted periosteal reaction
19. At low power, telangiectatic os is
composed of multiple blood-filled
sinusoids with little solid like aneurysmal
bone cyst,
At higher power, there is nuclear
pleomorphism and a high mitotic rate.
there is local destruction with permeation
to adjacent marrow
highly atypical cells lining the septa in a
telangiectatic osteosarcoma not seen in ABC
presence of several benign giant cells in the
septa can be mistaken for giant cell tumor.
20. SMALL CELL OSTEOSARCOMA
a rare histologic variant of osteosarcoma with histologic features
combining those of osteosarcoma and Ewing sarcoma.
It constitutes 1% and 2% of all osteosarcomas.
The radiologic features are not typical
21. permeative lytic bone destruction , a soft-tissue mass, and
periosteal reaction
sometimes with pathological fracture
22. Histologically, it may be mistaken for Ewing
sarcoma/primitive neuroectodermal tumor
(PNET) because its cells are small and have
round, hyperchromatic nuclei with very little
nuclear pleomorphism.
the production of osteoid by tumor cells is not a
feature of Ewing sarcoma,
The tumor above the bone trabecula is composed of small cells dominated by round, blue
nuclei suggestive of Ewing sarcoma/primitive neuroectodermal tumor.
The tumor below the trabecula demonstrates that the tumor cells are separated by pink
osteoid matrix
23. AT HIGHER MAGNIFICATION
the tumor cells above the trabecula are
indistinguishable from Ewing sarcoma
the tumor cells below the trabecula are
clearly producing osteoid matrix
24. EPITHELIOID OSTEOSARCOMA
an osteosarcoma in which the tumor cells are so poorly differentiated
that it is difficult to determine histologically whether the tumor is a
sarcoma or a carcinoma.
25. The tumor cells often are round or
polyhedral rather than spindle-
shaped.
Their round or ovoid enlarged nuclei
may contain 1 or more prominent
nucleoli,
The cells may demonstrate gland-like
structures or even contain cells
arranged in papillary configurations
clusters of polyhedral cells aggregated about
central cores resembling papillary structures;
some of these contain osteoid rather than
vessels.
26. Higher magnification -- epithelioid round cells loosely disposed
among a few wisps of osteoid
27. If tumors like these are seen in young patients, osteosarcoma
should be considered.
In older patients, the diagnosis of a poorly differentiated
metastatic carcinoma is more likely.
28. OSTEOBLASTOMA-LIKE AND
CHONDROBLASTOMA-LIKE OSTEOSARCOMA
Osteoblastoma-like osteosarcoma
produces the same sort of microtrabecular
bone lined by osteoblasts as does
osteoblastoma.
The radiographic appearance often
suggests a malignant.
a well-circumscribed tumor.
29. parameters for malignancy include
permeation of normal bone at its
interface with tumor and aneuploid
mitotic activity are seen in os
whereas benign osteoblastic tumors
shows maturation and circumscription at
their edges.
Microtrabecular osteoid lined by osteoblast-
like cells as seen in osteoblastomas
30. Chondroblastoma-like osteosarcoma may be epiphyseal.
When it is epiphyseal and well circumscribed, it is a very difficult diagnosis to make because
radiologic studies suggest a benign diagnosis.
In these cases, the diagnosis must be made histologically
radiographs demonstrate a well circumscribed radiolucency centered in the distal end of femur,
CT- Showed that the lesion is confined to the bone
31. This type of osteosarcoma is best distinguished by its osteoid or bone formation, atypical mitotic activity, and infiltration of
adjacent inter-trabecular spaces
1. a monotonous lesion composed of uniform cells with demarcated cytoplasmic borders and with bean-shaped, ovoid nuclei
and fine, lattice-like calcifications in a chondroid background
2. more thorough sampling revealed foci of typical lace-like osteoid infiltrating cancellous bone at the periphery, diagnostic of
osteosarcoma.
32. GIANT CELL–RICH OSTEOSARCOMA
About 25% of osteosarcomas contain
benign multinucleated giant cells.
Rarely, an osteosarcoma may contain so
many benign giant cells that the
malignant elements in the background
are obscured; and the lesion may be
mistaken for a giant cell tumor.
This is more apt to occur in the sacrum,
where giant cell tumor is much more
common
radiographs reveal a locally destructive tumor extending from
the metaphysis to the articular end of the bone.
There is internal circumscription and no periosteal reaction.
33. 1 3
2
2. nuclear atypia and atypical mitotic
activity are clearly shown ,
1. a giant cell rich lesion with
mononuclear background;
3. Individually malignant mononuclear
cells and even polyploid giant cells within
a collagenized matrix focally having the
properties of osteoid
34. the usual giant cell tumor tends to arise in skeletally mature
people and extends from the metaphyseal side of the growth
plate to the ends of the long bones.
In the absence of a fracture, a periosteal reaction also is
uncommon in an uncomplicated giant cell tumor.
A tumor that appears to be a giant cell tumor histologically but
arises in a skeletally immature person, should be regarded with
great suspicion and sampled widely to rule out osteosarcoma.
Specially if it is accompanied by a visible periosteal reaction.
35. GNATHIC OSTEOSARCOMA
Osteosarcomas of the mandible and
maxilla
usually manifest with swelling or pain.
Radiographically, they often are
radiolucent or a mixture of radiolucent
and radiodense areas.
36. often are high-grade tumors
histologically,
they give rise to uncontrolled local
disease,
small minority of patients develope
distant metastatic disease
Histologic sections demonstrate a mostly
cartilaginous, highly cellular tumor that contains
foci of immature osteoid production.
37. Low-Grade Central
Osteosarcoma
unusual variant of osteosarcoma
Its microtrabecular osseous matrix
architecture in a bland fibrous stroma
bears some resemblance to fibrous
dysplasia and other benign lesions.
but
atypical mitotic activity may lead
to the correct diagnosis.
1.The majority shows immature, poorly formed, woven trabeculae
without appositional osteoblastic activity in a modestly cellular
fibrous as in fibrous dysplasia but
2. nuclei at higher magnification revealed mitotic activity and
atypical mitoses
38. The imaging features suggests a lesion of
greater local aggressiveness than fibrous
dysplasia or other benign lesions.
These features include indistinct
circumscription, dense sclerosis, an
interrupted periosteal reaction, or
cortical infraction.
Although patients usually are treated
with surgery alone and their prognosis is
significantly better than in conventional
OS
radiographs demonstrate a mottled,
circumscribed lesion that resembles fibrous
dysplasia except for the very focal area of cortical
erosion of the lateral femoral metadiaphysis
39. Surface Osteosarcomas
these are osteosarcomas whose
epicenters are outside the cortex of the
underlying bone.
They usually arise in relation to the
periosteum or the cortex of the bone with
minimal or no involvement of the
medullary cavity.
usually arises in the third and fourth
decade.
The majority are low-grade neoplasms
with a propensity for local recurrence and
very limited capacity for distant
metastasis.
approximately 10% of surface
osteosarcomas are high-grade tumors.
40. Parosteal Osteosarcoma
This lesion is often confused with
osteochondroma and osteoma
3rd -4th decade
It has a unique presentation and anatomic
distribution
75% to 80% of cases arise as densely
radiopaque masses attached to the distal
posterior femur.
Clinically may give rise to a sensation of
fullness, prevent complete range of flexion,
and perceived as a mass through the
overlying soft tissues,
it is unusual for the entity to be spontaneously
painful.
41. Its radiodensity often is not uniform, often being
more radiodense centrally and less dense at its
periphery.
In contrast with osteochondroma, there is no usual
continuity with the adjacent cortex, and its inside is
not in continuity with the underlying medullary
cavity
In localized heterotopic ossification (so-called
myositis ossificans ) the ossification pattern is exactly
the opposite radiographically, with the densest
bone being outside and the least dense being
inside.
In parosteal osteosarcoma, there is an incomplete
radiolucent line separating most of the sclerotic
mass from the underlying cortex,
this radiolucent line corresponds to the underling
periosteum, to which the mass usually is fixed at one
point on the outside.
An underlying periosteal reaction is very unusual
because to produce such a reaction, the tumor
would have to lift the inner cambium layer of the
periosteum away from the cortex.
Parosteal osteosarcoma usually is not locally
aggressive enough to do this.
sclerotic mass, partially ill-defined posteriorly to the
distal femur
42. Histologically, parosteal osteosarcomas
consist of streamers of bone
trabeculae that often show a high
degree of parallel orientation similar to
that observed in a periosteal new bone
reaction.
There is histologic resemblance of this
bone formation to “flowing steel wool.”
There is a cellular cartilage cap
external to the osseous portion of the
lesion in about 25% to 30% of cases.
flowing steel wool appearance
cartilage cap
43. The histologic key to the correct
diagnosis is that a growing
osteochondroma has the same internal
development as a growing bone.
There is a medullary cavity with fat or
hematopoietic marrow in the
intertrabecular spaces of normal bone
and osteochondroma, whereas the
intertrabecular spaces of parosteal
osteosarcomas contain cellular fibrous
tissue.
The majority of parosteal osteosarcomas
are associated with the outer fibrous
layer of the periosteum, which does not
produce typical periosteal reactions.
Although the fibrous tissue between the bone spicules is
bland, there is no marrow evident.
A careful search in the fibrous component sometimes
reveals focal hypercellularity and early immature bone
formation
44. Periosteal Osteosarcoma
Although the lesion is associated with the bone
surface, it arises between the cortex and the
cambium layer of the periosteum, so that there
often is a periosteal reaction visible
radiographically.
There is underlying cortical thickening or
erosion
it usually occurs along the tibial or femoral
diaphysis rather than posterior to the
metaphysis of the distal femur.
Its histologic grade is intermediate
rarely it may extend into the underlying cortex,
but never is extend into the underlying
endosteum
45. Dedifferentiated Parosteal Osteosarcoma
histologically high-grade
arising in the clinical setting of
recurrent parosteal osteosarcoma of
the usual low-grade variety.
the dedifferentiation took place over
time in recurrences of well-
documented tumors that previously
were diagnosed as typical low-grade
parosteal osteosarcomas.
cloudy, radiodense tumor matrix in the soft tissues.
the portion of lateral femoral condyle that does not overlap
the patella and the upper medial metaphysis are markedly
radiolucent compared with the bone of the metadiaphysis
46. Histologically, the tissue is composed of an admixture of typical
appearing low-grade parosteal osteosarcoma and high-grade
conventional parosteal osteosarcoma
The is worse than that of low-grade parosteal osteosarcoma but
somewhat better than that of pure high-grade surface
47. HIGH-GRADE SURFACE
OSTEOSARCOMA
It manifests as a surface lesion of
bone, but is high grade histologically.
It may appear radiographically as
an ordinary low-grade parosteal
osteosarcoma with dense sclerosis.
its local growth and aggressiveness
are more accelerated.
patients with this disease have more
distressing symptoms and signs than
those with low-grade parosteal
osteosarcomas.
the underlying tibia shows no
gross invasion by the tumor
48. Microscopically, the tumor is entirely
high grade.
There usually is very little or no
medullary invasion by the tumor on
xrays.
a high-grade neoplasm producing wispy
osteoid
A computed tomography scan shows separation of the
mass from the underlying bone by a dark periosteal line.
49. Intracortical Osteosarcoma
very rare anatomic variant of
osteosarcoma,
a high-grade osteosarcoma entirely
confined within the bony cortex.
manifests as an area of cortical
radiolucency with peri-lesional sclerosis.
Depending on its size, it may be
confused with osteoid osteoma and
osteoblastoma, but it has cellular atypia
and is locally aggressive
Histologically, there is abundant osteoid
of bone formation.
50. MULTIFOCAL OSTEOSARCOMA
This extremely unusual condition affects multiple osseous sites
simultaneously at the time of presentation (synchronous form) or
multiple skeletal sites at varying intervals (metachronous type) .
The former variant tends to affect children and adolescents,
whereas the latter type occurs in adults.
The childhood synchronous form is radiodense, usually symmetric,
and a high-grade sarcoma with a rapidly fatal course.
In the adult metachronous form, after the appearance of the first
osteosarcoma, there is a disease-free interval of several months to
years followed by the development of one or several skeletal
osteosarcomas.
These lesions are not symmetric, they may have variable degrees of
sclerosis, and their histologic features may vary from high to low
grade.
The metachronous form have a longer survival interval than children
with the synchronous form
Synchronous Multifocal
Osteosarcoma
51. EXTRA-SKELETAL OSTEOSARCOMA
These accounts for less than 2% of all
soft tissue sarcomas.
it tends to occur in late adulthood,
the fifth to seventh decades of life
Most cases arise in the deep soft tissues
with a predilection for the thigh
followed by the buttocks, upper
extremities, and the retroperitoneum.
52. Patients usually have an enlarging soft tissue mass, and the mass
may be painful
Radiographs show a mass with mineralization
Histologically, the tumors demonstrate all types of osteosarcoma
seen in bone tumors.
The prognosis is poor in soft tissue osteosarcoma of the high-
grade type.
patients with the low-grade variant seem to have a better
prognosis
53. SKELETAL DISTRIBUTION
Distal femur
Proximal tibia
Proximal humerus
(sites of rapid bone growth)
others
Metaphyseal(89%)>diaphyseal(10%)>epiphyseal(1%)
53
54. CLINICAL PRESENTATION
m/c symptom -pain for several weeks or
months.
The most common sign is a mass of variable
consistency( soft to hard) and tender.
There may be superficial erythema, venous
distension, or other signs of hyper-vascularity.
55. There may be a limp, loss of function, or even
decreased range of motion
Fever, malaise or other constitutional symptoms are
not typical of osteosarcoma
56. COURSE
Metastasis occur early by hematogenous rout
Progressive pulmonary metastasis develop very early
Process is usually fatal within 2 years
57. X- RAY
Variable portions of radiopacities and
radiolucencies,
medullary and cortical bone destruction
wide zone of transition, permeative or
moth-eaten appearance
aggressive periosteal reaction
sunburst type
Codman triangle
lamellated (onion skin) reaction: less
frequently seen
soft-tissue mass
tumour matrix ossification/calcification
58. The cambium layer of the inner
periosteum reacts to separation from the
cortex by producing new bone, which is
sometimes visible as an incomplete bony
shell that appears attached to the bone
surface on only one end and is open in
the middle, so-called Codman angle.
Although periosteal new bone formation
sometimes is associated with benign
conditions, periosteal reactions
associated with malignant tumors usually
are discontinuous, implying that the
tumor growth is too rapid for periosteal
containment.
59. Lesions are usually permeative
Associated with destruction of the cancellous and
cortical elements of the bone
Ossification within the soft tissue component, if
tumour has broken through cortex
Borders are ill defined
Plain X-ray
59
60. PLAIN X-RAY
Periosteal reaction may appear as the
characteristic Codman triangle.
Extension of the tumor through the periosteum may
result in a so-called “sunburst” or “hair on end”
appearance.
61. QUESTION
A completely radiolucent area with
sclerotic, fairly circumscribed upper
border, mimicking a benign lesion.
but the lateral tibial border shows
that the cortex is interrupted and
there is a small interrupted
periosteal reaction
65. CT
Not of much use
CECT chest to detect lung metastasis
65
66. ANGIOGRAM • Determine vascularity of the tumour
• Detect vascular displacement
• Relationship of vessels to the tumour
66
67. BONE SCAN
A bone scan should be obtained
to look for skeletal metastases
or multi focal disease
Thallium scan –
Monitor effects of chemotherapy
Detect local recurrence of tumor
67
68. BIOPSY
to conform the diagnosis.
Types
Fine needle aspiration
Core needle biopsy
Open incisional biopsy
68
69. ENNEKING STAGING SYSTEM
The staging system is typically depicted as follows
Stage I: Low grade tumors
I-A intra compartmental
I-B extra compartmental
Stage II: High grade tumors
II-A intra compartmental
II-B extra compartmental
Stage III: Any tumors with evidence of
metastasis 69
70. ? HOW WE DEFINE AN ANATOMICAL COMPARTMENT
Anatomical compartment are determined by natural anatomical barriers
to tumor growth, such as cortical bone, articular cartilage, fascial septa, or
joint capsule.
Stage 1B and 2B lesions extend beyond the compartment of origin.
73. PROGNOSTIC FACTORS
Extent of the disease
Pts with pulmonary, non pulmonry (bone) or skip metastasis
have poor prognosis
Grade of the tumor
High grade tumor have poor prognosis
Size of the primary lesion
Large size tumors have worse prognosis then small size tumors
Skeletal location
proximal tumors do worse than distal tumors.
Secondary osteosarcoma: Poor prognosis
73
74. TREATMENT
Current standard of care
Radiological staging
Biopsy to confirm diagnosis
Preoperative chemotherapy
Repeat radiological staging (access chemo response,
finalize surgical treatment plan)
Surgical resection with wide margin
Reconstruction using one of many
techniques
Post op chemo based on preop response
74
75. CHEMOTHERAPY
Chemotherapy given preoperatively -Neoadjuvant
Given postoperatively - Adjuvant
Advantages of neoadjuvant chemotherapy -
regression of the primary tumor, making a successful limb
salvage operation easier.
may decrease the spread of tumor cells at the time of
surgery
Effectively treating micrometastases at the earliest time
possible.
It avoid tumor progression, which may occur during any
delay before surgery.
Given for about 3-4 weeks before definitive procedure
75
76. CHEMOTHERAPY
The drugs used most often to treat
osteosarcoma are:
Methotrexate with leucovorin (folinic
acid)
Doxorubicin (Adriamycin)
Cisplatin or carboplatin
Etoposide
Ifosfamide
Cyclophosphamide
Actinomycin D (dactinomycin)
Bleomycin
76
77. SURGERY
The main goal of surgery is to safely and
completely remove the tumor.
Historically – amputation.
Over the past few years - limb-sparing
procedures have become the standard,
mainly due to advances in chemotherapy
and sophisticated imaging techniques
Limb salvage procedures now can provide
rates of local control and long-term survival
equal to amputation. 77
78. SURGERY CHOICE
Surgical procedures fall into three basic
categories:
Amputation
Limb salvage
78
Rotationplasy
79. DECISION ???
If the tumor can be removed safely while
retaining a viable extremity, a limb sparing
procedure may be appropriate.
If major nerves or blood vessels are involved,
or if complete tumor removal results in
significant loss of function, amputation may be
a better choice.
Patient’s age, desired level of function,
cosmetic preference and long-term prognosis
must also be considered.
79
80. AMPUTATION
Amputation involves removal of the limb with
a safe margin between the end of the
retained portion and the tumor
It should not be viewed as a failure of
treatment, but rather as the first step towards
patient’s return to a more comfortable and
productive life.
80
81. AMPUTATION
Indication
1. Grossly displaced pathologic fracture
2. Encasement of neurovascular bundle
3. Tumor that enlarges during preop chemo and is
adjacent to neurovascular bundle
4. Palliative measure in metastatic disease
5. If the tumor has caused massive necrosis,
fungation, infection, or vascular compromise.
81
82. LIMB SALVAGE SURGERY
Removing the tumor with a normal cuff
of tissue surrounding it while preserving
vascular and nerve supply to the
extremity.
82
83. The skeletal defect must be reconstructed by
Endoprosthesis (most common) –
replacing the removed bone with a metal
implant
Allograft (cadaveric) bone
Vascularized bone acquired from the
patient
Allograft-prosthetic composite constructions
83
84. ROTATIONPLASTY
compromise between amputation and limb
salvage
most commonly used for osteosarcomas of
the distal femur in skeletally immature
patients
It is a procedure where the neurovascular
structures and distal aspect of the limb (leg)
are retained, and re-attached to the
proximal portion after the tumor has been
removed.
84
85. FOR FUNCTIONAL PURPOSES, THE DISTAL SEGMENT IS TURNED 180
DEGREES SO THAT THE ANKLE JOINT FUNCTIONS AS A KNEE JOINT,
THUS CONVERTING AN ABOVE-KNEE TO A BELOW-KNEE
AMPUTATION IN ORDER FOR PROSTHETIC USE TO BE MAXIMIZED
85
86. RADIOTHERAPY
Radiation therapy has no major role in
osteosarcoma
Radiation therapy may be useful in some cases
where the tumor cannot be completely removed
by surgery. E.g. in pelvic bones or in the bones of
the face.
Megavoltage (upto 6000-8000 rads)
86
87. FOLLOW UP AND PROGNOSIS
Signs of recurrence, metastasis and
treatment related complications
Physical examination,radiographs of the
primary site, serial chest imaging,bone scans
and laboratory examinations
50 % cases with high grade osteosarcoma
have some type of relapse in 5 months
If recurrence is detected, additional surgery
(radical amputation)and chemotherapy
may be warranted.
5 year survival rate is 5% - 23% 87
88. IN SUMMARY
OS occurs in metaphysis of long bones, slightly more common in males.
Xrays are must in any pt of 2nd decade complaining of bony pain
Carefully look for periosteal reaction on xray
Always get histopathological examination from an expert pathologist
CECT can help to detect early metastasis
Prognosis is poor
Treated with combination of chemotherapy and surgery.