groin injuries are common but neglected in orthopaedics and sports injuries field as region is an enigma as too mant structures are present in a small space. the present PPT describes approach and management of groin injuries
groin injuries are common but neglected in orthopaedics and sports injuries field as region is an enigma as too mant structures are present in a small space. the present PPT describes approach and management of groin injuries
Gout is a metabolic disorder manifesting in primary or secondary forms characterized by hyperuricemia & joint lesions .
A metabolic disease characterized by recurrent attack of acute inflammatory arthritis caused by elevated levels of uric acid in the blood (hyperuricemia).
Gout: Very painful form of arthritis characterized by the formation of uric acid crystals and severe inflammation.
Gout is a metabolic disorder of purine metabolism, characterized by intermittent attacks of acute pain, swelling and inflammation. • It always preceded by hyperuricemia
This is the presentation which was delivered to third year Bachelor of Physiotherapy students at Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal. Different schools of thoughts in manual therapy are the part of curriculum for the undergraduate students at KUSMS.
Exercise tolerance testing (also known as exercise testing or exercise stress testing) is used routinely in evaluating patients who present with chest pain, in patients who have chest pain on exertion, and in patients with known ischaemic heart disease.
Gout is a metabolic disorder manifesting in primary or secondary forms characterized by hyperuricemia & joint lesions .
A metabolic disease characterized by recurrent attack of acute inflammatory arthritis caused by elevated levels of uric acid in the blood (hyperuricemia).
Gout: Very painful form of arthritis characterized by the formation of uric acid crystals and severe inflammation.
Gout is a metabolic disorder of purine metabolism, characterized by intermittent attacks of acute pain, swelling and inflammation. • It always preceded by hyperuricemia
This is the presentation which was delivered to third year Bachelor of Physiotherapy students at Kathmandu University School of Medical Sciences (KUSMS), Dhulikhel, Nepal. Different schools of thoughts in manual therapy are the part of curriculum for the undergraduate students at KUSMS.
Exercise tolerance testing (also known as exercise testing or exercise stress testing) is used routinely in evaluating patients who present with chest pain, in patients who have chest pain on exertion, and in patients with known ischaemic heart disease.
These slides are for Yoga Teachers or students of Yoga for understanding the disease and what Yoga program we can offer to our client when they reach you for help. Although every individual is unique and Yoga Therapy should also be made considering what level of disease they are going through.
Disclaimer: We dont take any responsibility if someone starts to follow the program as mentioned in the PPT for any harm or injury.
Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage that cushions the ends of your bones wears down over time. Although osteoarthritis can damage any joint, the disorder most commonly affects joints in your hands, knees, hips and spine. A type of arthritis that occurs when flexible tissue at the ends of bones wears down.
The wearing down of the protective tissue at the ends of bones (cartilage) occurs gradually and worsens over time.
Joint pain in the hands, neck, lower back, knees or hips is the most common symptom.
Medication, physiotherapy and sometimes surgery can help reduce pain and maintain joint movement.
Arthritis is a large topic, and almost everyone who has a bone will develop some forms of arthritis at some point in their lives. This presentation addresses many types of arthritis, including osteoarthritis, septic arthritis, gout, rheumatoid arthritis and so forth.
This presentation focuses on different types of arthritis/joint disorders. It provides stepwise approach to evaluation and diagnoses and it's truly wonderful to have a broad overview of many joint conditions in one presentation - ranging from osteoarthritis, gout, rheumatoid arthritis, septic arthritis, to ankylosing spondilitis, and many others, including fibromyaligia.
Osteoporosis is a condition characterized by a decrease in the density of bone, decreasing its strength and resulting in fragile bones. Know the Risk Factors for Osteoporotic Fracture, Preventive Measures and exercise for osteoporosis. For more health Tips, Visit at http://gisurgery.info
Do you have osteoarthritis? Learn about what to expect throughout the 4 different stages of knee osteoarthritis and the proper treatment for each stage
Introduction to nervous system
Contents :
Parts of nervous system
Parts of brain
Sagittal section of the brain
Basic functions of the brain
Parts and functions of Diancephalon
Structures and functions of brainstem
Spinal cord
Peripheral nervous system
Somatic nervous system
Autonomic nervous system
Periarthritis shoulder or adhesive capsulitis or frozen shoulder is very common condition of shoulder joint.
Contents :
Definition
Epidemiology
Classification
Causes
clinical features
DIFFERENTIAL DIAGNOSIS
Diagnosis :- INVESTIGATION
Examination
MEDICAL TREATMENT
Ventilation refers to rate at which air enters or leave lungs
Contents
Definition
Pulmonary ventilation
Normal value and calculation
Alveolar ventilation
Normal value and calculation
Dead space
Anatomical dead space
Physiological dead space
Normal value of dead space
Ventilation/perfusion ratio
Significance of V/Q ratio
Mal practice is illigal act which is worldwide being done within all the fields
Here, mal practice in physiotherapy clinical practice is very well illustrated
Contents :
Definition
Standerd of care
Basic elements of mal practice
Necessity of injury
Targets
Medical malpractice claims
Examples of Mal practice
Proving mal practice claim
Damages
Informed consent
Medical malpractice lawsuit
Cost of litigation
Medical records rewiew
Glossary
Vojta technique is neuromuscular approach deals with all the conditions of CNS and Musculoskeletal system.
Contents :
Introduction
Definition
What is REFLEX LOCOMOTION
Indication
Stimulating Points
Reflex locomotion
Reflex Rolling phase 1
Reflex Rolling phase 2
Reflex creeping
Effects of Vojta technique
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. ▪“Osteoarthritis is a disease
characterized by degeneration
of cartilage and its underlying
bone within a joint as well as
bony overgrowth”
4. O – Obesity
S – Senility or old age
T – Trauma
E – Emotional stress
O – Osteoporosis
A – Alcohol
R – Rigorous lifestyles
T – Taxing professions
H – Hormonal imbalances
R – Repetitive injuries
I – Indian cultural habits
T – Axing sports
I – Improper postural habits
S – Smoking
▪ Multifactorial : Not understood well
▪ Ediopathic
▪ Wear and Tear
5. Primary OA
▪ Age related
▪ Mostly occures in weight bearing joints
like HIP, KNEE AND SPINE
▪ Trapeziometacarpal joint of thumb is
commonly affected
▪ Distal interphalangeal joints of fingers
are also commonly affected
▪ More common than Secondary OA
Secondary OA
▪ It is not age related
▪ Due to previous underlying bone or joint
disease or trauma
▪ Commonly at hip
▪ Predeposing fectors are as follows
1. Congenital malformations
2. Previous Trauma
3. Previous related injuries
4. Internal derangement of Joint
5. Malalignment of joint
6. Obesity and excessive weight
6. This degenerative
condition starts with
affecting to the
articular cartilage
Increase
water contant
Depletion of
protioglycans
Cartilage
erosion and
fibrillation
Abraded by
grinding
mechanism
Underlying
bone is now
exposed to get
erosed
Further rubbing
Subchondral
bonebecomes
hard and & Glossy
Margines of
rim of bone get
hypertrophied
Forms projecting spurs
known as osteophytes
formation
Same process occurs at
subchondral bone
forming spurs here it is
called subchondral cyst
Loose flacks of cartilage in
synovial fluid initiate synovial
inflammation
Thickening of
the capsule
Bony
deformities
7. • Mostly in elderly people
• Bilateral affection
• Morning stiffness (no longer than
an hour)
Earliest symptom : Pain
• In beginning :
• Dull pain
constant for 2-3
months to years
• Coared crepitus
• Late features
• Swelling due to
inflammation
• Stiffness due to
pain and muscle
spasm
• Locking and
instability due to
frayed maniscus
Geographical variation
Western lifestyle
Hip commonly affected
Asian lifestyle
Knee Commonly affected
On Examination
• Tenderness over joint line
• Crepitus
• Irregular & enlarged looking joint
• Deformities : Knee : varrus or valgus
: Hip : Flexion adduction
. And internal rotation
• Effusion mostly rare and transiant
• Limitations of movement
• Subluxation
• Wasting of related musculatures
9. Radiological investigation Other investigation
• Nerrowing of joint space
• Subchondral cyst
• Dense bone under the articular
surface
• Osteophytes formation
• Loose bodies
• Deformities
• Serologicall test :To rule out
Rheumatoid Arthritis
• Serum test :To rule out gout
• Sinovial fluid examination :To rule
out septic arthritis
10. PRINCIPLES
• Disease once started
progresses gradually
there is no way to stop it
1. Delay Occurance of
disease : if disease has
not yet begun
2. To stall progress of the
disease and relieve
symptoms : if the disease
is in early stage
3. To rehabilitatethe patient
if if his disabilities can be
partially or completely
elivated
Methods of treatment
Pharmacological
Treatment
Supportive
Therapy
Surgical
Method
Drugs :analgesics
( for pain relief)
Chondroprotactive
agents :
- Glusulphate
- Chondroitin sulphate
(Does not modify the
disease but it acts as an
mechanic of cartilage)
Viscosuplementation
Sodium hylarunon
(Improve cartilage
function)
• Weight loss
• Avoidance of
stress and
strain activities
in daily life
• Local heat
• Exercise
• Application of
local counter
irritants and
liniments
1. Osteotomy:
(A) High tibial osteotomy or
(B) Intertrochantaric osteotomy
2. Joint Replacement
Most common nowadays
3. Joint Debridement
Less common nowadays
4. Arthroscopic Procedure
Most popular these days
