Orientated foam sclerotherapy (OFS) is a new method for treating great saphenous vein (GSV) varicose veins that is safe, effective, and inexpensive. It involves inserting a catheter into the GSV under ultrasound guidance, then injecting and orienting sclerosing foam to fully fill the GSV and tributary veins. This is done under fluoroscopy to monitor foam distribution. OFS provides complete GSV occlusion in most cases with minimal complications. It can treat complex GSV anatomy more effectively than other options like surgery or thermal ablation. OFS allows immediate ambulation, has a high patient satisfaction rate, and may become the ideal treatment for GSV reflux.