Basics of Undergraduate/university fellows Nucleosome model of chromosome is proposed by ROGER KORNBERG (son of Arthur Kornberg) in 1974. It was confirmed and crystalised by P. Oudet et al., (1975). Nucleosome is the lowest level of Chromosome organization in eukaryotic cells. Nucleosome model is a scientific model which explains the organization of DNA and associated proteins in the chromosomes. Nucleosome model also explains the exact mechanism of the folding of DNA in thenucleus. It is the most accepted model of chromatin organization.