Lecture covers the pharmacology of anticholinergic drugs. Includes classification, therapeutic uses, adverse effects of anticholinergics. Atropine has been described as prototype drug.
Lecture covers the pharmacology of anticholinergic drugs. Includes classification, therapeutic uses, adverse effects of anticholinergics. Atropine has been described as prototype drug.
introduction ,classification of cholinergic receptor ,and its function ,anti cholinergic agents -atropine and its pharmacology ,semi synthetic and synthetic atropine substitutes
Hello friends. In this PPT I am talking about antiepileptic drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
learning objective includes : pathogenesis,clinical features, classification of migraine, pharmacology about specific antimigraine drugs, coverage to newer triptan- Lasmiditan and newer prophylactic drug Erenumab a CGRP receptor antagonist.
introduction ,classification of cholinergic receptor ,and its function ,anti cholinergic agents -atropine and its pharmacology ,semi synthetic and synthetic atropine substitutes
Hello friends. In this PPT I am talking about antiepileptic drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
learning objective includes : pathogenesis,clinical features, classification of migraine, pharmacology about specific antimigraine drugs, coverage to newer triptan- Lasmiditan and newer prophylactic drug Erenumab a CGRP receptor antagonist.
los siguientes mapas mentales es la explicación de el derecho civil como derecho privado y sus diferentes ramas, ademas de eso los antecedentes del código civil y las diferentes reformas según su reformas a través del tiempo. Y ademas los principios generales del código civil iniciando del primer articulo al articulo numero 14.
Psychostimulants ,Adaptogens, Analeptics, Antidepressants and Nootropic DrugsGanapathy Tamilselvan
This presentation gives you information about the phychostimulants , Adaptogens, Analeptics, Antidepressants and Nootropic Drugs with their classificaitons and mecanisms.
antipsychotics history, managment of psychosis,side effect of antipsychotics, mechanism of antipsychotics, atypical antipsychotics,2nd generation antipsychotics.
A disorder of the central nervous system that affects movement, often including tremors.
Nerve cell damage in the brain causes dopamine levels to drop, leading to the symptoms of Parkinson's.
Parkinson's often starts with a tremor in one hand. Other symptoms are slow movement, stiffness and loss of balance.
Treatment consists of medications to increase dopamine.
Get information about the drugs which affects the kidney and uterus functions, along with their classifciations and mechanism of action with clinical use.
This presentation gives detailed information about antihistamine agents ,immunopharmacology .They also give details about their classification and mechanism of action.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
3. MECHANISM OF ACTION:
blockade of dopamine D2-receptors
IN PERIPHERY :
BLOCK :
M - Cholinoreceptors
α - Adrenoreceptors
H1- Histamine Receptors
Serotonin (5-HT) Receptors
DIRECT SPASMOLYTIC ACTION
4. Pharmacological Effects:
Antipsychotic Actions:
Hallucination and Agitation
Antiemetic Effects
Extrapyramidal Effects:
D2-Rs blockade in the Nigrostriatal Pathways =>
=> Parkinsonian Symptoms
Anti-muscarinic Effects:
Blurred Vision, Dry Mouth, Sedation, Confusion,
Inhibition of GIT and Urinary Smooth Muscles
5.
6.
7. Extrapyramidal Еffects:
due to Blocking of D2 receptors in the Nigrostriatal Pathway:
Parkinsonian Symptoms
Akathisia (Motor Restlessness) - the inability to sit still
because of Uncontrollable Movement
Tardive Dyskinesia: Inappropriate Postures of the Neck,
Trunk, and Limbs
Malignant Neuroleptic Syndrome:
Skeletal Muscle Rigidity, Hyperthermia, Stupor
8. Clinical Uses of Neuroleptics
1. SCHIZOPHRENIA:
Positive Symptoms of Schizophrenia : DELUSIONS,
HALLUCINATIONS and THOUGHT DISORDERS
Negative Symptoms of Schizophrenia: withdrawal,
blunted emotions, reduced ability to relate to people
2. PREVENTION OF SEVERE NAUSEA and VOMITING:
Drug-induced nausea
3. OTHER USES: treatment of DRUG ADDICTION,
NEUROLEPTANESTHESIA, hypertensive crises
9. Aminazine (Chlorpromazine) -
blocks CNS D2 receptors
α-Recetor and GANGLIONIC BLOCKADE
HISTAMINE- and SEROTONIN -mediated activity.
It has great:
Sedative,
Hypotensive,
Antiallergic,
Anticonvulsant activity
It may produce Galactorrhea (excessive production of
milk – due to Prolactin release )
Clinical uses: Schizophrenia,
Acute Psychosis in Severely Agitated Patients
10. DROPERIDOL amp 0.25%-10 ml –
a BUTYROPHENONE derivative,
more potent and to have fewer autonomic effects than other
typical neuroleptics.
It blocks subcortical D2 and α-adrenergic receptors, and
blocks CNS receptors at the CTZ.
It has no CholinoBlock action.
The drug produces marked sedation and has an antiemetic
effect.
IM injection: Sedation begins in 3-10 min,
peaks at 30 min, and lasts for 2-4 hrs.
CLINICAL USE: a drug of choice at
NEUROLEPTANESTHESIA –the combination of neuroleptics
with opioid analgesics, FENTANYL.
Anesthetic Premedication,
Maintenance of General Anesthesia.
11. LITHIUM SALTS
Lithium Carbonate – Caps. 0.15 and 0.3 g; Tab. 0.3 g
Lithium Citrate – Syrup – 300 mg/5 ml (6% Syrup )
an “Anti-Manic” drug, but it also considered as
“mood-stabilizing” agent because of its primary action of
preventing MOOD SWINGS in patients with
Bipolar Affective (Manic-Depressive) Disorder.
Antimanic Action: antipsychotic and antimanic effects -
by competing with other cations for exchange at
the Na+/ K+ ion pump, thus altering cation exchange
at the tissue level.
Noradrenaline and Dopamine turnover
13. TRANQUILIZERS (ANXIOLYTIC DRUGS)
I. Benzodiazepines (BZDs):
Diazepam (Sibazon ) – amp. 0.5%-2 ml; Tab. 0.005 g
Chlordiazepoxide (Chlozepide) – Tab. 0.005 g
Nozepam (Oxazepam, Tazepam) – Tab. 0.01 g
Lorazepam – Tab. 1 and 2 mg
Phenasepam – Tab 0.5 and 1 mg
Alprazolam (Xanax) – Tab. 0.25 and 0.5 mg
Mezapam (Rudotel) – Tab. 10 mg
Tofizopam (Grandaxin) – Tab. 50 mg
II. Other Anxiolytics
Buspirone – Tab. 5 and 10 mg
Amyzyl – Tab. 1 and 2 mg
Hydroxyzine – amp. 5%-2 ml; Tab. 10 and 25 mg
14. BENZODIAZEPINES
according to their Duration of Action:
1. Long-acting (24-48 hours):
Diazepam
Phenasepam
Chlordiazepoxide
2. Intermediate-acting (6-24 hours):
Alprazolam
Nozepam
Lorazepam
3. Short-acting (< 6 hours):
Midazolam (Dormicum)
Gidazepam
15.
16. MECHANISM OF ACTION of BZDs:
Bind to the α-subunit of the GABAA Rs
surrounding the Cl ¯ channels
Designated as BZD Rs (OMEGA-RECEPTORS)
► Affinity of GABA Rs
► Frequency of Cl ¯ channel opening
► Cl ¯ Conductance => HYPERPOLARIZATION
=> POST-SYNAPTIC POTENTIAL away from
its FIRING THRESHOLD =>
►INHIBITION of ACTION POTENTIAL formation
& Further Neuronal Firing
17.
18. CLINICAL USES of BZDs
1.ANXIETY and PANIC DISORDERS
2. MUSCULAR DISORDERS:
DIAZEPAM –
Skeletal Muscle SPASMS in Muscle Strain
SPASTICITY from degenerative disorders,
such as Multiple Sclerosis
3. SEIZURES:
CLONAZEPAM – Epilepsy
DIAZEPAM – Grand Mal Epileptic Seizures
Status Epilepticus
CHLORDIAZEPOXIDE, DIAZEPAM,
NOZEPAM (OXAZEPAM) – Alcohol Withdrawal
4. SLEEP DISORDERS
19. Psychological and Physical Dependence -
if high doses are given over a prolonged period
ADVERSE EFFECTS of BZDs:
DROWSINESS
CONFUSION
ATAXIA
COGNITIVE IMPAIRMENT:
LONG-TERM RECALL
ACQUISITION of NEW KNOWLEDGE
Early Morning Insomnia
Daytime anxiety with AMNESIA and CONFUSION
20. BZD Antagonist:
FLUMAZENIL –
a GABA receptor competitive antagonist that
can rapidly reverse the effects of
BENZODIAZEPINES.
Blocks actions of BZDs
(and imidazopyridines) but does not
antagonize the CNS effects of other
sedative-hypnotic, ethanol, opioid, or
general anesthetics
21. DIAZEPAM (Sibazon) amp. 0.5%-2 ml; Tab. 0.005 g
is a Tranquilizer, a LONG ACTING BENZODIAZEPINE
MECHANISM OF ACTION: binds to BDZ receptors, which are
separate from but adjacent to the GABA receptors, trigger
an opening of a Cl- channel =>
=> in Cl- Conductance =>
=>HYPERPOLARIZATION that moves the postsynaptic
potential away from its firing threshold and inhibits
the Formation of Action Potentials.
PHARMACOLOGIC EFFECTS: anxiety, sedative and
hypnotic action, anticonvulsunt and myorelaxant action.
CLINICAL USES: neurotic and neurosis-like conditions with
symptoms of anxiety and phobia, increased irritability;
epilepsy and status epilepticus, alcohol withdrawal, muscle
spasm, as adjunct to anesthesia and endoscopic
procedures.
22. GIDAZEPAMUM Tab. 0.02 g; 0.05 g –
DAY TRANQUILIZER – has ACTIVATING EFFECT
a SHORT ACTING BZD with anxiolytic, anticonvulsive and
weakly expressed myorelaxant action.
It also stabilizes the functions of the Vegetative NS.
MECHANISM OF ACTION:
the effect of the GABA in the ASCENDING RETICULAR
ACTIVATING SYSTEM,=> increases inhibition and
blocks cortical and limbic arousal.
INDICATIONS:
Neurotic and Neurosis-like conditions with
symptoms of anxiety and phobia, increased irritability;
Acute alcohol withdrawal, Muscle spasm,
Convulsive disorders.
23. BUSBIRONE - Tab. 10 mg - an non-BZD anxiolytic
MECHANISM OF ACTION:
Blocks 5-HT1A SEROTONIN receptors and
presynaptic DOPAMINE receptors
NOREPINEPHRINE biotransformation
=> Indirect effect on BZD-GABA-CHLORINE receptor
complex or GABA receptors
=> has no anticonvulsant or muscle relaxant activity and
does not appear to cause physical dependence
The drug is 95% protein-bound;
onset of therapeutic effect may require 1 - 2 weeks.
INDICATIONS:
Anxiety disorders, major depression,
parkinsonian syndrome, premenstrual syndrome,
drug addiction.
24. Sedative Drugs:
1. BROMINE SALTS:
Sodium Bromide - NaBr
Potassium Bromide - KBr
2. VALERIAN’S PREPARATIONS:
(Valeriana officinalis)
Infusion, Tincture, Extract from
Rhizome and Root of VALERIAN
3. MOTHERWORT’S PREPARATIONS:
(Leonurus cardiaca)
Tincture from Plant Grass
(T-ra Leonuri)
Mechanism of Action:
Intensification of slowdown processes in the brain
Clinical Uses: Neurosis
Adverse Efects: Skin Rashes, Sedation,
Behavioral Changes.
25. BROMISM chronic intoxication with BROM salts
Bromides eliminate slowly (T1/2=12 days),
MANIFESTATION: total retardation, apathy,
memory disorders, skin rashes
The IRRITATIVE ACTION of bromides induces
Mucous Inflammations along with
COUGH, RHINITIS, CONJUNCTIVITIS, DIARRHEA.
TREATMENT: the drug should be discontinued and its
elimination must be accelerated.
Bromide excretion may be enhanced by using of :
Sodium Chloride, NaCl
abundant drinking, and diuretics (saluretics).
26. Valerian’s and Motherwort’s Preparations -
are widely used sedative drugs.
VALERIAN’S preparations - Infusion, Tincture, Extract –
are produced from Rhizome and Root of
VALERIANA OFFICINALIS which contain:
valerian acid, organic acids, alkaloids,
tannic substances
MOTHERWORT’S PREPARATIONS - Infusion and Tincture
from plant Grass - contain:
ether oils, alkaloids, saponins, tannic substances.
SEDATIVE and WEAK TRANQUILIZING EFFECTS
do not cause myorelaxation, ataxia, psyhologic and
physical dependence.
CLINICAL USES: Light Neurosis,
Somatic Diseases with Neurotic Syndrome
ADVERSE EFFECTS: Allergic Reactions.