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ANTIDEPRESSANTS Martha I. Dávila-García, Ph.D. Howard University College of Medicine Spring 2002
Classification of Major Affective Disorders
Episodal (reactive) Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Reactive (episodal) Depression ,[object Object],[object Object],[object Object],[object Object]
Major  Endogenous Depression   ,[object Object],[object Object],[object Object]
Major  Endogenous Depression   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Major  Endogenous Depression   ,[object Object],[object Object],[object Object]
Mania ,[object Object]
Mania ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
III.  Biological Correlates of Depression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IV. Biological Basis for Depression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],V.  Biogenic Theory of Depression
VI.  NE System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
VII.  Serotonin System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antidepressants ,[object Object],MAOIs SSRIs TCAs TCAs TCAs TCAs SSRIs SSRIs SSRIs SSRIs MAOIs MAOIs MAOIs MAOIs MAOIs MAOIs Venflaxine Venflaxine Venflaxine MAOIs MAOIs maprotiline Amoxepine doxepin isocarboxazide Nortriptyline
Antidepressants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object]
Tricyclic Antidepressants (TCAs) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object]
X. MAO INHIBITORS ,[object Object],[object Object],[object Object],[object Object]
XI. SSRIs ,[object Object],[object Object],[object Object],[object Object],[object Object]
XI. SSRIs ,[object Object],[object Object],[object Object],[object Object]
XI. SSRIs ,[object Object],[object Object],[object Object],[object Object]
XI. SSRIs ,[object Object],[object Object],[object Object],[object Object],[object Object]
XI. SSRIs ,[object Object],[object Object],[object Object],[object Object],[object Object]
XII. Heterocyclics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
XII. Heterocyclics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
XII. Heterocyclics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
XII. Heterocyclics ,[object Object],[object Object]
XII. Heterocyclics ,[object Object],[object Object]
XII. Heterocyclics  Third Generation   ,[object Object],[object Object],[object Object]
XII. Atypical/Heterocyclic  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Similar to TCAs 5-HT antagonists  2-AR antagonist SSRI-like  NE output
Noradrenergic Control of Serotonergic Release NE 5-HT NE  2 -AR  1 -AR 1 2 3 Mianserin 5-HT1   5-HT2 5-HT3 Receptors
XIV.  Alternative Therapies ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs PIP PIP 2 G IP 3 IP 2 IP 1 Inositol PI X Li + PLC DAG Ca  2+
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object]
XVI. Anti-Manic Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Seminar On Antidepressants

  • 1. ANTIDEPRESSANTS Martha I. Dávila-García, Ph.D. Howard University College of Medicine Spring 2002
  • 2. Classification of Major Affective Disorders
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  • 46. Noradrenergic Control of Serotonergic Release NE 5-HT NE  2 -AR  1 -AR 1 2 3 Mianserin 5-HT1 5-HT2 5-HT3 Receptors
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  • 57. XVI. Anti-Manic Drugs PIP PIP 2 G IP 3 IP 2 IP 1 Inositol PI X Li + PLC DAG Ca 2+
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Editor's Notes

  1. High correlation particularly among kin Reserpine, a drug used in the treatment o hypertension and schizophrenia can cause depression because it depletes the vesicular storage of amine neurotransmitters (NE, 5-HT, DA). Depression could be relieved by isoniazid, a drug used in the treatment of tuberculosis. TCAs, MAOIs, SSRIs, and all the new drugs. ECT causes a massive release of NTs and is a very effective antidepressant.