This document summarizes information on nerve allografts for repairing peripheral nerve injuries. It discusses the current gold standard of nerve autografts and limitations such as harvest site morbidity. Nerve allografts and acellularized nerve grafts are presented as alternatives, avoiding donor site issues. Acellularized grafts are harvested from cadavers, decellularized, and stored until use. Several animal and clinical studies show promising regeneration results using acellularized grafts compared to conduits. However, some surgeons remain skeptical and prefer autografts when possible due to lack of long-term data for motor and critical sensory nerves. Both options have pros and cons for different clinical scenarios.
Endovascular neurosurgery forms a subspecialty within neurosurgery which uses radiology & catheters so as to diagnose & treat various diseases & conditions pertaining to the central nervous system. Central nervous system embodies the brain along with the spinal cord. Endovascular neurosurgery medical specialty is also known as Neurointerventional Surgery. goo.gl/vH3cQr
Improved transcranial motor evoked potentials after craniovertebral decompres...Anurag Tewari MD
Surgical strategies towards the treatment of patients with symptomatic Chiari II malformations
(CIIM) are favorable. Despite immediate evaluation and treatment with CSF shunt revision
surgery, a significant population of CIIM patients requires hindbrain decompression. There is
growing evidence for the utility of intraoperative electrophysiological studies, particularly
combinatorial assessment with SSEPS and Tc-MEPs in spinal surgeries for brainstem
compression and myelopathy, but scarce in the pediatric CIIM and myelodysplasia literature.
Here, we report our use of a departmental IONM safety checklist and its efficacy in two cases of
infants presenting with progressive brainstem dysfunction and long-tract signs CIIM hindbrain
decompression.
High-intensity LEDs are embedded in the flash stimulation pad
The small disc shape and silicone properties of the pad make it both flexible and lightweight
Illuminance can be set up to 20,000 lux, and different light emission times and cycles can be chosen.
A common system for placing electrodes is the “10-20 International System” which is based on measurements of head size (Jasper, 1958).
The mid-occipital electrode location (OZ) is on the midline.
The distance above the inion calculated as 10 % of the distance between the inion and nasion, which is 3-4 cm in most adults
Lateral occipital electrodes are a similar distance off the midline.
To have reliable VEPs, Intraoperatively, the following factors are important
Maintaining normal intraoperative physiological/hemodynamic parameters
Use of TIVA instead of inhalational anesthesia
Better stimulus delivery methods
Recording intraoperative ERG to ensure good retinal stimulation and
Employing optimal recording parameters
Endovascular neurosurgery forms a subspecialty within neurosurgery which uses radiology & catheters so as to diagnose & treat various diseases & conditions pertaining to the central nervous system. Central nervous system embodies the brain along with the spinal cord. Endovascular neurosurgery medical specialty is also known as Neurointerventional Surgery. goo.gl/vH3cQr
Improved transcranial motor evoked potentials after craniovertebral decompres...Anurag Tewari MD
Surgical strategies towards the treatment of patients with symptomatic Chiari II malformations
(CIIM) are favorable. Despite immediate evaluation and treatment with CSF shunt revision
surgery, a significant population of CIIM patients requires hindbrain decompression. There is
growing evidence for the utility of intraoperative electrophysiological studies, particularly
combinatorial assessment with SSEPS and Tc-MEPs in spinal surgeries for brainstem
compression and myelopathy, but scarce in the pediatric CIIM and myelodysplasia literature.
Here, we report our use of a departmental IONM safety checklist and its efficacy in two cases of
infants presenting with progressive brainstem dysfunction and long-tract signs CIIM hindbrain
decompression.
High-intensity LEDs are embedded in the flash stimulation pad
The small disc shape and silicone properties of the pad make it both flexible and lightweight
Illuminance can be set up to 20,000 lux, and different light emission times and cycles can be chosen.
A common system for placing electrodes is the “10-20 International System” which is based on measurements of head size (Jasper, 1958).
The mid-occipital electrode location (OZ) is on the midline.
The distance above the inion calculated as 10 % of the distance between the inion and nasion, which is 3-4 cm in most adults
Lateral occipital electrodes are a similar distance off the midline.
To have reliable VEPs, Intraoperatively, the following factors are important
Maintaining normal intraoperative physiological/hemodynamic parameters
Use of TIVA instead of inhalational anesthesia
Better stimulus delivery methods
Recording intraoperative ERG to ensure good retinal stimulation and
Employing optimal recording parameters
Intraoperative Monitoring by Pablo Pazmino, MD. Intraoperative Monitoring is an important part of any surgery of the cervical and lumbar spine. If you or someone you know may benefit from a Intraoperative Monitoring feel free to contact us 1-8SPINECAL-1, doctor@beverlyspine.com, doctor@santamonicaspine.com or via the internet www.santamonicaspine.com or www.beverlyspine.com
This presentation describes the role of electrophsyiology in treatment of deafferent neuropathic pain during microcoagulation of dorsal root entry zone.
Intraoperative Monitoring by Pablo Pazmino, MD. Intraoperative Monitoring is an important part of any surgery of the cervical and lumbar spine. If you or someone you know may benefit from a Intraoperative Monitoring feel free to contact us 1-8SPINECAL-1, doctor@beverlyspine.com, doctor@santamonicaspine.com or via the internet www.santamonicaspine.com or www.beverlyspine.com
This presentation describes the role of electrophsyiology in treatment of deafferent neuropathic pain during microcoagulation of dorsal root entry zone.
Complex Fractures and Instability of the Elbow joint: Advances in Mechanism and Pathophysiology, Injury paterns, Treatment principals and Results are discussed in this presentation.
Οι εξελίξεις στην χειρουργική των σύνθετων καταγμάτων του αγκώνα συζητούνται σε αυτή την παρουσίαση
Περιφερικές Νευρομεταφορές για βλάβες του Ωλενίου Νεύρου- Distal Nerve transf...Nikos Darlis
The role of distal nerve tranfers from Median to an injured Ulnar nerve, basic principals, surgical technique and reported results
Ο ρόλος των περιφερικών νευρομεταφορών στην αντιμετώπιση υψηλών βλαβών του Ωλενιου νεύρου. Βασικές αρχές, χειρουργική τεχνική και δημοσιευμένα αποτελέσματα
Τρία κοινά κλινικά σενάρια που οδηγούν σε αρθροσκόπηση του καρπού- Three comm...Nikos Darlis
Three common clinical scenarios leading to wrist arthroscopy
Ομιλία στο 20ο Συνέδριο της Ελληνικής Εταιρείας Χειρουργικής του Χεριού, 4-6 Σεπ, Αλεξανδρούπολη,
3 common clinical scenarios leading to wrist arthroscopy. Alexandropolis 2014Νίκος Δαρλής
Overview of the 3 most common clinical scenarios leading to wrist arthroscopy. Invited lecture at the 20th Congress of the Hellenic Hand Surgery Society Meeting, Sep 4-6 2014.
Ανασκόπηση των 3 κυριοτέρων κλινικών Σεναρίων που οδηγούν σε αρθροσκόπηση του καρπού. Προσκεκλημένη Ομιλία στο 20ο Συνέδριο της Ελληνικής Εταιρείας Χειρουργικής του Χεριού, 4-6 Σεπ, Αλεξανδρούπολη,
Αρθροσκόπηση του Καρπού, απο την Κλινική Εξέταση στις Σύνθετες Επεμβάσεις- Wr...Nikos Darlis
Review of the clinical exam, radiologic findings and operative treatment of common wrist conditions treated with wrist arthroscopy
Ομιλία στο Σεμινάριο Χειρουργικής του Χεριού, Ιωάννινα 30 Οκτ- 1 Νοε, 2014. "Ανασκόπηση της Αρθροσκόπησης στο Χέρι".
Παθησεις καμπτήρων τενόντων του χεριού στα παιδιά- Hand Flexor tendon lesions...Nikos Darlis
Πρωτοπαθής συρραφή, Δευτεροπαθείς ανακατασκευές καμπτήρων τενόντων με ραβδους σιλικόνης, Εκτινασσώμενος αντιχειρας στα παιδιά
Primary repair , secondary reconstruction of flexor tendons in children and pediatric trigger thumb management
EDIC is pleased to announce a webinar with Dr. R. Bruce Donoff, the Dean at Harvard Dental School. Dr. Donoff’s presentation will cover the risk factors for inferior alveolar and lingual nerve injury after third molar extraction, as well as the proper documentation and follow up of nerve injuries. Dr. Donoff will also discuss the potential for recovery from paresthesia after surgical intervention. The webinar will be held on May 10, 2011 at 7:00 PM.
Nerve injuries extend from simple nerve compression lesions to complete nerve injuries and severe lacerations of the nerve trunks. A specific problem is brachial plexus injuries where nerve roots can be ruptured, or even avulsed from the spinal cord, by traction. An early and correct diagnosis of a nerve injury is important. A thorough knowledge of the anatomy of the peripheral nerve trunk as well as of basic neurobiological alterations in neurons and Schwann cells induced by the injury are crucial for the surgeon in making adequate decisions on how to repair and reconstruct nerves. The technique of peripheral nerve repair includes four important steps (preparation of nerve end, approximation, coaptation and maintenance). Nerves are usually repaired primarily with sutures applied in the different tissue components, but various tubes are available. Nerve grafts and nerve transfers are alternatives when the injury induces a nerve defect. Timing of nerve repair is essential. An early repair is preferable since it is advantageous for neurobiological reasons. Postoperative rehabilitation, utilising the patients' own coping strategies, with evaluation of outcome are additional important steps in treatment of peripheral nerve injuries. in the rehabilitation phase adequate handling of pain, allodynia and cold intolerance are emphasised.
Scand J Surg. 2008;97(4):310-6
At the end of the lecture the participant will be able to:
1. Understand the intracellular and extracellular processes that occur after a nerve injury, including Wallerian degeneration
2. Describe the classification of peripheral nerve injuries in relation to management and prognosis
3. Understand the physiology of nerve regeneration and its implication in modern nerve surgery including allografts and nerve conduits.
4. Describe the effects of peripheral nerve injury on distal structures (Motor and sensory end organs)
Διάγνωση και αντιμετώπιση της οξείας ασταθειας της απω κερκιδωλενικής. Acute distal radioulnar joint Instability, isolated and with concommitan fracture, diagnosis and treatment
Aνασκόπηση της Παθολογίας Αγκώνα & Αντιβραχίου Δαρλής 2014Nikos Darlis
Aνασκόπηση της Παθολογίας Αγκώνα & Αντιβραχίου. Από τις Α ρθροπλαστικές ως την Ω λένια νευρίτιδα. Πιεστικές Νευροπάθειες, Παθήσεις Τενόντων, Αρθρίτιδα, Αρθροσκόπηση και Αρθροπλαστικές
Review of the pathology of the elbow and forearm, compressive neuropahies, Tendon pathology, Arthritis Arthroscopy and Arthroplasties
TFCC Repair in 2014: from hammoc to icebergNikos Darlis
State of the art in Triangular FibroCartilage Complex lesion management. Current concepts in anatomy biomechanics and treatment with special focus in arthroscopic techniques. Detailed step by step description of the surgical technique with animations and video. See also https://www.youtube.com/watch?v=rgbemvKbtFk. Visit www.orthoinfo.gr
Συγχρονες τεχνικές αντιμετώπισης των βλαβών του Τρίφωνου Ινοχόνδρινου Συμπλέγματος στον Καρπό
Η Άσηπτη Νέκρωση του Μηνοειδούς: Τι δεν μάθαμε σε 100 χρόνια- Kienbock's dise...Nikos Darlis
State fo the art on Kienbock's disease (avascular necrosis of the lunate). One handred years after its first description, it remains a source for controversies. What is new and what is outdated? Where do we go next?
Η αρθροσκόπηση του Καρπού στα Κατάγματα της Περιφερικής Κερκίδας- Αrthroscop...Nikos Darlis
Indications, technique and limitations in the use of wrist arthroscopy in distal radius fracture fixation.
Ενδείξεις, τεχνική και περιορισμοί στην χρήση της αρθροσκόπησης του καρπού στα κατάγματα περιφερικής κερκίδας. Ομιλία στο 32ο Ετήσιο Συνέδριο της Ορθοπαιδικής και Τραυματολογικής Εταιρείας Μακεδονίας και Θράκης 9 -11 Μαϊου 2013
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
6. NERVE AUTOGRAFTING
Gold Standard in setting of a nerve gap
“ Expendable” donors:
• Sensory:
– MABC
– LABC
– Sural
Non‐immunogenic
• Sensory donors do not support motor regeneration
as well as mixed sensorimotor or pure motor nerves
• Motor:
-AIN
-PIN
-Nerve to gracilis
7. NERVE AUTOGRAFTING
the “down side”
• Harvest site morbidity (scarring,
neuroma formation, loss of donor
function)
(20-30% with painful donor site, cold
sensitivity, function alteration )
• Harvest time/cost
• Limited size and length available
8. Long Nerve grafts
• Long nerve grafts highly
successful in only one series
(biceps)
• Prognosis is nerve and site-
specific
• Axillary nerve graft results
mixed, generally 50% effective
• Reduced time to surgery,
shorter grafts associated with
improved outcomes
9. Vascularized nerve grafts
• Vascular pedicled ulnar nerve graft may offer some
advantages in poorly vascularized bed, but no
definitive data to support routine use
10. CONDUITS
• Often used for <3cm gaps in small-diameter sensory
nerves
• Potentially longer with biologic supplementation
• More questions about large mixed nerves
– Mackinnon, 2014 :In my practice, nerve conduits have
largely been replaced by acellularized nerve allografts
11. CONDUITS
the “down side”
• Use limited to small gaps;
– 34%-57% failure rate >5mm gaps
• cost
• lack laminin scaffolding
• lack Schwann Cells, which are crucial to axonal
regeneration
• Semi-rigid material cannot be used around joints
12. CONDUITS
the “down side”
• decreased concentration of neurotrophic factors
associated with larger diameter conduits
13. CONDUITS
the “down side”
• isograft is superior to nerve conduit even with minced nerve
• no significant difference in regeneration among motor,
sensory, or mixed minced nerves
15. NERVE ALLOGRAFTS
• taken from ABO blood‐type compatible individuals
– cadaveric
– living related donor
• small diameter nerves
(avoid necrosis of central aspect of nerve from lack of adequate
revascularization)
18. NERVE ALLOGRAFTS
• Mackinnon, 2014 :”should be reserved for unique
patients with irreparable peripheral nerve injuries,
which, left untreated, would lead to an essentially
nonfunctional limb”
19. ACELLULARIZED NERVE GRAFT
• Harvested from cadavers (Motor
nerves ,no branching)
• Decellularized with detergents
(Hudson et al.)
• Subjected to enzymatic
degradation of CSPGs with
chondroitinase (Neubauer et al.)
• Grafts sterilized with gamma
irradiation
• Stored at ‐80 C
26. ACELLULARIZED NERVE GRAFT
clinical studies
• RANGER® Study (ongoing)
• Meaningful Recovery (S3-S4 and M3-M5) in 87% of
nerve reconstructions
• No graft-related complications
27. ACELLULARIZED NERVE GRAFT
clinical studies
• MATCH® control arm of RANGER® study (ongoing)
• Outcomes are comparable to nerve autograft and
exceed those for nerve conduit in historical controls.
28. ACELLULARIZED NERVE GRAFT
skepticism
• McKinnon, 2014: “ contraindicated in motor nerve &
critical sensory nerve reconstruction ; autologous
repair with autograft or nerve transfer would always
be my reconstruction of choice in these defects”
• 2013 ASSH, San Francisco, CA: straw poll taken
during allograft nerve session found that the
overwhelming majority of surgeons would prefer
autograft to processed allograft if it were their own
mixed nerve being repaired.
32. • Pros
– Safe (as per studies)
– Single graft repair, no need for multiple cable graft orientation
– Multiple length and diameters (only up to 7cm length)
– Excellent handling properties
– Supporting clinical studies (ongoing)
– Time efficient
– ? Revision
• Cons
– Cost
– Must have a prediction of nerve and gap size
– Logistics ( scheduling, transfer and storage)
– Compromised host?/ previous infection?/ scarred bed?
cold preservation in University of Wisconsin solution antibiotics in solution
stored at 4 C for 7 days prior to implantation decreases immunogenicity
start FK506 three days pre‐operatively
Bassal laminae business. Chondroitin sulfate proteoglycans (CSPG deposits form a substantial barrier to regeneration