Nanopharmacology and nanotechnology
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This document discusses nanotechnology and electron beam technology for producing nanoparticles. It summarizes that electron beam technology can be used to evaporate materials to produce nanoparticles through vacuum evaporation. This technique is versatile, efficient and cost-effective for producing metallic and non-metallic nanoparticles. The document also discusses how nanoparticles of silver, silica and nanocomposites have been produced and studied for their antimicrobial properties and ability to decrease toxicity of drugs like antituberculosis medications.
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3) Both advantages like stronger and cheaper materials as well as faster computers and new medical technologies, and disadvantages like potential health issues and nano-pollution exist for nanotechnology.
nanotechnology in drug development.
Nanotechnology shows promise for improving drug development and delivery. It allows manipulation of matter at the nanoscale to create new materials and target drugs to specific sites. Nanoparticles, liposomes, dendrimers, and other nanocarriers can encapsulate drugs and release them only in desired locations like cancer sites. This spares healthy tissues and improves efficacy. Nanotech is now used at all stages from formulation to clinical trials. It has led to once-daily antibiotics and tumor-targeted cancer drugs in clinical trials. Further research is still needed but nanotechnology may transform medicine by improving drug delivery and reducing side effects.
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Bionanotechnology utilizes biological systems optimized through evolution like cells, proteins, and nucleic acids to create nanostructured materials. It combines nanotechnology and biotechnology. Recombinant DNA technology is a core technique that allows for manipulation of genes and mass production of proteins. Monoclonal antibodies are identical antibodies produced from a single clone that can be used as targeted delivery systems. Nanomaterials like silver nanoparticles show promise as antiviral agents due to their antibacterial properties. Nanowire biosensors could provide improved sensitivity, specificity, and parallelism by exploiting nanoscale properties and using techniques like field-effect transistors. Natural bionanomachinery provides examples of nanoscale functional applications that involve processes like self-assembly, energy conversion, and
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Nanobiotechnology has many potential applications in areas like medicine, genomics, and robotics. It offers novel opportunities for molecular disease imaging, targeted drug delivery, and therapeutic intervention. Some key areas of focus are using nanoparticles for controlled drug release, protein-based drug delivery systems, magnetic nanoparticles for imaging and therapy, and gene delivery vectors like liposomes and dendrimers. Nanotechnology also has applications in cancer research, cardiovascular disorders, neuroscience, molecular diagnostics, and gene therapy. It provides tools for protein analysis, single-cell studies, and tissue engineering scaffolds. Overall, nanobiotechnology holds promise for advancing healthcare through applications in various areas of medicine and biotechnology.
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The document discusses nano-toxicological issues, noting that nanoparticles can interact with cells depending on their size. Particles less than 100nm can enter cells, those under 40nm can enter the cell nucleus, and those under 35nm can pass through the blood-brain barrier. Studies aim to understand how physical and chemical properties of nanoparticles like size, shape, surface chemistry and aggregation affect toxic biological responses. Some toxic issues discussed are oxidative stress induced inflammation and mitochondrial dysfunction. Progress in reducing toxicity includes using approved materials in development and international efforts to standardize in vitro and in vivo testing protocols.
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Covid-19 testing using nanoparticles
1) Nanotechnology involves studying and manipulating matter at the nanoscale, and nanoparticles are particulate substances that are less than 100 nm in at least one dimension. 2) The COVID-19 pandemic has spread to over 197 countries, infecting over 53.9 million people and killing over 1.31 million as of now. 3) RT-PCR is commonly used to detect SARS-CoV-2 but requires laboratory processing and skilled personnel, limiting its effectiveness for outbreak control.
Nanotechnology in diagnostic Pathology
Nanotechnology offers promising applications in diagnostic pathology through the use of nanoscale devices and materials. Some key applications discussed in the document include using cantilevers to detect cancer biomarkers, nanopores for efficient DNA sequencing, nanotubes to map DNA mutations, nanoshells that absorb light for cancer treatment, dendrimers for drug delivery, magnetic nanoparticles as MRI contrast agents, quantum dots as fluorescent probes, and graphene oxide sheets for attaching antibodies for medical diagnosis. Overall, nanotechnology enables detection, imaging, and analysis at the molecular level for early disease diagnosis and targeted treatment.
Various nanoparticles with their application
This document discusses various applications of nanoparticles in fields like medicine, industries, and diagnostics. It mentions that silver nanoparticles have broad-spectrum antibacterial and antiviral properties and are used in cosmetics, food packaging, and disinfectants. It also explores uses of silicon, nickel, gold, and magnetic nanoparticles for applications like cancer therapy, stem cell tracking, protein purification, and electrochemical biosensing. The conclusion recognizes nanotechnology as a major area of research with implications across many dimensions and fields.
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This document discusses the application of nanotechnology in biomedical fields such as drug delivery, gene delivery, and tissue engineering. It provides background on the history and definition of nanotechnology. It then discusses various nanomaterials that can be used for targeted drug and gene delivery such as liposomes, polymeric micelles, dendrimers, and nanoparticles. It also describes how microfluidics and nanomaterials can be applied to sperm sorting, oocyte handling, embryo culture, and metabolomics. Overall, the document outlines the current and potential future uses of nanotechnology in biomedicine.
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This document discusses nanomedicine and its potential applications. Nanomedicine uses engineered nanodevices and nanostructures to monitor, repair, construct and control human biological systems at the molecular level. The goals of nanomedicine include improved diagnostics, treatment and prevention through a personalized single platform that integrates detection, diagnostics, treatment. Some potential applications discussed include using nanoparticles to deliver drugs precisely to tumor sites, detecting cancer at the molecular level, and developing multifunctional therapeutics. While nanomedicine is not fully realized yet, it could change medicine by making therapies more effective, economical and safe compared to current methods.
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Nanomedicine
Nanomedicine is an interdisciplinary field that uses nanotechnology for medical applications. It aims to diagnose, treat, and prevent disease at the molecular level using nano-scale tools. The document outlines the history of nanomedicine from Richard Feynman's 1959 talk introducing nanotechnology to current applications. Key applications discussed include drug delivery using nanoparticles like liposomes, imaging contrast agents, and miniaturized medical devices. Challenges also remain around potential toxicities of nanomaterials.
NANOBIOTECHNOLOGY
Bionanotechnology is an area that applies nanotechnology to biology and medicine. It uses biological materials to create nanoscale devices less than 100 nanometers in size to better understand life processes. Some examples include using nanoparticles like liposomes, dendrimers, carbon nanotubes, quantum dots and gold nanoparticles for applications in drug delivery, imaging, biosensing and gene therapy by taking advantage of their small sizes and unique properties. Bionanotechnology is a rapidly developing field that offers opportunities for new medical technologies at the nanoscale level.
Nanomedicine
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みなさんこんにちはこれ何文字まで入るの？40文字以下不可とか本当に意味わからないけどこれ限界文字数書いてないからマジでやばい文字数いけるんじゃないの？えこ...
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Nanopharmacology and nanotechnology
- 1. NANOTECHNOLOGY,NANOPHARMACOLOGY National O.O. Bogomolets Medical University E.O.Paton Electric Welding Institute Kyiv, Ukraine
- 2. 2 NANOTECHNOLOGY Nanotechnology is a complex of scientific knowledge, methods and means aimed at controllable assembly (synthesis) of various substances, materials and items with the linear size of structural elements of up to 100 nm (1 nm – 10-9 m; 1 nm = 10 Ǻ) from individual atoms and molecules.
- 3. 3 NANOTECHNOLOGY: PRODUCING OF NANOPARTICLES Mechanical disintegration. Chemical synthesis. Photochemical synthesis. Vacuumevaporation methods. Microbiological synthesis.
- 4. 4 ELECTRON BEAM TECHNOLOGY Electron beam evaporation of materials in vacuum differs from other methodsof vacuum evaporation – thermal and ion-plasma, primarily, by its versatility,technological flexibility, efficiency and cost-effectiveness. The electron beam is one of the most effective heat sources. At collision of the flying electron with the solid surface the main fraction of kinetic energy of the electrons is converted into thermal energy in a thin surface layer 1 – 2 μm thick. Therefore, at heating by the electron beam the heat source is in the solid itself and ensures the maximum complete conversion of electric energy into thermal energy.
- 5. 5 ELECTRON BEAM TECHNOLOGY Modernelectronbeamgunsof 50 – 100 kWpowerallowevaporationofmetallicandnon-metallicsubstancesatsufficientlyhighrates, approximatelyupto10-2g · cm-2 · s-1. Evaporatorsconsistingofacopperwater-cooledcrucible (cylinder),intowhichtheevaporationmaterialisplacedintheformofingot (castorcompacted)of 25 to 70 mmdiameter, havebecomethemostwidelyappliedinpractice.
- 6. 6 SCHEMATIC OF ELECTRON BEAM EVAPORATION
- 8. 8 ELECTRON BEAM TECHNOLOGY The International Center for Electron Beam Technologies of the E.O. Paton Electric Welding Institute designed and organized manufacturing of laboratory, pilotproductionand production electron beam equipment for realization of the consideredvariants of the technology.
- 9. 9 ELECTRON BEAM TECHNOLOGY More than 10 units have already been manufactured for universities, scientific centersand industrial enterprises of the USA, China, Canada and India.
- 10. 10 ELECTRON BEAM TECHNOLOGY Modern electron beam nanotechnology ofproducing advanced nanomaterialsand aircraft engine construction, has a real potential of furtherscientific and economic advances in medicine, pharmacology and pharmacy, inparticular in development and manufacturing of : 1. Heterogeneous inorganic and some variants of organic materials and coatings, in the solid and liquid states, in a broad range of shapes, nano- and microsizes of their structural elements. 2. Magnetic nanofluids. 3. Consolidated or discrete nanostructures of carbon and its compounds. 4. Filters. 5. Sorbents. 6. Graded biological coatings. 7. Catalyst carriers, catalysts and catalysis devices. 8. Components of medical instruments and equipment
- 11. 11 SILICA NANOPOWDER Scientists from the O.O. Chuiko Institute of Surface Chemistry (The National Academy of Sciences of Ukraine) and Vinnitsa National Pirogov Memorial Medical University developed a drug “Silics” - new sorbent of polydirected action, based on highly disperse amorphous silicaamorphous silica nanopowder, obtained by chemical synthesis.
- 12. 12 SILICA NANOPOWDER At the Department of Pharmacology and Clinical Pharmacology (National O.O. Bogomolets Medical University) drugs, created using nanotechnology, including those based on silica nanopowder, are studied. Unlike other sorbents silica nanopowder - a powder of aporose structure consisting of nanoparticles with size 5-20 nm
- 13. 13 FINE SILICA SUSPENSION: DECREASING TOXICITY OF ANTITUBERCULOUS DRUGS Ethambutol Isoniazid Pyrazinamide
- 14. 14 FINE SILICA SUSPENSION: DECREASING TOXICITY OF ANTITUBERCULOUS DRUGS
- 15. 15 FINE SILICA SUSPENSION: DECREASING HEPATOTOXICITY OF ETHYL ALCOHOL
- 16. 16 AG NANOPARTICLES FROM DRIED WATER SOLUTION
- 17. 17 EFFECTIVE CONCENTRATIONS OF AG-NANOIN COMPARISON WITH З AGNO3 Ag-nano
- 18. 18 NANOCOMPOSITES OF SILVER AND COPPER Using electron-beam technologies were received composite nanoparticles of silver and copper. It was established that this composite by antimicrobial activity much more potent than silver nanoparticles and copper nanoparticles.
- 19. 19 PROSPECTS OF INVESTIGATIONS 1. Development of new technologies of nanoparticles manufacturing, especially composites of organic and inorganic origin. 2. Design of new dosage forms for external and internal application and inhalation. 3. Study the therapeutic mechanisms of action of new nanodrugs. 4. Investigations of nanomaterials toxicity.
- 20. 20 CONTACTS
- 21. 21 CONTACTS