Nanoparticle
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Nanoparticles are sub-nanosized colloidal structures composed of synthetic or semi-synthetic polymers that can be used for drug delivery. They have a size range of 10-1000nm. Nanoparticles have several advantages like high drug carrying capacity, ability to sustain drug release, and increased drug shelf stability. Common preparation methods include emulsion solvent evaporation, double emulsion evaporation, salting out, emulsion diffusion, and solvent displacement. Nanoparticles find applications in targeted drug delivery through encapsulation and directing drugs to tissues using magnetic fields. They are being explored for drug delivery to the brain, eyes, and oral delivery of peptides.
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nanoparticle
This document discusses nanoparticles, which are subnanosized colloidal drug delivery systems ranging from 10-1000 nm in diameter. Nanoparticles provide several advantages over traditional drug delivery such as reduced dosage frequency and more uniform drug effects. They can be prepared through various methods like cross-linking, polymerization, and solvent evaporation. Nanoparticles are evaluated using techniques like particle size analysis, molecular weight determination, and surface element analysis. Finally, nanoparticles have various applications including cancer therapy, intracellular targeting, vaccine adjuvants, and crossing the blood-brain barrier.
Nanoparticles
This document discusses nanoparticles, which are sub-nanosized colloidal structures composed of synthetic or semi-synthetic polymers between 10-1000 nm in size. Nanoparticles can be nanocapsules or nanospheres depending on if the drug is confined in a cavity or dispersed in a matrix. They are classified based on their material and can be prepared through various polymerization or precipitation methods. Nanoparticles offer advantages like improved drug stability and targeting but also disadvantages like toxicity risks. The document outlines characterization techniques and applications in cancer therapy, vaccines, and crossing the blood brain barrier.
Nanoparticles- Target oriented drug delivery system
Nanoparticles- Definition, Adv, Preparation methods(solvent evaporation, solvent diffusion, nanoprecipitation, ionic gelation, polymerization,salting out etc),Evaluation (particle size, percentage yield, zeta potential,SEM,TEM, Drug entraptment etc) and Applications
Nanoparticle
This document discusses nanoparticles, which are sub-nanosized colloidal structures composed of synthetic or semi-synthetic polymers ranging in size from 1-100nm. It describes their types (nanospheres and nanocapsules), advantages for drug delivery, ideal characteristics, methods of preparation including molecular crosslinking and polymerization, characterization techniques, commercial products, and applications in cancer therapy, vaccines, and ocular delivery. The recent advances discussed are solid lipid nanoparticles for drug delivery and using dry powder aerosols for lung cancer treatment with nanoparticles.
Nanoparticle
Nanoparticles are defined as particulate dispersions or solid particles drug
carrier that may or may not be biodegradable. Several techniques are used for preparation of
nanoparticles like Solvent Evaporation, Double Emulsification method, Emulsions - Diffusion
Method, Nanoprecipitation, Coacervation method, Salting Out Method, Dialysis and
Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters
such as yield of nanoparticles, Drug Content / Surface entrapment / Drug entrapment, Particle
Size and Zeta Potential , Surface Morphology, Polydispersity index, In-vitro release Study,
Kinetic Study, Stability of nanoparticles
Nanoparticles
This document discusses nanoparticles and their methods of preparation. It begins with an introduction that defines nanoparticles as being between 10-1000 nanometers in size. It then discusses the advantages of nanoparticles for drug delivery including their small size allowing intravenous injection. The document outlines various types of nanoparticles and methods for their preparation including emulsion polymerization and ionic gelation. It also discusses challenges with nanoparticles and methods for characterizing them such as determining their size, surface charge, and drug release properties.
Nanoparticles ppt
This document provides an overview of nanoparticles, including their ideal properties for drug delivery, classifications, methods of preparation, polymers used in preparation, and applications. Nanoparticles are defined as particulate dispersions or solid particles ranging from 1-100nm in size. They can be used to deliver drugs encapsulated, entrapped or attached to a nanoparticle matrix. Common types are nanocapsules, which contain drugs within a polymer membrane, and nanospheres, which uniformly disperse drugs within a polymer matrix. Methods of preparation include crosslinking of amphiphilic macromolecules or polymerization techniques. Nanoparticles show advantages for targeted drug delivery and modifying drug release profiles.
Magnetic microspheres
Magnetic microspheres are small particles containing magnetite that can be guided to target tissues using external magnetic fields. They allow drugs to be delivered at lower doses directly to tissues while avoiding toxicity. Microspheres are prepared using methods like phase separation or solvent evaporation to encapsulate drugs and magnetite in carriers like albumin. Particle characteristics and drug release kinetics can be evaluated using techniques like dialysis, imaging, and microscopy. Magnetic microspheres show potential for targeted drug delivery but also have technical challenges for approval.
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nanoparticle
This document discusses nanoparticles, which are subnanosized colloidal drug delivery systems ranging from 10-1000 nm in diameter. Nanoparticles provide several advantages over traditional drug delivery such as reduced dosage frequency and more uniform drug effects. They can be prepared through various methods like cross-linking, polymerization, and solvent evaporation. Nanoparticles are evaluated using techniques like particle size analysis, molecular weight determination, and surface element analysis. Finally, nanoparticles have various applications including cancer therapy, intracellular targeting, vaccine adjuvants, and crossing the blood-brain barrier.
Nanoparticles
This document discusses nanoparticles, which are sub-nanosized colloidal structures composed of synthetic or semi-synthetic polymers between 10-1000 nm in size. Nanoparticles can be nanocapsules or nanospheres depending on if the drug is confined in a cavity or dispersed in a matrix. They are classified based on their material and can be prepared through various polymerization or precipitation methods. Nanoparticles offer advantages like improved drug stability and targeting but also disadvantages like toxicity risks. The document outlines characterization techniques and applications in cancer therapy, vaccines, and crossing the blood brain barrier.
Nanoparticles- Target oriented drug delivery system
Nanoparticles- Definition, Adv, Preparation methods(solvent evaporation, solvent diffusion, nanoprecipitation, ionic gelation, polymerization,salting out etc),Evaluation (particle size, percentage yield, zeta potential,SEM,TEM, Drug entraptment etc) and Applications
Nanoparticle
This document discusses nanoparticles, which are sub-nanosized colloidal structures composed of synthetic or semi-synthetic polymers ranging in size from 1-100nm. It describes their types (nanospheres and nanocapsules), advantages for drug delivery, ideal characteristics, methods of preparation including molecular crosslinking and polymerization, characterization techniques, commercial products, and applications in cancer therapy, vaccines, and ocular delivery. The recent advances discussed are solid lipid nanoparticles for drug delivery and using dry powder aerosols for lung cancer treatment with nanoparticles.
Nanoparticle
Nanoparticles are defined as particulate dispersions or solid particles drug
carrier that may or may not be biodegradable. Several techniques are used for preparation of
nanoparticles like Solvent Evaporation, Double Emulsification method, Emulsions - Diffusion
Method, Nanoprecipitation, Coacervation method, Salting Out Method, Dialysis and
Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters
such as yield of nanoparticles, Drug Content / Surface entrapment / Drug entrapment, Particle
Size and Zeta Potential , Surface Morphology, Polydispersity index, In-vitro release Study,
Kinetic Study, Stability of nanoparticles
Nanoparticles
This document discusses nanoparticles and their methods of preparation. It begins with an introduction that defines nanoparticles as being between 10-1000 nanometers in size. It then discusses the advantages of nanoparticles for drug delivery including their small size allowing intravenous injection. The document outlines various types of nanoparticles and methods for their preparation including emulsion polymerization and ionic gelation. It also discusses challenges with nanoparticles and methods for characterizing them such as determining their size, surface charge, and drug release properties.
Nanoparticles ppt
This document provides an overview of nanoparticles, including their ideal properties for drug delivery, classifications, methods of preparation, polymers used in preparation, and applications. Nanoparticles are defined as particulate dispersions or solid particles ranging from 1-100nm in size. They can be used to deliver drugs encapsulated, entrapped or attached to a nanoparticle matrix. Common types are nanocapsules, which contain drugs within a polymer membrane, and nanospheres, which uniformly disperse drugs within a polymer matrix. Methods of preparation include crosslinking of amphiphilic macromolecules or polymerization techniques. Nanoparticles show advantages for targeted drug delivery and modifying drug release profiles.
Magnetic microspheres
Magnetic microspheres are small particles containing magnetite that can be guided to target tissues using external magnetic fields. They allow drugs to be delivered at lower doses directly to tissues while avoiding toxicity. Microspheres are prepared using methods like phase separation or solvent evaporation to encapsulate drugs and magnetite in carriers like albumin. Particle characteristics and drug release kinetics can be evaluated using techniques like dialysis, imaging, and microscopy. Magnetic microspheres show potential for targeted drug delivery but also have technical challenges for approval.
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This document discusses various types of nanoparticles including their properties, preparation, and applications. It describes carbon-based nanoparticles like carbon nanotubes, solid-lipid nanoparticles, silicon-based nanoparticles, liposomes, nanosomes, and niosomes. Nanoparticles have sizes between 1-100 nanometers and unique optical, magnetic, mechanical, and thermal properties dependent on their size and structure. They are useful for drug and gene delivery, cancer therapy, and other medical applications due to properties like cell specificity and reduced toxicity.
NANOPARTICLE
This document provides an overview of nanoparticles for drug delivery. It defines nanoparticles as sub-nano sized colloidal structures composed of synthetic or semi-synthetic polymers with a size range of 10-1000 nm. The document then classifies nanoparticles and discusses commonly used polymer materials. It describes advantages such as improved drug stability and targeting abilities. Preparation methods like emulsion polymerization and solvent evaporation are summarized. Key characterization techniques and applications for cancer therapy and prolonged circulation are also highlighted.
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This document discusses nanotechnology and nanoparticles in pharmacy. It begins by defining nanotechnology as manipulating matter at the atomic scale between 1-1000 nm. In pharmacy, nanoparticles are used to synthesize, characterize, and screen particles at the nano range. The document then discusses various methods of nanoparticle preparation including emulsion polymerization, dispersion polymerization, and interfacial polymerization. It covers advantages and applications of nanoparticles in targeted drug delivery and concludes by discussing pharmaceutical aspects such as purification, freeze drying, and sterilization of nanoparticles.
Nanoscale drug delivery system
This document discusses nanoscale drug delivery systems for targeted cancer treatment. It describes how nano particles can be used to deliver drugs specifically to tumor sites to improve bioavailability and reduce toxicity. Common nanoscale delivery vehicles like liposomes, nanoparticles, and microemulsions are explained. The goals and advantages of these systems for targeted drug delivery, constant release kinetics, and improved stability are outlined. Barriers to conventional drug delivery and factors influencing delivery profiles are also reviewed. Magnetic hyperthermia for cancer using iron oxide nanoparticles is presented as a promising non-invasive treatment approach. Further refinement of reproducibility and reducing toxicity is still needed for these emerging nanotechnologies to fully realize their potential for chemotherapy.
MAGNETIC MICROSPHERE
This document discusses magnetic microspheres, which are small polymer particles containing magnetite that can be used for targeted drug delivery. Magnetic microspheres are small enough to circulate but can be dragged to nearby tissues using external magnetic fields. They allow high local drug concentrations at targeted sites with controlled release over 30 minutes to 30 hours. Magnetic microspheres are prepared using phase separation emulsion polymerization or continuous solvent evaporation techniques. However, magnetic targeting requires specialized equipment and trained personnel.
Nanoparticles
The seminar discussed nanoparticles for drug delivery. Nanoparticles are defined as sub-nanosized colloidal structures between 10-1000nm that can be used to dissolve, entrap, encapsulate or attach drugs. They are classified based on composition and include solid lipid nanoparticles, polymeric nanoparticles, ceramic nanoparticles, and others. Methods for preparing nanoparticles include polymerization, solvent evaporation, and supercritical fluid technology. Nanoparticles offer advantages for drug delivery such as targeted delivery and improved stability and therapeutic effects but also have challenges including potential toxicity. The seminar provided an overview of the types of nanoparticles, preparation methods, characterization techniques, and applications for drug delivery.
Nanoparticles
This document discusses nanoparticles and their uses in drug delivery. It defines nanoparticles as particulate dispersions between 10-1000nm in size. Nanoparticles are classified based on their method of preparation into nanocapsules and nanospheres. Some common types of nanoparticles discussed are solid lipid nanoparticles, polymeric nanoparticles, ceramic nanoparticles, and hydrogel nanoparticles. The document outlines advantages like increased shelf stability and ability to control drug release. Evaluation parameters for nanoparticles include particle size, molecular weight and in vitro drug release. Finally, applications like targeted drug delivery to the brain and topical formulations are mentioned.
Nano particle Preparation and Evaluation
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Solid lipid nanoparticles, nanostructured lipid carriers, nanosuspensions, and SMEDs/SNEDs were discussed. The document provided details on the composition, preparation, advantages, applications, and challenges of each drug delivery system. Solid lipid nanoparticles can solubilize lipophilic drugs and offer properties like small size and high drug loading. Nanostructured lipid carriers improve drug loading and release using both solid and liquid lipids. Nanosuspensions reduce particle size to below 1um to enhance dissolution and bioavailability of poorly soluble drugs.
Microsphere
Microspheres are small spherical particles used for controlled drug delivery. They can be made from either synthetic or natural polymers and loaded with drugs through various techniques. The drug is then released from the microspheres through diffusion, degradation of the polymer, or other mechanisms over an extended time period. Microspheres offer benefits over conventional drug therapy such as reduced dosing frequency and fewer side effects by targeting drug delivery.
Microspheres-Magnetic microspheres
The document discusses magnetic microspheres, which are microparticles that can be guided to target sites in the body using external magnetic fields. They are typically made of polymers and magnetite. Methods for producing them include solvent evaporation and phase separation emulsion polymerization. Magnetic microspheres offer advantages like controlled drug release and reduced toxicity. They can be used to deliver drugs, vaccines, and antigens to specific areas for localized treatment. Characterization techniques evaluate their size, shape, composition and drug release profiles. Magnetic targeting allows microspheres to accumulate drugs at disease sites while avoiding uptake by the reticuloendothelial system.
Nanotechnology
Nanotechnology offers drugs in the nanometer size range, which enhances the performance in a variety of dosage forms
Nanoparticle: Type & Preparation
Nanoparticles range in size from 10-1000 nm and can be prepared through various methods. They are classified based on their composition and include polymeric nanoparticles, solid lipid nanoparticles, liposomes, magnetic nanoparticles, and more. Common preparation techniques include solvent evaporation, salting out, emulsions-diffusion, and ionic gelation. The solvent evaporation method involves creating an organic phase with the drug and polymer dissolved in a solvent, and an aqueous phase with a surfactant. The phases are mixed and the solvent is evaporated to form nanoparticles.
Formulation and evaluation_of_microspheres[1]
The document discusses microspheres as carriers for controlled drug delivery. It defines microspheres as small, insoluble, spherical particles consisting of a polymer matrix and drug. Various methods for preparing microspheres are described, including single and double emulsion techniques. Characterization techniques like particle size analysis and release studies are also summarized. Potential applications of microspheres include vaccine delivery, targeted drug delivery to specific sites like the eyes, and controlled release formulations.
SOLID LIPID NANOPARTICLE ppt
Solid lipid nanoparticles (SLN) are colloidal carriers composed of a solid lipid core coated by surfactants. They are used to deliver poorly soluble drugs. SLN offer advantages over liposomes and emulsions like improved stability and avoidance of organic solvents. They can be prepared by various methods like high pressure homogenization. Characterization involves analyzing particle size, surface charge, drug release profile and stability. PEGylation of SLN produces stealth SLN that have prolonged circulation by avoiding uptake by the reticuloendothelial system. Applications of SLN include cancer therapy, vaccines, oral drug delivery, and gene/oligonucleotide delivery.
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Microspheres as drug delivery system
The document discusses microspheres, which are defined as solid, spherical particles ranging from 1 to 1000 μm made of polymeric, waxy, or other protective materials used for drug delivery. Microspheres can be matrix systems that homogeneously disperse drugs or reservoir systems that encapsulate drug cores. Common preparation methods include solvent evaporation, phase separation, spray drying, and polymerization. Microspheres offer benefits like controlled release, targeted delivery, and protection of unstable drugs. They find uses in applications such as vaccines, targeted drug delivery to tissues, controlled release, chemoembolization, and immunoconjugates.
Drug Delivery Through Microspheres
Microspheres are spherical & free flowing particles ranging in average particle size from 1 to 50 microns which consist of proteins or synthetic polymers. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microspheres as carriers for drugs. The target site drug deliver with Specificity & maintain the concentration at site of interest without untoward effects. It will find the central place in novel drug delivery. Drugs can be targeted to specific sites in the body using microspheres. Degree of targeting can be achieved by localization of the drug to a specific area in body (for example in lungs), to a particular group of cells and even to the intracellular structures. The rate of drug release from the microspheres dictates their therapeutic action.
MICROCAPSULE/ MICROSPHERES:- TYPES, PREPARATION & EVALUATION
Microparticles or microspheres are defined as small, insoluble, free flowing spherical particles consisting of a polymer matrix and drug. and sized from about 50 nm to about 2 mm. The term nanospheres is often applied to the smaller spheres (sized 10 to 500 nm) to distinguish them from larger microspheres.
Microspheres and magnetic
This document discusses microspheres and magnetic microspheres. It defines magnetic microspheres as microspheres containing magnetic substances that can be targeted using an external magnetic field. The document covers concepts like using magnetic microspheres for targeted drug delivery and their advantages like preventing rapid clearance and achieving controlled drug release. Preparation methods like single and double emulsion techniques are summarized. Characterization techniques and applications in areas like vaccine delivery and imaging are also mentioned.
nano
This document discusses nanoparticles, including their definition, advantages, disadvantages, ideal characteristics, and methods of preparation and evaluation. Nanoparticles are subnanosized colloidal drug delivery systems ranging from 10-1000 nm that can selectively target drugs to specific sites in the body. The document outlines various preparation methods like crosslinking, polymerization, solvent evaporation, and solvent displacement. Characterization techniques discussed include evaluating particle size, density, structure, and drug release profile. The goal of nanoparticles is to effectively deliver drugs to target sites while avoiding uptake by non-target tissues.
nano particles.pptx
Nanoparticles are solid colloidal particles ranging from 1 to 1000 nm in size that can be used for targeted drug delivery. There are two main types of nanoparticles - nanospheres, which are matrix structures where the drug is dispersed throughout, and nanocapsules, which have a liquid core surrounded by a membrane where the drug is housed. Nanoparticles can be formulated using various methods, the most common being solvent evaporation, solvent diffusion, and polymerization. They offer advantages for drug delivery such as reducing dosing frequency and side effects while increasing drug targeting to specific tissues.
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MAGNETIC MICROSPHERE
This document discusses magnetic microspheres, which are small polymer particles containing magnetite that can be used for targeted drug delivery. Magnetic microspheres are small enough to circulate but can be dragged to nearby tissues using external magnetic fields. They allow high local drug concentrations at targeted sites with controlled release over 30 minutes to 30 hours. Magnetic microspheres are prepared using phase separation emulsion polymerization or continuous solvent evaporation techniques. However, magnetic targeting requires specialized equipment and trained personnel.
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The seminar discussed nanoparticles for drug delivery. Nanoparticles are defined as sub-nanosized colloidal structures between 10-1000nm that can be used to dissolve, entrap, encapsulate or attach drugs. They are classified based on composition and include solid lipid nanoparticles, polymeric nanoparticles, ceramic nanoparticles, and others. Methods for preparing nanoparticles include polymerization, solvent evaporation, and supercritical fluid technology. Nanoparticles offer advantages for drug delivery such as targeted delivery and improved stability and therapeutic effects but also have challenges including potential toxicity. The seminar provided an overview of the types of nanoparticles, preparation methods, characterization techniques, and applications for drug delivery.
Nanoparticles
This document discusses nanoparticles and their uses in drug delivery. It defines nanoparticles as particulate dispersions between 10-1000nm in size. Nanoparticles are classified based on their method of preparation into nanocapsules and nanospheres. Some common types of nanoparticles discussed are solid lipid nanoparticles, polymeric nanoparticles, ceramic nanoparticles, and hydrogel nanoparticles. The document outlines advantages like increased shelf stability and ability to control drug release. Evaluation parameters for nanoparticles include particle size, molecular weight and in vitro drug release. Finally, applications like targeted drug delivery to the brain and topical formulations are mentioned.
Nano particle Preparation and Evaluation
The document discusses different types of nanoparticles used in drug delivery, including liposomes, solid nanoparticles, polymeric nanoparticles, nanocapsules, nanospheres, dendrimers, nanotubes, nanowires, and nanocrystals. It also describes several methods for preparing nanoparticles, such as solvent evaporation, emulsions-diffusion, nanoprecipitation, salting out, and dialysis. Evaluation methods for prepared nanoparticles are discussed, including measuring yield, drug content, particle size, zeta potential, surface morphology, polydispersity index, in-vitro release studies, and kinetic studies.
Nanoformulation
Solid lipid nanoparticles, nanostructured lipid carriers, nanosuspensions, and SMEDs/SNEDs were discussed. The document provided details on the composition, preparation, advantages, applications, and challenges of each drug delivery system. Solid lipid nanoparticles can solubilize lipophilic drugs and offer properties like small size and high drug loading. Nanostructured lipid carriers improve drug loading and release using both solid and liquid lipids. Nanosuspensions reduce particle size to below 1um to enhance dissolution and bioavailability of poorly soluble drugs.
Microsphere
Microspheres are small spherical particles used for controlled drug delivery. They can be made from either synthetic or natural polymers and loaded with drugs through various techniques. The drug is then released from the microspheres through diffusion, degradation of the polymer, or other mechanisms over an extended time period. Microspheres offer benefits over conventional drug therapy such as reduced dosing frequency and fewer side effects by targeting drug delivery.
Microspheres-Magnetic microspheres
The document discusses magnetic microspheres, which are microparticles that can be guided to target sites in the body using external magnetic fields. They are typically made of polymers and magnetite. Methods for producing them include solvent evaporation and phase separation emulsion polymerization. Magnetic microspheres offer advantages like controlled drug release and reduced toxicity. They can be used to deliver drugs, vaccines, and antigens to specific areas for localized treatment. Characterization techniques evaluate their size, shape, composition and drug release profiles. Magnetic targeting allows microspheres to accumulate drugs at disease sites while avoiding uptake by the reticuloendothelial system.
Nanotechnology
Nanotechnology offers drugs in the nanometer size range, which enhances the performance in a variety of dosage forms
Nanoparticle: Type & Preparation
Nanoparticles range in size from 10-1000 nm and can be prepared through various methods. They are classified based on their composition and include polymeric nanoparticles, solid lipid nanoparticles, liposomes, magnetic nanoparticles, and more. Common preparation techniques include solvent evaporation, salting out, emulsions-diffusion, and ionic gelation. The solvent evaporation method involves creating an organic phase with the drug and polymer dissolved in a solvent, and an aqueous phase with a surfactant. The phases are mixed and the solvent is evaporated to form nanoparticles.
Formulation and evaluation_of_microspheres[1]
The document discusses microspheres as carriers for controlled drug delivery. It defines microspheres as small, insoluble, spherical particles consisting of a polymer matrix and drug. Various methods for preparing microspheres are described, including single and double emulsion techniques. Characterization techniques like particle size analysis and release studies are also summarized. Potential applications of microspheres include vaccine delivery, targeted drug delivery to specific sites like the eyes, and controlled release formulations.
SOLID LIPID NANOPARTICLE ppt
Solid lipid nanoparticles (SLN) are colloidal carriers composed of a solid lipid core coated by surfactants. They are used to deliver poorly soluble drugs. SLN offer advantages over liposomes and emulsions like improved stability and avoidance of organic solvents. They can be prepared by various methods like high pressure homogenization. Characterization involves analyzing particle size, surface charge, drug release profile and stability. PEGylation of SLN produces stealth SLN that have prolonged circulation by avoiding uptake by the reticuloendothelial system. Applications of SLN include cancer therapy, vaccines, oral drug delivery, and gene/oligonucleotide delivery.
Pr esent ation of nanoparticle
This document provides an overview of nanoparticles including their classification, methods of preparation, evaluation, advantages, disadvantages, and applications. Nanoparticles are particles between 1-100 nanometers in size that can be classified based on their dimensions. They can be prepared using various methods such as micellar nucleation, polymerization, or dispersion polymerization. Nanoparticles are evaluated based on parameters like particle size, molecular weight, structure, and in vitro drug release profile. They provide benefits like targeted drug delivery and reduced toxicity but also have challenges like particle aggregation and limited drug loading. Nanoparticles have potential applications in drug delivery.
Microspheres as drug delivery system
The document discusses microspheres, which are defined as solid, spherical particles ranging from 1 to 1000 μm made of polymeric, waxy, or other protective materials used for drug delivery. Microspheres can be matrix systems that homogeneously disperse drugs or reservoir systems that encapsulate drug cores. Common preparation methods include solvent evaporation, phase separation, spray drying, and polymerization. Microspheres offer benefits like controlled release, targeted delivery, and protection of unstable drugs. They find uses in applications such as vaccines, targeted drug delivery to tissues, controlled release, chemoembolization, and immunoconjugates.
Drug Delivery Through Microspheres
Microspheres are spherical & free flowing particles ranging in average particle size from 1 to 50 microns which consist of proteins or synthetic polymers. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microspheres as carriers for drugs. The target site drug deliver with Specificity & maintain the concentration at site of interest without untoward effects. It will find the central place in novel drug delivery. Drugs can be targeted to specific sites in the body using microspheres. Degree of targeting can be achieved by localization of the drug to a specific area in body (for example in lungs), to a particular group of cells and even to the intracellular structures. The rate of drug release from the microspheres dictates their therapeutic action.
MICROCAPSULE/ MICROSPHERES:- TYPES, PREPARATION & EVALUATION
Microparticles or microspheres are defined as small, insoluble, free flowing spherical particles consisting of a polymer matrix and drug. and sized from about 50 nm to about 2 mm. The term nanospheres is often applied to the smaller spheres (sized 10 to 500 nm) to distinguish them from larger microspheres.
Microspheres and magnetic
This document discusses microspheres and magnetic microspheres. It defines magnetic microspheres as microspheres containing magnetic substances that can be targeted using an external magnetic field. The document covers concepts like using magnetic microspheres for targeted drug delivery and their advantages like preventing rapid clearance and achieving controlled drug release. Preparation methods like single and double emulsion techniques are summarized. Characterization techniques and applications in areas like vaccine delivery and imaging are also mentioned.
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MICROCAPSULE/ MICROSPHERES:- TYPES, PREPARATION & EVALUATION
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Nanoparticles ishita slideshare
this slides covers nanoparticles definiyion , types, method of preparation, advantages ,applications , in a simplified manner
Nanoparticles drug delivery system
Sr no Contents
1 Introduction
2 Advantages and disadvantages
3 Types of nanoparticle
4 Classification of Nanoparticle
5 Polymers used in nanoparticles
6 Method of preparation
7 Evaluation of nanoparticles
8 Application of nanoparticles
9 References
Nanoparticles is derived from the Greek word Nano means extremely small.
Nanoparticles are sub Nano sized colloidal drug delivery systems .
Particle size ranges from 10-1000 nm in diameter .
They are made up of natural, synthetic or semi synthetic polymers carrying drugs or proteinaceous substances, i.e. antigen(s) .
Drugs are entrapped either in the polymer matrix as a particulates or solid solutions or may be bound to particle surface by physical adsorption or by chemical reaction.
Drug can be added during preparation of nanoparticles or to the previously prepared nanoparticles
Nanoparticles can act as controlled release system depending on their polymeric composition.
As a targeted drug carrier nanoparticles reduce drug toxicity
Less amount of dose required.
They enhance aqueous solubility of poorly soluble drug therefore increase its bioavailability, therapeutic efficacy and Reduces side effects.
Nanoparticles can be administer by various routes including oral, nasal, parenteral, intra-ocular etc.
A) AMPHIPHILIC MACROMOLECULE CROSS-LINKING
B) Polymerization method
C)Polymer precipitation method
Heat cross-linking
Chemical cross-linking
Emulsion chemical dehydration
By Crosslinking in W/O Emulsion
PH-induced aggregation
Counter ion induced aggregation
Emulsion polymerization a)Micellar nucleation and polymerization b)Homogenous nucleation and polymerization)
Dispersion polymerization
Interfacial polymerization
Emulsion solvent evaporation method
Double emulsion and evaporation method
Solvent displacement
Salting out
Nanoprecipitation
Depot preparations
This document presents information on parenteral depot systems for long acting drug formulations. It discusses various approaches for controlled drug release including the use of viscous vehicles, polymeric microspheres, and drug derivatives. Common polymers used in depots are described as well as desirable characteristics. The main types of depot formulations are discussed - dissolution controlled, adsorption, encapsulation, and esterification. Examples of specific long acting preparations are provided for antibiotics, insulin, vitamin B12, and contraceptives. Evaluation methods and the development of depots are outlined.
Nanocapsules is a novel approach by pankaj patil.pptx
Nanocapsules are submicron colloidal systems with a polymeric membrane surrounding an inner liquid or solid core containing the active drug. They offer advantages over other drug delivery systems like higher drug loading, protection from degradation, and controlled release. Nanocapsules can be prepared using various methods such as nanoprecipitation, emulsion-diffusion, double emulsification, emulsion-coacervation, and polymer-coating. Their characterization involves analyzing particle size, surface charge, and drug localization. Nanocapsules find applications in oral and parenteral drug delivery, cancer treatment, bioimaging, and food science due to their ability to enhance bioavailability and target drug release.
Nanoparticle for drug delivery system
This document discusses nanoparticles, which are solid colloidal particles between 1-100 nm in size that can be used for drug delivery. Some key points discussed include:
- Nanoparticles offer advantages over microparticles for drug delivery due to their small size and ability to cross biological barriers.
- Common preparation methods include solvent evaporation, salting out, and nanoprecipitation.
- Particle size, surface charge, drug entrapment efficiency, and release kinetics are important characteristics to evaluate.
- Applications include cancer therapy, vaccines, and treatments requiring sustained or targeted drug delivery.
Microspheres USED AS DRUG DELIVERY SYSTEM
The document discusses microspheres, which are solid spherical particles made of polymeric substances that can encapsulate drugs. Microspheres range in size from 1-1000μm and enable controlled drug release. They were first developed in the 1930s and are now commonly used in pharmaceutical applications. Key manufacturing methods include single/double emulsion techniques, polymerization, coacervation, spray drying, and solvent extraction. Microspheres offer advantages like accurate dosing, protection of drugs, and controlled release profiles.
Nanoparticles and liposomes ppt
This document provides an introduction to targeted drug delivery and summarizes key points about nanoparticles and liposomes. It discusses advantages of targeted delivery including reducing toxicity and maximizing therapeutic effects. Nanoparticles and liposomes are described as methods for targeted delivery. Key preparation techniques for nanoparticles include solvent evaporation, double emulsification, and nano precipitation. Evaluation parameters like particle size, zeta potential, and in vitro drug release are also summarized. The document concludes with describing applications of liposomes for drug and gene delivery.
Microspheres
An overview of Microspheres including Advantages, Types, Method of preparation, Materials used in preparations, Characterization or Evaluation and Applications.
Pharmaceutical Nanoparticles
This document provides an overview of nanoparticles, including:
- A definition of nanoparticles as sub-nanosized colloidal drug delivery systems ranging from 1-100nm in diameter.
- The history of nanoparticles dating back to Richard Feynman in the 1960s.
- The need for and advantages of nanoparticles for site-specific drug targeting and reduced toxicity compared to traditional drugs.
- Common polymers and preparation methods used to produce nanoparticles, including emulsion solvent evaporation, salting out, and high pressure homogenization.
- Applications of nanoparticles in cancer chemotherapy and other areas.
Nanoparticle by ankit parulkar
This document discusses nanoparticles as drug delivery systems. Nanoparticles range from 10-1000 nm and are composed of polymers carrying drugs. They selectively localize drugs in target tissues while restricting access to non-target tissues. Ideal nanoparticles are biocompatible, stable, have controlled drug release, and are easily prepared. Common preparation methods include cross-linking, polymerization, and precipitation. Nanoparticles can be characterized and their drug release evaluated. Applications include cancer therapy, vaccines, and crossing the blood-brain barrier.
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Nanoparticle
- 1. C NANOPARTICLE Presented By: SANDIPA KUNDU M.PHARM,1ST YEAR PHARMACEUTICS GUPTA COLLEGE OF TECHMOLOGICAL SCIENCES
- 2. CONTENTS: • INTRODUCTION • CLASSIFICATION OF NANOPARTICLES • IDEAL CHARACTERISTICS • ADVANTAGES • DISADVANTAGEF • METHOD OF PREPARATION • APPLICATION • REFERANCE
- 3. INTRODUCTION : DEFINATION – Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 10-1000nm. Nanoparticles are sub-nanosized colloidal structures composed of synthetic or semi- synthetic polymers. They are composed of synthetic or semi synthetic polymers carrying drugs or proteinaceous substances, i.e. antigen(s). Drugs are entrapped in the polymer matrix particulates or solid solutions or may be bound to particle surface by physical adsorption or in chemical form
- 7. 1 • It should be biochemical inert , non toxic. 2 • It should be stable both physically and chemically in In-vivo & in vitro conditions. 3 • The preparation of the delivery system should be easy. 4 • Specific Therapeutic amount of drug release must be possessed. IDEAL CHARACTERISTICS:
- 8. 2.Suitable for combination therapy where two or more drug can be co-delivered 1.Carrying capacity of nanoparticles is high. 3. They are suitable for different routes of administration 4.Ability to sustain and control drug release patterns. 5.Shelf-stability of drug increases. ADVANTAGES:-
- 9. DISADVANTAGES:- 1) High cost 2)Productivity more difficult 3) Reduced ability to adjust the dose 4) Highly sophisticated technology 5) Requires skills to manufacture
- 10. METHOD OF PREPARATION: Emulsion-Solvent Evaporation Method Double Emulsion and Evaporation Method Salting Out Method Emulsions- Diffusion Method Solvent Displacement / Precipitation method
- 11. EMULSION SOLVENT EVAPORATION:
- 12. DOUBLE EMULSION EVAPORATION METHOD:
- 13. SALTING OUT METHOD:
- 14. • It consists in the formation of a conventional o/w emulsion between a partially water- miscible solvent containing the polymer and the drug, and an aqueous solution, containing a surfactant. • In contrast with methods based on solvent evaporation, in this technique the droplet size decreases suddenly in a millisecond time scale during solvent diffusion. • Nanospheres are produced by this method but nanocapsules can be obtained just by adding a small amount of oil, for example miglyol, in the organic phase. • Finally, depending on its boiling point, the solvent can be eliminated by evaporation or filtration. EMULSION DIFFUSION :
- 15. SOLVENT DISPLACEMENT/ PRECIPITATION METHOD:
- 16. Targeting drug delivery by encapsulation .Therapeutic drug molec ules have been immobilized on the surface of magnetic NanoParticles or nanocrystals and directed to a specific target tissue using a magnetic field gradient. Nanoparticles for drug delivery into the brain. Nanoparticle for ophthalmic delivery. Topical formulation. Nanoparticles for oral delivery of peptides & portions . APPLICATION OF NANOPARTICLE:
- 18. REFERENCE • Tropical Journal of Pharmaceutical Research, June 2006; 5 (1): 561-573Nanoparticles – A Review VJ Mohanraj* and Y Chen • NANOPARTICLE (pdf) Presented By- Chetan Vishwanath Pawar, PDEA’s S.G.R.S. College of Pharmacy Saswad. • Nanoparticle Use in Pharmaceutical Analysis, DR. PRITI J. MEHTA