1. FORMULATION AND EVALUATION OF MICROSPHERES PRESENTED BY DADHICHI K THAKKAR M.PHARM SEMISTER -I Guided by :-Dr UPENDRA PATEL DEPARTMENT OF PHARMACUETICAL TECHNOLOGY ARIHANT COLLEGE OF PHARMACY GUJARAT TECHNICAL UNIVERSITY. .
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17. SINGLE EMULSION BASED METHOD Aq.Solution/suspension of polymer Dispersion in organic phase (Oil/Chloroform) Microspheres in organic phase Microspheres in organic phase MICROSPHERES Stirring, Sonication CROSS LINKING Chemical cross linking (Glutaraldehyde/Formaldehyde/Butanol Heat denaturation Centrifugation, Washing, Separation
18. Aq.Solution of protein/polymer First emulsion (W/O) MICROSPHERES Dispersion in oil/organic phase Homogenization Separation, Washing, Drying Addition of aq. Solution of PVA Addition to large aq. Phase Denaturation/hardening Multiple emulsion Microspheres in solution DOUBLE EMULSION BASED METHOD
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21. PHASE SEPARATION METHOD Aqueous/Organic.Solution of polymer Drug dispersed or dissolved in polymer solution MICROSPHERES Drug Separation, Washing, Drying Hardening Polymer rich globules Microspheres in aq./organic phase