Myasthenia gravis is an autoimmune disorder that causes muscle weakness by interfering with signal transmission at the neuromuscular junction. It is characterized by varying degrees of weakness in the voluntary muscles. The most common cause is an acquired immunological abnormality where autoantibodies are produced against acetylcholine receptors, reducing the number available to stimulate the muscle. Symptoms include drooping eyelids, double vision, difficulty speaking, swallowing and breathing, and generalized weakness exacerbated by activity. Diagnosis involves tests like the Tensilon test and detecting autoantibodies. Treatment aims to improve transmission at the neuromuscular junction using cholinesterase inhibitors and immunosuppressants, and sometimes surgery to
Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking.
Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing.
Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking.
Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing.
Myasthenia gravis (MG) is a neuromuscular disorder characterized by weakness and fatigability of skeletal muscles.
The underlying defect is a decrease in the number of available acetylcholine receptors (AChRs) at neuromuscular junctions due to an antibody-mediated autoimmune attack
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Myasthenia gravis (MG) is a neuromuscular disorder characterized by weakness and fatigability of skeletal muscles.
The underlying defect is a decrease in the number of available acetylcholine receptors (AChRs) at neuromuscular junctions due to an antibody-mediated autoimmune attack
Amyotrophic lateral sclerosis (ALS), AKA "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
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AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
3. INTRODUCTION
The most common primary disorder of
neuromuscular transmission.
Usual cause is an acquired immunological
abnormality
But some cases result from genetic
abnormalities at the neuromuscular
junction.
4. DEFINITION
Myasthenia gravis, an autoimmune disorder
affecting the myoneural junction, is
characterized by varying degrees of
weakness of the voluntary muscles.
5. NEUROMUSCULAR TRANSMISSION
The normal neuromuscular junction releases
acetylcholine (ACh) from the motor nerve terminal in
discrete packages
The ACh quanta diffuse across the synaptic cleft and
bind to receptors on the folded muscle end-plate
membrane.
Stimulation of the motor nerve releases many ACh
quanta that depolarize the muscle end-plate region and
then the muscle membrane causing muscle contraction.
6.
7.
8. PATHOPHYSIOLOGY
Normally, a chemical impulse precipitates the release of
acetylcholine from vesicles on the nerve terminal at the
myoneuraljunction.
The acetylcholine attaches to receptor sites on the motor
end plate, stimulating muscle contraction.
Continuous binding of acetylcholine to the receptor site is
required for muscular contraction to be sustained.
9. PATHOPHYSIOLOGY…
In myasthenia gravis, autoantibodies directed at the
acetylcholine receptor sites impair transmission of
impulses across the myoneural junction.
Therefore, fewer receptors are available for stimulation,
resulting in voluntary muscle weakness that escalates
with continued activity.
10. THE THYMUS IN MYASTHENIA GRAVIS
80% of persons with myasthenia gravis have
either thymic hyperplasia or a thymic tumor and
the thymus gland is believed to be the site of
antibody production.
11.
12. Factors that worsen myasthenic symptoms
Emotional upset
Systemic illness
Hypothyroidism or hyperthyroidism
Pregnancy
The menstrual cycle
Drugs affecting neuromuscular transmission,
Increase in body temperature
13. TYPES
Ocular M.G: weakness of eye and lid
muscles only.
Bulbar M.G: Involves breathing, swallowing
and speech :C.N 9th & 12th
Generalized M.G: Involves the proximal
muscles of limbs and neck, usually with
ocular and/ or bulbar symptoms.
15. Clinical Manifestations…
Weakness of the muscles of the face and the throat,
and generalized weakness. Weakness of the facial
muscles results in bland facial expression.
Laryngeal irritation causes voice impairment and
dysphonias and increases the patient’s risk for
choking and aspiration.
16. Clinical Manifestations…
Generalized weakness of all the extremities and
the intercoastal muscles resulting in decreased
respiratory capacity and vital capacity.
Myasthenia gravis is purely a motor disorder with
no effect on the sensation and coordination.
17. CLINICAL PRESENTATION ( Cont..)
Sleepy mask like expression; horizontal
smile ( cranial nerves of face involvement )
Dysphonia (nasal quality to speech )
Easy fatigability
Weakness in proximal muscles (difficulty
climbing stairs, doing deep knee bends and
raising arms above head.)
20. The EdrophoniumChloride (Tensilon) Test
Tensilon ( short acting anticholinesterase which inhibit
cholinesterase which is an enzyme that breaks down Ach
in NM junction)
A test dose of 2 mg of Tensilon is injected first.( IV push)
If no adverse events ( increased weakness; change in
heart rate or rhythm; nausea or abdominal cramps), the
remaining 8 mg is injected. ( slow IV push)
An abrupt improvement in symptoms lasting 5 -10
minutes is a positive test.
21. DIAGNOSIS…
Neostigmine methylsulfate ( Prostigmin) :
long acting anticholinesteerase has longer
effect on muscle strength ( 1-2 hrs) which
allows better analysis of its effect.
Used in children
22. DIAGNOSIS ( Cont..)
Electromyography: measure and document electric current
produced by skeletal muscles ( muscle action potential).
Small needle electrodes are inserted into muscles being
assessed for nerve innervations. A stimulator is placed over
peripheral nerve being tested.
Repetitive Nerve Stimulation (RNS): Progressively decreasing
amplitude; decrementing response of muscle action
potential
CT / MRI: thymus tumor, hyperplasia
23. Osserman’s Classification in MG
Asymptomatic
1 Ocular signs and symptoms
2 Mild generalised weakness
3 Moderate generalised weakness, bulbar dysfunction, or both
4 Severe generalised weakness, respiratory dysfunction, or both
The severity and progress of the disease is assessed using the Osserman classification
26. Corticosteroids
To reduce level of serum Ach receptor antibodies
Prednisone
Initial dose: 15 to 25 mg /d
Stepwise increase: 5 mg / d at 2 –3 day interval until reached by 50 mg / d
Maintained for 1 – 3 months
Gradually modified , alternate day for 2 –3 months,
Until a dose of 100mg is reached , alt day
28. Immunomodulatory therapy
Intravenous Immune Globulin (IVIG)
(2 grams/kg infused over 2 to 5 days) I
Plasmapheresis to remove plasma protein
containing antibodies believed to cause M.G( plasma is
separated from formed elements of blood. Plasma is
discarded and packed RBCs are joined with albumin, N.S,
and electrolytes and returned back to client )
29. THYMECTOMY
The maximal favorable response generally
occurs 2 to 5 years after surgery.
The best responses to thymectomy are in
young people early in the course of their
disease, but improvement can occur even
after 30 years of symptoms.
30.
31. COMPLICATIONS
Severe generalized and rapidly increasing
weakness, dysphagia or resp failure.
Myasthenia crisis due to undermedication.
Increased BP, HR, secretions, lacrimation. Absent cough
and swallow reflex.
Cholinergic crisis due to overdose. Weakness with
swallowing, chewing , speaking, breathing. Increased
secretions
33. NURSING DIAGNOSIS
Risk for ineffective breathing pattern related to the weakness of
the respiratory muscles.
Impaired physical mobility related to voluntary muscle weakness.
High risk for aspiration related to weakness of the bulbar
muscles.
Impaired verbal communication related to the weakened speech
muscles.
Fatigue related to muscle weakness.
Sensory/perceptual alterations related to impaired vision.