This PPT covers the Pathophysiology of Myasthenia gravis which includes Pathophysiology, Symptoms, diagnosis and treament

1. PREPARED BY: JEGAN. S. NADAR
MYASTHENIA GRAVIS

2. MYASTHENIA GRAVIS
 Myasthenia gravis is an autoimmune disorder affecting the myoneural junction,
is characterized by varying degrees of weakness of the voluntary muscles.
 It is also a neuromuscular disorder
 It occurs when communication between nerve cells and muscles becomes
impaired
 This impairment prevents crucial muscle contractions from occurring, resulting in
muscle weakness Jegan

3.  MG is a neuromuscular disorder that’s usually caused by an autoimmune
problem.
 Autoimmune disorders occur when your immune system mistakenly attacks
healthy tissue.
 In this condition, antibodies, which are proteins that normally attack foreign,
harmful substances in the body, attack the Nicotinic acetylcholine receptor,
which is a crucial substance for communication between nerve cells and
muscles.
 This results in muscle weakness.
Jegan

4. MYASTHENIA GRAVIS
 The most commonly affected muscles are those of the eyes, face, and
mouth.
 It can result in
 Double vision
 Drooping eyelids
 Trouble talking
 Trouble walking Jegan

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8. SYMPTOMS
Ptosis
Dysphagia
Dysarthria
Facial weakness
Dyspnea
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10. DIAGNOSIS
 MG can be difficult to diagnose, as the symptoms can be subtle and hard
to distinguish from both normal variants and other neurological disorder
 Physical examination
 Blood test
 Electrodiagnostics
 MRI
Jegan

11. TREATMENT
 Treatment is by medication and/or surgery.
 Medication consists mainly of
 Acetylcholinesterase inhibitors to directly improve muscle function
 Immunosuppressant drugs to reduce the autoimmune process
Jegan

12. Thank You