1. The document discusses different types of mixing for solids and semi-solids used in pharmacy. It describes mixing mechanisms like convective, shear, and diffusive mixing.
2. Various mixers for solids are described, including tumbling mixers, agitator mixers, and special mixers. Factors that affect solid mixing like particle size and density are also discussed.
3. Mixers for semi-solids and pastes include beaters, kneaders, mixer-extruders, and mixing rolls. Different flow types for semi-solids are noted.
Mixer Machines Mixer Machines are used in a number of different applications and industries in order to produce a final product that is the result of mixing or combining two or more materials.
This document discusses milling processes used in pharmaceutical applications. It describes various types of mills and factors to consider for mill selection. The key points are:
1. Milling is used to reduce particle size for improved dissolution and bioavailability. Common mills include hammer, ball, fluid energy and roller mills.
2. Selection depends on the material properties, desired particle size, capacity needs, and whether wet or dry milling is required. Attrition, impact and cutting forces can be applied.
3. Particle size distribution is important and can be measured via microscopy, sieving or sedimentation. Narrow distributions are desirable for consistent drug effects.
This document discusses mixing and blending in the pharmaceutical industry. It defines mixing as a unit operation aimed at reducing non-uniformity in a material's properties. The main goals of mixing are producing a uniform blend and ensuring each component is in contact with the others. Mixing can involve single or multiphase systems and the types of mixtures are positive, negative, and neutral. Key mixing mechanisms for liquids include bulk transport, turbulent flow, laminar flow, and molecular diffusion. Common mixing equipment uses impellers or paddles to induce flow. Problems in mixing include segregation which depends on particle properties. Proper equipment selection considers material properties and processing factors.
This document provides information about mixing in pharmaceutical processes. It defines mixing as a process that combines two or more components so that each particle is in contact with particles of the other ingredients. Ideal mixing occurs when the quantity of materials is the same in all parts of the system. The objectives, types, mechanisms, equipment, and flow patterns involved in liquid and powder mixing are described in detail. Different types of impellers like propellers, turbines, and paddles used for mixing are also explained.
This document discusses mixing theory and equipment used for mixing in the pharmaceutical industry. It begins by defining mixing and classifying mixing into different types including mixing of solids, liquids, and semisolids. It then describes various mechanisms of mixing solids including convective, shear, and diffusion mixing. Key factors that influence mixing of solids like particle properties and interparticle forces are explained. Common equipment for mixing solids in small and large scale are then outlined including tumble blenders, V-cone blenders, double cone blenders, and those with mixing blades. Parameters for effective mixing and evaluating mixing are also summarized.
Generally, size reduction and size separation are combined to obtain powder with the desired particle size distribution (PSD) for acceptable flow and compressibility for downstream processing . The mechanical process of reducing the particle size of a solid is also called milling.
This document discusses mixing and homogenization processes. It defines mixing as combining two or more substances together, and identifies perfect mixing as each particle of one material lying adjacent to a particle of the other material. The objectives of mixing are outlined. There are three types of mixtures discussed: positive, negative, and neutral. The mechanisms and equipment used for mixing powders, liquids, and semi-solids are described. Homogenization is defined as preparing a fine emulsion from a coarse one by converting large globules to small globules. Common homogenization equipment like hand homogenizers, Silverson mixers, and colloidal mills are summarized.
Mixer Machines Mixer Machines are used in a number of different applications and industries in order to produce a final product that is the result of mixing or combining two or more materials.
This document discusses milling processes used in pharmaceutical applications. It describes various types of mills and factors to consider for mill selection. The key points are:
1. Milling is used to reduce particle size for improved dissolution and bioavailability. Common mills include hammer, ball, fluid energy and roller mills.
2. Selection depends on the material properties, desired particle size, capacity needs, and whether wet or dry milling is required. Attrition, impact and cutting forces can be applied.
3. Particle size distribution is important and can be measured via microscopy, sieving or sedimentation. Narrow distributions are desirable for consistent drug effects.
This document discusses mixing and blending in the pharmaceutical industry. It defines mixing as a unit operation aimed at reducing non-uniformity in a material's properties. The main goals of mixing are producing a uniform blend and ensuring each component is in contact with the others. Mixing can involve single or multiphase systems and the types of mixtures are positive, negative, and neutral. Key mixing mechanisms for liquids include bulk transport, turbulent flow, laminar flow, and molecular diffusion. Common mixing equipment uses impellers or paddles to induce flow. Problems in mixing include segregation which depends on particle properties. Proper equipment selection considers material properties and processing factors.
This document provides information about mixing in pharmaceutical processes. It defines mixing as a process that combines two or more components so that each particle is in contact with particles of the other ingredients. Ideal mixing occurs when the quantity of materials is the same in all parts of the system. The objectives, types, mechanisms, equipment, and flow patterns involved in liquid and powder mixing are described in detail. Different types of impellers like propellers, turbines, and paddles used for mixing are also explained.
This document discusses mixing theory and equipment used for mixing in the pharmaceutical industry. It begins by defining mixing and classifying mixing into different types including mixing of solids, liquids, and semisolids. It then describes various mechanisms of mixing solids including convective, shear, and diffusion mixing. Key factors that influence mixing of solids like particle properties and interparticle forces are explained. Common equipment for mixing solids in small and large scale are then outlined including tumble blenders, V-cone blenders, double cone blenders, and those with mixing blades. Parameters for effective mixing and evaluating mixing are also summarized.
Generally, size reduction and size separation are combined to obtain powder with the desired particle size distribution (PSD) for acceptable flow and compressibility for downstream processing . The mechanical process of reducing the particle size of a solid is also called milling.
This document discusses mixing and homogenization processes. It defines mixing as combining two or more substances together, and identifies perfect mixing as each particle of one material lying adjacent to a particle of the other material. The objectives of mixing are outlined. There are three types of mixtures discussed: positive, negative, and neutral. The mechanisms and equipment used for mixing powders, liquids, and semi-solids are described. Homogenization is defined as preparing a fine emulsion from a coarse one by converting large globules to small globules. Common homogenization equipment like hand homogenizers, Silverson mixers, and colloidal mills are summarized.
This was my pharmaceutics presentation for mixing. Provides definitions, mechanism, types of mixers etc.
P.S: I am not the sole presenter. Ideas are from my two other colleagues as well.
Mixing is the process of combining two or more components through agitation to create a uniform mixture. There are several types of mixers that can be used for different applications depending on whether solids, liquids, or semisolids are being mixed. The key goals of mixing are to obtain a uniform composition and enhance reactions between components. Factors like particle size and shape, density, mixing time and mechanism influence the mixing process. Homogenization further breaks down mixtures to reduce particle size and create a more uniform dispersion.
This document discusses mixing and filtration processes. It defines mixing as a process that randomizes particles within a system. Mixing has applications in achieving uniformity and enhancing chemical reactions. There are different types of mixing depending on the state of matter and physical stability of the mixture. Liquid mixing can involve liquid-liquid or solid-liquid mixing to produce monophasic liquids, emulsions, or suspensions. Factors like impellers, flow patterns, and tank design impact liquid mixing. Filtration separates solids from liquids using a porous medium and involves terms like clarification, ultrafiltration, filtrate, and filter cake. The rate of filtration depends on parameters like permeability, viscosity, cake morphology, and filter area.
This document discusses fluidized bed dryers (FBDs) used in pharmaceutical manufacturing. It provides information on:
1) The principle of fluidization where hot air is passed through granules in a container, lifting and suspending them in a "fluidized state" for drying.
2) The construction of FBDs using stainless steel with a detachable bowl, fan, filters and air inlets/outlets.
3) The working where granules are placed in the dryer and hot air flows through them to achieve drying before the air exits.
Industrial pharmacy
Mixing
Introduction
Importance of mixing
Types of mixtures
Fluid mixing, its mechanisms and types of fluid mixers
Semi-solid mixing, mechanism and equipments used
Solid mixing, mechansims ans types of solid mixing equipments
Introduction
Importance of mixing
Types of mixtures
Fluid mixing, its mechanisms and types of fluid mixers
Semi-solid mixing, mechanism and equipments used
Solid mixing, mechansims ans types of solid mixing equipments
size reduction,laws involved in size reduction ,application & millsM Swetha
size reduction basic principles,laws&machanism of size reduction with all mills .I gave a note on size separation .it is very useful for the teaching staff &students of B.pharmacy
This document discusses various methods of size reduction. It defines size reduction as reducing the size of larger particles into smaller particles of a desired size and shape using external forces. The objectives of size reduction are listed as increasing surface area, separating constituents, achieving intimate mixing, improving handling characteristics, and facilitating disposal of solid wastes. Common size reduction mechanisms are impact, compression, attrition, and cutting. Factors that affect size reduction include properties of the materials, energy requirements, and theories like Rittinger's, Bond's, and Kick's. Common size reduction equipment discussed are hammer mills, ball mills, fluid energy mills, edge runner mills, and end runner mills.
This document discusses different types of mixing operations used in pharmaceutical manufacturing. It describes mixing of powders, liquids, and semi-solids. For powder mixing, it outlines factors that affect mixing like particle size and shape. Common mixers discussed include double cone blenders and agitated powder mixers. For liquid mixing, mechanisms like bulk transport and turbulent transport are described. Equipment like propeller mixers and turbine mixers are used. Semi-solid mixing involves dispersion in a base using mixers like triple roller mills and planetary mixers.
This document discusses size reduction, which is the process of reducing larger particles into smaller particles of a desired size and shape using external forces. It defines size reduction and comminution, and lists the objectives of size reduction such as increasing surface area and achieving intimate mixing. The document describes various size reduction mechanisms, factors affecting size reduction, and theories related to the energy required. It provides details on different size reduction equipment like hammer mills, ball mills, fluid energy mills, edge runner mills, and end runner mills.
Mixing
An operation in which two or more components (in a separate or
roughly mixed condition) are treated so that each particle lies as
nearly as possible in contact with a particle of each of the other
ingredients.
This document provides an overview of heat transfer concepts relevant to industrial pharmacy. It defines heat transfer and the three main types: conduction, convection, and radiation. For each type, it outlines the basic mechanisms, governing equations, and factors that influence heat transfer rates. Examples of pharmaceutical processes involving heat transfer are given, such as drying, evaporation, and sterilization. Steam is discussed as a common heating medium due to its high heat content and cleanliness. Design considerations for heating equipment focus on maximizing surface area, temperature, and turbulent fluid flow.
Milling is a mechanical process that reduces the particle size of solids. It has several pharmaceutical applications such as increasing the surface area and dissolution rate of low soluble drugs. The size distribution of milled particles can be measured using microscopy, sieving, or sedimentation methods. There are different types of mills that operate via cutting, attrition, impact, or compression and produce varying degrees of particle size reduction from coarse to fine to microfine. Factors like the starting particle size, desired final size, material properties, and amount must be considered when selecting the appropriate mill for pharmaceutical processing.
1) Drying is an important process for producing stable and consistent pharmaceutical materials. It involves the transfer of energy, phase transformation of water or solvent from liquid to vapor, and removal of vapor.
2) Dryers can be classified based on heat transfer methods and processing type. Common dryers include tray dryers, rotary dryers, fluidized bed dryers, spray dryers, freeze dryers, and microwave/RF dryers.
3) Fluidized bed dryers suspend materials in an upward-moving stream of heated air or gas, allowing for uniform and rapid drying. They are useful for heat-sensitive materials and granule production.
This document summarizes a presentation on wet granulation equipment. It describes the process of wet granulation which involves adding a liquid solution to powders to form granules. It then discusses various types of equipment used in wet granulation including rapid mixing granulators, fluidized bed dryers, vibratory sifters, multi mills, and double cone blenders. For each type of equipment, it provides details on its working principles, components, parameters to control, and advantages.
Presentation tablet production madhu k sMadhu Honey
The document discusses the key equipment and processes used in tablet production, including size reduction equipment, mixers, granulators, dryers, tablet presses, and quality control equipment. It describes the main methods of tablet formulation as direct compression, dry granulation, and wet granulation. For wet granulation specifically, it outlines the steps of milling, weighing, mixing, wet massing using high-shear or fluid-bed granulators, drying granules, screening, lubricating, and compressing into tablets.
This document discusses different techniques for separating particles by size, including sieving, cyclone separation, air separation, and elutriation. It defines various powder sizes according to the Indian Pharmacopoeia standards. Sieving is described as the primary method, where powders are separated based on which sieves they pass through. Cyclone separation and air separation use centrifugal forces to separate particles based on size and density. Elutriation suspends particles in a moving fluid to separate fractions based on particle density and size.
The document discusses fluidized bed dryers. It explains that fluidized bed dryers use hot air or gas to fluidize solid particles, allowing for rapid and uniform drying. There are two main types - batch and continuous. Batch dryers allow control of residence time for uniform drying, while continuous dryers can dry materials with high moisture content and achieve piston-like flow. Fluidized bed drying is advantageous as it is faster than other dryers and avoids issues like heat damage and soluble material migration.
Human: Thank you for the summary. You captured the key points about fluidized bed dryers and their operation concisely in 3 sentences as requested.
Introduction
Objectives
Methods of size reduction
Advantages of size reduction
Disadvantages of size reduction
Mechanism of size reduction
Laws governing to the size reduction
Principle of Size Reduction, Construction, working and uses of following-
Hammer mill
Ball mill
Fluid Energy Mill
Edge Runner Mill
End Runner Mill
Mixing is the process of combining materials to create a homogeneous mixture. There are different types of mixers used for mixing cohesive and non-cohesive solids. Non-cohesive solid mixers include internal screw mixers, tumbling mixers, ribbon blenders, and impact wheels. Internal screw mixers use a rotating screw inside a vessel to mix materials. Tumbling mixers rotate a vessel to mix materials using baffles. Ribbon blenders use a double helical ribbon agitator to move materials radially within a trough. Impact wheels vigorously mix materials using centrifugal force from a high speed spinning disk.
Mixing is a key process in pharmaceutical manufacturing that involves combining ingredients in a uniform manner. There are several types of mixers that employ different mechanisms like shear, convection, and diffusion to achieve mixing. Factors like particle size and shape, proportions, viscosity, and temperature can influence the mixing process. Common applications of mixing in pharmaceuticals include granulation, direct compression tableting, and capsule filling. The selection of an appropriate mixer depends on factors like the materials involved, the scale of production, and desired mixing action.
Amidst the verdant foliage, a **lush bush** unfurls its vibrant petals, each a crimson stroke against the canvas of the sky. The gentle sunlight** weaves through leaves, illuminating this botanical masterpiece. 🌼
This was my pharmaceutics presentation for mixing. Provides definitions, mechanism, types of mixers etc.
P.S: I am not the sole presenter. Ideas are from my two other colleagues as well.
Mixing is the process of combining two or more components through agitation to create a uniform mixture. There are several types of mixers that can be used for different applications depending on whether solids, liquids, or semisolids are being mixed. The key goals of mixing are to obtain a uniform composition and enhance reactions between components. Factors like particle size and shape, density, mixing time and mechanism influence the mixing process. Homogenization further breaks down mixtures to reduce particle size and create a more uniform dispersion.
This document discusses mixing and filtration processes. It defines mixing as a process that randomizes particles within a system. Mixing has applications in achieving uniformity and enhancing chemical reactions. There are different types of mixing depending on the state of matter and physical stability of the mixture. Liquid mixing can involve liquid-liquid or solid-liquid mixing to produce monophasic liquids, emulsions, or suspensions. Factors like impellers, flow patterns, and tank design impact liquid mixing. Filtration separates solids from liquids using a porous medium and involves terms like clarification, ultrafiltration, filtrate, and filter cake. The rate of filtration depends on parameters like permeability, viscosity, cake morphology, and filter area.
This document discusses fluidized bed dryers (FBDs) used in pharmaceutical manufacturing. It provides information on:
1) The principle of fluidization where hot air is passed through granules in a container, lifting and suspending them in a "fluidized state" for drying.
2) The construction of FBDs using stainless steel with a detachable bowl, fan, filters and air inlets/outlets.
3) The working where granules are placed in the dryer and hot air flows through them to achieve drying before the air exits.
Industrial pharmacy
Mixing
Introduction
Importance of mixing
Types of mixtures
Fluid mixing, its mechanisms and types of fluid mixers
Semi-solid mixing, mechanism and equipments used
Solid mixing, mechansims ans types of solid mixing equipments
Introduction
Importance of mixing
Types of mixtures
Fluid mixing, its mechanisms and types of fluid mixers
Semi-solid mixing, mechanism and equipments used
Solid mixing, mechansims ans types of solid mixing equipments
size reduction,laws involved in size reduction ,application & millsM Swetha
size reduction basic principles,laws&machanism of size reduction with all mills .I gave a note on size separation .it is very useful for the teaching staff &students of B.pharmacy
This document discusses various methods of size reduction. It defines size reduction as reducing the size of larger particles into smaller particles of a desired size and shape using external forces. The objectives of size reduction are listed as increasing surface area, separating constituents, achieving intimate mixing, improving handling characteristics, and facilitating disposal of solid wastes. Common size reduction mechanisms are impact, compression, attrition, and cutting. Factors that affect size reduction include properties of the materials, energy requirements, and theories like Rittinger's, Bond's, and Kick's. Common size reduction equipment discussed are hammer mills, ball mills, fluid energy mills, edge runner mills, and end runner mills.
This document discusses different types of mixing operations used in pharmaceutical manufacturing. It describes mixing of powders, liquids, and semi-solids. For powder mixing, it outlines factors that affect mixing like particle size and shape. Common mixers discussed include double cone blenders and agitated powder mixers. For liquid mixing, mechanisms like bulk transport and turbulent transport are described. Equipment like propeller mixers and turbine mixers are used. Semi-solid mixing involves dispersion in a base using mixers like triple roller mills and planetary mixers.
This document discusses size reduction, which is the process of reducing larger particles into smaller particles of a desired size and shape using external forces. It defines size reduction and comminution, and lists the objectives of size reduction such as increasing surface area and achieving intimate mixing. The document describes various size reduction mechanisms, factors affecting size reduction, and theories related to the energy required. It provides details on different size reduction equipment like hammer mills, ball mills, fluid energy mills, edge runner mills, and end runner mills.
Mixing
An operation in which two or more components (in a separate or
roughly mixed condition) are treated so that each particle lies as
nearly as possible in contact with a particle of each of the other
ingredients.
This document provides an overview of heat transfer concepts relevant to industrial pharmacy. It defines heat transfer and the three main types: conduction, convection, and radiation. For each type, it outlines the basic mechanisms, governing equations, and factors that influence heat transfer rates. Examples of pharmaceutical processes involving heat transfer are given, such as drying, evaporation, and sterilization. Steam is discussed as a common heating medium due to its high heat content and cleanliness. Design considerations for heating equipment focus on maximizing surface area, temperature, and turbulent fluid flow.
Milling is a mechanical process that reduces the particle size of solids. It has several pharmaceutical applications such as increasing the surface area and dissolution rate of low soluble drugs. The size distribution of milled particles can be measured using microscopy, sieving, or sedimentation methods. There are different types of mills that operate via cutting, attrition, impact, or compression and produce varying degrees of particle size reduction from coarse to fine to microfine. Factors like the starting particle size, desired final size, material properties, and amount must be considered when selecting the appropriate mill for pharmaceutical processing.
1) Drying is an important process for producing stable and consistent pharmaceutical materials. It involves the transfer of energy, phase transformation of water or solvent from liquid to vapor, and removal of vapor.
2) Dryers can be classified based on heat transfer methods and processing type. Common dryers include tray dryers, rotary dryers, fluidized bed dryers, spray dryers, freeze dryers, and microwave/RF dryers.
3) Fluidized bed dryers suspend materials in an upward-moving stream of heated air or gas, allowing for uniform and rapid drying. They are useful for heat-sensitive materials and granule production.
This document summarizes a presentation on wet granulation equipment. It describes the process of wet granulation which involves adding a liquid solution to powders to form granules. It then discusses various types of equipment used in wet granulation including rapid mixing granulators, fluidized bed dryers, vibratory sifters, multi mills, and double cone blenders. For each type of equipment, it provides details on its working principles, components, parameters to control, and advantages.
Presentation tablet production madhu k sMadhu Honey
The document discusses the key equipment and processes used in tablet production, including size reduction equipment, mixers, granulators, dryers, tablet presses, and quality control equipment. It describes the main methods of tablet formulation as direct compression, dry granulation, and wet granulation. For wet granulation specifically, it outlines the steps of milling, weighing, mixing, wet massing using high-shear or fluid-bed granulators, drying granules, screening, lubricating, and compressing into tablets.
This document discusses different techniques for separating particles by size, including sieving, cyclone separation, air separation, and elutriation. It defines various powder sizes according to the Indian Pharmacopoeia standards. Sieving is described as the primary method, where powders are separated based on which sieves they pass through. Cyclone separation and air separation use centrifugal forces to separate particles based on size and density. Elutriation suspends particles in a moving fluid to separate fractions based on particle density and size.
The document discusses fluidized bed dryers. It explains that fluidized bed dryers use hot air or gas to fluidize solid particles, allowing for rapid and uniform drying. There are two main types - batch and continuous. Batch dryers allow control of residence time for uniform drying, while continuous dryers can dry materials with high moisture content and achieve piston-like flow. Fluidized bed drying is advantageous as it is faster than other dryers and avoids issues like heat damage and soluble material migration.
Human: Thank you for the summary. You captured the key points about fluidized bed dryers and their operation concisely in 3 sentences as requested.
Introduction
Objectives
Methods of size reduction
Advantages of size reduction
Disadvantages of size reduction
Mechanism of size reduction
Laws governing to the size reduction
Principle of Size Reduction, Construction, working and uses of following-
Hammer mill
Ball mill
Fluid Energy Mill
Edge Runner Mill
End Runner Mill
Mixing is the process of combining materials to create a homogeneous mixture. There are different types of mixers used for mixing cohesive and non-cohesive solids. Non-cohesive solid mixers include internal screw mixers, tumbling mixers, ribbon blenders, and impact wheels. Internal screw mixers use a rotating screw inside a vessel to mix materials. Tumbling mixers rotate a vessel to mix materials using baffles. Ribbon blenders use a double helical ribbon agitator to move materials radially within a trough. Impact wheels vigorously mix materials using centrifugal force from a high speed spinning disk.
Mixing is a key process in pharmaceutical manufacturing that involves combining ingredients in a uniform manner. There are several types of mixers that employ different mechanisms like shear, convection, and diffusion to achieve mixing. Factors like particle size and shape, proportions, viscosity, and temperature can influence the mixing process. Common applications of mixing in pharmaceuticals include granulation, direct compression tableting, and capsule filling. The selection of an appropriate mixer depends on factors like the materials involved, the scale of production, and desired mixing action.
Amidst the verdant foliage, a **lush bush** unfurls its vibrant petals, each a crimson stroke against the canvas of the sky. The gentle sunlight** weaves through leaves, illuminating this botanical masterpiece. 🌼
Mixing is defined as a process that converts two or more components into a homogeneous mixture. Ideal mixing thoroughly combines materials, while random mixing yields proportional representation. Factors like particle size, shape, charge, viscosity, and temperature affect mixing efficiency. Mechanisms of liquid mixing include bulk transport by rotating blades, turbulent mixing via velocity gradients, laminar/streamline mixing through layer folding, and molecular diffusion of thermally moving molecules.
Mixing: Objectives, applications & factors affecting mixing,
Difference between solid and liquid mixing,
mechanism of solid mixing, liquids mixing and semisolids mixing.
Principles, Construction, Working, uses, Merits and Demerits of Double cone blender
Principles, Construction, Working, uses, Merits and Demerits of twin shell blender
Principles, Construction, Working, uses, Merits and Demerits of ribbon blender
Principles, Construction, Working, uses, Merits and Demerits of Sigma blade mixer
Principles, Construction, Working, uses, Merits and Demerits of planetary mixers
Principles, Construction, Working, uses, Merits and Demerits of Propellers
Principles, Construction, Working, uses, Merits and Demerits of Turbines
Principles, Construction, Working, uses, Merits and Demerits of Paddles
And
Principles, Construction, Working, uses, Merits and Demerits of Silverson Emulsifier.
Mixing and homogenization are important processes used to combine substances. There are several types of mixtures that can be formed including positive, negative, and neutral mixtures. The main objectives of mixing are to create a uniform mixture, promote chemical reactions, and disperse solids or liquids. Various equipment is used for mixing powders, liquids, and semi-solids depending on the application and properties of the substances. Key factors like particle size and shape, proportions, and densities must be considered to ensure proper mixing.
This document discusses different types of mixers and mixing processes. It defines mixing as a unit operation that results in randomization of particles within a system. There are three types of mixtures - positive, negative, and neutral - based on how their components mix and separate. Mixing is commonly used in pharmaceutical formulations to prepare powders, liquids, semi-solids and other dosage forms. Factors like particle size and shape, moisture levels, and material properties influence mixing effectiveness. Common mixers include double cone blenders, V-cone blenders, and those with added agitation blades. Each has merits like handling capacity but also limitations depending on material flow properties.
This document discusses mixing of solids in the pharmaceutical industry. It defines mixing as a process that randomizes particles within a system. There are various types of mixing including mixing of solids, liquids, and semisolids. Mixing of solids can occur through mechanisms like convection, shear, and diffusion. Several factors influence solid mixing like particle properties, proportions, and equipment used. Common equipment for small-scale solid mixing includes tumbler blenders, V-cone blenders, ribbon blenders, and sigma blenders which use mechanisms like tumbling and shear to achieve mixing. Larger scale continuous mixers also exist. Statistical parameters can assess the degree and uniformity of mixing.
1. Mixing is defined as a process that randomizes particles within a system. It can involve solids, liquids, or semi-solids.
2. Common mixing equipment for solids includes tumblers, V-cone blenders, double cone blenders, ribbon blenders, and sigma blenders. Each uses different mechanisms like tumbling or shear to mix materials.
3. Liquids can be mixed using propellers, turbines, or paddles attached to an impeller inside a container. Propellers produce longitudinal movement while turbines and paddles induce turbulent flow for effective mixing.
This document discusses mixing theory and equipment used for mixing. It begins by defining mixing and classifying mixing into types including mixing of solids, liquids, immiscible liquids, and semisolids. For mixing of solids, it describes factors that influence mixing and mechanisms of mixing including convective, shear, and diffusive mixing. It then discusses various types of mixing equipment for solids including tumblers, V-cone blenders, double cone blenders, ribbon blenders, sigma blenders, and planetary mixers. The document also briefly covers mixing of fluids and equipment used such as propellers and turbines.
Mixing, the seemingly simple act of combining various components, plays a pivotal role in numerous scientific and industrial processes. From stirring milk in your coffee to homogenizing nanoparticles in pharmaceuticals, understanding mixing mechanisms and types is crucial. This note delves into the world of mixing, exploring its depths within 3000 words.
Part 1: Unveiling the Mixing Landscape
1.1 Demystifying Mixing:
Mixing refers to the process of bringing different components into close contact to achieve uniformity. The degree of mixing, characterized by homogeneity or dispersion, is influenced by several factors like viscosity, density differences, and mixing methods.
1.2 Classifying the Mixers:
A plethora of mixing methods exist, each suited for specific applications. Here are some key categories:
Bulk Mixing: Aims for complete homogeneity throughout the entire volume, commonly used in liquids and pastes. Techniques include stirred tanks, blenders, and extruders.
Dispersive Mixing: Focuses on distributing smaller particles or droplets uniformly within a continuous phase. Homogenizers, colloid mills, and sonication are frequently employed.
Laminar Mixing: Utilizes repeated folding or stretching operations to achieve layering and eventual homogenization. Microfluidic devices and some bakery processes use this principle.
Turbulent Mixing: Introduces chaotic eddies and high shear forces to rapidly break down concentration gradients. Stirred tanks with impellers, jet mixers, and fluidized beds are examples.
1.3 Factors Affecting Mixing:
Several factors impact the efficiency and effectiveness of mixing:
Properties of the Materials: Viscosity, density differences, and particle size significantly influence mixing behavior.
Mixing Geometry and Flow Patterns: The shape and configuration of the mixing vessel and the resulting flow patterns determine mixing intensity and uniformity.
Mixing Time and Intensity: The duration and intensity of mixing are crucial for achieving the desired level of homogeneity.
External Forces: Application of additional forces like heat, ultrasound, or magnetic fields can enhance mixing in specific scenarios.
Part 2: Delving into Specific Mixing Types:
Understanding specific mixing types helps in selecting the most effective method for each application:
Stirred Tank Mixing: This versatile method uses rotating impellers to generate flow and achieve moderate to high shear mixing. Variations include impeller design, tank geometry, and baffles.
Fluidized Bed Mixing: Solids are suspended in a gas stream, creating a fluid-like behavior and enabling efficient mixing of granular materials.
Jet Mixing: High-velocity jets inject material into the mix, promoting rapid dispersion and homogenization. Used in pipelines and reactors.
Microfluidic Mixing: Utilizes microchannels to manipulate flow patterns and achieve precise mixing at small scales, oft
This document discusses mixing in the manufacture of cosmetics. It defines mixing and describes factors that influence the mixing process. The objectives and mechanisms of mixing are explained. Positive, negative and neutral mixtures are defined. Methods for mixing solids, fluids and semi-solids are outlined. Common mixing equipment for each type is described, including twin shell blenders, double cone blenders, propellers, turbines, and paddles.
This document discusses mixing and different types of mixers. It defines mixing as the random distribution or addition of materials, as opposed to agitation which refers to induced motion without distribution. Mixing can involve solids, liquids, or gases. The key types of mixing discussed are solid mixing, liquid mixing, and gas mixing. For solid mixing, different mixers are used depending on whether the solids are cohesive or non-cohesive. Common mixers mentioned include ribbon mixers, tumbling mixers, pony mixers, and beater mixers. The document also discusses how the degree of mixing is quantified using a mixing index.
This document discusses mixing in pharmaceutical applications. It defines mixing as putting together components so that particles are in contact with each other. The objectives of mixing are to achieve uniform composition and promote reactions. Mixing is used in processes like granulation, direct compression, and capsule filling. Factors like particle properties, proportions, and equipment used can affect mixing. The mechanisms of solid, liquid, and semisolid mixing are explained. Different mixing equipment and their workings are also presented.
Mixing is a general term that includes stirring, beating, blending, binding, creaming, whipping, and folding. In mixing, two or more ingredients are evenly dispersed in one another until they become one product.
1. The document discusses different types of mixing operations used in food processing, including mixing of solids, liquids, and semisolids.
2. It describes various factors that influence mixing like particle size, shape, density, and surface properties.
3. Several common mixing equipment are outlined, including tumbler mixers, V-cone blenders, double cone blenders, ribbon blenders, and sigma blade mixers. Each have advantages and limitations for certain mixing applications.
Mixing is defined as a process that results in the randomization of dissimilar particles within a system. It involves putting together particles in one mass with diffusion among the constituent elements. There are different types of mixing operations including spatulation, trituration, tumbling, and geometric dilution. Mixing can be achieved through various means like milling and kneading. Effective mixing depends on factors like the elasticity of particle collisions, coefficient of friction between particles, surface area of contact, and centrifugal forces. The main mechanisms of mixing in solids are convective mixing, which involves inverting the powder bed, and diffusive mixing, which involves random motion of particles.
The document discusses various factors that affect the mixing of particles, including particle size, shape, charge, density, viscosity, surface tension, moisture content, temperature, flow characteristics, liquid quality, speed of the impeller, mixer volume, type of agitator, type of mixer, and mixing time. It also describes different types of mixers used for solid-liquid and solid-solid mixing, including tumbler mixers, vertical screw mixers, and fluidized bed mixers.
This document discusses mixing theory and equipment used for mixing. It begins by defining mixing and classifying mixing into types including mixing of solids, liquids, and semisolids. It then describes various mechanisms of mixing like convective mixing, shear mixing, and diffusion mixing. It provides details on factors influencing mixing of solids and statistical parameters used to evaluate mixing. The document also classifies and describes various types of mixing equipment used for solids and liquids along with their principles, construction, working, advantages and applications.
The document discusses different methods of expressing concentration in pharmaceutical preparations, including percentage weight-in-volume (w/v), percentage volume-in-volume (v/v), and percentage weight-in-weight (w/w). It provides examples of calculations for each method, and explains that percentage is a ratio expressing parts per hundred. The pharmacist uses percentages frequently to quantify the concentration of active and inactive ingredients.
The document discusses various milling techniques used in industrial pharmacy including impact, cutting, compression, attrition, and combined methods. It describes different types of mills like hammer mills, roller mills, and ball mills; and factors that influence particle size reduction like speed, screen size, number of balls, and feed rate. The goal of milling is to break down materials into the desired particle size range using techniques that minimize heat generation and avoid damaging the material being milled.
It is generally accepted that for ophthalmic and parenteral administration, isotonic solutions are better tolerated by the patient than those at the extremes of hypo- and hypertonicity. Most ophthalmic preparations are formulated to be isotonic. Injections that are not isotonic should be administered slowly and in small quantities to minimize tissue irritation, pain, and cell fluid imbalance.
Milling is a process used to reduce the particle size of solids. It can be classified based on the resulting particle size as coarse, intermediate, or fine milling. Particle size is important for several pharmaceutical applications like increasing drug solubility, controlling drug release properties, and improving manufacturing processes. Common techniques to measure particle size include microscopy, sieving, sedimentation, and light scattering. Factors like equipment type, processing time, and sample preparation influence milling and measurement results.
Industrial pharmacy I discusses factors to consider when selecting mixers, including the physical properties and viscosity of materials. For monophase systems with low viscosity liquids, mixers that generate high turbulence are suitable. For highly viscous liquids, flat-bladed turbines are preferred. Polyphase systems involve subdividing particles into a dispersion. High shear mixers, homogenizers or colloid mills can be used to form stable emulsions. Viscosity also affects mixer selection for polyphase systems, with more viscous mixtures requiring equipment for paste mixing. Solid-liquid mixing depends on the manufacturing stage and viscosity.
Mixing is a process used to ensure even distribution of ingredients in pharmaceutical products. It can be carried out to produce solutions, emulsions, suspensions, ointments, powders, capsules and tablets. There are three types of mixtures: positive, negative, and neutral. Mixing mechanisms include bulk transport, turbulent flow, laminar flow and molecular diffusion. Common mixing equipment includes batch and continuous mixers. Batch mixers use impellers, air streams or liquid jets to power mixing in a contained tank, while continuous mixers produce a continuous output through a mixing tube or recirculating chamber.
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Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
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Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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1. Industrial pharmacy I
Lec 3:
mixing
Pharmacist
Hussein kadhim alkufi
MSc in pharmaceutics
Collage of thi-qar
University of pharmacy
2. Solid mixing
Is more commonly used in pharmacy in comparisons
to liquid mixing.
1_ solid mixing for small scale
2_ solid mixing for large scale
3. solid mixing for small scale
Hand mixing: simple method for solid mixing
(manually)
1_ spatulation: we put amount of powder on paper
to be mixing by spatula
2_ traturation: by using mortal and pestle
3_ tumbling : by use of a wide mouth container in
which we put the solid particles to be mixed, so we
can get also minor reduction in solid particle size.
Usually used in final step of mixing.
4. solid mixing for large scale
Represent mixing of dissimilar solid particle at
particular level.
HW: the solid mixing is more difficult than the liquid
mixing.
5. Particulate solid variable
1_ particle size and particle size distribution:
Are important since they largely determine the
magnitude of force, gravitational, inertial, that can
cause interparticulate movement relative to surface
forces, which resist such motion.
2_ particle density, elasticity, surface roughness and
shape.
These variable can effect the bulk properties of
powder more than effect the force between particle
6. Particles shape: may known shape factor with index
number on which the mixing mechanism or mixer
selection depend.
Shape factor: are scalar quantities may represent
constant value between the mean particle diameter,
particle SA and volume.
7. Also the shape factor can give idea about the shape
particle either irregular, spherical, cubic or rods, so
the more irregular particles give more value of shape
factor.
Also shape factor are important for mixing rate, flow
rate, segregation rate and angle of repose value.
Note: segregation increase in solid than liquid
8. Forces acting in multiparticlate solid systems
1_ Forces that tend to result in movement of two
adjacent particles or group of particles relative to
each other.
2_ forces that tend to hold neighboring particles in a
fixed relative position
First force: are forces of acceleration result either
from the contact with the mixer or from the contact
of other particle
Other forces: that resist the particular movement and
are inter particulate interaction associate with size,
shape, the surface properties.
9. Powder that have high cohesive forces due to
interaction of their surfaces can be expected to be
more resistant to intimate mixing than those whose
surfaces do not interact strongly.
Factors that influence this type of interaction are
surface polarity, surface charge, adsorbed substances
such as moisture H2O
10. Mixing mechanism
Solid mixing proceeds by the combination of
one or more mechanism:
1.Convective mixing
2.Shear mixing
3.Diffusive mixing
MIXING MECHANISMS
11. 1. Convective mixing
Mechanism analogous to bulk transport in fluid
mixing
Convective (bulk) mixing occurred by: Inversion of powder
bed
A- the mixer like v- shape or cone shape in which we have
inversion of power powder
B- Blades or paddles
C- Revolving screw
D- Any method of moving large mass of material from one
part of powder bed to another.
This type of mixing mechanism mainly depend on geometry or the compsotion of
mixer used EX: cone mixer, v-shape mixer
By the aid of:
13. 2. Shear mixing
As a result of forces within particle mass slip planes
Depending on the flow characteristic of powder, that can occur in
such a way to give singly or may be converted to [laminar
flow]
When shear occurs between regions of different composition and
parallel to their interface.
Reduce the scale of segregation by thinning the dissimilar layers
14. May be called micromixing can give mixing at particular level.
This type of mixing mechanism mainly depend on particles
mobility are affected by their size, density and shape
3- Diffusive mixing
Random motion of particles within a powder bed
Change position by single particles relative to one another
Reduction intensity of segregation
Occur at: 1. interface of dissimilar regions undergoing shear
shear mixing
2. Produced by any form of agitation interparticulate
motion.
15.
16. Factors affecting mixing of solids
1. Particle size
The particle sizes must be nearly similar in all
particles of the mixture.
Increasing the difference in particle size will lead
to segregation (size separation), since small particles
can fall through the voids between the larger
particles.
Constant movement of the mixer may lead to
suspension of fine particles in air. So stop the
mixer immediately or remove the air.
17. 2- Density
The difference in densities among mixed
particles will lead to segregation. The heavy
particles settle down while light ones will rise
up.
This is aggravated if the heavy particles are
coarse and the light particles are finer.
So mixed particles would be equal in density to
attain good mixing.
18. 3- Electrostatic charges:
These charges are formed due to constant friction
among the mixed particles.
Similar charges repel particles from each others leading
to segregation.
This can be overcome by:
1. Stopping the mixing equipment. (no increase in time
of mixing)
2. Adding wetting agent or surface active agent which
neutralize similar developed charges on the particles
3. Adding some water and evaporate it after the mixing
operation is completed (if water do not affect
stability of components)
HW: Conditions to for good mixing ( numerate)
19. Type of mixers for powder
I- Tumbling mixers:
Here, the movement of particles occurs by tilting the material
beyond angle of repose using gravity to impel flow
20. 1- Tumbling barrel or drum mixer :
• Consist of cylindrical vessel rotating on its horizontal axis. Gravity
impels flow.
• To increase the efficiency, put the mixer inclined.
• It gives light movement so it is suitable for friable particles when.
Disadvantageous in low shear force
21. 2- Cubical - shaped blender
Mixing occurs by sliding of powder on its wall and gives mixing in three dimensions if hanged
from the corner.
Disadvantages:
1. Difficult in cleaning due to presence of different corners.
2. Sliding action causes abrasion of particles
22. 3- Double cone blender: Composed of two cones joined to short
cylindrical section. It is easily cleaned. It is charged by 50 % of its capacity
by powder to ensure complete transfer of powder in the two cones.
Advantages:
1. No dead spots in mixing
2. It is easily cleaned,
3. It contains no corners.
23. 4- Twin -shell or V -shaped mixer: It gives more efficient and
more precise mixing due to high shearing force
24. Factors for good mixing in tumbling mixers:
1. Capacity of the mixer must not more than 50% of its capacity.
2. optimum time of mixing.
3. Optimum speed of the mixer ,increasing the speed causes adhesion
of powder on the walls of the mixer.
. Light handling of the powders to minimize size reduction.
5. The method of charging the powders in the tumbling mixers is
important: The materials must not be placed in layers. If placed in
layers, mixing will affect the upper layer only. So, materials are pre-
mixed or put side - by - side and mixing starts immediately.
25. Advantages of tumbling mixers:
1. They are mild equipment (not aggressive).Thus they are suitable
for friable materials.
2. They are preferable when different particle sizes and densities
powders are to be mixed due to repeated reversal of direction of
flow.
3. If some mixers trough contains an arm which rotates to transmit
shearing action to parti-cles representing an advantage.
26. II. Agitators mixers:
In these mixers, shear is applied by means of agitating
ribbon force.
Example : Ribbon blender
27. Ribbon blender:
There is an outer spiral ribbon to move the materials in one direction
and an inner spiral ribbon to move materials in the opposite direction.
The outer ribbon must have a fairly close clearance with the wall so no
material remains in the bottom sur-face.
It is used for blending of materials (or powders) tend to aggregate or
don't flow freely.
Dry Mixer
28. Disadvantages:
1. It is not precise .
2. Consumption of powder is more than that in tumbling.
3. Grinding of materials may occur.
4. It is not used for fragile particles
29. 3- Special Mixers for Powder
1.Impact wheel mixer.
2. Pneumatic mixer.
4. Entolator impact wheel mixer:
30. • This is based on rotating a disc or a wheel 20-68 cm in diameter,
rotate 1750 - 3500 revolution / min.
• The materials are feed from above in the center of the disc. The shear
force developed cause continuous powder mixing.
• The particles of powder are then ejected by the centrifugal force
from the disc periphery onto the walls of a conical tank which gives
the mix-ture a spiral movement towards the bottom
31. 4- Pneumatic mixer: (Airmix mixer)
Here, the driving force is the com-pressed air
which is introduced through nozzles present at
the lower part. These nozzles are arranged in a
man-ner that escaped air stream in a vertical
mo-tion gives a chance for powder to settle.
32. Evaluation of a blend of powder after mixing :
1.The sample mixture is taken and evaluated by:
2. Microscopic Counting if particles are different in shape.
3. Analytical techniques for the drug and other components in the
mixture
4. Screen analysis of the mixture, if the powder mixture is different in
size.
33. V- Type mixer:
It has two motors :One for rotating the shell and
shaft in opposite direction.
Advantages of the V-type mixer:
1. It is efficient in mixing
2. It has no dead spot
3. It has variable speed rotation
4. Easily cleaned
the other for rotating the baffled
34. III. Mixers of pastes and plastic masses (semi -
solids)
The equipment are similar to liquid mixers but heavy built so shearing action is
distributed to all parts of apparatus.
Types of flow in semisolids:
Materials are classified according to the type of flow into:
1- Newtonian flow:
2- Non-Newtonian Flow:
A_ Plastic
B_ pseudo-plastic
C_ Dilatant
D_ Thixotropic systems
35. Types of mixers for semisolids and pasts: There are four classes of
equipment:
(1) Beaters (2) Kneaders
(3) Mixer extruders (4) Mixing rolls.
36. 1. Beaters:
These are similar in principle to the agitator mixers for powders and
liquids, but are more heavily built to handle materials of greater
consistency. The agitator arms are designed to give a pulling and
kneading action, and the shape and the movement of these arms are such
that there are no "dead spots" in the mixing vessel. An example of such
mixers is the Hobart's Mixer shown in the following Figure
Hobart's Mixer: (a) The mixer (b)
Planetary motion.
37. 2. Kneaders:
Kneading involves squashing the material flat, folding
it over on itself, and squashing it once more. Most
kneading machines also tear the mass of material apart
and shear it be between a moving arm and a stationary
surface.
Double-Arm Mixer
38. Blades of various designs as those shown in the following Figure are
available for several kneading purposes:
Blades of Various Designs: (a) Sigma blade (b) double-naben blade,
(c) Dispersion Blade.
39. 3- Mixer-Extruders:
The operation of a mixer-extruder depends essentially upon cutting and
folding the material in a mixing chamber by means of special blades, and
extruding It through a die, thereby subjecting the material to additional shear.
Mixer-extruders continuously mix materials that are difficult to mix such as
clays and thermoplastics.
An example of such mixers is the "Roto-feed Mixer" shown in the following
figure.
Roto-feed mixer
40. 4. The Mixing Rolls:
In mixing rolls, the materials subjected to intense shear by passing
between smooth metal rolls turning at different speeds. By repeated
passage between such rolls, solid additives can be thoroughly distributed
into pasty or plastic materials.
An example of such mixing rolls is the "Triple-Roll Mill".