The document discusses various factors that affect the mixing of particles, including particle size, shape, charge, density, viscosity, surface tension, moisture content, temperature, flow characteristics, liquid quality, speed of the impeller, mixer volume, type of agitator, type of mixer, and mixing time. It also describes different types of mixers used for solid-liquid and solid-solid mixing, including tumbler mixers, vertical screw mixers, and fluidized bed mixers.
Mixing and homogenization are important processes used to combine substances. There are several types of mixtures that can be formed including positive, negative, and neutral mixtures. The main objectives of mixing are to create a uniform mixture, promote chemical reactions, and disperse solids or liquids. Various equipment is used for mixing powders, liquids, and semi-solids depending on the application and properties of the substances. Key factors like particle size and shape, proportions, and densities must be considered to ensure proper mixing.
Mixing is a key process in pharmaceutical manufacturing that involves combining ingredients in a uniform manner. There are several types of mixers that employ different mechanisms like shear, convection, and diffusion to achieve mixing. Factors like particle size and shape, proportions, viscosity, and temperature can influence the mixing process. Common applications of mixing in pharmaceuticals include granulation, direct compression tableting, and capsule filling. The selection of an appropriate mixer depends on factors like the materials involved, the scale of production, and desired mixing action.
This document discusses mixing and filtration processes. It defines mixing as a process that randomizes particles within a system. Mixing has applications in achieving uniformity and enhancing chemical reactions. There are different types of mixing depending on the state of matter and physical stability of the mixture. Liquid mixing can involve liquid-liquid or solid-liquid mixing to produce monophasic liquids, emulsions, or suspensions. Factors like impellers, flow patterns, and tank design impact liquid mixing. Filtration separates solids from liquids using a porous medium and involves terms like clarification, ultrafiltration, filtrate, and filter cake. The rate of filtration depends on parameters like permeability, viscosity, cake morphology, and filter area.
1. Agitation involves inducing motion within a material while mixing distributes components randomly.
2. Mixing operations involve various combinations of gases, liquids, and solids and may require agitation to enhance mass and heat transfer between phases.
3. Effective agitation and mixing depends on factors like the impeller type, liquid properties, and vessel design which influence flow patterns within the vessel.
Mixing: Objectives, applications & factors affecting mixing,
Difference between solid and liquid mixing,
mechanism of solid mixing, liquids mixing and semisolids mixing.
Principles, Construction, Working, uses, Merits and Demerits of Double cone blender
Principles, Construction, Working, uses, Merits and Demerits of twin shell blender
Principles, Construction, Working, uses, Merits and Demerits of ribbon blender
Principles, Construction, Working, uses, Merits and Demerits of Sigma blade mixer
Principles, Construction, Working, uses, Merits and Demerits of planetary mixers
Principles, Construction, Working, uses, Merits and Demerits of Propellers
Principles, Construction, Working, uses, Merits and Demerits of Turbines
Principles, Construction, Working, uses, Merits and Demerits of Paddles
And
Principles, Construction, Working, uses, Merits and Demerits of Silverson Emulsifier.
This document discusses mixing and homogenization processes. It defines mixing as combining two or more substances together, and identifies perfect mixing as each particle of one material lying adjacent to a particle of the other material. The objectives of mixing are outlined. There are three types of mixtures discussed: positive, negative, and neutral. The mechanisms and equipment used for mixing powders, liquids, and semi-solids are described. Homogenization is defined as preparing a fine emulsion from a coarse one by converting large globules to small globules. Common homogenization equipment like hand homogenizers, Silverson mixers, and colloidal mills are summarized.
This document discusses mixing and different types of mixers. It defines mixing as the random distribution or addition of materials, as opposed to agitation which refers to induced motion without distribution. Mixing can involve solids, liquids, or gases. The key types of mixing discussed are solid mixing, liquid mixing, and gas mixing. For solid mixing, different mixers are used depending on whether the solids are cohesive or non-cohesive. Common mixers mentioned include ribbon mixers, tumbling mixers, pony mixers, and beater mixers. The document also discusses how the degree of mixing is quantified using a mixing index.
1. The document discusses different types of mixing for solids and semi-solids used in pharmacy. It describes mixing mechanisms like convective, shear, and diffusive mixing.
2. Various mixers for solids are described, including tumbling mixers, agitator mixers, and special mixers. Factors that affect solid mixing like particle size and density are also discussed.
3. Mixers for semi-solids and pastes include beaters, kneaders, mixer-extruders, and mixing rolls. Different flow types for semi-solids are noted.
Mixing and homogenization are important processes used to combine substances. There are several types of mixtures that can be formed including positive, negative, and neutral mixtures. The main objectives of mixing are to create a uniform mixture, promote chemical reactions, and disperse solids or liquids. Various equipment is used for mixing powders, liquids, and semi-solids depending on the application and properties of the substances. Key factors like particle size and shape, proportions, and densities must be considered to ensure proper mixing.
Mixing is a key process in pharmaceutical manufacturing that involves combining ingredients in a uniform manner. There are several types of mixers that employ different mechanisms like shear, convection, and diffusion to achieve mixing. Factors like particle size and shape, proportions, viscosity, and temperature can influence the mixing process. Common applications of mixing in pharmaceuticals include granulation, direct compression tableting, and capsule filling. The selection of an appropriate mixer depends on factors like the materials involved, the scale of production, and desired mixing action.
This document discusses mixing and filtration processes. It defines mixing as a process that randomizes particles within a system. Mixing has applications in achieving uniformity and enhancing chemical reactions. There are different types of mixing depending on the state of matter and physical stability of the mixture. Liquid mixing can involve liquid-liquid or solid-liquid mixing to produce monophasic liquids, emulsions, or suspensions. Factors like impellers, flow patterns, and tank design impact liquid mixing. Filtration separates solids from liquids using a porous medium and involves terms like clarification, ultrafiltration, filtrate, and filter cake. The rate of filtration depends on parameters like permeability, viscosity, cake morphology, and filter area.
1. Agitation involves inducing motion within a material while mixing distributes components randomly.
2. Mixing operations involve various combinations of gases, liquids, and solids and may require agitation to enhance mass and heat transfer between phases.
3. Effective agitation and mixing depends on factors like the impeller type, liquid properties, and vessel design which influence flow patterns within the vessel.
Mixing: Objectives, applications & factors affecting mixing,
Difference between solid and liquid mixing,
mechanism of solid mixing, liquids mixing and semisolids mixing.
Principles, Construction, Working, uses, Merits and Demerits of Double cone blender
Principles, Construction, Working, uses, Merits and Demerits of twin shell blender
Principles, Construction, Working, uses, Merits and Demerits of ribbon blender
Principles, Construction, Working, uses, Merits and Demerits of Sigma blade mixer
Principles, Construction, Working, uses, Merits and Demerits of planetary mixers
Principles, Construction, Working, uses, Merits and Demerits of Propellers
Principles, Construction, Working, uses, Merits and Demerits of Turbines
Principles, Construction, Working, uses, Merits and Demerits of Paddles
And
Principles, Construction, Working, uses, Merits and Demerits of Silverson Emulsifier.
This document discusses mixing and homogenization processes. It defines mixing as combining two or more substances together, and identifies perfect mixing as each particle of one material lying adjacent to a particle of the other material. The objectives of mixing are outlined. There are three types of mixtures discussed: positive, negative, and neutral. The mechanisms and equipment used for mixing powders, liquids, and semi-solids are described. Homogenization is defined as preparing a fine emulsion from a coarse one by converting large globules to small globules. Common homogenization equipment like hand homogenizers, Silverson mixers, and colloidal mills are summarized.
This document discusses mixing and different types of mixers. It defines mixing as the random distribution or addition of materials, as opposed to agitation which refers to induced motion without distribution. Mixing can involve solids, liquids, or gases. The key types of mixing discussed are solid mixing, liquid mixing, and gas mixing. For solid mixing, different mixers are used depending on whether the solids are cohesive or non-cohesive. Common mixers mentioned include ribbon mixers, tumbling mixers, pony mixers, and beater mixers. The document also discusses how the degree of mixing is quantified using a mixing index.
1. The document discusses different types of mixing for solids and semi-solids used in pharmacy. It describes mixing mechanisms like convective, shear, and diffusive mixing.
2. Various mixers for solids are described, including tumbling mixers, agitator mixers, and special mixers. Factors that affect solid mixing like particle size and density are also discussed.
3. Mixers for semi-solids and pastes include beaters, kneaders, mixer-extruders, and mixing rolls. Different flow types for semi-solids are noted.
This document discusses mixing in the manufacture of cosmetics. It defines mixing and describes factors that influence the mixing process. The objectives and mechanisms of mixing are explained. Positive, negative and neutral mixtures are defined. Methods for mixing solids, fluids and semi-solids are outlined. Common mixing equipment for each type is described, including twin shell blenders, double cone blenders, propellers, turbines, and paddles.
The presentation covered various topics related to solid-liquid mixing including:
- The definitions and goals of mixing to reduce non-uniformities and obtain a uniform mixture.
- The different types of mixing like solid-solid, liquid-liquid, and solid-liquid mixing.
- Factors that influence mixing like particle size and shape, moisture content, and mixer efficiency.
- Equipment used for mixing like kneaders, homogenizers, and paddle or propeller impellers.
- Applications of mixing in food and other industries like chemicals, polymers, cosmetics, and more.
This presentation discusses liquid mixing mechanisms and equipment. It introduces four mechanisms of liquid mixing - bulk transport, turbulent mixing, laminar mixing, and molecular diffusion. Common applications of liquid mixing include pharmaceutical preparations like suspensions, emulsions, and solutions. Typical mixing vessels include tanks equipped with impellers like propellers and turbines that impart tangential, radial, and axial flow patterns. Specific liquid mixing equipment covered are airjet mixers, jet mixers, and line/pipe mixers.
Types of Impeller(Propeller & Turbines)pptxSagarBhakare1
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The optimal configuration and placement of an impeller in a bioreactor depends on several factors:
1) The desired mixing regime, such as uniformly suspending cells or minimizing shear stress
2) The volume and geometry of the bioreactor
3) The rheological properties, such as viscosity, of the culture broth
4) The mass transfer requirements of the process, such as gas-liquid transfer
Key considerations include the impeller type, number, height from the bottom, distance from walls, and angle to achieve the desired mixing patterns while avoiding dead zones and preventing cell damage.
Mixing is a general term that includes stirring, beating, blending, binding, creaming, whipping, and folding. In mixing, two or more ingredients are evenly dispersed in one another until they become one product.
This document discusses mixing of solids in the pharmaceutical industry. It defines mixing as a process that randomizes particles within a system. There are various types of mixing including mixing of solids, liquids, and semisolids. Mixing of solids can occur through mechanisms like convection, shear, and diffusion. Several factors influence solid mixing like particle properties, proportions, and equipment used. Common equipment for small-scale solid mixing includes tumbler blenders, V-cone blenders, ribbon blenders, and sigma blenders which use mechanisms like tumbling and shear to achieve mixing. Larger scale continuous mixers also exist. Statistical parameters can assess the degree and uniformity of mixing.
Mixing, the seemingly simple act of combining various components, plays a pivotal role in numerous scientific and industrial processes. From stirring milk in your coffee to homogenizing nanoparticles in pharmaceuticals, understanding mixing mechanisms and types is crucial. This note delves into the world of mixing, exploring its depths within 3000 words.
Part 1: Unveiling the Mixing Landscape
1.1 Demystifying Mixing:
Mixing refers to the process of bringing different components into close contact to achieve uniformity. The degree of mixing, characterized by homogeneity or dispersion, is influenced by several factors like viscosity, density differences, and mixing methods.
1.2 Classifying the Mixers:
A plethora of mixing methods exist, each suited for specific applications. Here are some key categories:
Bulk Mixing: Aims for complete homogeneity throughout the entire volume, commonly used in liquids and pastes. Techniques include stirred tanks, blenders, and extruders.
Dispersive Mixing: Focuses on distributing smaller particles or droplets uniformly within a continuous phase. Homogenizers, colloid mills, and sonication are frequently employed.
Laminar Mixing: Utilizes repeated folding or stretching operations to achieve layering and eventual homogenization. Microfluidic devices and some bakery processes use this principle.
Turbulent Mixing: Introduces chaotic eddies and high shear forces to rapidly break down concentration gradients. Stirred tanks with impellers, jet mixers, and fluidized beds are examples.
1.3 Factors Affecting Mixing:
Several factors impact the efficiency and effectiveness of mixing:
Properties of the Materials: Viscosity, density differences, and particle size significantly influence mixing behavior.
Mixing Geometry and Flow Patterns: The shape and configuration of the mixing vessel and the resulting flow patterns determine mixing intensity and uniformity.
Mixing Time and Intensity: The duration and intensity of mixing are crucial for achieving the desired level of homogeneity.
External Forces: Application of additional forces like heat, ultrasound, or magnetic fields can enhance mixing in specific scenarios.
Part 2: Delving into Specific Mixing Types:
Understanding specific mixing types helps in selecting the most effective method for each application:
Stirred Tank Mixing: This versatile method uses rotating impellers to generate flow and achieve moderate to high shear mixing. Variations include impeller design, tank geometry, and baffles.
Fluidized Bed Mixing: Solids are suspended in a gas stream, creating a fluid-like behavior and enabling efficient mixing of granular materials.
Jet Mixing: High-velocity jets inject material into the mix, promoting rapid dispersion and homogenization. Used in pipelines and reactors.
Microfluidic Mixing: Utilizes microchannels to manipulate flow patterns and achieve precise mixing at small scales, oft
Amidst the verdant foliage, a **lush bush** unfurls its vibrant petals, each a crimson stroke against the canvas of the sky. The gentle sunlight** weaves through leaves, illuminating this botanical masterpiece. 🌼
This document discusses various filtration techniques used in pharmaceutical manufacturing. It begins by describing the mechanisms of filtration including straining and impingement. It then discusses various filter media and factors that influence the rate of filtration such as surface area, pressure, viscosity. Finally, it summarizes different types of filters including filter press, leaf filter, metafilter, cartridge filter, rotary drum filter, and membrane filter. It provides details on the construction and working of each type of filter.
This document discusses mechanisms and equipment for liquid mixing. It describes that mixing is done to produce a uniform mixture and requires both bulk flow and intensive mixing to break down inhomogeneities. The mechanisms of laminar and turbulent mixing are then covered. For laminar mixing, high viscosity liquids are elongated and thinned in regions of high shear near impellers. Turbulent mixing relies on eddy diffusion throughout the vessel. Common mixing equipment includes mechanical agitators with vessels, baffles and various impeller types selected based on liquid viscosity, as well as extruders and static mixers.
This document discusses mixing in industrial processes. It defines mixing as manipulating a heterogeneous system to make it more homogeneous by intermingling two or more separate components. The types of mixing covered include different materials like solids, liquids, and gases. The mechanisms of mixing include shear, diffusive, and convective mixing. Common mixers are tumbling mixers, convective mixers, ribbon blenders, and others. Factors that impact mixing include mixer selection, mixing time, power consumption, and degree of mixing achieved. Agitation is also discussed and compared to mixing.
This presentation give you basic information about mixing a mechanical operation.
Which includes the basic like type of impellers, mixing machines and power required to mix the solid liquid and liquid-liquid substance.
This document discusses fluidized bed extraction, which is a type of extraction that uses a fluidized bed extractor. It can be used to carry out multiphase reactions. The document defines fluidization and describes the different types. It then discusses three phase fluidized beds and their advantages and disadvantages. Various operating variables that affect fluidized bed extraction are also outlined.
1. The document discusses different types of mixing operations used in food processing, including mixing of solids, liquids, and semisolids.
2. It describes various factors that influence mixing like particle size, shape, density, and surface properties.
3. Several common mixing equipment are outlined, including tumbler mixers, V-cone blenders, double cone blenders, ribbon blenders, and sigma blade mixers. Each have advantages and limitations for certain mixing applications.
This document discusses various types of mixing mechanisms used in pharmaceutical manufacturing. It begins by defining mixing and dividing it into homogeneous and heterogeneous categories. The objectives, applications and factors affecting mixing are outlined. The key differences between solid, liquid and semisolid mixing are explained. Various mixing mechanisms for solids include convection, shear and diffusive mixing while mechanisms for liquids include bulk transport, turbulent and laminar mixing. Molecular mixing is described as the mechanism for semisolids. Common mixing equipment like propellers, turbines, paddles, ribbon blenders and planetary mixers are introduced along with their principles, construction, working and advantages/disadvantages. Vortex formation is discussed as a disadvantage of propellers.
This document discusses mixing and blending in the pharmaceutical industry. It defines mixing as a unit operation aimed at reducing non-uniformity in a material's properties. The main goals of mixing are producing a uniform blend and ensuring each component is in contact with the others. Mixing can involve single or multiphase systems and the types of mixtures are positive, negative, and neutral. Key mixing mechanisms for liquids include bulk transport, turbulent flow, laminar flow, and molecular diffusion. Common mixing equipment uses impellers or paddles to induce flow. Problems in mixing include segregation which depends on particle properties. Proper equipment selection considers material properties and processing factors.
This document discusses various types of mixing and homogenization. It defines mixing as combining two or more substances and describes different types of mixing like solid-liquid and gas-liquid mixing. It also defines positive, negative and neutral mixtures. The objectives, mechanisms and factors affecting mixing are explained. Finally, it describes common mixing and homogenization equipment like double cone blenders, propeller mixers, hand homogenizers, Silverson mixer homogenizers and colloidal mills and how they work.
The document discusses various non-thermal food processing techniques as alternatives to traditional thermal processing which can cause nutrient and flavor loss. It describes techniques such as microwave heating, pulsed electric field processing, high pressure processing, pulsed light technology, and ohmic heating. These non-thermal methods allow for higher production rates and better food quality compared to thermal processing.
This document discusses microbial spoilage of cereals and bakery foods. It outlines the roles of microorganisms in food, including spoilage, fermentation, and food production. Primary sources of microorganisms that can cause spoilage are identified as soil, water, plants, food utensils, humans, animals, air, and dust. Spoilage is defined as the process by which food deteriorates and becomes inedible. Major factors affecting microbial growth in food are identified as the characteristics, processing, storage, and preservation methods used. The major groups of microorganisms that can cause spoilage are molds, bacteria, and yeasts. Current methods for preserving cereal grains are also discussed.
This document discusses mixing in the manufacture of cosmetics. It defines mixing and describes factors that influence the mixing process. The objectives and mechanisms of mixing are explained. Positive, negative and neutral mixtures are defined. Methods for mixing solids, fluids and semi-solids are outlined. Common mixing equipment for each type is described, including twin shell blenders, double cone blenders, propellers, turbines, and paddles.
The presentation covered various topics related to solid-liquid mixing including:
- The definitions and goals of mixing to reduce non-uniformities and obtain a uniform mixture.
- The different types of mixing like solid-solid, liquid-liquid, and solid-liquid mixing.
- Factors that influence mixing like particle size and shape, moisture content, and mixer efficiency.
- Equipment used for mixing like kneaders, homogenizers, and paddle or propeller impellers.
- Applications of mixing in food and other industries like chemicals, polymers, cosmetics, and more.
This presentation discusses liquid mixing mechanisms and equipment. It introduces four mechanisms of liquid mixing - bulk transport, turbulent mixing, laminar mixing, and molecular diffusion. Common applications of liquid mixing include pharmaceutical preparations like suspensions, emulsions, and solutions. Typical mixing vessels include tanks equipped with impellers like propellers and turbines that impart tangential, radial, and axial flow patterns. Specific liquid mixing equipment covered are airjet mixers, jet mixers, and line/pipe mixers.
Types of Impeller(Propeller & Turbines)pptxSagarBhakare1
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The optimal configuration and placement of an impeller in a bioreactor depends on several factors:
1) The desired mixing regime, such as uniformly suspending cells or minimizing shear stress
2) The volume and geometry of the bioreactor
3) The rheological properties, such as viscosity, of the culture broth
4) The mass transfer requirements of the process, such as gas-liquid transfer
Key considerations include the impeller type, number, height from the bottom, distance from walls, and angle to achieve the desired mixing patterns while avoiding dead zones and preventing cell damage.
Mixing is a general term that includes stirring, beating, blending, binding, creaming, whipping, and folding. In mixing, two or more ingredients are evenly dispersed in one another until they become one product.
This document discusses mixing of solids in the pharmaceutical industry. It defines mixing as a process that randomizes particles within a system. There are various types of mixing including mixing of solids, liquids, and semisolids. Mixing of solids can occur through mechanisms like convection, shear, and diffusion. Several factors influence solid mixing like particle properties, proportions, and equipment used. Common equipment for small-scale solid mixing includes tumbler blenders, V-cone blenders, ribbon blenders, and sigma blenders which use mechanisms like tumbling and shear to achieve mixing. Larger scale continuous mixers also exist. Statistical parameters can assess the degree and uniformity of mixing.
Mixing, the seemingly simple act of combining various components, plays a pivotal role in numerous scientific and industrial processes. From stirring milk in your coffee to homogenizing nanoparticles in pharmaceuticals, understanding mixing mechanisms and types is crucial. This note delves into the world of mixing, exploring its depths within 3000 words.
Part 1: Unveiling the Mixing Landscape
1.1 Demystifying Mixing:
Mixing refers to the process of bringing different components into close contact to achieve uniformity. The degree of mixing, characterized by homogeneity or dispersion, is influenced by several factors like viscosity, density differences, and mixing methods.
1.2 Classifying the Mixers:
A plethora of mixing methods exist, each suited for specific applications. Here are some key categories:
Bulk Mixing: Aims for complete homogeneity throughout the entire volume, commonly used in liquids and pastes. Techniques include stirred tanks, blenders, and extruders.
Dispersive Mixing: Focuses on distributing smaller particles or droplets uniformly within a continuous phase. Homogenizers, colloid mills, and sonication are frequently employed.
Laminar Mixing: Utilizes repeated folding or stretching operations to achieve layering and eventual homogenization. Microfluidic devices and some bakery processes use this principle.
Turbulent Mixing: Introduces chaotic eddies and high shear forces to rapidly break down concentration gradients. Stirred tanks with impellers, jet mixers, and fluidized beds are examples.
1.3 Factors Affecting Mixing:
Several factors impact the efficiency and effectiveness of mixing:
Properties of the Materials: Viscosity, density differences, and particle size significantly influence mixing behavior.
Mixing Geometry and Flow Patterns: The shape and configuration of the mixing vessel and the resulting flow patterns determine mixing intensity and uniformity.
Mixing Time and Intensity: The duration and intensity of mixing are crucial for achieving the desired level of homogeneity.
External Forces: Application of additional forces like heat, ultrasound, or magnetic fields can enhance mixing in specific scenarios.
Part 2: Delving into Specific Mixing Types:
Understanding specific mixing types helps in selecting the most effective method for each application:
Stirred Tank Mixing: This versatile method uses rotating impellers to generate flow and achieve moderate to high shear mixing. Variations include impeller design, tank geometry, and baffles.
Fluidized Bed Mixing: Solids are suspended in a gas stream, creating a fluid-like behavior and enabling efficient mixing of granular materials.
Jet Mixing: High-velocity jets inject material into the mix, promoting rapid dispersion and homogenization. Used in pipelines and reactors.
Microfluidic Mixing: Utilizes microchannels to manipulate flow patterns and achieve precise mixing at small scales, oft
Amidst the verdant foliage, a **lush bush** unfurls its vibrant petals, each a crimson stroke against the canvas of the sky. The gentle sunlight** weaves through leaves, illuminating this botanical masterpiece. 🌼
This document discusses various filtration techniques used in pharmaceutical manufacturing. It begins by describing the mechanisms of filtration including straining and impingement. It then discusses various filter media and factors that influence the rate of filtration such as surface area, pressure, viscosity. Finally, it summarizes different types of filters including filter press, leaf filter, metafilter, cartridge filter, rotary drum filter, and membrane filter. It provides details on the construction and working of each type of filter.
This document discusses mechanisms and equipment for liquid mixing. It describes that mixing is done to produce a uniform mixture and requires both bulk flow and intensive mixing to break down inhomogeneities. The mechanisms of laminar and turbulent mixing are then covered. For laminar mixing, high viscosity liquids are elongated and thinned in regions of high shear near impellers. Turbulent mixing relies on eddy diffusion throughout the vessel. Common mixing equipment includes mechanical agitators with vessels, baffles and various impeller types selected based on liquid viscosity, as well as extruders and static mixers.
This document discusses mixing in industrial processes. It defines mixing as manipulating a heterogeneous system to make it more homogeneous by intermingling two or more separate components. The types of mixing covered include different materials like solids, liquids, and gases. The mechanisms of mixing include shear, diffusive, and convective mixing. Common mixers are tumbling mixers, convective mixers, ribbon blenders, and others. Factors that impact mixing include mixer selection, mixing time, power consumption, and degree of mixing achieved. Agitation is also discussed and compared to mixing.
This presentation give you basic information about mixing a mechanical operation.
Which includes the basic like type of impellers, mixing machines and power required to mix the solid liquid and liquid-liquid substance.
This document discusses fluidized bed extraction, which is a type of extraction that uses a fluidized bed extractor. It can be used to carry out multiphase reactions. The document defines fluidization and describes the different types. It then discusses three phase fluidized beds and their advantages and disadvantages. Various operating variables that affect fluidized bed extraction are also outlined.
1. The document discusses different types of mixing operations used in food processing, including mixing of solids, liquids, and semisolids.
2. It describes various factors that influence mixing like particle size, shape, density, and surface properties.
3. Several common mixing equipment are outlined, including tumbler mixers, V-cone blenders, double cone blenders, ribbon blenders, and sigma blade mixers. Each have advantages and limitations for certain mixing applications.
This document discusses various types of mixing mechanisms used in pharmaceutical manufacturing. It begins by defining mixing and dividing it into homogeneous and heterogeneous categories. The objectives, applications and factors affecting mixing are outlined. The key differences between solid, liquid and semisolid mixing are explained. Various mixing mechanisms for solids include convection, shear and diffusive mixing while mechanisms for liquids include bulk transport, turbulent and laminar mixing. Molecular mixing is described as the mechanism for semisolids. Common mixing equipment like propellers, turbines, paddles, ribbon blenders and planetary mixers are introduced along with their principles, construction, working and advantages/disadvantages. Vortex formation is discussed as a disadvantage of propellers.
This document discusses mixing and blending in the pharmaceutical industry. It defines mixing as a unit operation aimed at reducing non-uniformity in a material's properties. The main goals of mixing are producing a uniform blend and ensuring each component is in contact with the others. Mixing can involve single or multiphase systems and the types of mixtures are positive, negative, and neutral. Key mixing mechanisms for liquids include bulk transport, turbulent flow, laminar flow, and molecular diffusion. Common mixing equipment uses impellers or paddles to induce flow. Problems in mixing include segregation which depends on particle properties. Proper equipment selection considers material properties and processing factors.
This document discusses various types of mixing and homogenization. It defines mixing as combining two or more substances and describes different types of mixing like solid-liquid and gas-liquid mixing. It also defines positive, negative and neutral mixtures. The objectives, mechanisms and factors affecting mixing are explained. Finally, it describes common mixing and homogenization equipment like double cone blenders, propeller mixers, hand homogenizers, Silverson mixer homogenizers and colloidal mills and how they work.
The document discusses various non-thermal food processing techniques as alternatives to traditional thermal processing which can cause nutrient and flavor loss. It describes techniques such as microwave heating, pulsed electric field processing, high pressure processing, pulsed light technology, and ohmic heating. These non-thermal methods allow for higher production rates and better food quality compared to thermal processing.
This document discusses microbial spoilage of cereals and bakery foods. It outlines the roles of microorganisms in food, including spoilage, fermentation, and food production. Primary sources of microorganisms that can cause spoilage are identified as soil, water, plants, food utensils, humans, animals, air, and dust. Spoilage is defined as the process by which food deteriorates and becomes inedible. Major factors affecting microbial growth in food are identified as the characteristics, processing, storage, and preservation methods used. The major groups of microorganisms that can cause spoilage are molds, bacteria, and yeasts. Current methods for preserving cereal grains are also discussed.
This document discusses the structural hierarchy of proteins from primary to quaternary structure. It explains that proteins are made up of amino acids linked together in polypeptide chains. The primary structure is the sequence of amino acids in the chain. Secondary structures like alpha helices and beta sheets form due to hydrogen bonding. Tertiary structure is the 3D folding of secondary structures into the lowest energy state. Quaternary structure involves multiple polypeptide chains combining to form oligomeric proteins. The document also classifies proteins based on shape and constitution and discusses the functions of different types of proteins like enzymes, hormones, and structural proteins.
This document summarizes types of meat spoilage caused by microorganisms. It discusses how meat becomes contaminated during slaughter and processing, allowing microbes like bacteria, yeasts and molds to grow. The major types of spoilage include:
1. Aerobic bacteria can cause surface slime, discoloration, gas production, odor changes and fat decomposition. Pseudomonas is a common genus.
2. Anaerobic bacteria may cause souring through acid production or putrefaction involving foul odors. Clostridium species are major putrefiers.
3. Temperature influences spoilage microbes, with refrigeration permitting growth of psychrotrophs like Pseudomonas, Lactob
Canning is a method of preserving food by processing and sealing it in an airtight container. The canning process was developed in the late 18th century to preserve foods for Napoleon's armies. It involves packing food into containers, hermetically sealing them, applying heat to kill microbes, and cooling the sealed containers. Proper canning through thermal processing prevents microbial spoilage and allows canned foods to be safely stored at room temperature for 1-5 years. Improper canning that fails to sufficiently heat foods can result in spoilage from bacterial growth.
Shell and tube heat exchangers are widely used in process industries due to their large heat transfer area to volume ratio and mechanical robustness. They consist of tubes bundled together in a shell, with one fluid flowing inside the tubes and another outside in the shell. Key components include the shell, tubesheet, tubes, baffles, and nozzles. Baffles divert shell-side flow across the tube bundle to improve heat transfer and support the tubes. Segmental baffles are most common. Kern's integral method is a simple technique for calculating shell-side heat transfer coefficients and pressure drop. Design of a shell and tube heat exchanger involves initial decisions on fluid allocation and velocities, followed by thermal and hydraulic analysis of
1. Submitted To:
Prof. Shiv Kumar Katiyar
Head of the Department
Submitted By:
Ritik Kumar
M.Sc. 1stSemester
Roll no. 221155081018
2. Mixing operation:
Mixing is basically a process in which components are treated in such
manner so that particles of each component are available to the adjacent
particles of the other component that are required to be mixed.
Factors affecting mixing:
1. Particle size:
Smaller particle results in homogeneous mixture than the larger one.
2. Particle shape:
Particle should be spherical for uniform mixing. If there is irregular
shape of the particle then they become interconnected in such a way so
that their separation is relatively difficult after mixing than if the particle
shape is regular.
3. Particle charge:
If the particle has some electrostatic charge that cause attraction
forces between particles, then there are more chances of segregation or
separation.
3. 4. Nature if the particle:
Particle hardness, elasticity, porosity, texture, angularity and particle
vibrations are also the factors that affect mixing phenomena greatly.
5. Relative Density:
If the components are of different density, the denser material will sink
through the lighter one, the effect of which will depend on the relative
positions of the material in the mixer.
a. If the denser particles form the lower layer in a mixture at the start
of a mixing operation, the degree of mixing will increase gradually until
equilibrium is attained , not necessarily complete mixing.
b. If the denser component is above, the degree of mixing increases to
a maximum , then dropping to equilibrium as the denser component falls
through the lighter one , so that segregation has started.
4. 6. Viscosity:
Mixing is also affected by viscosity. More viscous particles causes
improper mixing as their higher viscosity affects their speed (slow) to flow
that is produced by forces to get mixing . so basically increasing viscosity
reduces mixing extent.
7. Surface tension of liquids:
Surface tension of liquid is also an important factor that effects mixing.
High surface tension reduces extend of mixing. In fact cohesiveness is the
tendency of material to adhere to itself causes difficulty in mixing as
agglomerates are formed.
8. Moisture:
Moisture present in particles heap also affects mixing phenomena. For
example mixing of dry clay is more rapid and efficient than wet mixing of
clay. In fact proper mixing requires specific moisture content in bulk.
5. 9. Temperature:
Temperature also affects mixing as viscosity is changing with temperature
changing.
10. Flow characteristics:
Flow properties are directly related to particle size . as due to
increase/decrease in particle size gravitational forces according to size
increases/decreases.
11. Liquid quality:
In solid-liquid mixing liquid (water) quality is also an important factor .
Liquid quality includes pH value, salt level, organic matter; foreign matter etc.
affects greatly the efficiency of mixing.
12. Speed/rpm of impeller:
Speed of impeller affects the homogeneity of the mixture. As with less rpm
mixture is more homogenous than with greater rpm.
6. 13. Mixer volume:
Mixer volume also affects mixing phenomena. Mixer volume should be
such that over filling should not be done as it decreases efficiency of mixing
and mostly material can’t be mixed thoroughly.
14. Type of agitator:
The shape, size, location and type of agitator present also affects the
extent of mixing achieved and the time required for mixing of specific
components . As the type of agitator required for mixing depends upon
the nature of substances that need to be mixed. However, generally speaking,
a. Impeller type mixers are used for solid-liquid mixing.
b. Paddle type mixers are used for solid-solid mixing operations.
c. The blades are further modified for kneading and dispersing purpose
cohesive solids are needed to be mixed.
7. 15. Type of mixer:
Type of mixer greatly effects on mixing phenomena . as in mixing there is
specific flow patterns due to which mixing taking place. Suitable flow pattern
for mixing can be obtained as a result of balanced components in mixer .
a. If the impeller shaft is vertical, excessive radial movement, especially if
solids are present , will take materials to the vessel periphery, where
they drop to the bottom and may revolve as a mass below the impeller.
b. If the tangential component is leading, a vortex is created and may
deepen until it extents the impeller, when aeration occurs.
c. If the longitudinal component is inadequate, liquids and solids may
present in films without mixing.
8. 16. Mixing time:
Mixing time is also very important for proper mixing. There is always an
optimum mixing time for specific conditions in which mixing is taken place.
As degree of mixing reaches to its limiting equilibrium value asymptotically.
17. Mechanism of mixing:
The mixer must apply suitable shear forces to bring about local mixing
and a convective movement to ensure that the bulk of the material passes
through this area . so this mechanism also affects the mixing process.
9. 1. Three-bladed marine propeller:
Many varieties are existing:
a. with cut out or perforated blades for grinding and breaking up lumps.
b. with saw tooth edges for cutting and scratching action,
c. And with other than three blades . The stabilizing ring sometimes is in
included.
to minimize shaft flutter and vibration particularly at low liquid level.
Where?
They are used at relatively high speeds (up to 1800rpm)
with low viscosity fluids, up to about 4000cP
10. 2. Flat vertical blades turbine:
The simple geometry of this design has stimulated extensivetesting so
that expectation of their action is on a more rationalbasis than that of
any other kind of impeller.
Where?
It is suitable for the vast majority of mixing duties up to 100,000CP
or so at high pumping capacity.
11. 3. Horizontal plate blades turbine:
Where?
The horizontal plate to which the impeller blades
of this turbineare attached has a stabilizing effect.
4. Shrouded turbines:
It is consisting of a rotor and a stator.
Where?
Ensures a high degree of radial flow and shearing action, and arewell
adapted to emulsification and dispersion
12. 5. Cage beaters:
Mostly they are mounted on the same shaft
along with a standard propeller. More violent
action may be achieved with spined blades .
Where?
It imparts a cutting and beating action.
6. Anchor paddles:
Anchor paddles fit the contour of the container.
Where?
It prevents sticking of pasty materials, and promotes good heattransfer
with the wall.
13. Types of mixtures for dry and paste materials
1. Tumbler Mixers:
Free-flowing non-segregating powders may be readily
mixed in batch by use of tumbler mixers. Tumbler mixers operate by
tumbling the mass of solids inside a revolving vessel. Blenders are available
in various geometries, affecting material movement, mixing efficiency and
ease of cleaning between batches. These vessels take various forms, such as
those illustrated , and may be fitted with baffles or stays to improve their
performance. A tumbling batch blender can be of four types, which are
described as follows:
a. Horizontal cylinder :
This cylindrical mixer has a tubular vessel mounted on trunnions. Internal
baffles or lifter bars are mounted along the inner walls of the vessel. The inlet
is typically located at the top center of the vessel and the outlet at the bottom
center. The blender tumbles and the internal baffles gently lift and aerate the
material preventing it from sliding along the blender bottom; they also de-
lump the material. See figure a
14. b. Double cone blender :
The double cone blender consists of two cone-shaped sections, typically with
45o slopes. The cone sections are welded at their ends to a center band. The
blender is mounted between two trunnions that permit the unit to tumble
end over end. An opening in one of the ends of the cones serves as inlet and
outlet, or the inlet can be in one cone end with the outlet in the other.
Cleaning access is through the outlet. The blender tumbles, and the material
in the vessel spreads out. The transition area at the band between the cones
prevents the material from sliding along the inner wall and instead causes
the material to fold over itself. This provides gentle mixing with only very
slight shear. See figure b
Horizontal and Vertical Trough Mixers
15.
16. C. V-cone blender and Y-cone blender :
The V-cone blender is similar to a double cone unit, but consists of two
large diameter pipe sections cut at a 45â—¦-angle and welded together to
form a V. In the same way, the Y-cone blender has a third section that
extends the volume of the blender in a bisectional direction with respect
to the other pipe sections. Inlets are typically located at both ends of the
V (or of the Y); the outlet is at the V point (or at the bottom of the Y).
The unit is also mounted on trunnions to allow it to tumble and can be
equipped with a spray line for liquid addition and an agitator for de-
lumping. The units tumble end over end as in the double cone blender.
The free-falling action combined with increased frictional contact
between the material and the long vessel sides result in less gentle
mixing than in a double cone blender.See figure c or d
17. 1.Vertical Screw Mixers :
In vertical screw mixers, a rotating vertical screw is located in a cylindrical
or cone shaped vessel. The screw may be mounted centrally in the vessel or
may rotate or orbit around the central axis of the vessel near the wall.
Materials are lifted from the bottom to the top of the hopper and are then
exchanged with materials on the way up. Such mixers are schematically
shown in . A vertical screw blender may be desired for larger batches
handled in a small space, while the orbiting screw mixer (Fig. 17.4b) is used
for difficult mixes. The latter arrangement is more effective and stagnant
layers near the wall are eliminated. Vertical screw mixers are quick,
efficient, and particularly useful for mixing small quantities of additives
into large masses of material. Specialized atmospheres as well as normal
temperatures and pressures are accessible for multipurpose operations.
see figure a or b on next slide
18.
19. 2.Fluidized Bed Mixers:
Food powders can also be mixed by aeration using a fluidized bed. The
resulting turbulence of passing air through a bed of particulate material
causes material to blend. Materials are moved upward by air jets, causing
differential movement. Stationary vessels using gas-flow agitation are used
primarily for batch mode mixing. Materials to be mixed have to be relatively
fine and fairly narrow in their size distribution, as well as not too cohesive.
Powders to be mixed can be charged to more than 70% of the vessel volume.
Mixing times required in fluidized beds are significantly lower than those
required in conventional powder mixers. The mixing is largely convective
with the circulation patterns set up by the bubble motion within the bed. An
important feature of the fluidized bed mixer is that several processing steps
(mixing reaction, coating, drying, etc. may be carried out in the same vessel.
Additional equipment can include blowers, dust collectors, and pressure
regulators, which will enlarge the system as a whole. A particular type of the
fluidized mixer is the fluidized paddle mixer . The mixer has twin troughs,
each with a center mounted rotating shaft. Flat paddles are welded to spokes
on each shaft. The paddles lift the material from the bottom and throw it into
a zero gravity, fluidized mixing zone, settling a random displacement pattern
for the material.figure seen on next slide…