This document discusses size reduction, which is the process of reducing larger particles into smaller particles of a desired size and shape using external forces. It defines size reduction and comminution, and lists the objectives of size reduction such as increasing surface area and achieving intimate mixing. The document describes various size reduction mechanisms, factors affecting size reduction, and theories related to the energy required. It provides details on different size reduction equipment like hammer mills, ball mills, fluid energy mills, edge runner mills, and end runner mills.
Objectives, applications, Mechanism, official standards of powders, Sieve, Standard for Sieve, Principles, construction, working, uses, merits and demerits of Air separator.
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Objectives, applications, Mechanism, official standards of powders, Sieve, Standard for Sieve, Principles, construction, working, uses, merits and demerits of Air separator.
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
objectives, applications, mechanism of size separation, the official standard of powders, sieves, sieve shaker, cyclone separator, air separator, bag filter, elutriation tank
Fluid energy mill for pharmacy principles, construction, working, uses, meri...ASHUTOSH SENGAR
this is an slideshare for pharmacy students, principles, construction, working, uses, merits and
demerits of , fluid energy mill its for b. pharm. and M. PHARM
Mixer Machines Mixer Machines are used in a number of different applications and industries in order to produce a final product that is the result of mixing or combining two or more materials.
Generally, size reduction and size separation are combined to obtain powder with the desired particle size distribution (PSD) for acceptable flow and compressibility for downstream processing . The mechanical process of reducing the particle size of a solid is also called milling.
Introduction
Objectives
Methods of size reduction
Advantages of size reduction
Disadvantages of size reduction
Mechanism of size reduction
Laws governing to the size reduction
Principle of Size Reduction, Construction, working and uses of following-
Hammer mill
Ball mill
Fluid Energy Mill
Edge Runner Mill
End Runner Mill
This presentation will help the students of Pharmacy in subjects like Pharmaceutics and industrial pharmacy. Hope you will find it better and helpful.
Regards
Amjad Anwar
email: amjadanwar77@gmail.com
Department of Pharmacy, University Of Malakand
Size reduction is a process of reducing large solid unit masses, coarse particles or fine particles.
Size reduction may be achieved by two methods:
1] Precipitation
2] Mechanical process
1] Precipitation method: Substance is dissolve in appropriate solvent.
2] Mechanical process: Mechanical force is introduce by using different equipments like ball mill, colloid mill etc.
objectives, applications, mechanism of size separation, the official standard of powders, sieves, sieve shaker, cyclone separator, air separator, bag filter, elutriation tank
Fluid energy mill for pharmacy principles, construction, working, uses, meri...ASHUTOSH SENGAR
this is an slideshare for pharmacy students, principles, construction, working, uses, merits and
demerits of , fluid energy mill its for b. pharm. and M. PHARM
Mixer Machines Mixer Machines are used in a number of different applications and industries in order to produce a final product that is the result of mixing or combining two or more materials.
Generally, size reduction and size separation are combined to obtain powder with the desired particle size distribution (PSD) for acceptable flow and compressibility for downstream processing . The mechanical process of reducing the particle size of a solid is also called milling.
Introduction
Objectives
Methods of size reduction
Advantages of size reduction
Disadvantages of size reduction
Mechanism of size reduction
Laws governing to the size reduction
Principle of Size Reduction, Construction, working and uses of following-
Hammer mill
Ball mill
Fluid Energy Mill
Edge Runner Mill
End Runner Mill
This presentation will help the students of Pharmacy in subjects like Pharmaceutics and industrial pharmacy. Hope you will find it better and helpful.
Regards
Amjad Anwar
email: amjadanwar77@gmail.com
Department of Pharmacy, University Of Malakand
Size reduction is a process of reducing large solid unit masses, coarse particles or fine particles.
Size reduction may be achieved by two methods:
1] Precipitation
2] Mechanical process
1] Precipitation method: Substance is dissolve in appropriate solvent.
2] Mechanical process: Mechanical force is introduce by using different equipments like ball mill, colloid mill etc.
SIZE REDUCTION AND FACTORS AFFECTING SIZE REDUCTION IN PHARMACEUTICAL INDUSTRYAkankshaPatel55
In the realm of pharmacy, size truly matters! Particle size reduction, often referred to as comminution, plays a crucial role in transforming raw materials into effective and readily absorbable medications. It's like shrinking giants - turning bulky substances into microscopic warriors ready to combat ailments.
Why is size reduction so important? Imagine trying to swallow a whole apple compared to taking a bite. The smaller the pieces, the greater the surface area exposed, and the faster and more efficiently something dissolves or reacts. In the world of medicine, this translates to:
Enhanced drug bioavailability: Smaller particles dissolve quicker and more readily in the digestive system, leading to faster absorption and action of the medication. Think of it as opening wider doors for the drug to enter the bloodstream and reach its target.
Improved drug stability: Smaller particles tend to be more stable and less prone to degradation, ensuring the medication's potency and effectiveness over time.
Uniformity and mixing: Precise size control allows for consistent drug distribution within a dosage form, guaranteeing accurate and reliable dosing.
Tailored drug delivery: Size reduction facilitates the development of specialized drug delivery systems, like inhalers or sublingual tablets, where minute particles are crucial for targeted action.
How is size reduction achieved? A variety of techniques are employed, each with its own advantages and best suited for specific materials:
Milling: Mechanical grinding using ball mills, hammer mills, or jet mills physically breaks down larger particles into smaller ones.
Micronization: Specialized techniques like air jet milling or fluidized bed milling achieve ultra-fine particle sizes in the micron range (1-10 micrometers).
Cryo-milling: Grinding at cryogenic temperatures minimizes heat generation, preserving sensitive drug compounds.
Size reduction isn't just about brute force. Choosing the right technique and particle size depends on various factors, including the drug's physical and chemical properties, desired release profile, and dosage form. It's a delicate dance between effectiveness, stability, and manufacturability.
The impact of size reduction extends far beyond individual medications. It enables the development of innovative drug delivery systems, like controlled-release tablets or transdermal patches, that improve patient compliance and treatment outcomes. It also plays a vital role in research and development, allowing scientists to study drug interactions and optimize formulations at the microscopic level.
So, the next time you pop a pill, remember the invisible giants behind it - the power of size reduction silently working its magic to deliver healing and hope.
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رَبِّ زدْنيِ عِلْماً (Arabic)..............Ameen.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
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Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
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The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
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2. DEFINITION:
Size reduction is the operation carried out
for reducing the size of bigger particles into
smaller one of desired size and shape with
the help of external forces.
COMMINUTION is another term used for
size reduction.
2
4. OBJECTIVES OF SIZE REDUCTION:
Increase the surface area because, in most
reactions involving solid particles, the rate of
reactions is directly proportional to the area
of contact with a second phase.
Break a material into very small particles in
order to separate the valuable amongst the
two constituents.
Achieve intimate mixing.
To dispose solid wastes easily .
To improve the handling characteristics.
To mix solid particle more intimately.
4
5. ADVANTAGES:
Content uniformity
Uniform flow
Effective drying
Increases surface area or viscosity
Uniform mixing and drying
Improve rate of absorption. Smaller the
particles greater is absorption.
Improve dissolution rate.
5
7. MECHANISM OF SIZE REDUCTION:
Impact- particle size reduced by a single
rigid force (hammer).
Compression- in this mode material is
crushed between rollers by the application
of pressure.
Attrition- arising from particles scraping
against one another or against a rigid
surface by rubbing action.
Cutting- the material is cut by means of
sharp blades. 7
10. MECHANISMS AND LAWS
The energy requirement for particle size
reduction is a function of input and output of
particle size, hardness, strength and other
properties of solids.
Various theories for energy requirement
are:-
Rittinger’s theory
Kick’s theory
Bond’s theory
10
13. RITTINGER’S THEORY
According to this theory energy E required
for size reduction of unit mass is directly
proportional to the new surface area
produced.
E=KR (Sn – Si) …. (3)
Where
• Si = initial surface area
• Sn = new specific surface area
• KR = Rittinger’s constant.
• E= amount of energy
13
14. BOND’S THEORY
According to bond theory the energy used in
crack propagation is proportional to the new
crack length produced.
It states that energy required for deforming a set
of particle of equivalent shape is proportional to
the change in particle dimensions.
14
15. KICK’S THEORY:
It states that energy required for deforming a set
of particle of equivalent shape is proportional to
the ratio of the change in particle size.
15
16. Rittinger’s theory:(n=2.0)
Energy α new surface area formed.
Bond’s theory:(n=1.5)
Energy used in crack propagation α Crack
length produced.
Energy α Ratio of change in particle
dimensions.
Kick’s theory:(n=1.0)
Energy α Ratio of change in size.
16
18. CONSTRUCTION & WORKING
Ahammer mill is essentially a steel drum containing
a vertical or horizontal rotating shaft or drum on
whichhammersare mounted.
The hammers swings on the ends or fixed to the
central rotor.
The rotor is rotates at a high speed inside the
drum while material isfed into a feed hopper.
The material is put into the hopper which is
connectedwith the drum.
The material is powdered to the desired size
due to fast rotation of hammers and is
collected under the screen.
18
19. This are mainly
operated at
2500 rpm or
1000 to 2500
rpm for the
reduction of the
large sized
particles. High
speed rotor
uses 10000 rpm
speed.
19
21. ADVANTAGES:
• It israpid in action, and iscapable of grinding many
different typesof materials.
• Theyare easyto install and operate, the operation
iscontinuous.
• There is little contamination of the product with
metal abraded from the mill as no surface move
againsteach other.
• The particle size of the material to be reduced can
be easily controlled by changing the speed of the
rotor, hammertype, shapeandsizeof the screen. 21
22. DISADVANTAGES:
Heat buildup during milling is more, therefore,
productdegradationispossible.
Hammer mills cannot be employed to mill sticky,
fibrousandhard materials.
Thescreensmayget clogged.
22
23. BALL MILL:
These are also knows as tumbling mills or
pebble mills.
Principle: The ball mill works on the
principle of impact between the rapidly
moving balls and the powder material, both
enclosed in a hollow cylinder.
At low speed the balls roll over each other
attrition will be mode of action thus in the
ball mill attrition and impact both
mechanisms takes place. 23
24. Construction:
It consists of a hollow cylinder which is mounted
on a metallic frame in such a way that it can be
rotated on its longitudinal axis.
The length of the cylinder is slightly higher than
its diameter.
The cylinder contains balls that occupy 30 to
50% of the mill volume.
The ball size depends on the size of the feed and
the diameter of the mill. Balls are made up of
steel, iron or stoneware and act as grinding
medium. 24
26. Working:
The drug to be ground is put into the cylinder of
the mill in such a quantity that it is filled to about
60% of the volume.
A fixed number of balls are introduced and the
cylinder is closed. The mill is allowed to rotate on
its longitudinal axis.
The speed of rotation is very important
26
27. Uses:
For fine grinding with a particle size of 100 to 5 mm
or less.
For production of ophthalmic and parenteral
products.
For milling dyes, pigments and insecticides at low
speed.
27
28. ADVANTAGES:
It can produce very fine powder.
Ball mill is used for both wet and dry grinding
processes.
Toxic substances can be ground, as the cylinder
is closed system.
Rod or bars can also be used as grinding media.
Sticky material are size reduced in ball mill,
Installation, operation and labor costs are low.
Since the mill is closed system used for sterile
products and oxygen sensitive products.
28
29. DISADVANTAGES:
The ball mill is a very noisy machine.
Ball mill is a slow process.
Soft, fibrous material cannot be milled by
ball mill.
29
30. FLUID ENERGY MILL/ JET MILL/ MICRONIZERS/
ULTRAFINE GRINDERS
Principle:
Fluid energy mill operates on the principle of
impact and attrition. Milling takes place because
of high velocity collisions between the suspended
particles.
Construction:
It consist of an elliptical pipe which has a height of
about 2 meters and diameter may be ranging from
20 to 200 mm. 30
32. The mill surface may be made up of either soft
stainless steel or tough ceramics.
Grinding nozzles are placed tangential and
opposed to the initial flow path of a powder.
Compressed air is used at 600 kilopascals to 1
megapascals.
Venturi feeder is provided in the path of the
airflow. An outlet with a classifier is fitted to allow
the escape of air.
32
34. Uses:
To reduce the particle size of most of drugs such
as antibiotics and vitamins.
Advantages:
It has no moving parts heat is not produced during
milling.
It is rapid and efficient method for reducing powder
to 30 mm or less.
No contamination is possible.
Disadvantages:
Not suitable for milling of soft, tacky and fibrous
material.
Equipment is expensive.
34
35. EDGE RUNNER MILL:
Principle:
The size reduction is done by crushing due to
heavy weight of stones.
Construction:
It consist of two heavy rollers and may weigh
several tons.
The roller move on a bed which is made up of
granite or stone.
Each roller has a central shaft and revolve on
its axis.
The rollers are mounted on horizontal shaft
and move around the bed.
35
37. WORKING:
The material to be ground is placed on the
bed with the help of the scrapper in such a
way that it comes in the path of the stone
wheel.
These stones revolve on its own axis and at
the same time travel around the shallow
stone bed.
The material is ground for definite period.
The powder is collected and passed through
a sieve to get powder of required size. 37
39. END RUNNER MILL:
Principle:
Size reduction is done by crushing due to
presence of heavy weight steel pestle.
Construction:
It is considered as mechanical mortar pestle.
It consist of a steel mortar which is fixed to a
plate.
The construction of mortar is connected to
horizontal shaft bearing a pulley so the plate
with mortar can be rotated at high speed.
The pestle is dumb-bell shaped and bottom of
pestle is flat.
39
41. Construction of pestle is done in such a way
that it can be raised from mortar for cleaning
and emptying.
Working:
The material to be ground is placed in the
mortar. The scraper puts the material in the
path of the pestle.
The mortar revolves at high speed and the
pestle is placed in the mortar.
The revolving mortar causes pestle to revolve.
The material is collected and passed through a
sieve to get the powder of desired size. 41