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Microbiota and Gut-Brain
Axis in Health
Presenated by
Hina Nawaz
M.Phil. (Molecular Medicine)
Table of contents
Disorders related to Gut
Dysbiosis
Crosstalk between Gut-Brain
axis
What is Gut Microbiome?
Introduction to Brain-The most
complex organ of the body
Enteric Nervous System:
Second brain of your
body
The Effects of Lifestyle on
Gut Microbiota
Composition
01
05
03
02
04
06
Introduction to Brain-The most complex
organ of the body
Venus has a beautiful
name and is the second
planet from the Sun
What is Gut Microbiome ?
 The microbes associated with human digestive-tract are referred to as the gut microbiome.
 To date, there are more than 50 bacterial phyla has been detected in the human gut.
 Microbial heterogeneity lie along the length of the GIT and it has been suggested that there is
a large number of variations existed in the composition of the microbiota in the transverse
section of intestine.
Crosstalk between
Gut-Brain axis
 The gut microbiota pathways interact with brain through Hypothalamic-pituitary-adrenal axis
(HPA axis) and autonomic nervous system (ANS). On the other hand vagus nerve and systemic
circulation microbiota-derived products, metabolites, neuroactive substances, gut hormones,
and inflammatory factors modulate the function of CNS.
 Microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), tryptophan precursors,
and metabolites may exert their central effects through interactions with host cells that express
the receptors located in various host tissues (including the gut, muscle, liver, pancreas, and
adipose tissues) or immune cells
Enteric Nervous System
Second brain of your body
 Enteric nervous system (ENS) is composed of intestinal submucosal and myenteric
plexuses.
 It may independently regulate intestinal digestive and absorptive function, and it is also
known as "the second brain" or gut brain
 ENS is connected with CNS through the feedback pathway (brain-gut-axis) of
sympathetic and parasympathetic nerves and peripheral primary sensory afferent
nerves to form the bidirectional brain-gut-axis, which may affect emotion, appetite and
behavioral states.
 In addition to aiding the movement of the digestive tract’s contents, the ENS
also controls blood flow, mucous secretions and play an important role in immune
system.
Role of Gut Neurotransmitters
 Neuroactive substances such as 5-HT, γ-aminobutyric acid (GABA),
and tryptophan metabolites play important roles in the CNS
modulation.
 These molecules could be synthesized and released by the gut
microbes.
 For example, Candida and Escherichia can utilize tryptophan in food
and produce 5-HT, and Bacillus can produce dopamine.
Disorders related to Gut Dysbiosis
Parkinson’s disease
Alzheimer’s disease
Multiple sclerosis Anxiety
Depression
Irritable bowel
syndrome (IBS)
Autism spectrum
disorder
Schizophrenia
Effects of lifestyle factors
on gut microbiota
composition
References
 Bull, M. J., & Plummer, N. T. (2014). Part 1: The Human Gut Microbiome in Health
and Disease. Integrative medicine (Encinitas, Calif.), 13(6), 17–22.
 Li, J. H., Duan, R., Li, L., Wood, J. D., Wang, X. Y., Shu, Y., & Wang, G. D.
(2020). Sheng li xue bao : [Acta physiologica Sinica], 72(3), 382–390.
 Barbosa, P. M., & Barbosa, E. R. (2020). The gut brain-axis in neurological
diseases. International Journal of Cardiovascular Sciences, 33, 528-536.
 Sun, L. J., Li, J. N., & Nie, Y. Z. (2020). Gut hormones in microbiota-gut-brain cross-
talk. Chinese medical journal, 133(7), 826–833.
 Chen, Y., Xu, J., & Chen, Y. (2021). Regulation of Neurotransmitters by the Gut
Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13(6),
2099.
Thanks!
Sindh Biotechnologists Association (SBA)

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Microbiota and Gut-Brain Axis in Health

  • 1. Microbiota and Gut-Brain Axis in Health Presenated by Hina Nawaz M.Phil. (Molecular Medicine)
  • 2. Table of contents Disorders related to Gut Dysbiosis Crosstalk between Gut-Brain axis What is Gut Microbiome? Introduction to Brain-The most complex organ of the body Enteric Nervous System: Second brain of your body The Effects of Lifestyle on Gut Microbiota Composition 01 05 03 02 04 06
  • 3.
  • 4. Introduction to Brain-The most complex organ of the body Venus has a beautiful name and is the second planet from the Sun
  • 5. What is Gut Microbiome ?  The microbes associated with human digestive-tract are referred to as the gut microbiome.  To date, there are more than 50 bacterial phyla has been detected in the human gut.  Microbial heterogeneity lie along the length of the GIT and it has been suggested that there is a large number of variations existed in the composition of the microbiota in the transverse section of intestine.
  • 7.  The gut microbiota pathways interact with brain through Hypothalamic-pituitary-adrenal axis (HPA axis) and autonomic nervous system (ANS). On the other hand vagus nerve and systemic circulation microbiota-derived products, metabolites, neuroactive substances, gut hormones, and inflammatory factors modulate the function of CNS.  Microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), tryptophan precursors, and metabolites may exert their central effects through interactions with host cells that express the receptors located in various host tissues (including the gut, muscle, liver, pancreas, and adipose tissues) or immune cells
  • 8.
  • 9. Enteric Nervous System Second brain of your body
  • 10.
  • 11.  Enteric nervous system (ENS) is composed of intestinal submucosal and myenteric plexuses.  It may independently regulate intestinal digestive and absorptive function, and it is also known as "the second brain" or gut brain  ENS is connected with CNS through the feedback pathway (brain-gut-axis) of sympathetic and parasympathetic nerves and peripheral primary sensory afferent nerves to form the bidirectional brain-gut-axis, which may affect emotion, appetite and behavioral states.  In addition to aiding the movement of the digestive tract’s contents, the ENS also controls blood flow, mucous secretions and play an important role in immune system.
  • 12. Role of Gut Neurotransmitters  Neuroactive substances such as 5-HT, γ-aminobutyric acid (GABA), and tryptophan metabolites play important roles in the CNS modulation.  These molecules could be synthesized and released by the gut microbes.  For example, Candida and Escherichia can utilize tryptophan in food and produce 5-HT, and Bacillus can produce dopamine.
  • 13.
  • 14.
  • 15. Disorders related to Gut Dysbiosis Parkinson’s disease Alzheimer’s disease Multiple sclerosis Anxiety Depression Irritable bowel syndrome (IBS) Autism spectrum disorder Schizophrenia
  • 16.
  • 17. Effects of lifestyle factors on gut microbiota composition
  • 18.
  • 19. References  Bull, M. J., & Plummer, N. T. (2014). Part 1: The Human Gut Microbiome in Health and Disease. Integrative medicine (Encinitas, Calif.), 13(6), 17–22.  Li, J. H., Duan, R., Li, L., Wood, J. D., Wang, X. Y., Shu, Y., & Wang, G. D. (2020). Sheng li xue bao : [Acta physiologica Sinica], 72(3), 382–390.  Barbosa, P. M., & Barbosa, E. R. (2020). The gut brain-axis in neurological diseases. International Journal of Cardiovascular Sciences, 33, 528-536.  Sun, L. J., Li, J. N., & Nie, Y. Z. (2020). Gut hormones in microbiota-gut-brain cross- talk. Chinese medical journal, 133(7), 826–833.  Chen, Y., Xu, J., & Chen, Y. (2021). Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13(6), 2099.