this slide focuses on all the acid base disorder pertaining to the respiratory system. it focus on the compensatory mechanism, causes, clinical features and treatment.
Concepts of acid base balance and its disorders are very important for practice of medicine.It is for the benefit of medical and students of allied fields.
this slide focuses on all the acid base disorder pertaining to the respiratory system. it focus on the compensatory mechanism, causes, clinical features and treatment.
Concepts of acid base balance and its disorders are very important for practice of medicine.It is for the benefit of medical and students of allied fields.
Short Review regarding Metabolic Acidosis
The Causes, anion gap,urine osmolal gap, Renal Tubular Acidosis, approach to Metabolic Acidosis in Final Slide
by the renowned pediatrician, Dr Satish Deopujari,
National Chairperson (Ex)
Intensive Care Chapter I A P
Founder Chairman.....
National conference on pediatric critical care
Professor of pediatrics ( Hon ) JNMC:Wardha
Nagpur : INDIA
Short Review regarding Metabolic Acidosis
The Causes, anion gap,urine osmolal gap, Renal Tubular Acidosis, approach to Metabolic Acidosis in Final Slide
by the renowned pediatrician, Dr Satish Deopujari,
National Chairperson (Ex)
Intensive Care Chapter I A P
Founder Chairman.....
National conference on pediatric critical care
Professor of pediatrics ( Hon ) JNMC:Wardha
Nagpur : INDIA
An arterial-blood gas test measures the amounts of arterial gases, such as oxygen and carbon dioxide. An ABG test requires that a small volume of blood be drawn from the radial artery with a syringe and a thin needle, but sometimes the femoral artery in the groin or another site is used.
The common indications for ABGs are:
Respiratory compromise, which leads to hypoxia or diminished ventilation.
Peri- or postcardiopulmonary arrest or collapse.
Medical conditions that cause significant metabolic derangement, such as sepsis, diabetic ketoacidosis, renal failure, heart failure, toxic substance ingestion, drug overdose, trauma, or burns.
Evaluating the effectiveness of therapies, monitoring the patient's clinical status, and determining treatment needs. For instance, clinicians often titrate oxygenation therapy, adjust the level of ventilator support, and make decisions about fluid and electrolyte therapy based on ABG results.
During the perioperative phase of major surgeries, which includes the preoperative, intraoperative, and postoperative care of the patient.
The components of an ABG analysis are PaO2, SaO2, hydrogen ion concentration (pH), PaCO2, HCO3-, base excess, and serum levels of hemoglobin, lactate, glucose, and electrolytes (sodium, potassium, calcium, and chloride).
Arterial blood gas test Diagnostic testjagan _jaggi
Arterial blood gas test
Diagnostic test
Description , An arterial-blood gas test measures the amounts of arterial gases, such as oxygen and carbon dioxide. An ABG test requires that a small volume of blood be drawn from the radial artery with a syringe and a thin needle, but sometimes the femoral artery in the groin or another site is used.
Provides a simple organized way for ABG analysis with special emphasis on Acid-base balance interpretation & its crucial rule in clinical toxicology practice.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. INTRODUCTION
¢Metabolic acidosis is a condition that occurs
when the body produces excessive quantities of
acid or when the kidneys are not removing
enough acid from the body. If unchecked,
metabolic acidosis leads to acidemia, i.e., blood
pH is low (less than 7.35) due to increased
production of hydrogen ions by the body or the
inability of the body to form bicarbonate (HCO3
−
)
in the kidney. Its causes are diverse, and its
consequences can be serious, including coma and
death. Together with respiratory acidosis, it is
one of the two general causes of acidemia.
3.
4. SIGNS AND SYMPTOMS:
¢Symptoms are not specific, and diagnosis can be
difficult unless the patient presents with clear
indications for arterial blood gas sampling. Symptoms
may include chest pain, palpitations, headache,
altered mental status such as severe anxiety due to
hypoxia, decreased visual acuity, nausea, vomiting,
abdominal pain, altered appetite and weight gain,
muscle weakness, bone pain and joint pain. Those in
metabolic acidosis may exhibit deep, rapid breathing
called Kussmaul respirations which is classically
associated with diabetic ketoacidosis. Rapid deep
breaths increase the amount of carbon dioxide
exhaled, thus lowering the serum carbon dioxide
levels, resulting in some degree of compensation.
5. ¢Extreme acidemia leads to neurological and
cardiac complications:
¢Neurological: lethargy, stupor, coma, seizures.
¢Cardiac: arrhythmias (ventricular tachycardia),
decreased response to epinephrine; both lead to
hypotension (low blood pressure).
¢Physical examination occasionally reveals signs
of disease, but is otherwise normal. Cranial nerve
abnormalities are reported in ethylene glycol
poisoning, and retinal edema can be a sign of
methanol (methyl alcohol) intoxication.
Longstanding chronic metabolic acidosis leads to
osteoporosis and can cause fractures.
6.
7. ANION GAP
¢The anion gap is the difference in the measured cations
(positively charged ions) and the measured anions
(negatively charged ions) in serum, plasma, or urine.
The magnitude of this difference (i.e., "gap") in the
serum is often calculated in medicine when attempting
to identify the cause of metabolic acidosis, a lower than
normal pH in the blood. If the gap is greater than
normal, then high anion gap metabolic acidosis is
diagnosed.
¢The term "anion gap" usually implies "serum anion gap",
but the urine anion gap is also a clinically useful
measure.
8.
9. NORMAL ANION GAP
¢In patients with a normal anion gap the drop in HCO3
−
is the primary pathology. Since there is only one other
major buffering anion, it must be compensated for
almost completely by an increase in Cl−
. This is
therefore also known as hyperchloremic acidosis.
¢The HCO3
−
lost is replaced by a chloride anion, and thus
there is a normal anion gap.
10. HIGH ANION GAP
¢The anion gap is affected by changes in unmeasured ions.
A high anion gap indicates acidosis. In uncontrolled
diabetes, there is an increase in ketoacids due to
metabolism of ketones. Ketoacids are unmeasured anions,
so there is a resulting increase in the anion gap. In these
conditions, bicarbonate concentrations decrease by acting
as a buffer against the increased presence of acids (as a
result of the underlying condition). The bicarbonate is
consumed by the unmeasured cation(H+) (via its action as
a buffer) resulting in a high anion gap.
11. LOW ANION GAP
¢A low anion gap is frequently caused by hypoalbuminemia.
Albumin is a negatively charged protein and its loss from the
serum results in the retention of other negatively charged ions
such as chloride and bicarbonate. As bicarbonate and chloride
anions are used to calculate the anion gap, there is a
subsequent decrease in the gap.
¢In hypoalbuminaemia the normal anion gap is decreased with
2.5 to 3 mmol/L per 1 g/dL decrease in serum
albumin.Common conditions that reduce serum albumin in the
clinical setting are hemorrhage nephrotic syndrome, intestinal
obstruction and liver cirrhosis.
¢The anion gap is sometimes reduced in multiple myeloma,
where there is an increase in plasma IgG (paraproteinaemia).
¢Corrections can be made for hypoalbuminemia to give an
accurate anion gap.
12. Causes of Metabolic Acidosis (classified by Anion Gap)
A: High Anion-Gap Acidosis
1. Ketoacidosis
•Diabetic ketoacidosis
•Alcoholic ketoacidosis
•Starvation ketoacidosis
2. Lactic Acidosis
•Type A Lactic acidosis (Impaired perfusion)
•Type B Lactic acidosis (Impaired carbohydrate metabolism)
3. Renal Failure
•Uraemic acidosis
•Acidosis with acute renal failure
4. Toxins
•Ethylene glycol
•Methanol
•Salicylates
CAUSES OF METABOLIC ACIDOSIS
13. B : Normal Anion-Gap Acidosis (or Hyperchloraemic acidosis)
1. Renal Causes
•Renal tubular acidosis
•Carbonic anhydrase inhibitors
2. GIT Causes
•Severe diarrhoea
•Uretero-enterostomy or Obstructed ileal conduit
•Drainage of pancreatic or biliary secretions
•Small bowel fistula
3. Other Causes
•Recovery from ketoacidosis
•Addition of HCl, NH4Cl
14.
15. PATHOPHYSIOLOGY
¢Pathophysiology of Metabolic Acidosis
¢Metabolic acidosis occurs when either an increase in
the production of nonvolatile acids or a loss of
bicarbonate from the body overwhelms the
mechanisms of acid-base homeostasis or when renal
acidification mechanisms are compromised.
¢Acid Production
¢Under normal dietary and metabolic conditions,
average net acid production is 1 mmol/kg per day in
adults and 1-3 mmol/kg per day in infants and
children. Abnormalities in intermediary metabolism,
such as those that occur in lactic acid synthesis or
ketogenesis, and ingestion of substances that are
metabolized to organic acids, such as methanol or
ethylene glycol, can increase acid production
severalfold
16. COMPENSATORY MECHANISM:
¢Metabolic acidosis is either due to increased
generation of acid or an inability to generate
sufficient bicarbonate. The body regulates the
acidity of the blood by four buffering mechanisms.
¢bicarbonate buffering system
¢Intracellular buffering by absorption of hydrogen
atoms by various molecules, including proteins,
phosphates and carbonate in bone.
¢Respiratory compensation
¢Renal compensation
17. BICARBONATE BUFFERING SYSTEM
¢The bicarbonate buffering system is an important
buffer system in the acid-base homeostasis of living
things, including humans. As a buffer, it tends to
maintain a relatively constant plasma pH and
counteract any force that would alter. In this system,
carbon dioxide (CO2) combines with water (H2O) to
form carbonic acid (H2CO3), which in turn rapidly
dissociates to form hydrogen ions (H+
) and
bicarbonate (HCO3
−
) .
¢The carbon dioxide - carbonic acid equilibrium is
catalyzed by the enzyme carbonic anhydrase; the
carbonic acid - bicarbonate equilibrium is simple
proton dissociation/association and needs no catalyst
18.
19. RESPIRATORY COMPENSATION
MECHANISM
¢Respiratory compensation is a mechanism by
which plasma pH can be altered by varying the
respiratory rate. It is faster than renal
compensation, but has less ability to restore
normal values.
¢In metabolic acidosis, chemoreceptors sense a
deranged acid-base system, and there is
increased breathing.
¢In metabolic alkalosis, the breathing rate is
decreased
20. RENAL COMPENSATION MECHANISM:
¢Renal compensation is a mechanism by which
the kidneys can regulate the plasma pH. It is
slower than respiratory compensation, but has a
greater ability to restore normal values.
¢In respiratory acidosis, the kidney produces and
excretes ammonium (NH4
+
) and monophosphate,
generating bicarbonate in the process while
clearing acid.
¢In respiratory alkalosis, less HCO3
−
is reabsorbed,
thus lowering the pH
21. ¢The decreased bicarbonate that distinguishes metabolic
acidosis is therefore due to two separate processes: the
buffer (from water and carbon dioxide) and additional
renal generation. The buffer reactions are:
¢The Henderson-Hasselbalch equation mathematically
describes the relationship between blood pH and the
components of the bicarbonate buffering system:
¢Using Henry's Law, we can say that [CO2]=0.03xPaCO2
(PaCO2 is the pressure of CO2 in arterial blood) Adding
the other normal values, we get
22. DIAGNOSIS
¢Arterial blood gas sampling is essential for the diagnosis. If
the pH is low (under 7.35) and the bicarbonate levels are
decreased (<24 mmol/l), metabolic acidemia is present, and
metabolic acidosis is presumed. Due to respiratory
compensation (hyperventilation), carbon dioxide is
decreased and conversely oxygen is increased. An ECG can
be useful to anticipate cardiac complications.
¢Other tests that are relevant in this context are
electrolytes (including chloride), glucose, renal function
and a full blood count. Urinalysis can reveal acidity
(salicylate poisoning) or alkalinity (renal tubular acidosis
type I). In addition, it can show ketones in ketoacidosis.
¢To distinguish between the main types of metabolic
acidosis, a clinical tool called the anion gap is considered
very useful. It is calculated by subtracting the chloride and
bicarbonate levels from the sodium.
23. ¢As sodium is the main extracellular cation, and
chloride and bicarbonate are the main anions, the
result should reflect the remaining anions.
Normally, this concentration is about 8-16 mmol/l
(12±4). An elevated anion gap (i.e. > 16 mmol/l)
can indicate particular types of metabolic
acidosis, particularly certain poisons, lactate
acidosis and ketoacidosis.
¢As the differential diagnosis is made, certain
other tests may be necessary, including
toxicological screening and imaging of the
kidneys. It is also important to differentiate
between acidosis-induced hyperventilation and
asthma; otherwise, treatment could lead to
inappropriate bronchodilatation.
24. TREATMENT PRINCIPLES
¢ The most important approach to managing a metabolic acidosis is to treat the
underlying disorder. Then with supportive management, the body will correct the
acid-base disorder. Accurate analysis & diagnosis is essential to ensure the correct
treatment is used. Fortunately, in most cases this is not particularly difficult in
principle. Remember though that a patient with a severe metabolic acidosis may
be very seriously ill and even with optimal management the patient may not
survive.
¢ The ECLS Approach to Management of Metabolic Acidosis
¢ 1. Emergency: Emergency management of immediately life-threatening conditions
always has the highest priority. For example, intubation and ventilation for airway
or ventilatory control; CPR ( cardiopulmonary resuscitation ); severe
hyperkalaemia
¢ 2. Cause: Treat the underlying disorder as the primary therapeutic goal.
Consequently, accurate diagnosis of the cause of the metabolic acidosis is very
important. I n some cases (e.g. methanol toxicity) there may be a substantial delay
become the diagnosis can be confirmed so management must be based on
suggestive evidence otherwise it will be too late.
¢ 3. Losses Replace losses (e.g. of fluids and electrolytes) where appropriate. Other
supportive care (oxygen administration) is useful. I n most cases, sodium
bicarbonate is NOT necessary, NOT helpful, and may even be harmful so is not
generally recommended.
25. ¢4. Specifics There are often specific problems or
complications associated with specific causes or specific
cases which require specific management. For example:
Ethanol blocking treatment with methanol ingestion;
haemodialysis can remove some toxins.
¢Some examples of specific treatments for underlying
disorders:
¢Fluid, insulin and electrolyte replacement is necessary for
diabetic ketoacidosis
¢Administration of bicarbonate and dialysis may be
required for acidosis associated with renal failure.
¢Restoration of an adequate intravascular volume and
peripheral perfusion is necessary in lactic acidosis.
¢The detailed treatment of the various specific disorders is
not considered here, but the important message is that
the treatment of each underlying disorder differs so an
accurate diagnosis is essential for selection of correct
treatment. Treatment of the underlying disorder will
result in correction of the metabolic acidosis (i.e. the
bicarbonate level will return to normal).