The document discusses anaesthesia for emergency surgery. It defines different categories of emergency based on the urgency of the surgery from immediate to elective. Issues related to emergency anaesthesia include limited preparation time, risk of aspiration, potential difficult airway, hypovolemia, coagulopathy, and co-existing medical problems. Anaesthesia for trauma surgery focuses on the primary survey, risks of hypothermia and aspiration, and uses rapid sequence induction. Anaesthesia for non-trauma emergency surgery emphasizes pre-operative optimization, and may use regional techniques like epidurals or awake fibreoptic intubation depending on the clinical situation.
Assessment and management of shock in acute trauma setting based on ATLS recommendations .Lecture given in Trauma update at Perintalmanna on19th August 2014.
This powepoint is aimed at undergraduate medical education. It gives information regarding the orhtopedic principles of management of closed and open fractures
Assessment and management of shock in acute trauma setting based on ATLS recommendations .Lecture given in Trauma update at Perintalmanna on19th August 2014.
This powepoint is aimed at undergraduate medical education. It gives information regarding the orhtopedic principles of management of closed and open fractures
Post-Cardiac Arrest Syndrome:
Epidemiology, Pathophysiology, Treatment, and Prognostication
A Consensus Statement From the International Liaison Committee on Resuscitation
Circulation. 2008;118:2452-2483
classification of soft tissue injuries. gustilo anderson classification, tscheren classification, hanover fracture scale and ao soft tissue grading system, types of wounds. orthopedic open fracture classification for management of soft tissue injuries
SUMMARY:
- Neurophysiologic monitoring not universally adopted but in many centers has become routine monitor for some surgical procedures
- Ideal neurophysiologic monitoring in the neurosurgical procedure should be: non-invasive (v.s invasive), high sensitivity & specificity, cost effective, easy to use, simple instrumentation, and real time or continous monitoring.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
Post-Cardiac Arrest Syndrome:
Epidemiology, Pathophysiology, Treatment, and Prognostication
A Consensus Statement From the International Liaison Committee on Resuscitation
Circulation. 2008;118:2452-2483
classification of soft tissue injuries. gustilo anderson classification, tscheren classification, hanover fracture scale and ao soft tissue grading system, types of wounds. orthopedic open fracture classification for management of soft tissue injuries
SUMMARY:
- Neurophysiologic monitoring not universally adopted but in many centers has become routine monitor for some surgical procedures
- Ideal neurophysiologic monitoring in the neurosurgical procedure should be: non-invasive (v.s invasive), high sensitivity & specificity, cost effective, easy to use, simple instrumentation, and real time or continous monitoring.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
Edward Fohrman shares some valuable insight into the postanesthesia recovery process.
For information about Edward and his work, visit EdwardFohrman.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Content
▪ Definition
▪ Issues related to emergency surgery
▪ Anaesthesia for trauma surgery
▪ Anaesthesia for non-trauma surgery
3. NCEPOD Classification of Intervention
Category Description Target time to
theatre
Example
Immediate Immediate life/limb or
organ-saving intervention
Resuscitation simultaneous
with surgical treatment
Within
minutes of
decision to
operate
Ruptured aortic aneurysm
Major trauma to abdomen or thorax
Fracture with major neurovascular deficit
Compartment syndrome
Acute myocarial infraction (AMI)
Urgent Acute onset or deterioration of
conditions that threaten life,
limb or organ survival; fixation
of fractures; relief of distressing
symptoms
Within hours
of decision to
operate and
normally once
resuscitation
completed
Compound fracture
Perforated bowel with peritonitis
Critical organ or limb ischaemia
Acute coronary syndromes (ACS)
Perforating eye injuries
Expedited Stable patient requiring early
intervention for a condition that
is not an immediate threat
to life, limb or organ survival
Within days of
decision to
operate
Tendon and nerve injuries
Stable & non-septic patients for wide range
of surgical procedures
Retinal detachment
Elective Surgical procedure planned or
booked in advance of routine
admission to hospital
Planned Encompasses all conditions not classified
as immediate, urgent or expedited.
4. Emergency Anaesthesia
▪ To identify and , if time
permits, correct major
physiological abnormalities
preoperatively.
▪ Be prepared for potential
complications arising as a
consequence of anaesthesizing
a patient in suboptimal
conditions.
5. Issues Related to Emergency
Anaesthesia
1. Limited time for preparation
2. Risk of aspiration
3. Potential difficult airway
4. Hypovolemia
5. Coagulopathy
6. Co-existing medical problems
6. 1. Limited time for preparation
⚫ Anticipate potential difficulties – unable to formulate a
suitable perioperative plan to avoid or minimize crisis
⚫ To ensure patient is medically fit and stable for surgery and
anaesthesia via preoperative optimization
⚫ Deciding the appropriate equipment, number of staff who will
be during administration of anaesthesia related to individual
comorbidities and type of surgery
⚫ Achieving a fully informed patient and to obtain consent
regarding planned anaesthetic technique
7. 2.Risk of Aspiration
▪ May have delayed gastric emptying/abnormal
peristalsis
▪ Rate of gastric emptying influences the risk of
PONV.
▪ Slowed by: anxiety, pain, mechanical obstruction, labour, drugs
(opioids, anticholinergic)
▪ Increased by: gastric distension, drug (metoclopramide)
6 hours Solid food, formula milk, other milk
4 hours Breast milk
2 hours Clear non-particulate and non-carbonated fluid
10. 4.Hypovolemia
▪ Blood loss
▪ GI loss – usually accompanied with electrolyte
imbalance
▪ Requires resuscitation with crystalloid, colloid
or blood before and during surgery.
▪ Complications:
▪ Difficult IV access
▪ Shock
▪ Multiorgan failure
▪ Cardiac arrest, death
11. 5.Coagulopathy
▪ Massive blood loss – major trauma; obstetric
haemorrhage
▪ Patient on anticoagulants requiring emergency
surgery
▪ Dilutional coagulopathy
▪ Complications:
▪ Uncontrolled bleeding
▪ Shock
▪ Death
12. 6.Co-existing Medical Conditions
▪ Unknown medical condition in unconscious patients
▪ Limited time to elicit further medical history
▪ Conditions not optimised – bronchial asthma, HPT,
IHD, CCF, DM
13. Anaesthesia for Trauma Surgery
▪ Primary Survey – Airway,
Cervical Spine Control, Breathing
▪ Assume all trauma patient at risk of
cervical spine injuries until proven
otherwise.
▪ Do not try to intubate with a cervical
collar in place.
▪ Perform manual in line immobilization
during intubation.
▪ Insert chest drain simultaneously
/before mechanical ventilation started
if signs suggestive of pneumothorax or
surgical emphysema
15. Anaesthesia for Trauma Surgery
▪ Circulation
▪ Difficult peripheral IV access🡪
external jugular/ femoral vein.
▪ Early use of blood products in
those with massive bleeding.
▪ Warm IV fluids 🡪avoid
hypothermia.
▪ Adverse effects of hypothermia:
▪ Gradual decline in heart rate
and cardiac output.
▪ Left-sided shift of
oxyhaemoglobin dissociation
curve – reduced peripheral O2
delivery.
▪ Shivering compounds lactic
acidosis.
▪ Impair coagulation.
▪ Disability
▪ Rapid neurological
assessment
▪ Pupil size and reaction to
light.
▪ GCS
▪ Exposure/
Environmental Control
▪ Undress patient completely
▪ Protect from hypothermia with
warm blankets
▪ Secondary Survey
▪ A detailed head-to-toe survey
of a trauma patient is not
undertaken until vital signs
are relatively stable.
16. Anaesthesia for Trauma Surgery
▪ Risk of aspiration of
gastric content must be
weighed against risk of
delaying an urgent
procedure.
▪ Nasogastric /orogastric
tube : decompress stomach
and to provide a low
pressure vent for
regurgitation
▪ Rapid sequence
intubation
▪ Regional Anaesthesia
▪ May be considered as an
adjunct.
▪ Often impractical due to
preoperative urgency,
haemodynamic instability
and coagulopathy.
17. Rapid Sequence Induction
▪ Aim to minimise
duration of time between
loss of consciousness and
tracheal intubation (period
during which patient is at
greatest risk of aspiration).
▪ Pre-oxygenation to
denitrogenate the lung
and to maximise oxygen
reservoir so that onset of
hypoxia will be delayed.
▪ Requires a skilled assistant
to perform cricoid
pressure (Sellick’s
manoeuvre).
18. Rapid Sequence Induction
▪ Pre-calculated dose of IV anaesthetic induction agent
▪ Neuromuscular blocking agents without waiting to
assess the effect of induction.
▪ As soon as the jaw is relaxed or fasciculation has
stopped, direct laryngoscopy and tracheal intubation are
performed.
▪ Maintain cricoid pressure till confirm correct placement
of ETT
▪ Disadvantage of RSI:
▪ Haemodynamic instability if the dose of induction agent is
excessive (hypotension, circulatory collapse) or inadequate
(hypertension, tachycardia).
20. Intraoperative Monitoring
Indications for
postoperative ICU
admission and ventilation
▪ Standard monitoring
▪ Insertion of arterial line
for IABP and ABG
monitoring
▪ Unstable haemodynamic
status
▪ Head injuries requiring
cerebral protection
▪ Overt gastric acid
aspiration
▪ Severe chest injuries
▪ Massive blood loss with
DIVC with massive
blood transfusion
Anaesthesia for Trauma Surgery
21. Anaesthesia for Non-Trauma
Surgery
▪ Pre-operative Management
▪ History and physical examination to assess pre-morbidities
▪ Relevant investigations
▪ Optimise patient’s conditions
▪ Volume status / fluid deficit
▪ Electrolytes
▪ Haematological indices – Hb, platelet, coagulation profile
▪ Fasting time
22. Anaesthesia for Non-Trauma Surgery
▪ Rapid sequence induction
▪ Awake fiberoptic intubation
▪ Regional anaesthesia
▪ Subarachoid anaesthesia
▪ Epidural anaesthesia
▪ Combined spinal and epidural anaesthesia
▪ Nerve blocks
▪ A common surgical misconception that subarachnoid or
epidural blocks are safer than GA for patients in poor
physical conditions.
25. Regional anaesthesia
Epidural Spinal
High dose ( 10-20ml) Low dose ( 1.5- 2ml)
Slow onset ( 25-30m) Fast onset ( 5min)
Do not cause significant
neuromuscular block
Cause significant
neuromuscular block
Possible for multiple
dosage
Single dose only
can be given at various
point of backbone
Below L1/L2 level ( avoid
spinal cord damage)
26. Combined spinal epidural
Two method :
▪Two- level technique
▪Epidural catheter inserted first
and tested, then spinal done
one/ two interspace below level
of epidural
▪+: able to test epidural catheter
▪-: trauma/ discomfort from
multilevel injection
▪Single level insertion:
▪Needle –through-needle
technique (using epidural
needle as introducer for spinal
needle)