This document provides an overview of preoperative anesthetic assessment and premedication. It discusses the objectives of the preoperative evaluation, which includes obtaining a full medical history and physical exam and understanding how patient comorbidities may impact the anesthetic plan. Key aspects of the history that are covered include cardiovascular, respiratory, neurological and other medical conditions, as well as drug allergies and social history. Elements of the physical exam like airway assessment are also outlined. Guidelines for additional preoperative testing and medical referrals are provided. Factors that increase perioperative mortality risk are noted. The goals and components of informed consent, premedication and the perioperative patient journey are summarized.