HELLO GUYS, THIS PRESENTATION IS ABOUT CONVENTIONAL CONTRAST STUDY USED IN RADIOGRAPHY FOR EXAMINING LOWER URINARY TRACT AND TO CHECK VARIOUS PATHOLOGIES OR VESICO URETRO REFLUX. CONTRAST MEDIA IS USED TO VISUALIZE THE TRACT. M.C.U. is also known as Voiding Cystourography.
HELLO GUYS, THIS PRESENTATION IS ABOUT CONVENTIONAL CONTRAST STUDY USED IN RADIOGRAPHY FOR EXAMINING LOWER URINARY TRACT AND TO CHECK VARIOUS PATHOLOGIES OR VESICO URETRO REFLUX. CONTRAST MEDIA IS USED TO VISUALIZE THE TRACT. M.C.U. is also known as Voiding Cystourography.
A presentation about Imaging the urinary tract using contrast.
contains 45 slides, and covers the following methods :
1 - Antegrade urography
2 - Retrograde urography
3 - Retrograde cystography
4 - Voiding cystography
5 - Retrograde Urethrography
Intravenous urography is covered in a separate presentation, that you can read and download from here :
http://www.slideshare.net/abdallamutwakil/intravenous-urography-ivu-35107052
This presentation was prepared and presented by me in the tutorials of the Radiology Department of Sebha Medical Center.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
1. SHARDA UNIVERSITY
PREP BY : AASIF MAJEED LONE
email: fisaalone99@gmail.com
MCU
MICTURATING
CYSTOURETHROGRAM
2. MICTURATING
CYSTOURETHROGRAM
• Voiding cystourethrogram
demonstrates the
lower urinary tract & helps to detect
VUR ,
bladder pathology , congenital or
aquired
anamolies of bladder
• It is performed by passing a catheter
through
the urethra into the bladder, filling the
bladder with contrast material and then
taking
radiographs while the patient voids.
3. INDICATIONS
• CHILDREN:
• RECURRENT UTI
• VOIDING DIFFUCULTIES
• VUR
• MENINGOMYELOCELE, SACRAL
AGENESIS,
RECTAL ANAMOLIES
• BASELINE STUDY PRIOR TO
LOWER URINARY
TRACT SURGERY
4. • POST OP EVALUATION OF
URETERIC
ABNORMALITIES
• PELVIC TRAUMA
• IN RENAL FAILURE TO EXCLUDE
REFLUX
• POSTERIOR URETHRAL VALVE OR
POLYP
• CONGENITAL ANAMOLIES OF
BLADDER &
URETHRA.
5. ADULTS
• Trauma to urethra
• Urethral stricture
• Urethral diverticulum
• Recurrent UTI
• Reflux nephropathy prior to renal
transplant
• Follow up patients of spinal cord
injury
• Stress incontinience
6. Contrast media
• The estimated volume of contrast medium to be
given during the
examination is determined mainly by the age of the
child except for
children less than one year of age in whom it is
determined by
weight.
Less than one year,
Weight (kg) × 7 = capacity (ml)
Less than two years,
(2 × age in years + 2) × 30 = capacity (ml)
More than two years,
(Age in years/2 + 6) × 30 = capacity (ml)
7. • Contrast media: Water soluble
contrast media
like urograffin 60% is used which is
diluted
with normal saline in 1:3 ratio.
EQUIPMENT
- Preferably under fluroscopy.
- Foley`s catheter & syringe
- In infants – feeding tube no 5 – 7 F
• Preparation : none , rule out acute UTI.
8. Procedure
• Using a sterile technique , a catheter is
introduced into
the bladder.
• A 5f feeding tube with side holes are
used for children
and in older children or adults 8f r 10 f
catheters are
used .
• In girls after initial inspection of
perineum to identify
any local genitilia abnormalities
(cystoceles or labial
fusion ) the catheter is introduced..
• When it enters the bladder a varying
amount of urine
will flow through it .if no flow a catheter is
introduced
9. till urine is obtained.
Suprapubic pressure Is sometimes helpful.
In males , foreskin is retracted and
catheter is introduced .
The catheter should be lubricated with
anaesthetic jelly
and inserted slowly and gently into the
urthera holding the
penis is vertical position .
The normal bladder capacity in children is
estimated to be
1 ounce ie 29 cc .
For newborns -30 to 35 cc can be instilled.
• For upto 3 yrs – 200 to 250 cc
Adequate capacity is reached when the
child becomes
uncomfortable and begins voiding around the
catheter.
Bladder capacity (in milliliters) is variable
but can often be
10. predicted with the previous mentioned
formula
Filming
In children : upto 2 yrs of age bladder is
filled by hand
injection . For older children contrast medium is
instilled from
a bottle elevated one metre above the
examination table.
During filming , fluroscopic screening is
performed at short
intervals to see any vu reflux ,diverticuli .
The child is turned oblique on both sides to
ensure that
minimal reflux is not overlooked.
In infants : voiding starts the moment
catheter is removed. At
the end of voiding ,frontal film is taken which
includes entire
11. abdomen including the kidney region to
prevent overlooking
the vu reflux which is apparent only on
termination of voiding
and may reach upper collecting system.
In adult male : bladder is filled in
the usual
way as in older child and voiding
filming
done in both oblique projection
views.
The voiding study in male adults
can be
modified by getting the patient to
void
resistance i.e. by compression of
distal
13. ALTERNATE
TECHNIQUES
1) SUPRAPUBIC BLADDER
PUNCTURE.
Sometimes in PUV & pelvic trauma –
not possible to catheterize.
2) URETHROCYSTOGRAPHY
Contrast medium introduced into the
bladder during RGU.
3) EXCRETION MCU ( MCU
followed by IVU )
Advantage – avoid catheterization and
related risk of infection.
Disadvantage - VUR can not be
visualized properly .
takes longer time.
14. Excretion MCU : (MCU
followed by
IVP)
• This method makes use of contrast
media accumulated
in the urinary bladdder during ivp
• Advantages : avoidance of physical and
psychological
trauma of catherization
• Avoidance of infection
• More physiological procedure hence
more reliable.
• Disadvatanges : visualization is not
usually adequate
• Takes longer time
• Vu reflux visualised poorly.
15. COMPICATIONS
Contrast reaction.
Contrast induced cystitis.
UTI.
Catheter trauma.
Bladder perforation –
overfilling.
Retention of a foley catheter.
Catheterisation of vagina /
ectopic ureter.
Radiation exposure
Autonomic dysreflexia- in
paraplegic patients due
16. to spinal cord injury at or above
t6 level, forceful
injection of contrast causes
severe headache
,sweating ,hypertension with
bradycardia due to
forceful opening of bladder
neck
18. Posterior urethral
valves
Congenital thick folds of mucous
membrane located in the posterior
urethra
prostatic + membranous) distal to the
verumontanum.
Most common cause of severe
obstructive uropathy in children.
Almost exclusively in males.
Leading cause of end stage renal disease
in boys.
Now rare for them to present with severe
UTI and septicaemia -diagnosis is
generally made in early infancy and
antenatal period.
19. Micturiting cystourethrography
Procedure of choice for defining the
valves.
Indication -Thick walled bladder &
dilated ureters on USG.
Combination of ultrasound and MCU
allows both urologist and
nephrologist to plan immediate
management.
Repeated 3 months after ablation.
23. Posterior urethral valve -image shows a
dilated posterior urethra with an abrupt
transition to a normal-calibre anterior urethra
with bladder neck hypertrophy, the irregular
trabeculated bladder wall, and the left-sided
grade III vesicoureteric reflux.
24. Urachal diverticulum :
• persistence of a segment of the
urachus,
present as a protrusion at the
vertex of the
bladder. It may predispose to
urolith
formation.
26. Prostatic utricle
• The prostatic utricle is a small,
blind-ending
midline pouch arising from the
prostatic
urethra at the level of the
verumontanum
• A large prostatic utricle may be
associated
with urinary retention, stasis, and
infection
27. MCU image shows a diverticulum resulting from spontaneous
opacification of a prostatic utricle